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'''Lysosomal acid phosphatase''' is an [[enzyme]] that in humans is encoded by the ''ACP2'' [[gene]].<ref name="pmid975882">{{cite journal | vauthors = Shows TB, Brown JA, Lalley PA | title = Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11 | journal = Cytogenet Cell Genet | volume = 16 | issue = 1-5 | pages = 231–4 |date=Dec 1976 | pmid = 975882 | pmc = | doi =10.1159/000130598 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACP2 acid phosphatase 2, lysosomal| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53| accessdate = }}</ref> | |||
'''Lysosomal [[acid phosphatase]]''' is composed of two subunits, alpha and beta, and is chemically and genetically distinct from [[red cell acid phosphatase]]. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze [[orthophosphoric monoester]]s to [[alcohol]] and [[phosphate]]. [[Acid phosphatase deficiency]] is caused by [[mutation]]s in the ACP2 (beta subunit) and [[ACP3]] (alpha subunit) genes.<ref name="entrez"/> | |||
==References== | |||
{{reflist}} | |||
==External links== | |||
* {{UCSC gene info|ACP2}} | |||
==Further reading== | |||
{{refbegin | 2}} | |||
{{PBB_Further_reading | |||
| citations = | |||
*{{cite journal | vauthors=Moss DW, Raymond FD, Wile DB |title=Clinical and biological aspects of acid phosphatase. |journal=Critical reviews in clinical laboratory sciences |volume=32 |issue= 4 |pages= 431–67 |year= 1995 |pmid= 7576159 |doi=10.3109/10408369509084690 }} | |||
*{{cite journal | vauthors=Gierek T, Lisiewicz T, Pilch J |title=Intracellular enzymatic response of lymphocytes and neutrophils in patients with cancer of the larynx. |journal=Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. |volume=104 |issue= 2 |pages= 208–15 |year= 1977 |pmid= 69583 |doi= }} | |||
*{{cite journal | vauthors=Jones C, Kao FT |title=Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11. |journal=Hum. Genet. |volume=45 |issue= 1 |pages= 1–10 |year= 1979 |pmid= 730175 |doi=10.1007/BF00277567 }} | |||
*{{cite journal | vauthors=Geier C, von Figura K, Pohlmann R |title=Structure of the human lysosomal acid phosphatase gene. |journal=Eur. J. Biochem. |volume=183 |issue= 3 |pages= 611–6 |year= 1989 |pmid= 2776754 |doi=10.1111/j.1432-1033.1989.tb21090.x }} | |||
*{{cite journal | vauthors=Lemansky P, Gieselmann V, Hasilik A, von Figura K |title=Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts. |journal=J. Biol. Chem. |volume=260 |issue= 15 |pages= 9023–30 |year= 1985 |pmid= 3160696 |doi= }} | |||
*{{cite journal | vauthors=Pohlmann R, Krentler C, Schmidt B |title=Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment. |journal=EMBO J. |volume=7 |issue= 8 |pages= 2343–50 |year= 1989 |pmid= 3191910 |doi= | pmc=457099 |display-authors=etal}} | |||
*{{cite journal | vauthors=Waheed A, Van Etten RL |title=Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells. |journal=Arch. Biochem. Biophys. |volume=243 |issue= 1 |pages= 274–83 |year= 1985 |pmid= 3904632 |doi=10.1016/0003-9861(85)90796-9 }} | |||
*{{cite journal | vauthors=Nadler HL, Egan TJ |title=Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder. |journal=N. Engl. J. Med. |volume=282 |issue= 6 |pages= 302–7 |year= 1970 |pmid= 5410815 |doi=10.1056/NEJM197002052820604 }} | |||
*{{cite journal | vauthors=Bass DA, Lewis JC, Szejda P |title=Activation of lysosomal acid phosphatase of eosinophil leukocytes. |journal=Lab. Invest. |volume=44 |issue= 5 |pages= 403–9 |year= 1981 |pmid= 6164873 |doi= |display-authors=etal}} | |||
*{{cite journal | vauthors=Chappard D, Alexandre C, Riffat G |title=Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies. |journal=Basic and Applied Histochemistry |volume=27 |issue= 2 |pages= 75–85 |year= 1983 |pmid= 6193776 |doi= }} | |||
*{{cite journal | vauthors=Moszczyński P, Lisiewicz J |title=Beta-glucuronidase of lymphocytes in ontogenetic development of man. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=31 |issue= 2 |pages= 171–6 |year= 1984 |pmid= 6651479 |doi= }} | |||
*{{cite journal | vauthors=Radzun HJ, Parwaresch MR |title=Isoelectric focusing pattern of acid phosphatase and acid esterase in human blood cells, including thymocytes, T lymphocytes, and B lymphocytes. |journal=Exp. Hematol. |volume=8 |issue= 6 |pages= 737–41 |year= 1981 |pmid= 6970673 |doi= }} | |||
