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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''TATA-binding protein-associated factor 172''' is a [[protein]] that in humans is encoded by the ''BTAF1'' [[gene]].<ref name="pmid9342322">{{cite journal | vauthors = van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT | title = Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 22 | pages = 11827–32 | date = Dec 1997 | pmid = 9342322 | pmc = 23617 | doi = 10.1073/pnas.94.22.11827 }}</ref><ref name="pmid9488487">{{cite journal | vauthors = Chicca JJ, Auble DT, Pugh BF | title = Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1 | journal = Mol Cell Biol | volume = 18 | issue = 3 | pages = 1701–10 | date = Mar 1998 | pmid = 9488487 | pmc = 108885 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9044| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)
| HGNCid = 17307
| Symbol = BTAF1
| AltSymbols =; KIAA0940; MGC138406; MOT1; TAF(II)170; TAF172; TAFII170
| OMIM = 605191
| ECnumber = 
| Homologene = 31978
| MGIid = 2147538
| GeneAtlas_image1 = PBB_GE_BTAF1_209430_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9044
    | Hs_Ensembl = ENSG00000095564
    | Hs_RefseqProtein = NP_003963
    | Hs_RefseqmRNA = NM_003972
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 93673716
    | Hs_GenLoc_end = 93780058
    | Hs_Uniprot = O14981
    | Mm_EntrezGene = 107182
    | Mm_Ensembl = ENSMUSG00000040565
    | Mm_RefseqmRNA = XM_001001026
    | Mm_RefseqProtein = XP_001001026
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 37051590
    | Mm_GenLoc_end = 37077897
    | Mm_Uniprot = 
  }}
}}
'''BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)''', also known as '''BTAF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9044| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9044| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
BTAF1 has been shown to [[Protein-protein interaction|interact]] with [[TATA binding protein]].<ref name=pmid9488487 /><ref name=pmid9159119>{{cite journal | vauthors = Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD | title = BRCA1 is a component of the RNA polymerase II holoenzyme | journal = [[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] | volume = 94 | issue = 11 | pages = 5605–10 | date = May 1997 | pmid = 9159119 | pmc = 20825 | doi = 10.1073/pnas.94.11.5605 }}</ref>
 
