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{{Infobox_gene}}
{{PBB_Controls
'''Oxidoreductase HTATIP2''' is an [[enzyme]] that in humans is encoded by the ''HTATIP2'' [[gene]].<ref name="pmid9482853">{{cite journal | vauthors = Xiao H, Tao Y, Greenblatt J, Roeder RG | title = A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 5 | pages = 2146–51 | date = Apr 1998 | pmid = 9482853 | pmc = 19278 | doi = 10.1073/pnas.95.5.2146 }}</ref><ref name="pmid9174052">{{cite journal | vauthors = Shtivelman E | title = A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma | journal = Oncogene | volume = 14 | issue = 18 | pages = 2167–73 | date = Jun 1997 | pmid = 9174052 | pmc =  | doi = 10.1038/sj.onc.1201059 }}</ref><ref name="pmid19027726">{{cite journal | vauthors = Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U | title = The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative | journal = Chem Biol Interact | volume = 178 | issue = 1–3 | pages = 94–8 | date = Feb 2009 | pmid = 19027726 | pmc = 2896744 | doi = 10.1016/j.cbi.2008.10.040 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10553| accessdate = }}</ref> It may be a [[metastasis suppressor]].
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = PBB_Protein_HTATIP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bka.
| PDB = {{PDB2|2bka}}, {{PDB2|2fmu}}
| Name = HIV-1 Tat interactive protein 2, 30kDa
| HGNCid = 16637
| Symbol = HTATIP2
| AltSymbols =; CC3; TIP30
| OMIM = 605628
| ECnumber = 
| Homologene = 4676
| MGIid = 1859271
| GeneAtlas_image1 = PBB_GE_HTATIP2_209448_at_tn.png
| GeneAtlas_image2 = PBB_GE_HTATIP2_207180_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045765 |text = regulation of angiogenesis}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0051170 |text = nuclear import}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10553
    | Hs_Ensembl = ENSG00000109854
    | Hs_RefseqProtein = NP_006401
    | Hs_RefseqmRNA = NM_006410
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 20341924
    | Hs_GenLoc_end = 20361904
    | Hs_Uniprot = Q9BUP3
    | Mm_EntrezGene = 53415
    | Mm_Ensembl = ENSMUSG00000039745
    | Mm_RefseqmRNA = NM_016865
    | Mm_RefseqProtein = NP_058561
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 49627174
    | Mm_GenLoc_end = 49642016
    | Mm_Uniprot = Q3U816
  }}
}}
'''HIV-1 Tat interactive protein 2, 30kDa''', also known as '''HTATIP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10553| accessdate = }}</ref> It may be a [[metastasis suppressor]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
*{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal | vauthors = Baker ME | title = TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases | journal = Curr. Biol. | volume = 9 | issue = 13 | pages = R471 | year = 1999 | pmid = 10395547 | doi = 10.1016/S0960-9822(99)80297-8 }}
*{{cite journal  | author=Shtivelman E |title=A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. |journal=Oncogene |volume=14 |issue= 18 |pages= 2167-73 |year= 1997 |pmid= 9174052 |doi= 10.1038/sj.onc.1201059 }}
*{{cite journal | vauthors = Whitman S, Wang X, Shalaby R, Shtivelman E | title = Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis | journal = Mol. Cell. Biol. | volume = 20 | issue = 2 | pages = 583–93 | year = 2000 | pmid = 10611237 | pmc = 85138 | doi = 10.1128/MCB.20.2.583-593.2000 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | vauthors = Xiao H, Palhan V, Yang Y, Roeder RG | title = TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes | journal = EMBO J. | volume = 19 | issue = 5 | pages = 956–63 | year = 2000 | pmid = 10698937 | pmc = 305635 | doi = 10.1093/emboj/19.5.956 }}
*{{cite journal  | author=Xiao H, Tao Y, Greenblatt J, Roeder RG |title=A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2146-51 |year= 1998 |pmid= 9482853 |doi=  }}
*{{cite journal | vauthors = Baker ME, Yan L, Pear MR | title = Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression | journal = Cell. Mol. Life Sci. | volume = 57 | issue = 5 | pages = 851–8 | year = 2000 | pmid = 10892349 | doi = 10.1007/s000180050047 }}
*{{cite journal | author=Baker ME |title=TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases. |journal=Curr. Biol. |volume=9 |issue= 13 |pages= R471 |year= 1999 |pmid= 10395547 |doi= }}
*{{cite journal | vauthors = NicAmhlaoibh R, Shtivelman E | title = Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro | journal = Oncogene | volume = 20 | issue = 2 | pages = 270–5 | year = 2001 | pmid = 11313954 | doi = 10.1038/sj.onc.1204075 }}
*{{cite journal | author=Whitman S, Wang X, Shalaby R, Shtivelman E |title=Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. |journal=Mol. Cell. Biol. |volume=20 |issue= 2 |pages= 583-93 |year= 2000 |pmid= 10611237 |doi= }}
*{{cite journal | vauthors = Ito M, Jiang C, Krumm K, Zhang X, Pecha J, Zhao J, Guo Y, Roeder RG, Xiao H | title = TIP30 deficiency increases susceptibility to tumorigenesis | journal = Cancer Res. | volume = 63 | issue = 24 | pages = 8763–7 | year = 2004 | pmid = 14695192 | doi =  }}
*{{cite journal | author=Xiao H, Palhan V, Yang Y, Roeder RG |title=TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes. |journal=EMBO J. |volume=19 |issue= 5 |pages= 956-63 |year= 2000 |pmid= 10698937 |doi= 10.1093/emboj/19.5.956 }}
