PPP3CB: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Underlinked|date=June 2016}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform''' ('''PP2BB''') is an [[enzyme]] that in humans is encoded by the ''PPP3CB'' [[gene]].<ref>{{UniProt Full|P16298|Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform}}</ref><ref name="pmid1659808">{{cite journal | vauthors = Giri PR, Higuchi S, Kincaid RL | title = Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit | journal = Biochem Biophys Res Commun | volume = 181 | issue = 1 | pages = 252–8 |date=Jan 1992 | pmid = 1659808 | pmc = | doi =10.1016/S0006-291X(05)81410-X }}</ref><ref name="pmid2558868">{{cite journal | vauthors = Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB | title = Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase | journal = DNA | volume = 8 | issue = 9 | pages = 675–82 |date=Mar 1990 | pmid = 2558868 | pmc =  | doi =  10.1089/dna.1.1989.8.675}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5532| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
| HGNCid = 9315
| Symbol = PPP3CB
| AltSymbols =; CALNA2; CALNB
| OMIM = 114106
| ECnumber = 
| Homologene = 56429
| MGIid = 107163
| GeneAtlas_image1 = PBB_GE_PPP3CB_209817_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPP3CB_202432_at_tn.png
| Function = {{GNF_GO|id=GO:0004721 |text = phosphoprotein phosphatase activity}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
  | Component = {{GNF_GO|id=GO:0005955 |text = calcineurin complex}}  
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006351 |text = transcription, DNA-dependent}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0030217 |text = T cell differentiation}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5532
    | Hs_Ensembl = ENSG00000107758
    | Hs_RefseqProtein = NP_066955
    | Hs_RefseqmRNA = NM_021132
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 74866192
    | Hs_GenLoc_end = 74925765
    | Hs_Uniprot = P16298
    | Mm_EntrezGene = 19056
    | Mm_Ensembl = ENSMUSG00000021816
    | Mm_RefseqmRNA = NM_008914
    | Mm_RefseqProtein = NP_032940
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 19288592
    | Mm_GenLoc_end = 19335096
    | Mm_Uniprot = Q3UXV4
  }}
}}
'''Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform''', also known as '''PPP3CB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5532| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
Line 56: Line 9:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chen MX, Chen YH, Cohen PT |title=Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases. |journal=FEBS Lett. |volume=306 |issue= 1 |pages= 54-8 |year= 1992 |pmid= 1321058 |doi=  }}
*{{cite journal  | vauthors=Chen MX, Chen YH, Cohen PT |title=Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases. |journal=FEBS Lett. |volume=306 |issue= 1 |pages= 54–8 |year= 1992 |pmid= 1321058 |doi=10.1016/0014-5793(92)80836-6 }}
*{{cite journal  | author=Giri PR, Higuchi S, Kincaid RL |title=Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. |journal=Biochem. Biophys. Res. Commun. |volume=181 |issue= 1 |pages= 252-8 |year= 1992 |pmid= 1659808 |doi=  }}
*{{cite journal  | vauthors=McPartlin AE, Barker HM, Cohen PT |title=Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta. |journal=Biochim. Biophys. Acta |volume=1088 |issue= 2 |pages= 308–10 |year= 1991 |pmid= 1848109 |doi=  10.1016/0167-4781(91)90069-x}}
*{{cite journal  | author=McPartlin AE, Barker HM, Cohen PT |title=Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta. |journal=Biochim. Biophys. Acta |volume=1088 |issue= 2 |pages= 308-10 |year= 1991 |pmid= 1848109 |doi= }}
*{{cite journal  | vauthors=Guerini D, Klee CB |title=Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 23 |pages= 9183–7 |year= 1990 |pmid= 2556704 |doi=10.1073/pnas.86.23.9183  | pmc=298458  }}
*{{cite journal  | author=Guerini D, Klee CB |title=Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 23 |pages= 9183-7 |year= 1990 |pmid= 2556704 |doi=  }}
*{{cite journal  | vauthors=Shibasaki F, McKeon F |title=Calcineurin functions in Ca(2+)-activated cell death in mammalian cells. |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 735–43 |year= 1995 |pmid= 7593193 |doi=10.1083/jcb.131.3.735  | pmc=2120616 }}
*{{cite journal  | author=Guerini D, Krinks MH, Sikela JM, ''et al.'' |title=Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase. |journal=DNA |volume=8 |issue= 9 |pages= 675-82 |year= 1990 |pmid= 2558868 |doi=  }}
*{{cite journal  | vauthors=Muramatsu T, Kincaid RL |title=Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha). |journal=Biochim. Biophys. Acta |volume=1178 |issue= 1 |pages= 117–20 |year= 1993 |pmid= 8392375 |doi=10.1016/0167-4889(93)90117-8 }}
*{{cite journal | author=Shibasaki F, McKeon F |title=Calcineurin functions in Ca(2+)-activated cell death in mammalian cells. |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 735-43 |year= 1995 |pmid= 7593193 |doi= }}
*{{cite journal   |vauthors=Kissinger CR, Parge HE, Knighton DR, etal |title=Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. |journal=Nature |volume=378 |issue= 6557 |pages= 641–4 |year= 1996 |pmid= 8524402 |doi= 10.1038/378641a0 }}
*{{cite journal | author=Muramatsu T, Kincaid RL |title=Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha). |journal=Biochim. Biophys. Acta |volume=1178 |issue= 1 |pages= 117-20 |year= 1993 |pmid= 8392375 |doi=  }}
*{{cite journal   |vauthors=Wang MG, Yi H, Guerini D, etal |title=Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 236–41 |year= 1997 |pmid= 8978785 |doi=10.1159/000134198 }}
