CLNS1A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Methylosome subunit pICln''' is a [[protein]] that in humans is encoded by the ''CLNS1A'' [[gene]].<ref name="pmid7887970">{{cite journal | vauthors = Anguita J, Chalfant ML, Civan MM, Coca-Prados M | title = Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium | journal = Biochem Biophys Res Commun | volume = 208 | issue = 1 | pages = 89–95 | date = Apr 1995 | pmid = 7887970 | pmc =  | doi = 10.1006/bbrc.1995.1309 }}</ref><ref name="pmid8975725">{{cite journal | vauthors = Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M | title = Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln | journal = Genomics | volume = 38 | issue = 3 | pages = 438–41 | date = Mar 1997 | pmid = 8975725 | pmc = | doi = 10.1006/geno.1996.0651 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1207| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_CLNS1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zyi.
| PDB = {{PDB2|1zyi}}
| Name = Chloride channel, nucleotide-sensitive, 1A
| HGNCid = 2080
| Symbol = CLNS1A
| AltSymbols =; CLNS1B; ICln; CLCI
| OMIM = 602158
| ECnumber = 
| Homologene = 990
| MGIid = 109638
| GeneAtlas_image1 = PBB_GE_CLNS1A_209143_s_at_tn.png
| Function = {{GNF_GO|id=GO:0015457 |text = auxiliary transport protein activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006821 |text = chloride transport}} {{GNF_GO|id=GO:0006884 |text = regulation of cell volume}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1207
    | Hs_Ensembl = ENSG00000074201
    | Hs_RefseqProtein = NP_001284
    | Hs_RefseqmRNA = NM_001293
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 77004847
    | Hs_GenLoc_end = 77026495
    | Hs_Uniprot = P54105
    | Mm_EntrezGene = 12729
    | Mm_Ensembl = ENSMUSG00000025439
    | Mm_RefseqmRNA = NM_023671
    | Mm_RefseqProtein = NP_076160
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 97571891
    | Mm_GenLoc_end = 97594109
    | Mm_Uniprot = P97506
  }}
}}
'''Chloride channel, nucleotide-sensitive, 1A''', also known as '''CLNS1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1207| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box BotSee Template:PBB_Controls to Stop updates. -->
CLNS1A has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[ITGA2B]],<ref name = pmid15075326>{{cite journal | vauthors = Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N | title = ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation | journal = J. Biol. Chem. | volume = 279 | issue = 26 | pages = 27286–93 | date = Jun 2004 | pmid = 15075326 | doi = 10.1074/jbc.M402159200 }}</ref>
| section_title =  
* [[Protein arginine methyltransferase 5|PRMT5]],<ref name = pmid11713266/><ref name = pmid9556550>{{cite journal | vauthors = Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE | title = pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology | journal = J. Biol. Chem. | volume = 273 | issue = 18 | pages = 10811–4 | date = May 1998 | pmid = 9556550 | doi = 10.1074/jbc.273.18.10811}}</ref><ref name = pmid11756452>{{cite journal | vauthors = Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G | title = A novel WD repeat protein component of the methylosome binds Sm proteins | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8243–7 | date = Mar 2002 | pmid = 11756452 | doi = 10.1074/jbc.M109984200 }}</ref>
| summary_text =  
* [[Small nuclear ribonucleoprotein D1|SNRPD1]],<ref name = pmid11713266>{{cite journal | vauthors = Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G | title = The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins | journal = Mol. Cell. Biol. | volume = 21 | issue = 24 | pages = 8289–300 | date = Dec 2001 | pmid = 11713266 | pmc = 99994 | doi = 10.1128/MCB.21.24.8289-8300.2001 }}</ref> and
}}
* [[SNRPD3]].<ref name = pmid11713266/>


