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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''Nicotinamide N-methyltransferase''' is an [[enzyme]] that in humans is encoded by the ''NNMT'' [[gene]].<ref name="pmid8575745">{{cite journal | vauthors = Aksoy S, Brandriff BF, Ward A, Little PF, Weinshilboum RM | title = Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization | journal = Genomics | volume = 29 | issue = 3 | pages = 555–61 |date=Mar 1996 | pmid = 8575745 | pmc = | doi = 10.1006/geno.1995.9966 }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = PBB_Protein_NNMT_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2iip.
| PDB = {{PDB2|2iip}}
| Name = Nicotinamide N-methyltransferase
| HGNCid = 7861
| Symbol = NNMT
| AltSymbols =;
| OMIM = 600008
| ECnumber = 
| Homologene = 4496
| MGIid = 1099443
| GeneAtlas_image1 = PBB_GE_NNMT_202237_at_tn.png
| GeneAtlas_image2 = PBB_GE_NNMT_202238_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008112 |text = nicotinamide N-methyltransferase activity}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4837
    | Hs_Ensembl = ENSG00000166741
    | Hs_RefseqProtein = NP_006160
    | Hs_RefseqmRNA = NM_006169
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 113633763
    | Hs_GenLoc_end = 113688448
    | Hs_Uniprot = P40261
    | Mm_EntrezGene = 18113
    | Mm_Ensembl = ENSMUSG00000032271
    | Mm_RefseqmRNA = NM_010924
    | Mm_RefseqProtein = NP_035054
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 48343844
    | Mm_GenLoc_end = 48357120
    | Mm_Uniprot = Q9D9X3
  }}
}}
'''Nicotinamide N-methyltransferase''', also known as '''NNMT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NNMT nicotinamide N-methyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4837| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.<ref name="entrez">{{cite web | title = Entrez Gene: NNMT nicotinamide N-methyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4837| accessdate = }}</ref>
| summary_text = N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.<ref name="entrez">{{cite web | title = Entrez Gene: NNMT nicotinamide N-methyltransferase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4837| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Williams AC, Cartwright LS, Ramsden DB |title=Parkinson's disease: the first common neurological disease due to auto-intoxication? |journal=QJM : monthly journal of the Association of Physicians |volume=98 |issue= 3 |pages= 215-26 |year= 2005 |pmid= 15728403 |doi= 10.1093/qjmed/hci027 }}
*{{cite journal  | vauthors=Williams AC, Cartwright LS, Ramsden DB |title=Parkinson's disease: the first common neurological disease due to auto-intoxication? |journal=QJM : Monthly Journal of the Association of Physicians |volume=98 |issue= 3 |pages= 215–26 |year= 2005 |pmid= 15728403 |doi= 10.1093/qjmed/hci027 }}
*{{cite journal  | author=Sano A, Endo N, Takitani S |title=Fluorometric assay of rat tissue N-methyltransferases with nicotinamide and four isomeric methylnicotinamides. |journal=Chem. Pharm. Bull. |volume=40 |issue= 1 |pages= 153-6 |year= 1992 |pmid= 1533573 |doi=  }}
*{{cite journal  | vauthors=Sano A, Endo N, Takitani S |title=Fluorometric assay of rat tissue N-methyltransferases with nicotinamide and four isomeric methylnicotinamides. |journal=Chem. Pharm. Bull. |volume=40 |issue= 1 |pages= 153–6 |year= 1992 |pmid= 1533573 |doi=  10.1248/cpb.40.153}}
*{{cite journal  | author=Aksoy S, Szumlanski CL, Weinshilboum RM |title=Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. |journal=J. Biol. Chem. |volume=269 |issue= 20 |pages= 14835-40 |year= 1994 |pmid= 8182091 |doi=  }}
*{{cite journal  | vauthors=Aksoy S, Szumlanski CL, Weinshilboum RM |title=Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. |journal=J. Biol. Chem. |volume=269 |issue= 20 |pages= 14835–40 |year= 1994 |pmid= 8182091 |doi=  }}
*{{cite journal  | author=Aksoy S, Brandriff BF, Ward A, ''et al.'' |title=Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. |journal=Genomics |volume=29 |issue= 3 |pages= 555-61 |year= 1996 |pmid= 8575745 |doi= 10.1006/geno.1995.9966 }}
*{{cite journal  | vauthors=Scheller T, Orgacka H, Szumlanski CL, Weinshilboum RM |title=Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains. |journal=Pharmacogenetics |volume=6 |issue= 1 |pages= 43–53 |year= 1996 |pmid= 8845860 |doi=10.1097/00008571-199602000-00003 }}
*{{cite journal  | author=Scheller T, Orgacka H, Szumlanski CL, Weinshilboum RM |title=Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains. |journal=Pharmacogenetics |volume=6 |issue= 1 |pages= 43-53 |year= 1996 |pmid= 8845860 |doi=  }}
*{{cite journal   |vauthors=Smith ML, Burnett D, Bennett P, etal |title=A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol. |journal=Biochim. Biophys. Acta |volume=1442 |issue= 2–3 |pages= 238–44 |year= 1998 |pmid= 9804963 |doi=  10.1016/s0167-4781(98)00177-8}}
