PARVA: Difference between revisions

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{{Other uses|Parva (disambiguation){{!}}Parva}}
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{{Infobox_gene}}
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'''Alpha-parvin''' is a [[protein]] that in humans is encoded by the ''PARVA'' [[gene]].<ref name="pmid11171322">{{cite journal | vauthors = Olski TM, Noegel AA, Korenbaum E | title = Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily | journal = J Cell Sci | volume = 114 | issue = Pt 3 | pages = 525–38 |date=Feb 2001 | pmid = 11171322 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PARVA parvin, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55742| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Parvin, alpha
| HGNCid = 14652
| Symbol = PARVA
| AltSymbols =; FLJ10793; FLJ12254; MXRA2
| OMIM = 608120
| ECnumber = 
| Homologene = 10077
| MGIid = 1931144
| GeneAtlas_image1 = PBB_GE_PARVA_217890_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55742
    | Hs_Ensembl = ENSG00000197702
    | Hs_RefseqProtein = NP_060692
    | Hs_RefseqmRNA = NM_018222
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 12355679
    | Hs_GenLoc_end = 12508914
    | Hs_Uniprot = Q9NVD7
    | Mm_EntrezGene = 57342
    | Mm_Ensembl = ENSMUSG00000030770
    | Mm_RefseqmRNA = NM_020606
    | Mm_RefseqProtein = NP_065631
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 112218887
    | Mm_GenLoc_end = 112382873
    | Mm_Uniprot = Q3UF75
  }}
}}
'''Parvin, alpha''', also known as '''PARVA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PARVA parvin, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55742| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Members of the parvin family, including PARVA, are actin-binding proteins associated with focal contacts.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PARVA parvin, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55742| accessdate = }}</ref>
| summary_text = Members of the parvin family, including PARVA, [[PARVB]] and [[PARVG]], are actin-binding proteins associated with focal contacts.[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nikolopoulos SN, Turner CE |title=Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion. |journal=J. Cell Biol. |volume=151 |issue= 7 |pages= 1435-48 |year= 2001 |pmid= 11134073 |doi=  }}
*{{cite journal  | vauthors=Nikolopoulos SN, Turner CE |title=Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion. |journal=J. Cell Biol. |volume=151 |issue= 7 |pages= 1435–48 |year= 2001 |pmid= 11134073 |doi=  10.1083/jcb.151.7.1435| pmc=2150668 }}
*{{cite journal  | author=Olski TM, Noegel AA, Korenbaum E |title=Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. |journal=J. Cell. Sci. |volume=114 |issue= Pt 3 |pages= 525-38 |year= 2001 |pmid= 11171322 |doi=  }}
*{{cite journal   |vauthors=Tu Y, Huang Y, Zhang Y, etal |title=A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. |journal=J. Cell Biol. |volume=153 |issue= 3 |pages= 585–98 |year= 2001 |pmid= 11331308 |doi= 10.1083/jcb.153.3.585| pmc=2190577 }}
*{{cite journal | author=Tu Y, Huang Y, Zhang Y, ''et al.'' |title=A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. |journal=J. Cell Biol. |volume=153 |issue= 3 |pages= 585-98 |year= 2001 |pmid= 11331308 |doi=  }}
*{{cite journal  | vauthors=Nikolopoulos SN, Turner CE |title=Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1568–75 |year= 2002 |pmid= 11694518 |doi= 10.1074/jbc.M108612200 }}
*{{cite journal  | author=Nikolopoulos SN, Turner CE |title=Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1568-75 |year= 2002 |pmid= 11694518 |doi= 10.1074/jbc.M108612200 }}
*{{cite journal  | vauthors=Korenbaum E, Olski TM, Noegel AA |title=Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. |journal=Gene |volume=279 |issue= 1 |pages= 69–79 |year= 2002 |pmid= 11722847 |doi=10.1016/S0378-1119(01)00743-0 }}
*{{cite journal  | author=Korenbaum E, Olski TM, Noegel AA |title=Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. |journal=Gene |volume=279 |issue= 1 |pages= 69-79 |year= 2002 |pmid= 11722847 |doi=  }}
*{{cite journal   |vauthors=Zhang Y, Chen K, Tu Y, etal |title=Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. |journal=J. Cell Sci. |volume=115 |issue= Pt 24 |pages= 4777–86 |year= 2003 |pmid= 12432066 |doi=10.1242/jcs.00166 }}
*{{cite journal | author=Zhang Y, Chen K, Tu Y, ''et al.'' |title=Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. |journal=J. Cell. Sci. |volume=115 |issue= Pt 24 |pages= 4777-86 |year= 2003 |pmid= 12432066 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Aboulaich N, Vainonen JP, Strålfors P, Vener AV |title=Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 237–48 |year= 2005 |pmid= 15242332 |doi= 10.1042/BJ20040647 | pmc=1134064 }}
*{{cite journal  | author=Aboulaich N, Vainonen JP, Strålfors P, Vener AV |title=Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 237-48 |year= 2005 |pmid= 15242332 |doi= 10.1042/BJ20040647 }}
*{{cite journal  | vauthors=Zhang Y, Chen K, Tu Y, Wu C |title=Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41695–705 |year= 2004 |pmid= 15284246 |doi= 10.1074/jbc.M401563200 }}
*{{cite journal  | author=Zhang Y, Chen K, Tu Y, Wu C |title=Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41695-705 |year= 2004 |pmid= 15284246 |doi= 10.1074/jbc.M401563200 }}
*{{cite journal  | vauthors=Clarke DM, Brown MC, LaLonde DP, Turner CE |title=Phosphorylation of actopaxin regulates cell spreading and migration. |journal=J. Cell Biol. |volume=166 |issue= 6 |pages= 901–12 |year= 2004 |pmid= 15353548 |doi= 10.1083/jcb.200404024 | pmc=2172128 }}
*{{cite journal  | author=Clarke DM, Brown MC, LaLonde DP, Turner CE |title=Phosphorylation of actopaxin regulates cell spreading and migration. |journal=J. Cell Biol. |volume=166 |issue= 6 |pages= 901-12 |year= 2004 |pmid= 15353548 |doi= 10.1083/jcb.200404024 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=LaLonde DP, Brown MC, Bouverat BP, Turner CE |title=Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. |journal=J. Biol. Chem. |volume=280 |issue= 22 |pages= 21680–8 |year= 2005 |pmid= 15817463 |doi= 10.1074/jbc.M500752200 }}
*{{cite journal  | author=LaLonde DP, Brown MC, Bouverat BP, Turner CE |title=Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. |journal=J. Biol. Chem. |volume=280 |issue= 22 |pages= 21680-8 |year= 2005 |pmid= 15817463 |doi= 10.1074/jbc.M500752200 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:32, 8 November 2017

For other uses, see Parva.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Alpha-parvin is a protein that in humans is encoded by the PARVA gene.[1][2]

Members of the parvin family, including PARVA, PARVB and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM][2]

References

  1. ↑ Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. PMID 11171322.
  2. ↑ 2.0 2.1 "Entrez Gene: PARVA parvin, alpha".

Further reading



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