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{{Infobox_gene}}
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'''Basic salivary proline-rich protein 1''' is a [[protein]] that in humans is encoded by the ''PRB1'' [[gene]].<ref name="pmid8317492">{{cite journal | vauthors = Azen EA, Latreille P, Niece RL | title = PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs) | journal = Am J Hum Genet | volume = 53 | issue = 1 | pages = 264–78 |date=Jul 1993 | pmid = 8317492 | pmc = 1682219 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5542| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Proline-rich protein BstNI subfamily 1
| HGNCid = 9337
| Symbol = PRB1
| AltSymbols =; PM; PMF; PMS; PRB1L; PRB1M; Ps 1; Ps 2; PRPPRB1; Ps; cP7
| OMIM = 180989
| ECnumber = 
| Homologene = 74537
| MGIid = 2681872
| GeneAtlas_image1 = PBB_GE_PRB1_207752_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRB1_216881_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRB1_210597_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0005575 |text = cellular_component}}
  | Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5542
    | Hs_Ensembl = ENSG00000173342
    | Hs_RefseqProtein = NP_005030
    | Hs_RefseqmRNA = NM_005039
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 11437028
    | Hs_GenLoc_end = 11439753
    | Hs_Uniprot = P02811
    | Mm_EntrezGene = 381833
    | Mm_Ensembl = ENSMUSG00000067543
    | Mm_RefseqmRNA = XM_904800
    | Mm_RefseqProtein = XP_909893
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 132079910
    | Mm_GenLoc_end = 132176209
    | Mm_Uniprot = 
  }}
}}
'''Proline-rich protein BstNI subfamily 1''', also known as '''PRB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5542| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5542| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Azen EA, Maeda N |title=Molecular genetics of human salivary proteins and their polymorphisms. |journal=Adv. Hum. Genet. |volume=17 |issue=  |pages= 141-99 |year= 1988 |pmid= 3055850 |doi=  }}
*{{cite journal  | vauthors=Azen EA, Maeda N |title=Molecular genetics of human salivary proteins and their polymorphisms |journal=Adv. Hum. Genet. |volume=17 |issue=  |pages= 141–99 |year= 1988 |pmid= 3055850 |doi=  10.1007/978-1-4613-0987-1_5}}
*{{cite journal  | author=Bennick A |title=Salivary proline-rich proteins. |journal=Mol. Cell. Biochem. |volume=45 |issue= 2 |pages= 83-99 |year= 1982 |pmid= 6810092 |doi=  }}
*{{cite journal  | author=Bennick A |title=Salivary proline-rich proteins |journal=Mol. Cell. Biochem. |volume=45 |issue= 2 |pages= 83–99 |year= 1982 |pmid= 6810092 |doi=10.1007/BF00223503 }}
*{{cite journal  | author=Ikemoto S, Minaguchi K, Suzuki K, Tomita K |title=New Genetic marker in human parotid saliva (pm). |journal=Science |volume=197 |issue= 4301 |pages= 378-9 |year= 1977 |pmid= 877561 |doi=  }}
*{{cite journal  | vauthors=Ikemoto S, Minaguchi K, Suzuki K, Tomita K |title=New Genetic marker in human parotid saliva (pm) |journal=Science |volume=197 |issue= 4301 |pages= 378–9 |year= 1977 |pmid= 877561 |doi=10.1126/science.877561 }}
*{{cite journal  | author=Castle AM, Stahl LE, Castle JD |title=A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=267 |issue= 18 |pages= 13093-100 |year= 1992 |pmid= 1618808 |doi=  }}
*{{cite journal  | vauthors=Castle AM, Stahl LE, Castle JD |title=A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum |journal=J. Biol. Chem. |volume=267 |issue= 18 |pages= 13093–100 |year= 1992 |pmid= 1618808 |doi=  }}
*{{cite journal  | author=Lyons KM, Stein JH, Smithies O |title=Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over. |journal=Genetics |volume=120 |issue= 1 |pages= 267-78 |year= 1989 |pmid= 2851479 |doi=  }}
*{{cite journal  | vauthors=Lyons KM, Stein JH, Smithies O |title=Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over |journal=Genetics |volume=120 |issue= 1 |pages= 267–78 |year= 1989 |pmid= 2851479 |doi= | pmc=1203497 }}
*{{cite journal  | author=Maeda N, Kim HS, Azen EA, Smithies O |title=Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system. |journal=J. Biol. Chem. |volume=260 |issue= 20 |pages= 11123-30 |year= 1985 |pmid= 2993301 |doi=  }}
*{{cite journal  | vauthors=Maeda N, Kim HS, Azen EA, Smithies O |title=Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system |journal=J. Biol. Chem. |volume=260 |issue= 20 |pages= 11123–30 |year= 1985 |pmid= 2993301 |doi=  }}
*{{cite journal  | author=Kauffman D, Hofmann T, Bennick A, Keller P |title=Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6. |journal=Biochemistry |volume=25 |issue= 9 |pages= 2387-92 |year= 1986 |pmid= 3521730 |doi=  }}
