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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''Sperm surface protein Sp17''' is a [[protein]] that in humans is encoded by the ''SPA17'' [[gene]].<ref name="pmid8688458">{{cite journal | vauthors = Lea IA, Richardson RT, Widgren EE, O'Rand MG | title = Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17 | journal = Biochim Biophys Acta | volume = 1307 | issue = 3 | pages = 263–6 |date=Aug 1996 | pmid = 8688458 | pmc =  | doi =  10.1016/0167-4781(96)00077-2}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPA17 sperm autoantigenic protein 17| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53340| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Sperm autoantigenic protein 17
| HGNCid = 11210
| Symbol = SPA17
| AltSymbols =; SP17; SP17-1
| OMIM = 608621
| ECnumber = 
| Homologene = 7951
| MGIid = 1333778
| GeneAtlas_image1 = PBB_GE_SPA17_205406_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008603 |text = cAMP-dependent protein kinase regulator activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0007339 |text = binding of sperm to zona pellucida}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 53340
    | Hs_Ensembl = ENSG00000064199
    | Hs_RefseqProtein = NP_059121
    | Hs_RefseqmRNA = NM_017425
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 124048950
    | Hs_GenLoc_end = 124069895
    | Hs_Uniprot = Q15506
    | Mm_EntrezGene = 20686
    | Mm_Ensembl = ENSMUSG00000001948
    | Mm_RefseqmRNA = NM_011449
    | Mm_RefseqProtein = NP_035579
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 37352969
    | Mm_GenLoc_end = 37363285
    | Mm_Uniprot = Q545M2
  }}
}}
'''Sperm autoantigenic protein 17''', also known as '''SPA17''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPA17 sperm autoantigenic protein 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53340| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein present at the cell surface. Studies in rabbit suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbit suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.<ref name="entrez">{{cite web | title = Entrez Gene: SPA17 sperm autoantigenic protein 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53340| accessdate = }}</ref>
| summary_text = This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=McLeskey SB, Dowds C, Carballada R, ''et al.'' |title=Molecules involved in mammalian sperm-egg interaction. |journal=Int. Rev. Cytol. |volume=177 |issue=  |pages= 57-113 |year= 1997 |pmid= 9378618 |doi=  }}
*{{cite journal   |vauthors=McLeskey SB, Dowds C, Carballada R, etal |title=Molecules involved in mammalian sperm-egg interaction |journal=Int. Rev. Cytol. |volume=177 |issue=  |pages= 57–113 |year= 1997 |pmid= 9378618 |doi=10.1016/S0074-7696(08)62231-7 }}
*{{cite journal  | author=Richardson RT, Yamasaki N, O'Rand MG |title=Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction. |journal=Dev. Biol. |volume=165 |issue= 2 |pages= 688-701 |year= 1994 |pmid= 7525387 |doi= 10.1006/dbio.1994.1285 }}
*{{cite journal  | vauthors=Richardson RT, Yamasaki N, O'Rand MG |title=Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction |journal=Dev. Biol. |volume=165 |issue= 2 |pages= 688–701 |year= 1994 |pmid= 7525387 |doi= 10.1006/dbio.1994.1285 }}
*{{cite journal  | author=Kong M, Richardson RT, Widgren EE, O'Rand MG |title=Sequence and localization of the mouse sperm autoantigenic protein, Sp17. |journal=Biol. Reprod. |volume=53 |issue= 3 |pages= 579-90 |year= 1995 |pmid= 7578682 |doi= }}
*{{cite journal  | vauthors=Kong M, Richardson RT, Widgren EE, O'Rand MG |title=Sequence and localization of the mouse sperm autoantigenic protein, Sp17 |journal=Biol. Reprod. |volume=53 |issue= 3 |pages= 579–90 |year= 1995 |pmid= 7578682 |doi=10.1095/biolreprod53.3.579 }}
*{{cite journal  | author=Lea IA, Richardson RT, Widgren EE, O'Rand MG |title=Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. |journal=Biochim. Biophys. Acta |volume=1307 |issue= 3 |pages= 263-6 |year= 1996 |pmid= 8688458 |doi= }}
*{{cite journal   |vauthors=Fujita A, Nakamura K, Kato T, etal |title=Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella |journal=J. Cell Sci. |volume=113 |issue=  1|pages= 103–12 |year= 2000 |pmid= 10591629 |doi=  }}
*{{cite journal | author=Fujita A, Nakamura K, Kato T, ''et al.'' |title=Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. |journal=J. Cell. Sci. |volume=113 ( Pt 1) |issue=  |pages= 103-12 |year= 2000 |pmid= 10591629 |doi=  }}
*{{cite journal  | vauthors=Wen Y, Richardson RT, Widgren EE, O'Rand MG |title=Characterization of Sp17: a ubiquitous three domain protein that binds heparin |journal=Biochem. J. |volume=357 |issue= Pt 1 |pages= 25–31 |year= 2001 |pmid= 11415432 |doi=10.1042/0264-6021:3570025  | pmc=1221924 }}
*{{cite journal  | author=Wen Y, Richardson RT, Widgren EE, O'Rand MG |title=Characterization of Sp17: a ubiquitous three domain protein that binds heparin. |journal=Biochem. J. |volume=357 |issue= Pt 1 |pages= 25-31 |year= 2001 |pmid= 11415432 |doi=  }}