*{{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}} | |||
*{{cite journal | vauthors=Whitelock RB, Fukuchi T, Zhou L |title=Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas. |journal=Invest. Ophthalmol. Vis. Sci. |volume=38 |issue= 2 |pages= 529–34 |year= 1997 |pmid= 9040486 |doi= |display-authors=etal}} | |||
*{{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}} | |||
*{{cite journal | vauthors=Obermüller S, Kiecke C, von Figura K, Höning S |title=The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targeting to lysosomes. |journal=J. Cell Sci. |volume=115 |issue= Pt 1 |pages= 185–94 |year= 2002 |pmid= 11801736 |doi= }} | |||
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | |||
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | |||
}} | |||
{{refend}} | |||
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[[Category:Human proteins]] | |||
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Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.[1][2]
Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.[2]
References
- ↑ Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet. 16 (1–5): 231–4. doi:10.1159/000130598. PMID 975882.
- ↑ 2.0 2.1 "Entrez Gene: ACP2 acid phosphatase 2, lysosomal".
External links
- Human ACP2 genome location and ACP2 gene details page in the UCSC Genome Browser.
Further reading
- Moss DW, Raymond FD, Wile DB (1995). "Clinical and biological aspects of acid phosphatase". Critical reviews in clinical laboratory sciences. 32 (4): 431–67. doi:10.3109/10408369509084690. PMID 7576159.
- Gierek T, Lisiewicz T, Pilch J (1977). "Intracellular enzymatic response of lymphocytes and neutrophils in patients with cancer of the larynx". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 104 (2): 208–15. PMID 69583.
- Jones C, Kao FT (1979). "Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11". Hum. Genet. 45 (1): 1–10. doi:10.1007/BF00277567. PMID 730175.
- Geier C, von Figura K, Pohlmann R (1989). "Structure of the human lysosomal acid phosphatase gene". Eur. J. Biochem. 183 (3): 611–6. doi:10.1111/j.1432-1033.1989.tb21090.x. PMID 2776754.
- Lemansky P, Gieselmann V, Hasilik A, von Figura K (1985). "Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts". J. Biol. Chem. 260 (15): 9023–30. PMID 3160696.
- Pohlmann R, Krentler C, Schmidt B, et al. (1989). "Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment". EMBO J. 7 (8): 2343–50. PMC 457099. PMID 3191910.
- Waheed A, Van Etten RL (1985). "Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells". Arch. Biochem. Biophys. 243 (1): 274–83. doi:10.1016/0003-9861(85)90796-9. PMID 3904632.
- Nadler HL, Egan TJ (1970). "Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder". N. Engl. J. Med. 282 (6): 302–7. doi:10.1056/NEJM197002052820604. PMID 5410815.
- Bass DA, Lewis JC, Szejda P, et al. (1981). "Activation of lysosomal acid phosphatase of eosinophil leukocytes". Lab. Invest. 44 (5): 403–9. PMID 6164873.
- Chappard D, Alexandre C, Riffat G (1983). "Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies". Basic and Applied Histochemistry. 27 (2): 75–85. PMID 6193776.
- Moszczyński P, Lisiewicz J (1984). "Beta-glucuronidase of lymphocytes in ontogenetic development of man". Arch. Immunol. Ther. Exp. (Warsz.). 31 (2): 171–6. PMID 6651479.
- Radzun HJ, Parwaresch MR (1981). "Isoelectric focusing pattern of acid phosphatase and acid esterase in human blood cells, including thymocytes, T lymphocytes, and B lymphocytes". Exp. Hematol. 8 (6): 737–41. PMID 6970673.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Whitelock RB, Fukuchi T, Zhou L, et al. (1997). "Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas". Invest. Ophthalmol. Vis. Sci. 38 (2): 529–34. PMID 9040486.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Obermüller S, Kiecke C, von Figura K, Höning S (2002). "The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targeting to lysosomes". J. Cell Sci. 115 (Pt 1): 185–94. PMID 11801736.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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