*{{cite journal | author=Smith ML, Burnett D, Bennett P, ''et al.'' |title=A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol. |journal=Biochim. Biophys. Acta |volume=1442 |issue= 2-3 |pages= 238-44 |year= 1998 |pmid= 9804963 |doi=  }}
*{{cite journal  | vauthors=Yan L, Otterness DM, Weinshilboum RM |title=Human nicotinamide N-methyltransferase pharmacogenetics: gene sequence analysis and promoter characterization |journal=Pharmacogenetics |volume=9 |issue= 3 |pages= 307–16 |year= 1999 |pmid= 10471062 |doi=10.1097/00008571-199906000-00005 }}
*{{cite journal  | author=Yan L, Otterness DM, Weinshilboum RM |title=Human nicotinamide N-methyltransferase pharmacogenetics: gene sequence analysis and promoter characterization. |journal=Pharmacogenetics |volume=9 |issue= 3 |pages= 307-16 |year= 1999 |pmid= 10471062 |doi=  }}
*{{cite journal  | vauthors=Hubbard MJ, McHugh NJ |title=Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping |journal=Electrophoresis |volume=21 |issue= 17 |pages= 3785–96 |year= 2001 |pmid= 11271497 |doi= 10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2 }}
*{{cite journal  | author=Hubbard MJ, McHugh NJ |title=Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping. |journal=Electrophoresis |volume=21 |issue= 17 |pages= 3785-96 |year= 2001 |pmid= 11271497 |doi= 10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2 }}
*{{cite journal   |vauthors=Parsons RB, Smith ML, Williams AC, etal |title=Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain |journal=J. Neuropathol. Exp. Neurol. |volume=61 |issue= 2 |pages= 111–24 |year= 2002 |pmid= 11853016 |doi=  }}
*{{cite journal | author=Parsons RB, Smith ML, Williams AC, ''et al.'' |title=Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain. |journal=J. Neuropathol. Exp. Neurol. |volume=61 |issue= 2 |pages= 111-24 |year= 2002 |pmid= 11853016 |doi=  }}
*{{cite journal  | vauthors=((Kassem HSh)), Sangar V, Cowan R|title=A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer |journal=Int. J. Cancer |volume=101 |issue= 5 |pages= 454–60 |year= 2002 |pmid= 12216074 |doi= 10.1002/ijc.10631 |display-authors=etal}}
*{{cite journal  | author=Kassem HSh, Sangar V, Cowan R, ''et al.'' |title=A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer. |journal=Int. J. Cancer |volume=101 |issue= 5 |pages= 454-60 |year= 2002 |pmid= 12216074 |doi= 10.1002/ijc.10631 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Xu J, Capezzone M, Xu X, Hershman JM |title=Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells |journal=Mol. Endocrinol. |volume=19 |issue= 2 |pages= 527–39 |year= 2005 |pmid= 15486044 |doi= 10.1210/me.2004-0215 }}
*{{cite journal  | author=Xu J, Capezzone M, Xu X, Hershman JM |title=Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells. |journal=Mol. Endocrinol. |volume=19 |issue= 2 |pages= 527-39 |year= 2005 |pmid= 15486044 |doi= 10.1210/me.2004-0215 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Souto JC, Blanco-Vaca F, Soria JM, etal |title=A Genomewide Exploration Suggests a New Candidate Gene at Chromosome 11q23 as the Major Determinant of Plasma Homocysteine Levels: Results from the GAIT Project |journal=Am. J. Hum. Genet. |volume=76 |issue= 6 |pages= 925–33 |year= 2005 |pmid= 15849667 |doi= 10.1086/430409 | pmc=1196452 }}
*{{cite journal | author=Souto JC, Blanco-Vaca F, Soria JM, ''et al.'' |title=A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. |journal=Am. J. Hum. Genet. |volume=76 |issue= 6 |pages= 925-33 |year= 2005 |pmid= 15849667 |doi= 10.1086/430409 }}
*{{cite journal   |vauthors=Roessler M, Rollinger W, Palme S, etal |title=Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer |journal=Clin. Cancer Res. |volume=11 |issue= 18 |pages= 6550–7 |year= 2005 |pmid= 16166432 |doi= 10.1158/1078-0432.CCR-05-0983 }}
*{{cite journal | author=Roessler M, Rollinger W, Palme S, ''et al.'' |title=Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 18 |pages= 6550-7 |year= 2005 |pmid= 16166432 |doi= 10.1158/1078-0432.CCR-05-0983 }}
*{{cite journal  | vauthors=Xu J, Hershman JM |title=Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells |journal=Thyroid |volume=16 |issue= 2 |pages= 151–60 |year= 2006 |pmid= 16676400 |doi=10.1089/thy.2006.16.151 }}
*{{cite journal  | author=Xu J, Hershman JM |title=Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells. |journal=Thyroid |volume=16 |issue= 2 |pages= 151-60 |year= 2006 |pmid= 16676400 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4837}}
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Latest revision as of 13:07, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nicotinamide N-methyltransferase is an enzyme that in humans is encoded by the NNMT gene.[1][2]

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.[2]

References

  1. ↑ Aksoy S, Brandriff BF, Ward A, Little PF, Weinshilboum RM (Mar 1996). "Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization". Genomics. 29 (3): 555–61. doi:10.1006/geno.1995.9966. PMID 8575745.
  2. ↑ 2.0 2.1 "Entrez Gene: NNMT nicotinamide N-methyltransferase".

Further reading



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