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{{Other uses}}
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{{Infobox_gene}}
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'''Serine-threonine kinase receptor-associated protein''' is an [[enzyme]] that in humans is encoded by the ''STRAP'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STRAP serine/threonine kinase receptor associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11171| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Serine/threonine kinase receptor associated protein
| HGNCid = 30796
| Symbol = STRAP
| AltSymbols =; MAWD; PT-WD; UNRIP
| OMIM = 605986
| ECnumber = 
| Homologene = 43881
| MGIid = 1329037
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0030512 |text = negative regulation of transforming growth factor beta receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11171
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_009109
    | Hs_RefseqmRNA = NM_007178
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 20901
    | Mm_Ensembl = ENSMUSG00000030224
    | Mm_RefseqmRNA = NM_011499
    | Mm_RefseqProtein = NP_035629
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 137699320
    | Mm_GenLoc_end = 137715461
    | Mm_Uniprot = Q8BP89
  }}
}}
'''Serine/threonine kinase receptor associated protein''', also known as '''STRAP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STRAP serine/threonine kinase receptor associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11171| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
STRAP has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[Mothers against decapentaplegic homolog 2]],<ref name = pmid10757800/>
| summary_text =  
* [[Mothers against decapentaplegic homolog 3]],<ref name = pmid10757800/>
}}
* [[Mothers against decapentaplegic homolog 6]],<ref name = pmid10757800>{{cite journal | vauthors = Datta PK, Moses HL | title = STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling | journal = Mol. Cell. Biol. | volume = 20 | issue = 9 | pages = 3157–67 | date = May 2000 | pmid = 10757800 | pmc = 85610 | doi =  10.1128/mcb.20.9.3157-3167.2000}}</ref>
* [[Mothers against decapentaplegic homolog 7]],<ref name = pmid10757800/>
* [[TGF beta receptor 1]],<ref name = pmid10757800/><ref name = pmid9856985/> and
* [[TGF beta receptor 2]].<ref name = pmid10757800/><ref name = pmid9856985>{{cite journal | vauthors = Datta PK, Chytil A, Gorska AE, Moses HL | title = Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling | journal = J. Biol. Chem. | volume = 273 | issue = 52 | pages = 34671–4  | date = December 1998 | pmid = 9856985 | doi = 10.1074/jbc.273.52.34671}}</ref>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Datta PK, Chytil A, Gorska AE, Moses HL | title = Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling | journal = J. Biol. Chem. | volume = 273 | issue = 52 | pages = 34671–4 | year = 1998 | pmid = 9856985 | doi = 10.1074/jbc.273.52.34671 }}
| citations =
* {{cite journal | vauthors = Hunt SL, Hsuan JJ, Totty N, Jackson RJ | title = unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA | journal = Genes Dev. | volume = 13 | issue = 4 | pages = 437–48 | year = 1999 | pmid = 10049359 | pmc = 316477 | doi = 10.1101/gad.13.4.437 }}
*{{cite journal | author=Datta PK, Chytil A, Gorska AE, Moses HL |title=Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34671-4 |year= 1999 |pmid= 9856985 |doi= }}
* {{cite journal | vauthors = Matsuda S, Katsumata R, Okuda T, Yamamoto T, Miyazaki K, Senga T, Machida K, Thant AA, Nakatsugawa S, Hamaguchi M | title = Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer | journal = Cancer Res. | volume = 60 | issue = 1 | pages = 13–7 | year = 2000 | pmid = 10646843 | doi =  }}
*{{cite journal | author=Hunt SL, Hsuan JJ, Totty N, Jackson RJ |title=unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA. |journal=Genes Dev. |volume=13 |issue= 4 |pages= 437-48 |year= 1999 |pmid= 10049359 |doi= }}
* {{cite journal | vauthors = Datta PK, Moses HL | title = STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling | journal = Mol. Cell. Biol. | volume = 20 | issue = 9 | pages = 3157–67 | year = 2000 | pmid = 10757800 | pmc = 85610 | doi = 10.1128/MCB.20.9.3157-3167.2000 }}
*{{cite journal | author=Matsuda S, Katsumata R, Okuda T, ''et al.'' |title=Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer. |journal=Cancer Res. |volume=60 |issue= 1 |pages= 13-7 |year= 2000 |pmid= 10646843 |doi=  }}
* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Res. | volume = 10 | issue = 10 | pages = 1546–60 | year = 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
*{{cite journal | author=Datta PK, Moses HL |title=STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3157-67 |year= 2000 |pmid= 10757800 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
* {{cite journal | vauthors = Iriyama C, Matsuda S, Katsumata R, Hamaguchi M | title = Cloning and sequencing of a novel human gene which encodes a putative hydroxylase | journal = J. Hum. Genet. | volume = 46 | issue = 5 | pages = 289–92 | year = 2001 | pmid = 11355021 | doi = 10.1007/s100380170081 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D | title = Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing | journal = Genes Dev. | volume = 17 | issue = 18 | pages = 2321–33 | year = 2003 | pmid = 12975319 | pmc = 196468 | doi = 10.1101/gad.274403 }}