*{{cite journal | author=Kissinger CR, Parge HE, Knighton DR, ''et al.'' |title=Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. |journal=Nature |volume=378 |issue= 6557 |pages= 641-4 |year= 1996 |pmid= 8524402 |doi= 10.1038/378641a0 }}
*{{cite journal   |vauthors=Sun L, Youn HD, Loh C, etal |title=Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. |journal=Immunity |volume=8 |issue= 6 |pages= 703–11 |year= 1998 |pmid= 9655484 |doi=10.1016/S1074-7613(00)80575-0  }}
*{{cite journal | author=Wang MG, Yi H, Guerini D, ''et al.'' |title=Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 236-41 |year= 1997 |pmid= 8978785 |doi=  }}
*{{cite journal   |vauthors=Aramburu J, Garcia-Cózar F, Raghavan A, etal |title=Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. |journal=Mol. Cell |volume=1 |issue= 5 |pages= 627–37 |year= 1998 |pmid= 9660947 |doi=10.1016/S1097-2765(00)80063-5 }}
*{{cite journal | author=Sun L, Youn HD, Loh C, ''et al.'' |title=Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. |journal=Immunity |volume=8 |issue= 6 |pages= 703-11 |year= 1998 |pmid= 9655484 |doi= }}
*{{cite journal   |vauthors=Okamura H, Aramburu J, García-Rodríguez C, etal |title=Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. |journal=Mol. Cell |volume=6 |issue= 3 |pages= 539–50 |year= 2000 |pmid= 11030334 |doi=10.1016/S1097-2765(00)00053-8  }}
*{{cite journal  | author=Aramburu J, Garcia-Cózar F, Raghavan A, ''et al.'' |title=Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. |journal=Mol. Cell |volume=1 |issue= 5 |pages= 627-37 |year= 1998 |pmid= 9660947 |doi=  }}
*{{cite journal  | vauthors=Frey N, Richardson JA, Olson EN |title=Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14632–7 |year= 2001 |pmid= 11114196 |doi= 10.1073/pnas.260501097 | pmc=18970 }}
*{{cite journal | author=Okamura H, Aramburu J, García-Rodríguez C, ''et al.'' |title=Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. |journal=Mol. Cell |volume=6 |issue= 3 |pages= 539-50 |year= 2000 |pmid= 11030334 |doi= }}
*{{cite journal   |vauthors=Esau C, Boes M, Youn HD, etal |title=Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. |journal=J. Exp. Med. |volume=194 |issue= 10 |pages= 1449–59 |year= 2001 |pmid= 11714752 |doi=10.1084/jem.194.10.1449  | pmc=2193671  }}
*{{cite journal  | author=Frey N, Richardson JA, Olson EN |title=Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14632-7 |year= 2001 |pmid= 11114196 |doi= 10.1073/pnas.260501097 }}
*{{cite journal  | vauthors=Frey N, Olson EN |title=Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13998–4004 |year= 2002 |pmid= 11842093 |doi= 10.1074/jbc.M200712200 }}
*{{cite journal | author=Esau C, Boes M, Youn HD, ''et al.'' |title=Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. |journal=J. Exp. Med. |volume=194 |issue= 10 |pages= 1449-59 |year= 2001 |pmid= 11714752 |doi=  }}
*{{cite journal   |vauthors=Banerjee A, Banks AS, Nawijn MC, etal |title=Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp. |journal=J. Immunol. |volume=168 |issue= 9 |pages= 4277–81 |year= 2002 |pmid= 11970967 |doi=  10.4049/jimmunol.168.9.4277}}
*{{cite journal | author=Frey N, Olson EN |title=Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13998-4004 |year= 2002 |pmid= 11842093 |doi= 10.1074/jbc.M200712200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Banerjee A, Banks AS, Nawijn MC, ''et al.'' |title=Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp. |journal=J. Immunol. |volume=168 |issue= 9 |pages= 4277-81 |year= 2002 |pmid= 11970967 |doi=  }}
*{{cite journal  | vauthors=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=10.1006/viro.2002.1676 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Genescà L, Aubareda A, Fuentes JJ, etal |title=Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. |journal=Biochem. J. |volume=374 |issue= Pt 2 |pages= 567–75 |year= 2003 |pmid= 12809556 |doi= 10.1042/BJ20030267 | pmc=1223619 }}
*{{cite journal | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174-80 |year= 2003 |pmid= 12482669 |doi=  }}
*{{cite journal   |vauthors=Bell O, Gaberman E, Kilav R, etal |title=The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. |journal=Mol. Endocrinol. |volume=19 |issue= 2 |pages= 516–26 |year= 2005 |pmid= 15514034 |doi= 10.1210/me.2004-0108 }}
*{{cite journal  | author=Genescà L, Aubareda A, Fuentes JJ, ''et al.'' |title=Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. |journal=Biochem. J. |volume=374 |issue= Pt 2 |pages= 567-75 |year= 2003 |pmid= 12809556 |doi= 10.1042/BJ20030267 }}
*{{cite journal | author=Bell O, Gaberman E, Kilav R, ''et al.'' |title=The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. |journal=Mol. Endocrinol. |volume=19 |issue= 2 |pages= 516-26 |year= 2005 |pmid= 15514034 |doi= 10.1210/me.2004-0108 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{WikiDoc Sources}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-10-stub}}

Latest revision as of 18:36, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.[1][2][3][4]


References

  1. ↑ Universal protein resource accession number P16298 for "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform" at UniProt.
  2. ↑ Giri PR, Higuchi S, Kincaid RL (Jan 1992). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit". Biochem Biophys Res Commun. 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808.
  3. ↑ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.
  4. ↑ "Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=PPP3CB&oldid=1414247"