CKAP5: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
 
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cytoskeleton-associated protein 5''' is a [[microtubule-associated protein]] that in humans is encoded by the ''CKAP5'' [[gene]].<ref name="pmid7788527">{{cite journal | vauthors = Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H | title = Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res. | volume = 2 | issue = 1 | pages = 37–43  | date = Jul 1995 | pmid = 7788527 | pmc =  | doi = 10.1093/dnares/2.1.37 }}</ref><ref name="pmid8536682">{{cite journal | vauthors = Charrasse S, Mazel M, Taviaux S, Berta P, Chow T, Larroque C | title = Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors | journal = Eur. J. Biochem. | volume = 234 | issue = 2 | pages = 406–13 | date = Feb 1996 | pmid = 8536682 | pmc =  | doi = 10.1111/j.1432-1033.1995.406_b.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CKAP5 cytoskeleton associated protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9793| accessdate = }}</ref> It is the homolog of the ''[[Xenopus]]'' protein [[XMAP215-Dis1 family|XMAP215]]<ref>{{cite journal | vauthors = Cassimeris L, Morabito J | title = TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly | journal = Mol. Biol. Cell | volume = 15 | issue = 4 | pages = 1580–90 | year = 2004 | pmid = 14718566 | pmc = 379257 | doi = 10.1091/mbc.E03-07-0544 }}</ref> and is also known as '''ch-Tog'''.
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
It has at least two distinct roles in [[spindle apparatus|spindle]] formation: it protects [[kinetochore]] [[microtubule]]s from depolymerization by MCAK ([[KIF2C]]), and ch-Tog plays an essential role in [[centrosome|centrosomal]] microtubule assembly, a function independent of MCAK activity.<ref>{{cite journal | vauthors = Barr AR, Gergely F | title = MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics | journal = Mol. Cell. Biol. | volume = 28 | issue = 23 | pages = 7199–211 | year = 2008 | pmid = 18809577 | pmc = 2593372 | doi = 10.1128/MCB.01040-08 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cytoskeleton associated protein 5
| HGNCid = 28959
| Symbol = CKAP5
| AltSymbols =; FLJ35359; KIAA0097; TOG; TOGp; ch-TOG
| OMIM = 
| ECnumber = 
| Homologene = 8844
| MGIid = 1923036
| GeneAtlas_image1 = PBB_GE_CKAP5_212832_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000930 |text = gamma-tubulin complex}} {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0030951 |text = establishment and/or maintenance of microtubule cytoskeleton polarity}} {{GNF_GO|id=GO:0050658 |text = RNA transport}} {{GNF_GO|id=GO:0051297 |text = centrosome organization and biogenesis}} {{GNF_GO|id=GO:0051300 |text = spindle pole body organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9793
    | Hs_Ensembl = ENSG00000175216
    | Hs_RefseqProtein = NP_001008938
    | Hs_RefseqmRNA = NM_001008938
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 46721662
    | Hs_GenLoc_end = 46824419
    | Hs_Uniprot = Q14008
    | Mm_EntrezGene = 75786
    | Mm_Ensembl = ENSMUSG00000040549
    | Mm_RefseqmRNA = NM_029437
    | Mm_RefseqProtein = NP_083713
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 91327634
    | Mm_GenLoc_end = 91421504
    | Mm_Uniprot =
  }}
}}
'''Cytoskeleton associated protein 5''', also known as '''CKAP5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CKAP5 cytoskeleton associated protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9793| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
CKAP5 has been shown to [[Protein-protein interaction|interact]] with [[TACC1]].<ref name=pmid14603251>{{cite journal | vauthors = Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D | title = TACC1-chTOG-Aurora A protein complex in breast cancer | journal = Oncogene | volume = 22 | issue = 50 | pages = 8102–16  | date = Nov 2003 | pmid = 14603251 | doi = 10.1038/sj.onc.1206972 }}</ref><ref name=pmid11903063>{{cite journal | vauthors = Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH | title = Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells | journal = Biochem. J. | volume = 363 | issue = Pt 1 | pages = 195–200  | date = Apr 2002 | pmid = 11903063 | pmc = 1222467 | doi = 10.1042/0264-6021:3630195 }}</ref>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CKAP5}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW | title = Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans | journal = J. Cell Sci. | volume = 120 | issue = Pt 7 | pages = 1278–87 | year = 2007 | pmid = 17376965 | doi = 10.1242/jcs.000604 }}
| citations =
* {{cite journal | vauthors = Kosturko LD, Maggipinto MJ, D'Sa C, Carson JH, Barbarese E | title = The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2 | journal = Mol. Biol. Cell | volume = 16 | issue = 4 | pages = 1938–47 | year = 2005 | pmid = 15703215 | pmc = 1073673 | doi = 10.1091/mbc.E04-08-0709 }}