*{{cite journal | author=Iriyama C, Matsuda S, Katsumata R, Hamaguchi M |title=Cloning and sequencing of a novel human gene which encodes a putative hydroxylase. |journal=J. Hum. Genet. |volume=46 |issue= 5 |pages= 289-92 |year= 2001 |pmid= 11355021 |doi= }}
* {{cite journal | vauthors = Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL | title = Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity | journal = Science | volume = 307 | issue = 5715 | pages = 1603–9 | year = 2005 | pmid = 15761148 | doi = 10.1126/science.1105718 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | year = 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
*{{cite journal | author=Pillai RS, Grimmler M, Meister G, ''et al.'' |title=Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. |journal=Genes Dev. |volume=17 |issue= 18 |pages= 2321-33 |year= 2003 |pmid= 12975319 |doi= 10.1101/gad.274403 }}
* {{cite journal | vauthors = Carissimi C, Baccon J, Straccia M, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L | title = Unrip is a component of SMN complexes active in snRNP assembly | journal = FEBS Lett. | volume = 579 | issue = 11 | pages = 2348–54 | year = 2005 | pmid = 15848170 | doi = 10.1016/j.febslet.2005.03.034 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U | title = Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization | journal = Hum. Mol. Genet. | volume = 14 | issue = 20 | pages = 3099–111 | year = 2005 | pmid = 16159890 | doi = 10.1093/hmg/ddi343 }}
*{{cite journal | author=Ozdamar B, Bose R, Barrios-Rodiles M, ''et al.'' |title=Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. |journal=Science |volume=307 |issue= 5715 |pages= 1603-9 |year= 2005 |pmid= 15761148 |doi= 10.1126/science.1105718 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
* {{cite journal | vauthors = Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY | title = Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress | journal = Biochem. Biophys. Res. Commun. | volume = 337 | issue = 4 | pages = 1308–18 | year = 2005 | pmid = 16236267 | doi = 10.1016/j.bbrc.2005.09.191 }}
*{{cite journal | author=Carissimi C, Baccon J, Straccia M, ''et al.'' |title=Unrip is a component of SMN complexes active in snRNP assembly. |journal=FEBS Lett. |volume=579 |issue= 11 |pages= 2348-54 |year= 2005 |pmid= 15848170 |doi= 10.1016/j.febslet.2005.03.034 }}
* {{cite journal | vauthors = Seong HA, Jung H, Choi HS, Kim KT, Ha H | title = Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein | journal = J. Biol. Chem. | volume = 280 | issue = 52 | pages = 42897–908 | year = 2005 | pmid = 16251192 | doi = 10.1074/jbc.M507539200 }}
*{{cite journal  | author=Grimmler M, Otter S, Peter C, ''et al.'' |title=Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. |journal=Hum. Mol. Genet. |volume=14 |issue= 20 |pages= 3099-111 |year= 2006 |pmid= 16159890 |doi= 10.1093/hmg/ddi343 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Carissimi C, Saieva L, Gabanella F, Pellizzoni L | title = Gemin8 is required for the architecture and function of the survival motor neuron complex | journal = J. Biol. Chem. | volume = 281 | issue = 48 | pages = 37009–16 | year = 2006 | pmid = 17023415 | doi = 10.1074/jbc.M607505200 }}
*{{cite journal | author=Guo D, Han J, Adam BL, ''et al.'' |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308-18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191 }}
* {{cite journal | vauthors = Seong HA, Jung H, Ha H | title = NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling | journal = J. Biol. Chem. | volume = 282 | issue = 16 | pages = 12075–96 | year = 2007 | pmid = 17314099 | doi = 10.1074/jbc.M609832200 }}
*{{cite journal | author=Seong HA, Jung H, Choi HS, ''et al.'' |title=Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42897-908 |year= 2006 |pmid= 16251192 |doi= 10.1074/jbc.M507539200 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Carissimi C, Saieva L, Gabanella F, Pellizzoni L |title=Gemin8 is required for the architecture and function of the survival motor neuron complex. |journal=J. Biol. Chem. |volume=281 |issue= 48 |pages= 37009-16 |year= 2007 |pmid= 17023415 |doi= 10.1074/jbc.M607505200 }}
*{{cite journal | author=Seong HA, Jung H, Ha H |title=NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12075-96 |year= 2007 |pmid= 17314099 |doi= 10.1074/jbc.M609832200 }}
}}
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Latest revision as of 07:13, 11 September 2017

For other uses, see STRAP (disambiguation).
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene.[1]

Interactions

STRAP has been shown to interact with:

References

  1. ↑ "Entrez Gene: STRAP serine/threonine kinase receptor associated protein".
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Datta PK, Moses HL (May 2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling". Mol. Cell. Biol. 20 (9): 3157–67. doi:10.1128/mcb.20.9.3157-3167.2000. PMC 85610. PMID 10757800.
  3. ↑ 3.0 3.1 Datta PK, Chytil A, Gorska AE, Moses HL (December 1998). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling". J. Biol. Chem. 273 (52): 34671–4. doi:10.1074/jbc.273.52.34671. PMID 9856985.

Further reading


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