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{{Infobox_gene}}
{{PBB_Controls
'''CAP-GLY domain containing linker protein 1''', also known as '''CLIP1''', is a [[protein]] which in humans is encoded by the ''CLIP1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6249| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_CLIP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cp5.
| PDB = {{PDB2|2cp5}}, {{PDB2|2cp6}}, {{PDB2|2cp7}}
| Name = CAP-GLY domain containing linker protein 1
| HGNCid = 10461
| Symbol = CLIP1
| AltSymbols =; CLIP; CLIP-170; CLIP170; CYLN1; MGC131604; RSN
| OMIM = 179838
| ECnumber = 
| Homologene = 74455
| MGIid = 1928401
| GeneAtlas_image1 = PBB_GE_CLIP1_201975_at_tn.png
| GeneAtlas_image2 = PBB_GE_CLIP1_210716_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005881 |text = cytoplasmic microtubule}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
| Process = {{GNF_GO|id=GO:0007067 |text = mitosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6249
    | Hs_Ensembl = ENSG00000130779
    | Hs_RefseqProtein = NP_002947
    | Hs_RefseqmRNA = NM_002956
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 121321934
    | Hs_GenLoc_end = 121473069
    | Hs_Uniprot = P30622
    | Mm_EntrezGene = 56430
    | Mm_Ensembl = ENSMUSG00000049550
    | Mm_RefseqmRNA = NM_019765
    | Mm_RefseqProtein = NP_062739
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 123839688
    | Mm_GenLoc_end = 123944909
    | Mm_Uniprot = Q9QZF4
  }}
}}
'''CAP-GLY domain containing linker protein 1''', also known as '''CLIP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6249| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CLIP1 has been shown to [[Protein-protein interaction|interact]] with [[IQGAP1]],<ref name=pmid12110184>{{cite journal | vauthors = Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K | title = Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 | journal = Cell | volume = 109 | issue = 7 | pages = 873–85 | date = Jun 2002 | pmid = 12110184 | doi = 10.1016/S0092-8674(02)00800-0 }}</ref> [[Mammalian target of rapamycin]]<ref name=pmid12231510>{{cite journal | vauthors = Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF | title = The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase | journal = EMBO Reports | volume = 3 | issue = 10 | pages = 988–94 | date = Oct 2002 | pmid = 12231510 | pmc = 1307618 | doi = 10.1093/embo-reports/kvf197 }}</ref> and [[PAFAH1B1]].<ref name=pmid11940666>{{cite journal | vauthors = Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O | title = LIS1, CLIP-170's key to the dynein/dynactin pathway | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 3089–102 | date = May 2002 | pmid = 11940666 | pmc = 133759 | doi = 10.1128/MCB.22.9.3089-3102.2002 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
==External links==
* {{UCSC gene info|CLIP1}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Galjart N | title = CLIPs and CLASPs and cellular dynamics | journal = Nature Reviews Molecular Cell Biology | volume = 6 | issue = 6 | pages = 487–98 | date = Jun 2005 | pmid = 15928712 | doi = 10.1038/nrm1664 }}
| citations =
* {{cite journal | vauthors = Pierre P, Scheel J, Rickard JE, Kreis TE | title = CLIP-170 links endocytic vesicles to microtubules | journal = Cell | volume = 70 | issue = 6 | pages = 887–900 | date = Sep 1992 | pmid = 1356075 | doi = 10.1016/0092-8674(92)90240-D }}
*{{cite journal | author=Galjart N |title=CLIPs and CLASPs and cellular dynamics. |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 487-98 |year= 2005 |pmid= 15928712 |doi= 10.1038/nrm1664 }}
* {{cite journal | vauthors = Bilbe G, Delabie J, Brüggen J, Richener H, Asselbergs FA, Cerletti N, Sorg C, Odink K, Tarcsay L, Wiesendanger W | title = Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease | journal = The EMBO Journal | volume = 11 | issue = 6 | pages = 2103–13 | date = Jun 1992 | pmid = 1600942 | pmc = 556677 | doi =  }}
*{{cite journal | author=Pierre P, Scheel J, Rickard JE, Kreis TE |title=CLIP-170 links endocytic vesicles to microtubules. |journal=Cell |volume=70 |issue= 6 |pages= 887-900 |year= 1992 |pmid= 1356075 |doi= }}