*{{cite journal | author=Basto R, Gergely F, Draviam VM, ''et al.'' |title=Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans. |journal=J. Cell. Sci. |volume=120 |issue= Pt 7 |pages= 1278-87 |year= 2007 |pmid= 17376965 |doi= 10.1242/jcs.000604 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Kosturko LD, Maggipinto MJ, D'Sa C, ''et al.'' |title=The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2. |journal=Mol. Biol. Cell |volume=16 |issue= 4 |pages= 1938-47 |year= 2005 |pmid= 15703215 |doi= 10.1091/mbc.E04-08-0709 }}
* {{cite journal | vauthors = Cassimeris L, Morabito J | title = TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly | journal = Mol. Biol. Cell | volume = 15 | issue = 4 | pages = 1580–90 | year = 2004 | pmid = 14718566 | pmc = 379257 | doi = 10.1091/mbc.E03-07-0544 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D | title = TACC1-chTOG-Aurora A protein complex in breast cancer | journal = Oncogene | volume = 22 | issue = 50 | pages = 8102–16 | year = 2003 | pmid = 14603251 | doi = 10.1038/sj.onc.1206972 }}
*{{cite journal | author=Cassimeris L, Morabito J |title=TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. |journal=Mol. Biol. Cell |volume=15 |issue= 4 |pages= 1580-90 |year= 2004 |pmid= 14718566 |doi= 10.1091/mbc.E03-07-0544 }}
* {{cite journal | vauthors = Gergely F, Draviam VM, Raff JW | title = The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells | journal = Genes Dev. | volume = 17 | issue = 3 | pages = 336–41 | year = 2003 | pmid = 12569123 | pmc = 195983 | doi = 10.1101/gad.245603 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
*{{cite journal  | author=Conte N, Delaval B, Ginestier C, ''et al.'' |title=TACC1-chTOG-Aurora A protein complex in breast cancer. |journal=Oncogene |volume=22 |issue= 50 |pages= 8102-16 |year= 2003 |pmid= 14603251 |doi= 10.1038/sj.onc.1206972 }}
* {{cite journal | vauthors = Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH | title = Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells | journal = Biochem. J. | volume = 363 | issue = Pt 1 | pages = 195–200 | year = 2002 | pmid = 11903063 | pmc = 1222467 | doi = 10.1042/0264-6021:3630195 }}
*{{cite journal | author=Gergely F, Draviam VM, Raff JW |title=The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. |journal=Genes Dev. |volume=17 |issue= 3 |pages= 336-41 |year= 2003 |pmid= 12569123 |doi= 10.1101/gad.245603 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Nakamura S, Grigoriev I, Nogi T, Hamaji T, Cassimeris L, Mimori-Kiyosue Y | title = Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells | journal = PLoS ONE | volume = 7 | issue = 12 | pages = e51442 | year = 2012 | pmid = 23251535 | doi = 10.1371/journal.pone.0051442 | pmc=3520847}}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
* {{cite journal | vauthors = Zanic M, Widlund PO, Hyman AA, Howard J | title = Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels | journal = Nat. Cell Biol. | volume = 15 | issue = 6 | pages = 688–93 | year = 2013 | pmid = 23666085 | doi = 10.1038/ncb2744 }}
*{{cite journal | author=Lauffart B, Howell SJ, Tasch JE, ''et al.'' |title=Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. |journal=Biochem. J. |volume=363 |issue= Pt 1 |pages= 195-200 |year= 2002 |pmid= 11903063 |doi= }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Charrasse S, Mazel M, Taviaux S, ''et al.'' |title=Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors. |journal=Eur. J. Biochem. |volume=234 |issue= 2 |pages= 406-13 |year= 1996 |pmid= 8536682 |doi= }}
*{{cite journal | author=Nagase T, Miyajima N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37-43 |year= 1995 |pmid= 7788527 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Centrosome}}
{{WikiDoc Sources}}
 
 
{{gene-11-stub}}

Latest revision as of 19:34, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene.[1][2][3] It is the homolog of the Xenopus protein XMAP215[4] and is also known as ch-Tog.

It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.[5]

Interactions

CKAP5 has been shown to interact with TACC1.[6][7]

References

  1. ↑ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  2. ↑ Charrasse S, Mazel M, Taviaux S, Berta P, Chow T, Larroque C (Feb 1996). "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors". Eur. J. Biochem. 234 (2): 406–13. doi:10.1111/j.1432-1033.1995.406_b.x. PMID 8536682.
  3. ↑ "Entrez Gene: CKAP5 cytoskeleton associated protein 5".
  4. ↑ Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4): 1580–90. doi:10.1091/mbc.E03-07-0544. PMC 379257. PMID 14718566.
  5. ↑ Barr AR, Gergely F (2008). "MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics". Mol. Cell. Biol. 28 (23): 7199–211. doi:10.1128/MCB.01040-08. PMC 2593372. PMID 18809577.
  6. ↑ Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
  7. ↑ Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (Apr 2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.

External links

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=CKAP5&oldid=1414961"