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{{Infobox_gene}}
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'''Ankyrin repeat and SOCS box protein 2''' is a [[protein]] that in humans is encoded by the ''ASB2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ASB2 ankyrin repeat and SOCS box-containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51676| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Ankyrin repeat and SOCS box-containing 2
| HGNCid = 16012
| Symbol = ASB2
| AltSymbols =; ASB-2; MGC40044
| OMIM = 605759
| ECnumber = 
| Homologene = 69202
| MGIid = 1929743
| GeneAtlas_image1 = PBB_GE_ASB2_gnf1h00212_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51676
    | Hs_Ensembl = ENSG00000100628
    | Hs_RefseqProtein = NP_057234
    | Hs_RefseqmRNA = NM_016150
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 93470266
    | Hs_GenLoc_end = 93493520
    | Hs_Uniprot = Q96Q27
    | Mm_EntrezGene = 65256
    | Mm_Ensembl = ENSMUSG00000021200
    | Mm_RefseqmRNA = XM_977651
    | Mm_RefseqProtein = XP_982745
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 103722192
    | Mm_GenLoc_end = 103757051
    | Mm_Uniprot = Q8K0L0
  }}
}}
'''Ankyrin repeat and SOCS box-containing 2''', also known as '''ASB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ASB2 ankyrin repeat and SOCS box-containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51676| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.<ref name="entrez">{{cite web | title = Entrez Gene: ASB2 ankyrin repeat and SOCS box-containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51676| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the [[ankyrin repeat]] and [[Suppressor of cytokine signalling|SOCS]] box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans [[retinoic acid]]. In [[myeloid leukemia]] cells, the expression of this encoded protein has been shown to induce [[growth inhibition]] and [[chromatin condensation]]. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ASB2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kile BT, Schulman BA, Alexander WS, ''et al.'' |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235-41 |year= 2002 |pmid= 12076535 |doi=  }}
*{{cite journal  | vauthors=Kile BT, Schulman BA, Alexander WS |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235–41 |year= 2002 |pmid= 12076535 |doi=10.1016/S0968-0004(02)02085-6 |display-authors=etal}}
*{{cite journal  | author=Hilton DJ, Richardson RT, Alexander WS, ''et al.'' |title=Twenty proteins containing a C-terminal SOCS box form five structural classes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 114-9 |year= 1998 |pmid= 9419338 |doi=  }}
*{{cite journal  | vauthors=Hilton DJ, Richardson RT, Alexander WS |title=Twenty proteins containing a C-terminal SOCS box form five structural classes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 114–9 |year= 1998 |pmid= 9419338 |doi=10.1073/pnas.95.1.114  | pmc=18144 |display-authors=etal}}
*{{cite journal  | author=Kile BT, Viney EM, Willson TA, ''et al.'' |title=Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. |journal=Gene |volume=258 |issue= 1-2 |pages= 31-41 |year= 2001 |pmid= 11111040 |doi=  }}
*{{cite journal  | vauthors=Kile BT, Viney EM, Willson TA |title=Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. |journal=Gene |volume=258 |issue= 1–2 |pages= 31–41 |year= 2001 |pmid= 11111040 |doi=10.1016/S0378-1119(00)00402-9 |display-authors=etal}}
*{{cite journal  | author=Kile BT, Metcalf D, Mifsud S, ''et al.'' |title=Functional analysis of Asb-1 using genetic modification in mice. |journal=Mol. Cell. Biol. |volume=21 |issue= 18 |pages= 6189-97 |year= 2001 |pmid= 11509662 |doi=  }}
*{{cite journal  | vauthors=Kile BT, Metcalf D, Mifsud S |title=Functional analysis of Asb-1 using genetic modification in mice |journal=Mol. Cell. Biol. |volume=21 |issue= 18 |pages= 6189–97 |year= 2001 |pmid= 11509662 |doi=10.1128/MCB.21.18.6189-6197.2001 | pmc=87336  |display-authors=etal}}
*{{cite journal  | author=Kohroki J, Fujita S, Itoh N, ''et al.'' |title=ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells. |journal=FEBS Lett. |volume=505 |issue= 2 |pages= 223-8 |year= 2001 |pmid= 11566180 |doi=  }}
*{{cite journal  | vauthors=Kohroki J, Fujita S, Itoh N |title=ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells |journal=FEBS Lett. |volume=505 |issue= 2 |pages= 223–8 |year= 2001 |pmid= 11566180 |doi=10.1016/S0014-5793(01)02829-0 |display-authors=etal}}
*{{cite journal  | author=Guibal FC, Moog-Lutz C, Smolewski P, ''et al.'' |title=ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 218-24 |year= 2002 |pmid= 11682484 |doi= 10.1074/jbc.M108476200 }}
*{{cite journal  | vauthors=Guibal FC, Moog-Lutz C, Smolewski P |title=ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 218–24 |year= 2002 |pmid= 11682484 |doi= 10.1074/jbc.M108476200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Namciu SJ, Friedman RD, Marsden MD, ''et al.'' |title=Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. |journal=Mamm. Genome |volume=15 |issue= 3 |pages= 162-78 |year= 2004 |pmid= 15014966 |doi= 10.1007/s00335-003-2311-y }}
*{{cite journal  | vauthors=Namciu SJ, Friedman RD, Marsden MD |title=Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1 |journal=Mamm. Genome |volume=15 |issue= 3 |pages= 162–78 |year= 2004 |pmid= 15014966 |doi= 10.1007/s00335-003-2311-y |display-authors=etal}}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | vauthors=Colland F, Jacq X, Trouplin V |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Heuzé ML, Guibal FC, Banks CA, ''et al.'' |title=ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5468-74 |year= 2005 |pmid= 15590664 |doi= 10.1074/jbc.M413040200 }}
*{{cite journal  | vauthors=Heuzé ML, Guibal FC, Banks CA |title=ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5468–74 |year= 2005 |pmid= 15590664 |doi= 10.1074/jbc.M413040200 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Kohroki J, Nishiyama T, Nakamura T, Masuho Y |title=ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. |journal=FEBS Lett. |volume=579 |issue= 30 |pages= 6796-802 |year= 2006 |pmid= 16325183 |doi= 10.1016/j.febslet.2005.11.016 }}
*{{cite journal  | vauthors=Kohroki J, Nishiyama T, Nakamura T, Masuho Y |title=ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes |journal=FEBS Lett. |volume=579 |issue= 30 |pages= 6796–802 |year= 2006 |pmid= 16325183 |doi= 10.1016/j.febslet.2005.11.016 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:18, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.[1]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ASB2 ankyrin repeat and SOCS box-containing 2".

External links

Further reading



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