* {{cite journal | vauthors = Pierre P, Pepperkok R, Kreis TE | title = Molecular characterization of two functional domains of CLIP-170 in vivo | journal = Journal of Cell Science | volume = 107 | issue = 7 | pages = 1909–20 | date = Jul 1994 | pmid = 7983157 | doi =  }}
*{{cite journal | author=Bilbe G, Delabie J, Brüggen J, ''et al.'' |title=Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease. |journal=EMBO J. |volume=11 |issue= 6 |pages= 2103-13 |year= 1992 |pmid= 1600942 |doi=  }}
* {{cite journal | vauthors = Hilliker C, Delabie J, Speleman F, Bilbe G, Bruggen J, Van Leuven F, Van den Berghe H | title = Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus | journal = Cytogenetics and Cell Genetics | volume = 65 | issue = 3 | pages = 172–6 | year = 1993 | pmid = 8222754 | doi = 10.1159/000133625 }}
*{{cite journal | author=Pierre P, Pepperkok R, Kreis TE |title=Molecular characterization of two functional domains of CLIP-170 in vivo. |journal=J. Cell. Sci. |volume=107 ( Pt 7) |issue= |pages= 1909-20 |year= 1995 |pmid= 7983157 |doi=  }}
* {{cite journal | vauthors = Griparic L, Keller TC | title = Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle | journal = Biochimica et Biophysica Acta | volume = 1405 | issue = 1-3 | pages = 35–46 | date = Oct 1998 | pmid = 9784600 | doi = 10.1016/S0167-4889(98)00096-2 }}
*{{cite journal | author=Hilliker C, Delabie J, Speleman F, ''et al.'' |title=Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. |journal=Cytogenet. Cell Genet. |volume=65 |issue= 3 |pages= 172-6 |year= 1993 |pmid= 8222754 |doi= }}
* {{cite journal | vauthors = Perez F, Diamantopoulos GS, Stalder R, Kreis TE | title = CLIP-170 highlights growing microtubule ends in vivo | journal = Cell | volume = 96 | issue = 4 | pages = 517–27 | date = Feb 1999 | pmid = 10052454 | doi = 10.1016/S0092-8674(00)80656-X }}
*{{cite journal | author=Griparic L, Keller TC |title=Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle. |journal=Biochim. Biophys. Acta |volume=1405 |issue= 1-3 |pages= 35-46 |year= 1998 |pmid= 9784600 |doi= }}
* {{cite journal | vauthors = Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N | title = Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts | journal = Cell | volume = 104 | issue = 6 | pages = 923–35 | date = Mar 2001 | pmid = 11290329 | doi = 10.1016/S0092-8674(01)00288-4 }}
*{{cite journal | author=Perez F, Diamantopoulos GS, Stalder R, Kreis TE |title=CLIP-170 highlights growing microtubule ends in vivo. |journal=Cell |volume=96 |issue= 4 |pages= 517-27 |year= 1999 |pmid= 10052454 |doi= }}
* {{cite journal | vauthors = Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O | title = LIS1, CLIP-170's key to the dynein/dynactin pathway | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 3089–102 | date = May 2002 | pmid = 11940666 | pmc = 133759 | doi = 10.1128/MCB.22.9.3089-3102.2002 }}
*{{cite journal | author=Akhmanova A, Hoogenraad CC, Drabek K, ''et al.'' |title=Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. |journal=Cell |volume=104 |issue= 6 |pages= 923-35 |year= 2001 |pmid= 11290329 |doi= }}
* {{cite journal | vauthors = Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ | title = The cytoplasmic linker protein CLIP-170 is a human autoantigen | journal = Clinical and Experimental Immunology | volume = 127 | issue = 3 | pages = 533–8 | date = Mar 2002 | pmid = 11966772 | pmc = 1906301 | doi = 10.1046/j.1365-2249.2002.01756.x }}
*{{cite journal | author=Coquelle FM, Caspi M, Cordelières FP, ''et al.'' |title=LIS1, CLIP-170's key to the dynein/dynactin pathway. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 3089-102 |year= 2002 |pmid= 11940666 |doi= }}
* {{cite journal | vauthors = Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K | title = Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 | journal = Cell | volume = 109 | issue = 7 | pages = 873–85 | date = Jun 2002 | pmid = 12110184 | doi = 10.1016/S0092-8674(02)00800-0 }}
*{{cite journal | author=Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ |title=The cytoplasmic linker protein CLIP-170 is a human autoantigen. |journal=Clin. Exp. Immunol. |volume=127 |issue= 3 |pages= 533-8 |year= 2002 |pmid= 11966772 |doi= }}
