TSC22D1: Difference between revisions

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{{Infobox_gene}}
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'''TSC22 domain family protein 1''' is a [[protein]] that in humans is encoded by the ''TSC22D1'' [[gene]].<ref name="pmid8651929">{{cite journal | vauthors = Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P | title = Cloning of the human homologue of the TGF beta-stimulated clone 22 gene | journal = Biochem Biophys Res Commun | volume = 222 | issue = 3 | pages = 821–6 |date=Jul 1996 | pmid = 8651929 | pmc =  | doi = 10.1006/bbrc.1996.0825 }}</ref><ref name="pmid9022669">{{cite journal | vauthors = Ohta S, Shimekake Y, Nagata K | title = Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter | journal = Eur J Biochem | volume = 242 | issue = 3 | pages = 460–6 |date=Mar 1997 | pmid = 9022669 | pmc = | doi =10.1111/j.1432-1033.1996.460rr.x  }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
TSC22 encodes a [[transcription factor]] and belongs to the large family of [[immediate early gene|early response genes]].<ref name="entrez">{{cite web | title = Entrez Gene: TSC22D1 TSC22 domain family, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8848| accessdate = }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = TSC22 domain family, member 1
| HGNCid = 16826
| Symbol = TSC22D1
| AltSymbols =; DKFZp686O19206; MGC17597; RP11-269C23.2; TGFB1I4; TSC22
| OMIM = 607715
| ECnumber = 
| Homologene = 7573
| MGIid = 109127
| GeneAtlas_image1 = PBB_GE_TSC22D1_215111_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8848
    | Hs_Ensembl = ENSG00000102804
    | Hs_RefseqProtein = NP_006013
    | Hs_RefseqmRNA = NM_006022
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 43905663
    | Hs_GenLoc_end = 44048210
    | Hs_Uniprot = Q15714
    | Mm_EntrezGene = 21807
    | Mm_Ensembl = ENSMUSG00000022010
    | Mm_RefseqmRNA = NM_009366
    | Mm_RefseqProtein = NP_033392
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 75149847
    | Mm_GenLoc_end = 75241922
    | Mm_Uniprot = Q3UXU0
  }}
}}
'''TSC22 domain family, member 1''', also known as '''TSC22D1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TSC22D1 TSC22 domain family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8848| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
TSC22D1 forms homodimers via its conserved [[leucine zipper]] domain and heterodimerizes with [[TSC22D4]]. TSC22D1 has transcriptional [[repressor]] activity.<ref name="pmid10488076">{{cite journal | vauthors = Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B | title = Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity | journal = J. Biol. Chem. | volume = 274 | issue = 39 | pages = 27439–47 |date=September 1999 | pmid = 10488076 | doi = 10.1074/jbc.274.39.27439 | url =  }}</ref>
{{PBB_Summary
| section_title =
| summary_text = TSC22 encodes a transcription factor and belongs to the large family of early response genes.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TSC22D1 TSC22 domain family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8848| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Shibanuma M, Kuroki T, Nose K |title=Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10219-24 |year= 1992 |pmid= 1587811 |doi=  }}
*{{cite journal  | vauthors=Shibanuma M, Kuroki T, Nose K |title=Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10219–24 |year= 1992 |pmid= 1587811 |doi=  }}
*{{cite journal | author=Jay P, Ji JW, Marsollier C, ''et al.'' |title=Cloning of the human homologue of the TGF beta-stimulated clone 22 gene. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 3 |pages= 821-6 |year= 1996 |pmid= 8651929 |doi= 10.1006/bbrc.1996.0825 }}
*{{cite journal   |vauthors=Dmitrenko VV, Garifulin OM, Shostak EA, etal |title=[The characteristics of different types of mRNA expressed in the human brain] |journal=Tsitol. Genet. |volume=30 |issue= 5 |pages= 41–7 |year= 1997 |pmid= 9026990 |doi= }}
*{{cite journal | author=Ohta S, Shimekake Y, Nagata K |title=Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. |journal=Eur. J. Biochem. |volume=242 |issue= 3 |pages= 460-6 |year= 1997 |pmid= 9022669 |doi= }}
*{{cite journal   |vauthors=Kester HA, Blanchetot C, den Hertog J, etal |title=Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27439–47 |year= 1999 |pmid= 10488076 |doi=10.1074/jbc.274.39.27439  }}
*{{cite journal | author=Dmitrenko VV, Garifulin OM, Shostak EA, ''et al.'' |title=[The characteristics of different types of mRNA expressed in the human brain] |journal=Tsitol. Genet. |volume=30 |issue= 5 |pages= 41-7 |year= 1997 |pmid= 9026990 |doi= }}
*{{cite journal   |vauthors=Hino S, Kawamata H, Uchida D, etal |title=Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 659–64 |year= 2001 |pmid= 11095965 |doi= 10.1006/bbrc.2000.3840 }}
*{{cite journal | author=Kester HA, Blanchetot C, den Hertog J, ''et al.'' |title=Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27439-47 |year= 1999 |pmid= 10488076 |doi=  }}
*{{cite journal   |vauthors=Hino S, Kawamata H, Omotehara F, etal |title=Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells. |journal=Oncol. Rep. |volume=9 |issue= 2 |pages= 371–4 |year= 2002 |pmid= 11836610 |doi=  10.3892/or.9.2.371}}