*{{cite journal  | vauthors=De Jong A, Buchli R, Robbins D |title=Characterization of sperm protein 17 in human somatic and neoplastic tissue |journal=Cancer Lett. |volume=186 |issue= 2 |pages= 201–9 |year= 2003 |pmid= 12213290 |doi=10.1016/S0304-3835(02)00350-6 }}
*{{cite journal  | author=De Jong A, Buchli R, Robbins D |title=Characterization of sperm protein 17 in human somatic and neoplastic tissue. |journal=Cancer Lett. |volume=186 |issue= 2 |pages= 201-9 |year= 2003 |pmid= 12213290 |doi=  }}
*{{cite journal  | vauthors=Buchli R, De Jong A, Robbins DL |title=Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model |journal=Biochim. Biophys. Acta |volume=1578 |issue= 1–3 |pages= 29–42 |year= 2002 |pmid= 12393185 |doi=  10.1016/S0167-4781(02)00478-5}}
*{{cite journal  | author=Buchli R, De Jong A, Robbins DL |title=Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. |journal=Biochim. Biophys. Acta |volume=1578 |issue= 1-3 |pages= 29-42 |year= 2002 |pmid= 12393185 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Frayne J, Hall L |title=A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding |journal=Reproduction |volume=124 |issue= 6 |pages= 767–74 |year= 2003 |pmid= 12530914 |doi=10.1530/rep.0.1240767 }}
*{{cite journal  | author=Frayne J, Hall L |title=A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding. |journal=Reproduction |volume=124 |issue= 6 |pages= 767-74 |year= 2003 |pmid= 12530914 |doi=  }}
*{{cite journal   |vauthors=Takeoka Y, Kenny TP, Yago H, etal |title=Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes |journal=Dev. Immunol. |volume=9 |issue= 2 |pages= 97–102 |year= 2004 |pmid= 12739786 |doi=10.1080/1044667021000095186  | pmc=2276097 }}
*{{cite journal | author=Takeoka Y, Kenny TP, Yago H, ''et al.'' |title=Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes. |journal=Dev. Immunol. |volume=9 |issue= 2 |pages= 97-102 |year= 2004 |pmid= 12739786 |doi=  }}
*{{cite journal   |vauthors=Chiriva-Internati M, Wang Z, Pochopien S, etal |title=Identification of a sperm protein 17 CTL epitope restricted by HLA-A1 |journal=Int. J. Cancer |volume=107 |issue= 5 |pages= 863–5 |year= 2004 |pmid= 14566839 |doi= 10.1002/ijc.11486 }}
*{{cite journal | author=Chiriva-Internati M, Wang Z, Pochopien S, ''et al.'' |title=Identification of a sperm protein 17 CTL epitope restricted by HLA-A1. |journal=Int. J. Cancer |volume=107 |issue= 5 |pages= 863-5 |year= 2004 |pmid= 14566839 |doi= 10.1002/ijc.11486 }}
*{{cite journal   |vauthors=Straughn JM, Shaw DR, Guerrero A, etal |title=Expression of sperm protein 17 (Sp17) in ovarian cancer |journal=Int. J. Cancer |volume=108 |issue= 6 |pages= 805–11 |year= 2004 |pmid= 14712480 |doi= 10.1002/ijc.11617 }}
*{{cite journal | author=Straughn JM, Shaw DR, Guerrero A, ''et al.'' |title=Expression of sperm protein 17 (Sp17) in ovarian cancer. |journal=Int. J. Cancer |volume=108 |issue= 6 |pages= 805-11 |year= 2004 |pmid= 14712480 |doi= 10.1002/ijc.11617 }}
*{{cite journal  | vauthors=Lea IA, Widgren EE, O'Rand MG |title=Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella |journal=Reprod. Biol. Endocrinol. |volume=2 |issue=  |pages= 57 |year= 2004 |pmid= 15257753 |doi= 10.1186/1477-7827-2-57 | pmc=484205 }}
*{{cite journal  | author=Lea IA, Widgren EE, O'Rand MG |title=Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. |journal=Reprod. Biol. Endocrinol. |volume=2 |issue=  |pages= 57 |year= 2004 |pmid= 15257753 |doi= 10.1186/1477-7827-2-57 }}
*{{cite journal   |vauthors=Wang Z, Zhang Y, Ramsahoye B, etal |title=Sp17 gene expression in myeloma cells is regulated by promoter methylation |journal=Br. J. Cancer |volume=91 |issue= 8 |pages= 1597–603 |year= 2004 |pmid= 15381930 |doi= 10.1038/sj.bjc.6602160 | pmc=2409933 }}
*{{cite journal | author=Wang Z, Zhang Y, Ramsahoye B, ''et al.'' |title=Sp17 gene expression in myeloma cells is regulated by promoter methylation. |journal=Br. J. Cancer |volume=91 |issue= 8 |pages= 1597-603 |year= 2004 |pmid= 15381930 |doi= 10.1038/sj.bjc.6602160 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gupta G, Sharma R, Chattopadhyay TK, etal |title=Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer |journal=Int. J. Cancer |volume=120 |issue= 8 |pages= 1739–47 |year= 2007 |pmid= 17230514 |doi= 10.1002/ijc.22463 }}
*{{cite journal | author=Gupta G, Sharma R, Chattopadhyay TK, ''et al.'' |title=Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer. |journal=Int. J. Cancer |volume=120 |issue= 8 |pages= 1739-47 |year= 2007 |pmid= 17230514 |doi= 10.1002/ijc.22463 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:53, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.[1][2]

This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.[2]

References

  1. ↑ Lea IA, Richardson RT, Widgren EE, O'Rand MG (Aug 1996). "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17". Biochim Biophys Acta. 1307 (3): 263–6. doi:10.1016/0167-4781(96)00077-2. PMID 8688458.
  2. ↑ 2.0 2.1 "Entrez Gene: SPA17 sperm autoantigenic protein 17".

Further reading



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