SHANK2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''SH3 and multiple ankyrin repeat domains protein 2''' is a [[protein]] that in humans is encoded by the ''SHANK2'' [[gene]].<ref name="pmid10506216">{{cite journal | vauthors = Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, Kim E | title = Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development | journal = J Biol Chem | volume = 274 | issue = 41 | pages = 29510–8 | date = November 1999 | pmid = 10506216 | pmc =  | doi = 10.1074/jbc.274.41.29510 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SHANK2 SH3 and multiple ankyrin repeat domains 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22941| accessdate = }}</ref> Two alternative splice variants, encoding distinct [[protein isoforms|isoforms]], are reported. Additional splice variants exist but their full-length nature has not been determined.<ref name="entrez" />
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SH3 and multiple ankyrin repeat domains 2
| HGNCid = 14295
| Symbol = SHANK2
| AltSymbols =; CORTBP1; CTTNBP1; ProSAP1; SHANK; SPANK-3
| OMIM = 603290
| ECnumber = 
| Homologene = 83270
| MGIid = 2671987
| GeneAtlas_image1 = PBB_GE_SHANK2_213307_at_tn.png
| GeneAtlas_image2 = PBB_GE_SHANK2_213308_at_tn.png
| GeneAtlas_image3 = PBB_GE_SHANK2_215829_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030160 |text = GKAP/Homer scaffold activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22941
    | Hs_Ensembl = ENSG00000162105
    | Hs_RefseqProtein = NP_036441
    | Hs_RefseqmRNA = NM_012309
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 69991609
    | Hs_GenLoc_end = 70536020
    | Hs_Uniprot = Q9UPX8
    | Mm_EntrezGene = 210274
    | Mm_Ensembl = ENSMUSG00000037541
    | Mm_RefseqmRNA = XM_001002370
    | Mm_RefseqProtein = XP_001002370
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 143985283
    | Mm_GenLoc_end = 144230525
    | Mm_Uniprot = Q80Z38
  }}
}}
'''SH3 and multiple ankyrin repeat domains 2''', also known as '''SHANK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SHANK2 SH3 and multiple ankyrin repeat domains 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22941| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the [[postsynaptic density]] (PSD). Shank proteins contain multiple domains for protein-protein interaction, including [[ankyrin repeat]]s, an [[SH3 domain]], a [[DLG4|PSD-95]]/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a [[PDZ domain]], a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The [[alternative splicing]] demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: SHANK2 SH3 and multiple ankyrin repeat domains 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22941| accessdate = }}</ref>
}}


==References==
It is thought that SHANK2 might play a role in [[synaptogenesis]] by attaching [[metabotropic glutamate receptor]]s (mGluRs) to an existing pool of [[NMDA receptor]]s (NMDA-R), bylinking to the NMDA-R through PSD-95, and the mGluRs through [[HOMER1]].<ref name="pmid12065602">{{cite journal | vauthors = Boeckers TM, Bockmann J, Kreutz MR, Gundelfinger ED | title = ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease | journal = J. Neurochem. | volume = 81 | issue = 5 | pages = 903–10 | date = June 2002 | pmid = 12065602 | doi = 10.1046/j.1471-4159.2002.00931.x | url =  | issn =  }}</ref> An alternative hypothesis is that the Homer/Shank/GKAP/PSD-95 assembly mediates physical association of the NMDAR with IP3R/RYR and intracellular Ca2+ stores.
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Sheng M, Kim E |title=The Shank family of scaffold proteins. |journal=J. Cell. Sci. |volume=113 ( Pt 11) |issue=  |pages= 1851-6 |year= 2000 |pmid= 10806096 |doi=  }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | author=Du Y, Weed SA, Xiong WC, ''et al.'' |title=Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5838-51 |year= 1998 |pmid= 9742101 |doi=  }}
*{{cite journal  | author=Zitzer H, Richter D, Kreienkamp HJ |title=Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18153-6 |year= 1999 |pmid= 10373412 |doi=  }}
*{{cite journal  | author=Tu JC, Xiao B, Naisbitt S, ''et al.'' |title=Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. |journal=Neuron |volume=23 |issue= 3 |pages= 583-92 |year= 1999 |pmid= 10433269 |doi=  }}
*{{cite journal  | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
*{{cite journal | author=Lim S, Naisbitt S, Yoon J, ''et al.'' |title=Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29510-8 |year= 1999 |pmid= 10506216 |doi=  }}
*{{cite journal  | author=Boeckers TM, Winter C, Smalla KH, ''et al.'' |title=Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 247-52 |year= 1999 |pmid= 10527873 |doi= 10.1006/bbrc.1999.1489 }}
*{{cite journal  | author=Kreienkamp HJ, Zitzer H, Gundelfinger ED, ''et al.'' |title=The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32387-90 |year= 2000 |pmid= 10964907 |doi= 10.1074/jbc.C000490200 }}
*{{cite journal  | author=Kreienkamp HJ, Zitzer H, Richter D |title=Identification of proteins interacting with the rat somatostatin receptor subtype 2. |journal=J. Physiol. Paris |volume=94 |issue= 3-4 |pages= 193-8 |year= 2001 |pmid= 11087996 |doi=  }}
*{{cite journal  | author=Okamoto PM, Gamby C, Wells D, ''et al.'' |title=Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48458-65 |year= 2002 |pmid= 11583995 |doi= 10.1074/jbc.M104927200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Soltau M, Richter D, Kreienkamp HJ |title=The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 575-83 |year= 2003 |pmid= 12504591 |doi=  }}
*{{cite journal  | author=Park E, Na M, Choi J, ''et al.'' |title=The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19220-9 |year= 2003 |pmid= 12626503 |doi= 10.1074/jbc.M301052200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Han W, Kim KH, Jo MJ, ''et al.'' |title=Shank2 associates with and regulates Na+/H+ exchanger 3. |journal=J. Biol. Chem. |volume=281 |issue= 3 |pages= 1461-9 |year= 2006 |pmid= 16293618 |doi= 10.1074/jbc.M509786200 }}
*{{cite journal  | author=Taylor TD, Noguchi H, Totoki Y, ''et al.'' |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497-500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 }}
}}
{{refend}}