==References==
== See also ==
{{reflist|2}}
* [[Chloride channel]]
==Further reading==
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P | title = New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium | journal = Front. Biosci. | volume = 11 | issue =  | pages = 1646–66 | year = 2006 | pmid = 16368544 | doi = 10.2741/1911 }}
| citations =
* {{cite journal | vauthors = Buyse G, de Greef C, Raeymaekers L, Droogmans G, Nilius B, Eggermont J | title = The ubiquitously expressed pICln protein forms homomeric complexes in vitro | journal = Biochem. Biophys. Res. Commun. | volume = 218 | issue = 3 | pages = 822–7 | year = 1996 | pmid = 8579598 | doi = 10.1006/bbrc.1996.0146 }}
*{{cite journal | author=Calinisan V, Gravem D, Chen RP, ''et al.'' |title=New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. |journal=Front. Biosci. |volume=11 |issue=  |pages= 1646-66 |year= 2006 |pmid= 16368544 |doi= }}
* {{cite journal | vauthors = Schwartz RS, Rybicki AC, Nagel RL | title = Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin | journal = Biochem. J. | volume = 327 | issue = 2 | pages = 609–16 | year = 1997 | pmid = 9359436 | pmc = 1218836 | doi =  }}
*{{cite journal  | author=Anguita J, Chalfant ML, Civan MM, Coca-Prados M |title=Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium. |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 1 |pages= 89-95 |year= 1995 |pmid= 7887970 |doi=  }}
* {{cite journal | vauthors = Bekri S, Adélaïde J, Merscher S, Grosgeorge J, Caroli-Bosc F, Perucca-Lostanlen D, Kelley PM, Pébusque MJ, Theillet C, Birnbaum D, Gaudray P | title = Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma | journal = Cytogenet. Cell Genet. | volume = 79 | issue = 1–2 | pages = 125–31 | year = 1998 | pmid = 9533029 | doi = 10.1159/000134699 }}
*{{cite journal | author=Buyse G, de Greef C, Raeymaekers L, ''et al.'' |title=The ubiquitously expressed pICln protein forms homomeric complexes in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=218 |issue= 3 |pages= 822-7 |year= 1996 |pmid= 8579598 |doi= 10.1006/bbrc.1996.0146 }}
* {{cite journal | vauthors = Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE | title = pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology | journal = J. Biol. Chem. | volume = 273 | issue = 18 | pages = 10811–4 | year = 1998 | pmid = 9556550 | doi = 10.1074/jbc.273.18.10811 }}
*{{cite journal | author=Nagl UO, Erdel M, Schmarda A, ''et al.'' |title=Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln. |journal=Genomics |volume=38 |issue= 3 |pages= 438-41 |year= 1997 |pmid= 8975725 |doi= 10.1006/geno.1996.0651 }}
* {{cite journal | vauthors = Tang CJ, Tang TK | title = The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation | journal = Blood | volume = 92 | issue = 4 | pages = 1442–7 | year = 1998 | pmid = 9694734 | doi =  }}
*{{cite journal  | author=Schwartz RS, Rybicki AC, Nagel RL |title=Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin. |journal=Biochem. J. |volume=327 ( Pt 2) |issue= |pages= 609-16 |year= 1997 |pmid= 9359436 |doi=  }}
* {{cite journal | vauthors = Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE | title = pICln inhibits snRNP biogenesis by binding core spliceosomal proteins | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4113–20 | year = 1999 | pmid = 10330151 | pmc = 104370 | doi =  }}
*{{cite journal | author=Bekri S, Adélaïde J, Merscher S, ''et al.'' |title=Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 125-31 |year= 1998 |pmid= 9533029 |doi= }}
* {{cite journal | vauthors = Hubert MD, Levitan I, Hoffman MM, Zraggen M, Hofreiter ME, Garber SS | title = Modulation of volume regulated anion current by I(Cln) | journal = Biochim. Biophys. Acta | volume = 1466 | issue = 1–2 | pages = 105–14 | year = 2000 | pmid = 10825435 | doi = 10.1016/S0005-2736(00)00177-2 }}
*{{cite journal | author=Krapivinsky G, Pu W, Wickman K, ''et al.'' |title=pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 10811-4 |year= 1998 |pmid= 9556550 |doi= }}
* {{cite journal | vauthors = Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G | title = The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins | journal = Mol. Cell. Biol. | volume = 21 | issue = 24 | pages = 8289–300 | year = 2001 | pmid = 11713266 | pmc = 99994 | doi = 10.1128/MCB.21.24.8289-8300.2001 }}
*{{cite journal | author=Tang CJ, Tang TK |title=The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation. |journal=Blood |volume=92 |issue= 4 |pages= 1442-7 |year= 1998 |pmid= 9694734 |doi=  }}
* {{cite journal | vauthors = Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U | title = Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln | journal = Curr. Biol. | volume = 11 | issue = 24 | pages = 1990–4 | year = 2002 | pmid = 11747828 | doi = 10.1016/S0960-9822(01)00592-9 }}
*{{cite journal | author=Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE |title=pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4113-20 |year= 1999 |pmid= 10330151 |doi=  }}
