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{{Infobox_gene}}
{{PBB_Controls
'''Latent-transforming growth factor beta-binding protein 2''' is a [[protein]] that in humans is encoded by the ''LTBP2'' [[gene]].<ref name="pmid7798248">{{cite journal |vauthors=Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH | title = Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein | journal = J Biol Chem | volume = 269 | issue = 51 | pages = 32469–78 |date=Jan 1995 | pmid = 7798248 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4053| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Latent transforming growth factor beta binding protein 2
| HGNCid = 6715
| Symbol = LTBP2
| AltSymbols =; C14orf141; LTBP3; MSTP031
| OMIM = 602091
| ECnumber = 
| Homologene = 369
| MGIid = 99502
| GeneAtlas_image1 = PBB_GE_LTBP2_204682_at_tn.png
| GeneAtlas_image2 = PBB_GE_LTBP2_gnf1h00588_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0019838 |text = growth factor binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0006858 |text = extracellular transport}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0009306 |text = protein secretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4053
    | Hs_Ensembl = ENSG00000119681
    | Hs_RefseqProtein = NP_000419
    | Hs_RefseqmRNA = NM_000428
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 74034642
    | Hs_GenLoc_end = 74148787
    | Hs_Uniprot = Q14767
    | Mm_EntrezGene = 16997
    | Mm_Ensembl = ENSMUSG00000002020
    | Mm_RefseqmRNA = NM_013589
    | Mm_RefseqProtein = NP_038617
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 85672960
    | Mm_GenLoc_end = 85766280
    | Mm_Uniprot = O08999
  }}
}}
'''Latent transforming growth factor beta binding protein 2''', also known as '''LTBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4053| accessdate = }}</ref>