{{protein-stub}}
== Interactions ==
{{WikiDoc Sources}}
 
SHANK2 has been shown to [[Protein-protein interaction|interact]] with:
* [[ARHGEF7]],<ref name=pmid12626503>{{cite journal | vauthors = Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E | title = The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42 | journal = J. Biol. Chem. | volume = 278 | issue = 21 | pages = 19220–9 | date = May 2003 | pmid = 12626503 | doi = 10.1074/jbc.M301052200 | authorlink =  }}</ref>
* [[Cortactin]],<ref name=pmid9742101>{{cite journal | vauthors = Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT | title = Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons | journal = Mol. Cell. Biol. | volume = 18 | issue = 10 | pages = 5838–51 | date = October 1998 | pmid = 9742101 | pmc = 109170 | authorlink =  }}</ref>
* [[DLG4]],<ref name=pmid10844022>{{cite journal | vauthors = Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M | title = Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein | journal = J. Neurosci. | volume = 20 | issue = 12 | pages = 4524–34 | date = June 2000 | pmid = 10844022 | authorlink =  }}</ref><ref name=pmid10527873>{{cite journal | vauthors = Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, Gundelfinger ED | title = Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family | journal = Biochem. Biophys. Res. Commun. | volume = 264 | issue = 1 | pages = 247–52 | date = October 1999 | pmid = 10527873 | doi = 10.1006/bbrc.1999.1489 | authorlink =  }}</ref>
* [[DLGAP1]],<ref name=pmid10844022/><ref name=pmid10527873/> and
* [[DNM2]].<ref name=pmid11583995>{{cite journal | vauthors = Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB | title = Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton | journal = J. Biol. Chem. | volume = 276 | issue = 51 | pages = 48458–65 | date = Dec 2001 | pmid = 11583995 | pmc = 2715172 | doi = 10.1074/jbc.M104927200 | authorlink =  }}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Sheng M, Kim E | title = The Shank family of scaffold proteins. | journal = J. Cell Sci. | volume = ( Pt 11) | issue =  | pages = 1851–6 | year = 2000 | pmid = 10806096 | doi =  | series = 113 }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction. | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing. | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
* {{cite journal | vauthors = Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT | title = Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. | journal = Mol. Cell. Biol. | volume = 18 | issue = 10 | pages = 5838–51 | year = 1998 | pmid = 9742101 | pmc = 109170 | doi =  }}
* {{cite journal | vauthors = Zitzer H, Richter D, Kreienkamp HJ | title = Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1. | journal = J. Biol. Chem. | volume = 274 | issue = 26 | pages = 18153–6 | year = 1999 | pmid = 10373412 | doi = 10.1074/jbc.274.26.18153 }}
* {{cite journal | vauthors = Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF | title = Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. | journal = Neuron | volume = 23 | issue = 3 | pages = 583–92 | year = 1999 | pmid = 10433269 | doi = 10.1016/S0896-6273(00)80810-7 }}
* {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | journal = DNA Res. | volume = 6 | issue = 3 | pages = 197–205 | year = 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
* {{cite journal | vauthors = Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, Gundelfinger ED | title = Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. | journal = Biochem. Biophys. Res. Commun. | volume = 264 | issue = 1 | pages = 247–52 | year = 1999 | pmid = 10527873 | doi = 10.1006/bbrc.1999.1489 }}
* {{cite journal | vauthors = Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM | title = The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. | journal = J. Biol. Chem. | volume = 275 | issue = 42 | pages = 32387–90 | year = 2000 | pmid = 10964907 | doi = 10.1074/jbc.C000490200 }}