* {{cite journal | vauthors = Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF | title = The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase | journal = EMBO Reports | volume = 3 | issue = 10 | pages = 988–94 | date = Oct 2002 | pmid = 12231510 | pmc = 1307618 | doi = 10.1093/embo-reports/kvf197 }}
*{{cite journal | author=Fukata M, Watanabe T, Noritake J, ''et al.'' |title=Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. |journal=Cell |volume=109 |issue= 7 |pages= 873-85 |year= 2002 |pmid= 12110184 |doi= }}
* {{cite journal | vauthors = Sahin U, Neumann F, Tureci O, Schmits R, Perez F, Pfreundschuh M | title = Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells | journal = Blood | volume = 100 | issue = 12 | pages = 4139–45 | date = Dec 2002 | pmid = 12433698 | doi = 10.1182/blood.V100.12.4139 }}
*{{cite journal | author=Choi JH, Bertram PG, Drenan R, ''et al.'' |title=The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. |journal=EMBO Rep. |volume=3 |issue= 10 |pages= 988-94 |year= 2003 |pmid= 12231510 |doi= 10.1093/embo-reports/kvf197 }}
* {{cite journal | vauthors = Goodson HV, Skube SB, Stalder R, Valetti C, Kreis TE, Morrison EE, Schroer TA | title = CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms | journal = Cell Motility and the Cytoskeleton | volume = 55 | issue = 3 | pages = 156–73 | date = Jul 2003 | pmid = 12789661 | doi = 10.1002/cm.10114 }}
*{{cite journal | author=Sahin U, Neumann F, Tureci O, ''et al.'' |title=Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells. |journal=Blood |volume=100 |issue= 12 |pages= 4139-45 |year= 2003 |pmid= 12433698 |doi= 10.1182/blood.V100.12.4139 }}
* {{cite journal | vauthors = Ho SM, Lau KM, Mok SC, Syed V | title = Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells | journal = Oncogene | volume = 22 | issue = 27 | pages = 4243–56 | date = Jul 2003 | pmid = 12833147 | doi = 10.1038/sj.onc.1206437 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Goodson HV, Skube SB, Stalder R, ''et al.'' |title=CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms. |journal=Cell Motil. Cytoskeleton |volume=55 |issue= 3 |pages= 156-73 |year= 2004 |pmid= 12789661 |doi= 10.1002/cm.10114 }}
* {{cite journal | vauthors = Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain | journal = Molecular & Cellular Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | date = Nov 2004 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 }}
*{{cite journal | author=Ho SM, Lau KM, Mok SC, Syed V |title=Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells. |journal=Oncogene |volume=22 |issue= 27 |pages= 4243-56 |year= 2003 |pmid= 12833147 |doi= 10.1038/sj.onc.1206437 }}
* {{cite journal | vauthors = Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K | title = Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration | journal = Developmental Cell | volume = 7 | issue = 6 | pages = 871–83 | date = Dec 2004 | pmid = 15572129 | doi = 10.1016/j.devcel.2004.10.017 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | author=Watanabe T, Wang S, Noritake J, ''et al.'' |title=Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. |journal=Dev. Cell |volume=7 |issue= 6 |pages= 871-83 |year= 2005 |pmid= 15572129 |doi= 10.1016/j.devcel.2004.10.017 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=6249}}
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{{gene-12-stub}}

Latest revision as of 09:49, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CAP-GLY domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.[1]

Interactions

CLIP1 has been shown to interact with IQGAP1,[2] Mammalian target of rapamycin[3] and PAFAH1B1.[4]

References

  1. ↑ "Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1".
  2. ↑ Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell. 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184.
  3. ↑ Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
  4. ↑ Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.

External links

Further reading


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