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{{Infobox_gene}}
{{PBB_Controls
'''NGFI-A-binding protein 2''' also known as '''EGR-1-binding protein 2''' or '''melanoma-associated delayed early response protein''' (MADER) is a [[protein]] that in humans is encoded by the ''NAB2'' [[gene]].<ref name="pmid8668170">{{cite journal |vauthors=Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J | title = NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli | journal = Mol Cell Biol | volume = 16 | issue = 7 | pages = 3545–53 |date=Aug 1996 | pmid = 8668170 | pmc = 231349 | doi =  }}</ref><ref name="pmid8649813">{{cite journal |vauthors=Kirsch KH, Korradi Y, Johnson JP | title = Mader: a novel nuclear protein over expressed in human melanomas | journal = Oncogene | volume = 12 | issue = 5 | pages = 963–71 |date=Jul 1996 | pmid = 8649813 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4665| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Function==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = NGFI-A binding protein 2 (EGR1 binding protein 2)
| HGNCid = 7627
| Symbol = NAB2
| AltSymbols =; MADER; MGC75085
| OMIM = 602381
| ECnumber = 
| Homologene = 4353
| MGIid = 107563
| GeneAtlas_image1 = PBB_GE_NAB2_212803_at_tn.png
| GeneAtlas_image2 = PBB_GE_NAB2_216017_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001958 |text = endochondral ossification}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0014037 |text = Schwann cell differentiation}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0042552 |text = myelination}} {{GNF_GO|id=GO:0045682 |text = regulation of epidermis development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4665
    | Hs_Ensembl = ENSG00000166886
    | Hs_RefseqProtein = NP_005958
    | Hs_RefseqmRNA = NM_005967
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 55769157
    | Hs_GenLoc_end = 55775525
    | Hs_Uniprot = Q15742
    | Mm_EntrezGene = 17937
    | Mm_Ensembl = ENSMUSG00000025402
    | Mm_RefseqmRNA = NM_008668
    | Mm_RefseqProtein = NP_032694
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 127063868
    | Mm_GenLoc_end = 127069627
    | Mm_Uniprot = Q3TBL2
  }}
}}
'''NGFI-A binding protein 2 (EGR1 binding protein 2)''', also known as '''NAB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4665| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress or activate [[Transcription (genetics)|transcription]] induced by some members of the [[Early growth response proteins|EGR]] (early growth response) family of [[transactivators]]. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the [[nucleosome]] remodeling and deactylase (NuRD) complex. [[Alternative splicing|Alternatively spliced]] transcript variants have been described, but their biological validity has not been determined.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
==Pathology==
| summary_text = This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4665| accessdate = }}</ref>
 