* {{cite journal | vauthors = Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G | title = A novel WD repeat protein component of the methylosome binds Sm proteins | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8243–7 | year = 2002 | pmid = 11756452 | doi = 10.1074/jbc.M109984200 }}
*{{cite journal | author=Hubert MD, Levitan I, Hoffman MM, ''et al.'' |title=Modulation of volume regulated anion current by I(Cln). |journal=Biochim. Biophys. Acta |volume=1466 |issue= 1-2 |pages= 105-14 |year= 2000 |pmid= 10825435 |doi= }}
* {{cite journal | vauthors = Meyer G, Rodighiero S, Guizzardi F, Bazzini C, Bottà G, Bertocchi C, Garavaglia L, Dossena S, Manfredi R, Sironi C, Catania A, Paulmichl M | title = Volume-regulated Cl<sup>−</sup> channels in human pleural mesothelioma cells | journal = FEBS Lett. | volume = 559 | issue = 1–3 | pages = 45–50 | year = 2004 | pmid = 14960305 | doi = 10.1016/S0014-5793(04)00020-1 }}
*{{cite journal | author=Friesen WJ, Paushkin S, Wyce A, ''et al.'' |title=The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. |journal=Mol. Cell. Biol. |volume=21 |issue= 24 |pages= 8289-300 |year= 2001 |pmid= 11713266 |doi= 10.1128/MCB.21.24.8289-8300.2001 }}
* {{cite journal | vauthors = Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N | title = ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation | journal = J. Biol. Chem. | volume = 279 | issue = 26 | pages = 27286–93 | year = 2004 | pmid = 15075326 | doi = 10.1074/jbc.M402159200 }}
*{{cite journal | author=Meister G, Eggert C, Bühler D, ''et al.'' |title=Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln. |journal=Curr. Biol. |volume=11 |issue= 24 |pages= 1990-4 |year= 2002 |pmid= 11747828 |doi= }}
* {{cite journal | vauthors = Fürst J, Schedlbauer A, Gandini R, Garavaglia ML, Saino S, Gschwentner M, Sarg B, Lindner H, Jakab M, Ritter M, Bazzini C, Botta G, Meyer G, Kontaxis G, Tilly BC, Konrat R, Paulmichl M | title = ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4 | journal = J. Biol. Chem. | volume = 280 | issue = 35 | pages = 31276–82 | year = 2005 | pmid = 15905169 | doi = 10.1074/jbc.M500541200 }}
*{{cite journal | author=Friesen WJ, Wyce A, Paushkin S, ''et al.'' |title=A novel WD repeat protein component of the methylosome binds Sm proteins. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8243-7 |year= 2002 |pmid= 11756452 |doi= 10.1074/jbc.M109984200 }}
* {{cite journal | vauthors = Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D | title = Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes | journal = J. Biol. Chem. | volume = 280 | issue = 41 | pages = 34435–40 | year = 2005 | pmid = 16087681 | doi = 10.1074/jbc.M505077200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Meyer G, Rodighiero S, Guizzardi F, ''et al.'' |title=Volume-regulated Cl- channels in human pleural mesothelioma cells. |journal=FEBS Lett. |volume=559 |issue= 1-3 |pages= 45-50 |year= 2004 |pmid= 14960305 |doi= 10.1016/S0014-5793(04)00020-1 }}
*{{cite journal | author=Larkin D, Murphy D, Reilly DF, ''et al.'' |title=ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27286-93 |year= 2004 |pmid= 15075326 |doi= 10.1074/jbc.M402159200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Fürst J, Schedlbauer A, Gandini R, ''et al.'' |title=ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4. |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 31276-82 |year= 2005 |pmid= 15905169 |doi= 10.1074/jbc.M500541200 }}
*{{cite journal | author=Azzouz TN, Pillai RS, Däpp C, ''et al.'' |title=Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34435-40 |year= 2005 |pmid= 16087681 |doi= 10.1074/jbc.M505077200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{MeshName|CLNS1A+protein,+human}}
* {{UCSC gene info|CLNS1A}}
 
{{NLM content}}
{{PDB Gallery|geneid=1207}}
{{Ion channels|g4}}
 
[[Category:Ion channels]]
 
 
{{gene-11-stub}}

Latest revision as of 09:50, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene.[1][2][3]

Interactions

CLNS1A has been shown to interact with:

See also

References

  1. Anguita J, Chalfant ML, Civan MM, Coca-Prados M (Apr 1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium". Biochem Biophys Res Commun. 208 (1): 89–95. doi:10.1006/bbrc.1995.1309. PMID 7887970.
  2. Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M (Mar 1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln". Genomics. 38 (3): 438–41. doi:10.1006/geno.1996.0651. PMID 8975725.
  3. "Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A".
  4. Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26): 27286–93. doi:10.1074/jbc.M402159200. PMID 15075326.
  5. 5.0 5.1 5.2 Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC 99994. PMID 11713266.
  6. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE (May 1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology". J. Biol. Chem. 273 (18): 10811–4. doi:10.1074/jbc.273.18.10811. PMID 9556550.
  7. Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.