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.<ref name="entrez">{{cite web | title = Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4053| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Chambaz EM, Souchelnitskiy S, Pellerin S, ''et al.'' |title=Transforming growth factors-beta s: a multifunctional cytokine family. Implication in the regulation of adrenocortical cell endocrine functions. |journal=Horm. Res. |volume=45 |issue= 3-5 |pages= 222-6 |year= 1996 |pmid= 8964588 |doi= }}
*{{cite journal   |vauthors=Chambaz EM, Souchelnitskiy S, Pellerin S, etal |title=Transforming growth factors-beta s: a multifunctional cytokine family. Implication in the regulation of adrenocortical cell endocrine functions |journal=Horm. Res. |volume=45 |issue= 3–5 |pages= 222–6 |year= 1996 |pmid= 8964588 |doi= 10.1159/000184792 }}
*{{cite journal | author=Munger JS, Harpel JG, Gleizes PE, ''et al.'' |title=Latent transforming growth factor-beta: structural features and mechanisms of activation. |journal=Kidney Int. |volume=51 |issue= 5 |pages= 1376-82 |year= 1997 |pmid= 9150447 |doi=  }}
*{{cite journal   |vauthors=Munger JS, Harpel JG, Gleizes PE, etal |title=Latent transforming growth factor-beta: structural features and mechanisms of activation |journal=Kidney Int. |volume=51 |issue= 5 |pages= 1376–82 |year= 1997 |pmid= 9150447 |doi=10.1038/ki.1997.188 }}
*{{cite journal  | author=Taipale J, Saharinen J, Keski-Oja J |title=Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion. |journal=Adv. Cancer Res. |volume=75 |issue=  |pages= 87-134 |year= 1998 |pmid= 9709808 |doi=  }}
*{{cite journal  |vauthors=Taipale J, Saharinen J, Keski-Oja J |title=Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion |journal=Adv. Cancer Res. |volume=75 |issue=  |pages= 87–134 |year= 1998 |pmid= 9709808 |doi=10.1016/S0065-230X(08)60740-X  | chapter=Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion  | series=Advances in Cancer Research  | isbn=978-0-12-006675-9 }}
*{{cite journal  | author=Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J |title=Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 2 |pages= 99-117 |year= 2000 |pmid= 10743502 |doi=  }}
*{{cite journal  |vauthors=Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J |title=Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 2 |pages= 99–117 |year= 2000 |pmid= 10743502 |doi=10.1016/S1359-6101(99)00010-6 }}
*{{cite journal  | author=Oklü R, Hesketh R |title=The latent transforming growth factor beta binding protein (LTBP) family. |journal=Biochem. J. |volume=352 Pt 3 |issue=  |pages= 601-10 |year= 2001 |pmid= 11104663 |doi=  }}
*{{cite journal  |vauthors=Oklü R, Hesketh R |title=The latent transforming growth factor beta binding protein (LTBP) family |journal=Biochem. J. |volume=352 Pt 3 |issue=  |pages= 601–10 |year= 2001 |pmid= 11104663 |doi= 10.1042/0264-6021:3520601| pmc=1221494 }}
*{{cite journal | author=Li X, Yin W, Pérez-Jurado L, ''et al.'' |title=Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2). |journal=Mamm. Genome |volume=6 |issue= 1 |pages= 42-5 |year= 1995 |pmid= 7719025 |doi= }}
*{{cite journal   |vauthors=Li X, Yin W, Pérez-Jurado L, etal |title=Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2) |journal=Mamm. Genome |volume=6 |issue= 1 |pages= 42–5 |year= 1995 |pmid= 7719025 |doi=10.1007/BF00350892 }}
*{{cite journal  | author=Morén A, Olofsson A, Stenman G, ''et al.'' |title=Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. |journal=J. Biol. Chem. |volume=269 |issue= 51 |pages= 32469-78 |year= 1995 |pmid= 7798248 |doi= }}
*{{cite journal   |vauthors=Bashir MM, Han MD, Abrams WR, etal |title=Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2 |journal=Int. J. Biochem. Cell Biol. |volume=28 |issue= 5 |pages= 531–42 |year= 1996 |pmid= 8697098 |doi=10.1016/1357-2725(95)00167-0 }}
*{{cite journal | author=Bashir MM, Han MD, Abrams WR, ''et al.'' |title=Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2. |journal=Int. J. Biochem. Cell Biol. |volume=28 |issue= 5 |pages= 531-42 |year= 1996 |pmid= 8697098 |doi=  }}
*{{cite journal  |vauthors=Hyytiäinen M, Taipale J, Heldin CH, Keski-Oja J |title=Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20669–76 |year= 1998 |pmid= 9685426 |doi=10.1074/jbc.273.32.20669 }}
*{{cite journal  | author=Hyytiäinen M, Taipale J, Heldin CH, Keski-Oja J |title=Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20669-76 |year= 1998 |pmid= 9685426 |doi=  }}
*{{cite journal  |vauthors=Saharinen J, Keski-Oja J |title=Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta |journal=Mol. Biol. Cell |volume=11 |issue= 8 |pages= 2691–704 |year= 2000 |pmid= 10930463 |doi= 10.1091/mbc.11.8.2691| pmc=14949 }}
*{{cite journal  | author=Saharinen J, Keski-Oja J |title=Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. |journal=Mol. Biol. Cell |volume=11 |issue= 8 |pages= 2691-704 |year= 2000 |pmid= 10930463 |doi=  }}
*{{cite journal   |vauthors=Wu X, Blanck A, Norstedt G, etal |title=Identification of genes with higher expression in human uterine leiomyomas than in the corresponding myometrium |journal=Mol. Hum. Reprod. |volume=8 |issue= 3 |pages= 246–54 |year= 2002 |pmid= 11870232 |doi=10.1093/molehr/8.3.246 }}
*{{cite journal | author=Wu X, Blanck A, Norstedt G, ''et al.'' |title=Identification of genes with higher expression in human uterine leiomyomas than in the corresponding myometrium. |journal=Mol. Hum. Reprod. |volume=8 |issue= 3 |pages= 246-54 |year= 2002 |pmid= 11870232 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Heilig R, Eckenberg R, Petit JL, etal |title=The DNA sequence and analysis of human chromosome 14 |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
*{{cite journal | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
*{{cite journal  |vauthors=Vehviläinen P, Hyytiäinen M, Keski-Oja J |title=Latent transforming growth factor-beta-binding protein 2 is an adhesion protein for melanoma cells |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24705–13 |year= 2003 |pmid= 12716902 |doi= 10.1074/jbc.M212953200 }}
*{{cite journal  | author=Vehviläinen P, Hyytiäinen M, Keski-Oja J |title=Latent transforming growth factor-beta-binding protein 2 is an adhesion protein for melanoma cells. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24705-13 |year= 2003 |pmid= 12716902 |doi= 10.1074/jbc.M212953200 }}
*{{cite journal  |vauthors=Hirani R, Hanssen E, Gibson MA |title=LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein |journal=Matrix Biol. |volume=26 |issue= 4 |pages= 213–23 |year= 2007 |pmid= 17293099 |doi= 10.1016/j.matbio.2006.12.006 }}
*{{cite journal  | author=Hirani R, Hanssen E, Gibson MA |title=LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein. |journal=Matrix Biol. |volume=26 |issue= 4 |pages= 213-23 |year= 2007 |pmid= 17293099 |doi= 10.1016/j.matbio.2006.12.006 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=glc  GeneReview/NCBI/NIH/UW entry on Primary Congenital Glaucoma]
 
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Latest revision as of 18:12, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.[1][2]

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.[2]

References

  1. ↑ Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH (Jan 1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J Biol Chem. 269 (51): 32469–78. PMID 7798248.
  2. ↑ 2.0 2.1 "Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2".

Further reading

External links



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