*{{cite journal  | vauthors=Kauffman D, Hofmann T, Bennick A, Keller P |title=Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6 |journal=Biochemistry |volume=25 |issue= 9 |pages= 2387–92 |year= 1986 |pmid= 3521730 |doi=10.1021/bi00357a013 }}
*{{cite journal | author=Azen E, Lyons KM, McGonigal T, ''et al.'' |title=Clones from the human gene complex coding for salivary proline-rich proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 17 |pages= 5561-5 |year= 1984 |pmid= 6089212 |doi=  }}
*{{cite journal   |vauthors=Azen E, Lyons KM, McGonigal T, etal |title=Clones from the human gene complex coding for salivary proline-rich proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 17 |pages= 5561–5 |year= 1984 |pmid= 6089212 |doi=10.1073/pnas.81.17.5561  | pmc=391746 }}
*{{cite journal  | author=Saitoh E, Isemura S, Sanada K |title=Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H. |journal=J. Biochem. |volume=94 |issue= 6 |pages= 1991-9 |year= 1984 |pmid= 6671974 |doi=  }}
*{{cite journal  | vauthors=Saitoh E, Isemura S, Sanada K |title=Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H |journal=J. Biochem. |volume=94 |issue= 6 |pages= 1991–9 |year= 1984 |pmid= 6671974 |doi=  }}
*{{cite journal  | author=Kauffman D, Wong R, Bennick A, Keller P |title=Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair. |journal=Biochemistry |volume=21 |issue= 25 |pages= 6558-62 |year= 1983 |pmid= 6924859 |doi=  }}
*{{cite journal  | vauthors=Kauffman D, Wong R, Bennick A, Keller P |title=Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair |journal=Biochemistry |volume=21 |issue= 25 |pages= 6558–62 |year= 1983 |pmid= 6924859 |doi=10.1021/bi00268a036 }}
*{{cite journal  | author=Isemura S, Saitoh E, Sanada K |title=Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E. |journal=J. Biochem. |volume=91 |issue= 6 |pages= 2067-75 |year= 1982 |pmid= 7118863 |doi=  }}
*{{cite journal  | vauthors=Isemura S, Saitoh E, Sanada K |title=Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E |journal=J. Biochem. |volume=91 |issue= 6 |pages= 2067–75 |year= 1982 |pmid= 7118863 |doi=  }}
*{{cite journal | author=Azen EA, Latreille P, Niece RL |title=PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs). |journal=Am. J. Hum. Genet. |volume=53 |issue= 1 |pages= 264-78 |year= 1993 |pmid= 8317492 |doi=  }}
*{{cite journal   |vauthors=Kim HS, Lyons KM, Saitoh E, etal |title=The structure and evolution of the human salivary proline-rich protein gene family |journal=Mamm. Genome |volume=4 |issue= 1 |pages= 3–14 |year= 1993 |pmid= 8422499 |doi=10.1007/BF00364656 }}
*{{cite journal  | author=Kim HS, Lyons KM, Saitoh E, ''et al.'' |title=The structure and evolution of the human salivary proline-rich protein gene family. |journal=Mamm. Genome |volume=4 |issue= 1 |pages= 3-14 |year= 1993 |pmid= 8422499 |doi=  }}
*{{cite journal  | vauthors=Castle AM, Castle JD |title=Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein |journal=Mol. Biol. Cell |volume=9 |issue= 3 |pages= 575–83 |year= 1998 |pmid= 9487127 |doi= 10.1091/mbc.9.3.575| pmc=25286 }}
*{{cite journal  | author=Castle AM, Castle JD |title=Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein. |journal=Mol. Biol. Cell |volume=9 |issue= 3 |pages= 575-83 |year= 1998 |pmid= 9487127 |doi=  }}
*{{cite journal   |vauthors=Harrington JJ, Sherf B, Rundlett S, etal |title=Creation of genome-wide protein expression libraries using random activation of gene expression |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal | author=Harrington JJ, Sherf B, Rundlett S, ''et al.'' |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440-5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal  | vauthors=Chan M, Bennick A |title=Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases |journal=Eur. J. Biochem. |volume=268 |issue= 12 |pages= 3423–31 |year= 2001 |pmid= 11422372 |doi=10.1046/j.1432-1327.2001.02241.x }}
*{{cite journal  | author=Chan M, Bennick A |title=Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases. |journal=Eur. J. Biochem. |volume=268 |issue= 12 |pages= 3423-31 |year= 2001 |pmid= 11422372 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Salivary proline-rich proteins]]

Latest revision as of 18:38, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.[1][2]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.[2]

References

  1. ↑ Azen EA, Latreille P, Niece RL (Jul 1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)". Am J Hum Genet. 53 (1): 264–78. PMC 1682219. PMID 8317492.
  2. ↑ 2.0 2.1 "Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1".

Further reading



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