}}
Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and [[STAT6]], located at chromosomal region 12q13, have been identified in [[solitary fibrous tumor]]s.<ref>{{Cite journal
| pmid = 15867200
| year = 2005
| author1 = Kabbinavar
| first1 = F. F.
| title = Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
| journal = Journal of Clinical Oncology
| volume = 23
| issue = 16
| pages = 3706–12
| last2 = Hambleton
| first2 = J
| last3 = Mass
| first3 = R. D.
| last4 = Hurwitz
| first4 = H. I.
| last5 = Bergsland
| first5 = E
| last6 = Sarkar
| first6 = S
| doi = 10.1200/JCO.2005.00.232
}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Svaren J, Apel ED, Simburger KS, etal |title=The Nab2 and Stat6 genes share a common transcription termination region. |journal=Genomics |volume=41 |issue= 1 |pages= 33–9 |year= 1997 |pmid= 9126479 |doi= 10.1006/geno.1997.4609 }}
| citations =
*{{cite journal   |vauthors=Qu Z, Wolfraim LA, Svaren J, etal |title=The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. |journal=J. Cell Biol. |volume=142 |issue= 4 |pages= 1075–82 |year= 1998 |pmid= 9722618 |doi=10.1083/jcb.142.4.1075  | pmc=2132876 }}
*{{cite journal  | author=Kirsch KH, Korradi Y, Johnson JP |title=Mader: a novel nuclear protein over expressed in human melanomas. |journal=Oncogene |volume=12 |issue= 5 |pages= 963-71 |year= 1996 |pmid= 8649813 |doi=  }}
*{{cite journal   |vauthors=Svaren J, Sevetson BR, Golda T, etal |title=Novel mutants of NAB corepressors enhance activation by Egr transactivators. |journal=EMBO J. |volume=17 |issue= 20 |pages= 6010–9 |year= 1998 |pmid= 9774344 |doi= 10.1093/emboj/17.20.6010 | pmc=1170927 }}
*{{cite journal  | author=Svaren J, Sevetson BR, Apel ED, ''et al.'' |title=NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3545-53 |year= 1996 |pmid= 8668170 |doi=  }}
*{{cite journal   |vauthors=Abdulkadir SA, Qu Z, Garabedian E, etal |title=Impaired prostate tumorigenesis in Egr1-deficient mice. |journal=Nat. Med. |volume=7 |issue= 1 |pages= 101–7 |year= 2001 |pmid= 11135623 |doi= 10.1038/83231 }}
*{{cite journal | author=Svaren J, Apel ED, Simburger KS, ''et al.'' |title=The Nab2 and Stat6 genes share a common transcription termination region. |journal=Genomics |volume=41 |issue= 1 |pages= 33-9 |year= 1997 |pmid= 9126479 |doi= 10.1006/geno.1997.4609 }}
*{{cite journal   |vauthors=Abdulkadir SA, Carbone JM, Naughton CK, etal |title=Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. |journal=Hum. Pathol. |volume=32 |issue= 9 |pages= 935–9 |year= 2001 |pmid= 11567222 |doi= 10.1053/hupa.2001.27102 }}
*{{cite journal | author=Qu Z, Wolfraim LA, Svaren J, ''et al.'' |title=The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. |journal=J. Cell Biol. |volume=142 |issue= 4 |pages= 1075-82 |year= 1998 |pmid= 9722618 |doi=  }}
*{{cite journal   |vauthors=Venken K, Di Maria E, Bellone E, etal |title=Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. |journal=Neurogenetics |volume=4 |issue= 1 |pages= 37–41 |year= 2003 |pmid= 12030330 |doi=10.1007/s10048-001-0124-2 }}
*{{cite journal | author=Svaren J, Sevetson BR, Golda T, ''et al.'' |title=Novel mutants of NAB corepressors enhance activation by Egr transactivators. |journal=EMBO J. |volume=17 |issue= 20 |pages= 6010-9 |year= 1998 |pmid= 9774344 |doi= 10.1093/emboj/17.20.6010 }}
*{{cite journal   |vauthors=Lucerna M, Mechtcheriakova D, Kadl A, etal |title=NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11433–40 |year= 2003 |pmid= 12427750 |doi= 10.1074/jbc.M204937200 }}
*{{cite journal | author=Abdulkadir SA, Qu Z, Garabedian E, ''et al.'' |title=Impaired prostate tumorigenesis in Egr1-deficient mice. |journal=Nat. Med. |volume=7 |issue= 1 |pages= 101-7 |year= 2001 |pmid= 11135623 |doi= 10.1038/83231 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Abdulkadir SA, Carbone JM, Naughton CK, ''et al.'' |title=Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. |journal=Hum. Pathol. |volume=32 |issue= 9 |pages= 935-9 |year= 2001 |pmid= 11567222 |doi= 10.1053/hupa.2001.27102 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Venken K, Di Maria E, Bellone E, ''et al.'' |title=Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. |journal=Neurogenetics |volume=4 |issue= 1 |pages= 37-41 |year= 2003 |pmid= 12030330 |doi=  }}
*{{cite journal  |vauthors=Kumbrink J, Gerlinger M, Johnson JP |title=Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42785–93 |year= 2005 |pmid= 16260776 |doi= 10.1074/jbc.M511079200 }}
*{{cite journal | author=Lucerna M, Mechtcheriakova D, Kadl A, ''et al.'' |title=NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11433-40 |year= 2003 |pmid= 12427750 |doi= 10.1074/jbc.M204937200 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Srinivasan R, Mager GM, Ward RM, etal |title=NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. |journal=J. Biol. Chem. |volume=281 |issue= 22 |pages= 15129–37 |year= 2006 |pmid= 16574654 |doi= 10.1074/jbc.M600775200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Kumbrink J, Gerlinger M, Johnson JP |title=Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42785-93 |year= 2006 |pmid= 16260776 |doi= 10.1074/jbc.M511079200 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Srinivasan R, Mager GM, Ward RM, ''et al.'' |title=NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. |journal=J. Biol. Chem. |volume=281 |issue= 22 |pages= 15129-37 |year= 2006 |pmid= 16574654 |doi= 10.1074/jbc.M600775200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
{{WikiDoc Sources}}
 
 
{{gene-12-stub}}

Latest revision as of 12:24, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene.[1][2][3]

Function

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress or activate transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

Pathology

Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors.[4]

References

  1. ↑ Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. PMC 231349. PMID 8668170.
  2. ↑ Kirsch KH, Korradi Y, Johnson JP (Jul 1996). "Mader: a novel nuclear protein over expressed in human melanomas". Oncogene. 12 (5): 963–71. PMID 8649813.
  3. ↑ 3.0 3.1 "Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)".
  4. ↑ Kabbinavar, F. F.; Hambleton, J; Mass, R. D.; Hurwitz, H. I.; Bergsland, E; Sarkar, S (2005). "Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer". Journal of Clinical Oncology. 23 (16): 3706–12. doi:10.1200/JCO.2005.00.232. PMID 15867200.

Further reading


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