*{{cite journal | vauthors = Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H | title = TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription | journal = J. Biol. Chem. | volume = 279 | issue = 26 | pages = 27781–9 | year = 2004 | pmid = 15073177 | doi = 10.1074/jbc.M401809200 }}
*{{cite journal | author=Baker ME, Yan L, Pear MR |title=Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression. |journal=Cell. Mol. Life Sci. |volume=57 |issue= 5 |pages= 851-8 |year= 2000 |pmid= 10892349 |doi= }}
*{{cite journal | vauthors = Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S, Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani M, Yamaoka T, Inoue H, Itakura M | title = The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD) | journal = Am. J. Hum. Genet. | volume = 74 | issue = 6 | pages = 1255–61 | year = 2004 | pmid = 15124103 | pmc = 1182089 | doi = 10.1086/421527 }}
*{{cite journal | author=NicAmhlaoibh R, Shtivelman E |title=Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. |journal=Oncogene |volume=20 |issue= 2 |pages= 270-5 |year= 2001 |pmid= 11313954 |doi= 10.1038/sj.onc.1204075 }}
*{{cite journal | vauthors = King FW, Shtivelman E | title = Inhibition of nuclear import by the proapoptotic protein CC3 | journal = Mol. Cell. Biol. | volume = 24 | issue = 16 | pages = 7091–101 | year = 2004 | pmid = 15282309 | pmc = 479715 | doi = 10.1128/MCB.24.16.7091-7101.2004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 | year = 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal  | author=Ito M, Jiang C, Krumm K, ''et al.'' |title=TIP30 deficiency increases susceptibility to tumorigenesis. |journal=Cancer Res. |volume=63 |issue= 24 |pages= 8763-7 |year= 2004 |pmid= 14695192 |doi=  }}
*{{cite journal | vauthors = Sun L, Feng S, Reséndiz JC, Lu X, Durante W, Kroll MH | title = Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation | journal = Annals of Biomedical Engineering | volume = 32 | issue = 9 | pages = 1193–201 | year = 2005 | pmid = 15493507 | doi = 10.1114/B:ABME.0000039353.97347.28 }}
*{{cite journal | author=Jiang C, Ito M, Piening V, ''et al.'' |title=TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27781-9 |year= 2004 |pmid= 15073177 |doi= 10.1074/jbc.M401809200 }}
*{{cite journal | vauthors = Shi M, Zhang X, Wang P, Zhang HW, Zhang BH, Wu MC | title = TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway | journal = World J. Gastroenterol. | volume = 11 | issue = 2 | pages = 221–7 | year = 2005 | pmid = 15633220 | doi =  10.3748/wjg.v11.i2.221}}
*{{cite journal | author=Tsutsumi S, Kamata N, Vokes TJ, ''et al.'' |title=The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1255-61 |year= 2004 |pmid= 15124103 |doi= 10.1086/421527 }}
*{{cite journal | vauthors = El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK | title = Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor | journal = J. Biol. Chem. | volume = 280 | issue = 18 | pages = 18229–36 | year = 2005 | pmid = 15728189 | doi = 10.1074/jbc.M501113200 }}
*{{cite journal | author=King FW, Shtivelman E |title=Inhibition of nuclear import by the proapoptotic protein CC3. |journal=Mol. Cell. Biol. |volume=24 |issue= 16 |pages= 7091-101 |year= 2004 |pmid= 15282309 |doi= 10.1128/MCB.24.16.7091-7101.2004 }}
*{{cite journal | vauthors = Caldwell RL, Lane KB, Shepherd VL | title = HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription | journal = Arch. Biochem. Biophys. | volume = 449 | issue = 1–2 | pages = 27–33 | year = 2006 | pmid = 16615932 | doi = 10.1016/j.abb.2006.02.020 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Sun L, Feng S, Reséndiz JC, ''et al.'' |title=Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation. |journal=Annals of biomedical engineering |volume=32 |issue= 9 |pages= 1193-201 |year= 2005 |pmid= 15493507 |doi= }}
*{{cite journal | author=Shi M, Zhang X, Wang P, ''et al.'' |title=TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway. |journal=World J. Gastroenterol. |volume=11 |issue= 2 |pages= 221-7 |year= 2005 |pmid= 15633220 |doi=  }}
*{{cite journal | author=El Omari K, Bird LE, Nichols CE, ''et al.'' |title=Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18229-36 |year= 2005 |pmid= 15728189 |doi= 10.1074/jbc.M501113200 }}
*{{cite journal | author=Caldwell RL, Lane KB, Shepherd VL |title=HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription. |journal=Arch. Biochem. Biophys. |volume=449 |issue= 1-2 |pages= 27-33 |year= 2006 |pmid= 16615932 |doi= 10.1016/j.abb.2006.02.020 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=10553}}
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{{gene-11-stub}}

Latest revision as of 14:07, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Oxidoreductase HTATIP2 is an enzyme that in humans is encoded by the HTATIP2 gene.[1][2][3][4] It may be a metastasis suppressor.

References

  1. ↑ Xiao H, Tao Y, Greenblatt J, Roeder RG (Apr 1998). "A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription". Proc Natl Acad Sci U S A. 95 (5): 2146–51. doi:10.1073/pnas.95.5.2146. PMC 19278. PMID 9482853.
  2. ↑ Shtivelman E (Jun 1997). "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma". Oncogene. 14 (18): 2167–73. doi:10.1038/sj.onc.1201059. PMID 9174052.
  3. ↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  4. ↑ "Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa".

Further reading


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