== References ==
{{Reflist}}
 
==External links==
* {{UCSC gene info|BTAF1}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zhou Q, Sharp PA | title = Novel mechanism and factor for regulation by HIV-1 Tat | journal = EMBO J. | volume = 14 | issue = 2 | pages = 321–8 | year = 1995 | pmid = 7835343 | pmc = 398086 | doi =  }}
| citations =
* {{cite journal | vauthors = Parada CA, Yoon JB, Roeder RG | title = A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro | journal = J. Biol. Chem. | volume = 270 | issue = 5 | pages = 2274–83 | year = 1995 | pmid = 7836461 | doi = 10.1074/jbc.270.5.2274 }}
*{{cite journal | author=Zhou Q, Sharp PA |title=Novel mechanism and factor for regulation by HIV-1 Tat. |journal=EMBO J. |volume=14 |issue= 2 |pages= 321-8 |year= 1995 |pmid= 7835343 |doi=  }}
* {{cite journal | vauthors = Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB | title = Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function | journal = J. Virol. | volume = 68 | issue = 11 | pages = 7188–99 | year = 1994 | pmid = 7933101 | pmc = 237158 | doi =  }}
*{{cite journal | author=Parada CA, Yoon JB, Roeder RG |title=A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro. |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2274-83 |year= 1995 |pmid= 7836461 |doi= }}
* {{cite journal | vauthors = Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang CM, Roeder RG, Brady JN | title = Direct interaction of human TFIID with the HIV-1 transactivator tat | journal = Nature | volume = 367 | issue = 6460 | pages = 295–9 | year = 1994 | pmid = 8121496 | doi = 10.1038/367295a0 }}
*{{cite journal | author=Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB |title=Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. |journal=J. Virol. |volume=68 |issue= 11 |pages= 7188-99 |year= 1994 |pmid= 7933101 |doi=  }}
* {{cite journal | vauthors = Wang Z, Morris GF, Rice AP, Xiong W, Morris CB | title = Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro | journal = J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. | volume = 12 | issue = 2 | pages = 128–38 | year = 1996 | pmid = 8680883 | doi = 10.1097/00042560-199606010-00005 }}
*{{cite journal | author=Kashanchi F, Piras G, Radonovich MF, ''et al.'' |title=Direct interaction of human TFIID with the HIV-1 transactivator tat. |journal=Nature |volume=367 |issue= 6460 |pages= 295-9 |year= 1994 |pmid= 8121496 |doi= 10.1038/367295a0 }}
* {{cite journal | vauthors = Pendergrast PS, Morrison D, Tansey WP, Hernandez N | title = Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly | journal = J. Virol. | volume = 70 | issue = 8 | pages = 5025–34 | year = 1996 | pmid = 8764009 | pmc = 190456 | doi =  }}
*{{cite journal | author=Wang Z, Morris GF, Rice AP, ''et al.'' |title=Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=12 |issue= 2 |pages= 128-38 |year= 1996 |pmid= 8680883 |doi= }}
* {{cite journal | vauthors = Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN | title = Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex | journal = J. Virol. | volume = 70 | issue = 8 | pages = 5503–10 | year = 1996 | pmid = 8764062 | pmc = 190508 | doi =  }}
*{{cite journal | author=Pendergrast PS, Morrison D, Tansey WP, Hernandez N |title=Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly. |journal=J. Virol. |volume=70 |issue= 8 |pages= 5025-34 |year= 1996 |pmid= 8764009 |doi=  }}
* {{cite journal | vauthors = Zhou Q, Sharp PA | title = Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat | journal = Science | volume = 274 | issue = 5287 | pages = 605–10 | year = 1996 | pmid = 8849451 | doi = 10.1126/science.274.5287.605 }}
*{{cite journal | author=Kashanchi F, Khleif SN, Duvall JF, ''et al.'' |title=Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex. |journal=J. Virol. |volume=70 |issue= 8 |pages= 5503-10 |year= 1996 |pmid= 8764062 |doi=  }}
* {{cite journal | vauthors = García-Martínez LF, Ivanov D, Gaynor RB | title = Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes | journal = J. Biol. Chem. | volume = 272 | issue = 11 | pages = 6951–8 | year = 1997 | pmid = 9054383 | doi = 10.1074/jbc.272.11.6951 }}
*{{cite journal | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605-10 |year= 1996 |pmid= 8849451 |doi= }}
* {{cite journal | vauthors = Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD | title = BRCA1 is a component of the RNA polymerase II holoenzyme | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 11 | pages = 5605–10 | year = 1997 | pmid = 9159119 | pmc = 20825 | doi = 10.1073/pnas.94.11.5605 }}