*{{cite journal | author=Hino S, Kawamata H, Uchida D, ''et al.'' |title=Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 659-64 |year= 2001 |pmid= 11095965 |doi= 10.1006/bbrc.2000.3840 }}
*{{cite journal   |vauthors=Hino S, Kawamata H, Omotehara F, etal |title=Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 4 |pages= 957–63 |year= 2002 |pmid= 11944908 |doi= 10.1006/bbrc.2002.6776 }}
*{{cite journal | author=Hino S, Kawamata H, Omotehara F, ''et al.'' |title=Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells. |journal=Oncol. Rep. |volume=9 |issue= 2 |pages= 371-4 |year= 2002 |pmid= 11836610 |doi=  }}
*{{cite journal   |vauthors=Ohara O, Nagase T, Mitsui G, etal |title=Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. |journal=DNA Res. |volume=9 |issue= 2 |pages= 47–57 |year= 2003 |pmid= 12056414 |doi=10.1093/dnares/9.2.47 }}
*{{cite journal | author=Hino S, Kawamata H, Omotehara F, ''et al.'' |title=Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 4 |pages= 957-63 |year= 2002 |pmid= 11944908 |doi= 10.1006/bbrc.2002.6776 }}
*{{cite journal   |vauthors=Gupta RA, Sarraf P, Brockman JA, etal |title=Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7431–8 |year= 2003 |pmid= 12468551 |doi= 10.1074/jbc.M208076200 }}
*{{cite journal | author=Ohara O, Nagase T, Mitsui G, ''et al.'' |title=Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. |journal=DNA Res. |volume=9 |issue= 2 |pages= 47-57 |year= 2003 |pmid= 12056414 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Gupta RA, Sarraf P, Brockman JA, ''et al.'' |title=Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7431-8 |year= 2003 |pmid= 12468551 |doi= 10.1074/jbc.M208076200 }}
*{{cite journal   |vauthors=Sugawara F, Yamada Y, Watanabe R, etal |title=The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy. |journal=Diabetes Res. Clin. Pract. |volume=60 |issue= 3 |pages= 191–7 |year= 2004 |pmid= 12757981 |doi=10.1016/S0168-8227(03)00038-X  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Uchida D, Omotehara F, Nakashiro K, etal |title=Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 4 |pages= 846–54 |year= 2003 |pmid= 12767908 |doi=10.1016/S0006-291X(03)00854-4  }}
*{{cite journal | author=Sugawara F, Yamada Y, Watanabe R, ''et al.'' |title=The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy. |journal=Diabetes Res. Clin. Pract. |volume=60 |issue= 3 |pages= 191-7 |year= 2004 |pmid= 12757981 |doi= }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Uchida D, Omotehara F, Nakashiro K, ''et al.'' |title=Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 4 |pages= 846-54 |year= 2003 |pmid= 12767908 |doi=  }}
*{{cite journal   |vauthors=Choi SJ, Moon JH, Ahn YW, etal |title=Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation. |journal=Mol. Cell. Biochem. |volume=271 |issue= 1-2 |pages= 23–8 |year= 2005 |pmid= 15881652 |doi=10.1007/s11010-005-3456-7 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rentsch CA, Cecchini MG, Schwaninger R, etal |title=Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer. |journal=Int. J. Cancer |volume=118 |issue= 4 |pages= 899–906 |year= 2006 |pmid= 16106424 |doi= 10.1002/ijc.21449 }}
*{{cite journal | author=Choi SJ, Moon JH, Ahn YW, ''et al.'' |title=Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation. |journal=Mol. Cell. Biochem. |volume=271 |issue= 1-2 |pages= 23-8 |year= 2005 |pmid= 15881652 |doi= }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Rentsch CA, Cecchini MG, Schwaninger R, ''et al.'' |title=Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer. |journal=Int. J. Cancer |volume=118 |issue= 4 |pages= 899-906 |year= 2006 |pmid= 16106424 |doi= 10.1002/ijc.21449 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal   |vauthors=Lu Y, Kitaura J, Oki T, etal |title=Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. |journal=Leukemia |volume=21 |issue= 11 |pages= 2246–57 |year= 2007 |pmid= 17690703 |doi= 10.1038/sj.leu.2404883 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Lu Y, Kitaura J, Oki T, ''et al.'' |title=Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. |journal=Leukemia |volume=21 |issue= 11 |pages= 2246-57 |year= 2007 |pmid= 17690703 |doi= 10.1038/sj.leu.2404883 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{MeshName|TSC22D1+protein,+human|3=TSC22D1 protein, human}}
 
{{NLM content}}
 
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[[Category:Transcription factors]]
 
 
{{gene-13-stub}}

Latest revision as of 12:20, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.[1][2]

TSC22 encodes a transcription factor and belongs to the large family of early response genes.[3]

TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.[4]

References

  1. ↑ Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P (Jul 1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene". Biochem Biophys Res Commun. 222 (3): 821–6. doi:10.1006/bbrc.1996.0825. PMID 8651929.
  2. ↑ Ohta S, Shimekake Y, Nagata K (Mar 1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter". Eur J Biochem. 242 (3): 460–6. doi:10.1111/j.1432-1033.1996.460rr.x. PMID 9022669.
  3. ↑ "Entrez Gene: TSC22D1 TSC22 domain family, member 1".
  4. ↑ Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B (September 1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi:10.1074/jbc.274.39.27439. PMID 10488076.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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