RNF41: Difference between revisions
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{{ | '''E3 ubiquitin-protein ligase NRDP1''' is an [[enzyme]] that in humans is encoded by the ''RNF41'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF41 ring finger protein 41| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10193| accessdate = }}</ref> | ||
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== Function == | |||
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref name="entrez" /> | |||
==See also== | == Interactions == | ||
RNF41 has been shown to [[Protein-protein interaction|interact]] with [[USP8]].<ref name=pmid15314180>{{cite journal | vauthors = Wu X, Yen L, Irwin L, Sweeney C, Carraway KL | title = Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 | journal = Mol. Cell. Biol. | volume = 24 | issue = 17 | pages = 7748–57 | date = September 2004 | pmid = 15314180 | pmc = 506982 | doi = 10.1128/MCB.24.17.7748-7757.2004 }}</ref> | |||
== See also == | |||
* [[RING finger domain]] | * [[RING finger domain]] | ||
==References== | == References == | ||
{{reflist | {{reflist}} | ||
==Further reading== | == Further reading == | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Cao Z, Wu X, Yen L, Sweeney C, Carraway KL | title = Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1 | journal = Mol. Cell. Biol. | volume = 27 | issue = 6 | pages = 2180–8 | year = 2007 | pmid = 17210635 | pmc = 1820496 | doi = 10.1128/MCB.01245-06 }} | |||
* {{cite journal | vauthors = Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S | title = Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8) | journal = J. Biol. Chem. | volume = 281 | issue = 49 | pages = 38061–70 | year = 2006 | pmid = 17035239 | doi = 10.1074/jbc.M606704200 }} | |||
*{{cite journal | * {{cite journal | vauthors = Wu X, Yen L, Irwin L, Sweeney C, Carraway KL | title = Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 | journal = Mol. Cell. Biol. | volume = 24 | issue = 17 | pages = 7748–57 | year = 2004 | pmid = 15314180 | pmc = 506982 | doi = 10.1128/MCB.24.17.7748-7757.2004 }} | ||
*{{cite journal | * {{cite journal | vauthors = Qiu XB, Markant SL, Yuan J, Goldberg AL | title = Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis | journal = EMBO J. | volume = 23 | issue = 4 | pages = 800–10 | year = 2004 | pmid = 14765125 | pmc = 380992 | doi = 10.1038/sj.emboj.7600075 }} | ||
*{{cite journal | * {{cite journal | vauthors = Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G | title = Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network | journal = J. Biol. Chem. | volume = 279 | issue = 13 | pages = 12804–11 | year = 2004 | pmid = 14676191 | doi = 10.1074/jbc.M312171200 }} | ||
* {{cite journal | vauthors = Qiu XB, Goldberg AL | title = Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 23 | pages = 14843–8 | year = 2002 | pmid = 12411582 | pmc = 137506 | doi = 10.1073/pnas.232580999 }} | |||
*{{cite journal | * {{cite journal | vauthors = Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL | title = An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2866–71 | year = 2002 | pmid = 11867753 | pmc = 122439 | doi = 10.1073/pnas.052709799 }} | ||
*{{cite journal | * {{cite journal | vauthors = Abdullah JM, Li X, Nachtman RG, Jurecic R | title = FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors | journal = Blood Cells Mol. Dis. | volume = 27 | issue = 1 | pages = 320–33 | year = 2001 | pmid = 11358394 | doi = 10.1006/bcmd.2001.0390 }} | ||
*{{cite journal | * {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }} | ||
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }} | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
== External links == | == External links == | ||
* {{MeshName|RNF41+protein,+human}} | * {{MeshName|RNF41+protein,+human}} | ||
* {{UCSC genome browser|RNF41}} | |||
* {{UCSC gene details|RNF41}} | |||
{{PDB Gallery|geneid=10193}} | |||
[[Category:RING finger proteins]] | |||
{{ | {{gene-12-stub}} | ||
Latest revision as of 09:21, 10 September 2017
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Identifiers | |||||||
Aliases | |||||||
External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.[1]
Function
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.[1]
Interactions
RNF41 has been shown to interact with USP8.[2]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: RNF41 ring finger protein 41".
- ↑ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
Further reading
- Cao Z, Wu X, Yen L, Sweeney C, Carraway KL (2007). "Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1". Mol. Cell. Biol. 27 (6): 2180–8. doi:10.1128/MCB.01245-06. PMC 1820496. PMID 17210635.
- Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S (2006). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". J. Biol. Chem. 281 (49): 38061–70. doi:10.1074/jbc.M606704200. PMID 17035239.
- Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
- Qiu XB, Markant SL, Yuan J, Goldberg AL (2004). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992. PMID 14765125.
- Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
- Qiu XB, Goldberg AL (2002). "Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14843–8. doi:10.1073/pnas.232580999. PMC 137506. PMID 12411582.
- Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL (2002). "An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2866–71. doi:10.1073/pnas.052709799. PMC 122439. PMID 11867753.
- Abdullah JM, Li X, Nachtman RG, Jurecic R (2001). "FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors". Blood Cells Mol. Dis. 27 (1): 320–33. doi:10.1006/bcmd.2001.0390. PMID 11358394.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
External links
- RNF41+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- RNF41 human gene location in the UCSC Genome Browser.
- RNF41 human gene details in the UCSC Genome Browser.
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