*{{cite journal | author=García-Martínez LF, Ivanov D, Gaynor RB |title=Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 6951-8 |year= 1997 |pmid= 9054383 |doi= }}
* {{cite journal | vauthors = Van Der Knaap JA, Van Den Boom V, Kuipers J, Van Eijk MJ, Van Der Vliet PC, Timmers HT | title = The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization | journal = Biochem. J. | volume = 345 Pt 3 | issue = Pt 3 | pages = 521–7 | year = 2000 | pmid = 10642510 | pmc = 1220786 | doi = 10.1042/0264-6021:3450521 }}
*{{cite journal | author=Scully R, Anderson SF, Chao DM, ''et al.'' |title=BRCA1 is a component of the RNA polymerase II holoenzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5605-10 |year= 1997 |pmid= 9159119 |doi= }}
* {{cite journal | vauthors = Wadhwa R, Yaguchi T, Hasan MK, Taira K, Kaul SC | title = Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation | journal = Biochem. Biophys. Res. Commun. | volume = 302 | issue = 4 | pages = 735–42 | year = 2003 | pmid = 12646231 | doi = 10.1016/S0006-291X(03)00226-2 }}
*{{cite journal  | author=van der Knaap JA, Borst JW, van der Vliet PC, ''et al.'' |title=Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 22 |pages= 11827-32 |year= 1997 |pmid= 9342322 |doi=  }}
* {{cite journal | vauthors = Pereira LA, Klejman MP, Ruhlmann C, Kavelaars F, Oulad-Abdelghani M, Timmers HT, Schultz P | title = Molecular architecture of the basal transcription factor B-TFIID | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 21802–7 | year = 2004 | pmid = 14988402 | doi = 10.1074/jbc.M313519200 }}
*{{cite journal  | author=Chicca JJ, Auble DT, Pugh BF |title=Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1701-10 |year= 1998 |pmid= 9488487 |doi=  }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Van Der Knaap JA, Van Den Boom V, Kuipers J, ''et al.'' |title=The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization. |journal=Biochem. J. |volume=345 Pt 3 |issue= |pages= 521-7 |year= 2000 |pmid= 10642510 |doi=  }}
* {{cite journal | vauthors = Klejman MP, Pereira LA, van Zeeburg HJ, Gilfillan S, Meisterernst M, Timmers HT | title = NC2α Interacts with BTAF1 and Stimulates Its ATP-Dependent Association with TATA-Binding Protein | journal = Mol. Cell. Biol. | volume = 24 | issue = 22 | pages = 10072–82 | year = 2004 | pmid = 15509807 | pmc = 525489 | doi = 10.1128/MCB.24.22.10072-10082.2004 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Grob P, Cruse MJ, Inouye C, Peris M, Penczek PA, Tjian R, Nogales E | title = Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues | journal = Structure | volume = 14 | issue = 3 | pages = 511–20 | year = 2006 | pmid = 16531235 | doi = 10.1016/j.str.2005.11.020 }}
*{{cite journal | author=Wadhwa R, Yaguchi T, Hasan MK, ''et al.'' |title=Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. |journal=Biochem. Biophys. Res. Commun. |volume=302 |issue= 4 |pages= 735-42 |year= 2003 |pmid= 12646231 |doi= }}
*{{cite journal | author=Pereira LA, Klejman MP, Ruhlmann C, ''et al.'' |title=Molecular architecture of the basal transcription factor B-TFIID. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 21802-7 |year= 2004 |pmid= 14988402 |doi= 10.1074/jbc.M313519200 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Klejman MP, Pereira LA, van Zeeburg HJ, ''et al.'' |title=NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein. |journal=Mol. Cell. Biol. |volume=24 |issue= 22 |pages= 10072-82 |year= 2004 |pmid= 15509807 |doi= 10.1128/MCB.24.22.10072-10082.2004 }}
*{{cite journal | author=Grob P, Cruse MJ, Inouye C, ''et al.'' |title=Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues. |journal=Structure |volume=14 |issue= 3 |pages= 511-20 |year= 2006 |pmid= 16531235 |doi= 10.1016/j.str.2005.11.020 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{Gene-10-stub}}

Latest revision as of 02:41, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.[1][2][3]

Function

Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM][3]

Interactions

BTAF1 has been shown to interact with TATA binding protein.[2][4]

References

  1. ↑ van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT (Dec 1997). "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila". Proc Natl Acad Sci U S A. 94 (22): 11827–32. doi:10.1073/pnas.94.22.11827. PMC 23617. PMID 9342322.
  2. ↑ 2.0 2.1 Chicca JJ, Auble DT, Pugh BF (Mar 1998). "Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1". Mol Cell Biol. 18 (3): 1701–10. PMC 108885. PMID 9488487.
  3. ↑ 3.0 3.1 "Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)".
  4. ↑ Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.

External links

Further reading


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