* {{cite journal | vauthors = Kreienkamp HJ, Zitzer H, Richter D | title = Identification of proteins interacting with the rat somatostatin receptor subtype 2 | journal = J. Physiol. Paris | volume = 94 | issue = 3–4 | pages = 193–8 | year = 2001 | pmid = 11087996 | doi = 10.1016/S0928-4257(00)00204-7 }}
* {{cite journal | vauthors = Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB | title = Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. | journal = J. Biol. Chem. | volume = 276 | issue = 51 | pages = 48458–65 | year = 2002 | pmid = 11583995 | pmc = 2715172 | doi = 10.1074/jbc.M104927200 }}
* {{cite journal | vauthors = Soltau M, Richter D, Kreienkamp HJ | title = The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. | journal = Mol. Cell. Neurosci. | volume = 21 | issue = 4 | pages = 575–83 | year = 2003 | pmid = 12504591 | doi = 10.1006/mcne.2002.1201 }}
* {{cite journal | vauthors = Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E | title = The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. | journal = J. Biol. Chem. | volume = 278 | issue = 21 | pages = 19220–9 | year = 2003 | pmid = 12626503 | doi = 10.1074/jbc.M301052200 }}
* {{cite journal | vauthors = Han W, Kim KH, Jo MJ, Lee JH, Yang J, Doctor RB, Moe OW, Lee J, Kim E, Lee MG | title = Shank2 associates with and regulates Na+/H+ exchanger 3. | journal = J. Biol. Chem. | volume = 281 | issue = 3 | pages = 1461–9 | year = 2006 | pmid = 16293618 | doi = 10.1074/jbc.M509786200 }}
* {{cite journal | vauthors = Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y | title = Human chromosome 11 DNA sequence and analysis including novel gene identification. | journal = Nature | volume = 440 | issue = 7083 | pages = 497–500 | year = 2006 | pmid = 16554811 | doi = 10.1038/nature04632 }}
{{Refend}}
 
 
{{Gene-11-stub}}

Latest revision as of 20:50, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene.[1][2] Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.[2]

Function

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.[2]

It is thought that SHANK2 might play a role in synaptogenesis by attaching metabotropic glutamate receptors (mGluRs) to an existing pool of NMDA receptors (NMDA-R), bylinking to the NMDA-R through PSD-95, and the mGluRs through HOMER1.[3] An alternative hypothesis is that the Homer/Shank/GKAP/PSD-95 assembly mediates physical association of the NMDAR with IP3R/RYR and intracellular Ca2+ stores.

Interactions

SHANK2 has been shown to interact with:

References

  1. ↑ Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, Kim E (November 1999). "Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development". J Biol Chem. 274 (41): 29510–8. doi:10.1074/jbc.274.41.29510. PMID 10506216.
  2. ↑ 2.0 2.1 2.2 "Entrez Gene: SHANK2 SH3 and multiple ankyrin repeat domains 2".
  3. ↑ Boeckers TM, Bockmann J, Kreutz MR, Gundelfinger ED (June 2002). "ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease". J. Neurochem. 81 (5): 903–10. doi:10.1046/j.1471-4159.2002.00931.x. PMID 12065602.
  4. ↑ Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503.
  5. ↑ Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT (October 1998). "Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons". Mol. Cell. Biol. 18 (10): 5838–51. PMC 109170. PMID 9742101.
  6. ↑ 6.0 6.1 Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. 20 (12): 4524–34. PMID 10844022.
  7. ↑ 7.0 7.1 Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, Gundelfinger ED (October 1999). "Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family". Biochem. Biophys. Res. Commun. 264 (1): 247–52. doi:10.1006/bbrc.1999.1489. PMID 10527873.
  8. ↑ Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (Dec 2001). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172. PMID 11583995.

Further reading


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