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{{Infobox gene}}
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'''Milk fat globule-EGF factor 8 protein''' ('''Mfge8'''), also known as '''lactadherin''', is a [[protein]] which in humans is encoded by the ''MFGE8'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4240| accessdate = }}</ref><ref name="pmid9027496">{{cite journal |vauthors=Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G | title = Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25 | journal = Genomics | volume = 39 | issue = 1 | pages = 117–8 |date=January 1997 | pmid = 9027496 | doi = 10.1006/geno.1996.4425 | url = }}</ref>
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== Species distribution ==
| update_protein_box = yes
 
| update_summary = yes
Mfge8 is secreted protein found in vertebrates, including mammals as well as birds.
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fiber in arteries.<ref name="pmid16911961">{{cite journal |vauthors=Larsson A, Peng S, Persson H, Rosenbloom J, Abrams WR, Wassberg E, Thelin S, Sletten K, Gerwins P, Westermark P | title = Lactadherin binds to elastin--a starting point for medin amyloid formation? | journal = Amyloid | volume = 13 | issue = 2 | pages = 78–85 |date=June 2006 | pmid = 16911961 | doi = 10.1080/13506120600722530 }}</ref> An [[amyloid]] fragment of MFGE8 known as medin accumulates in the aorta with [[aging]].<ref name="pmid16011985">{{cite journal |vauthors=Peng S, Glennert J, Westermark P | title = Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body | journal = Amyloid | volume = 12 | issue = 2 | pages = 96–102 |date=June 2005 | pmid = 16011985 | doi = 10.1080/13506120500107006 }}</ref> MFGE8 in the vasculature of adults can induce recovery from [[ischemia]] by facilitating [[angiogenesis]].<ref name="pmid15834428">{{cite journal |vauthors=Silvestre JS, Théry C, Hamard G, Boddaert J, Aguilar B, Delcayre A, Houbron C, Tamarat R, Blanc-Brude O, Heeneman S, Clergue M, Duriez M, Merval R, Lévy B, Tedgui A, Amigorena S, Mallat Z | title = Lactadherin promotes VEGF-dependent neovascularization | journal = Nat. Med. | volume = 11 | issue = 5 | pages = 499–506 |date=May 2005 | pmid = 15834428 | doi = 10.1038/nm1233 }}</ref> It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer.<ref name="pmid19204935">{{cite journal |vauthors=Raymond A, Ensslin MA, Shur BD | title = SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions | journal = J. Cell. Biochem. | volume = 106 | issue = 6 | pages = 957–66 |date=April 2009 | pmid = 19204935 | pmc = 2742659 | doi = 10.1002/jcb.22076 }}</ref>
| image =
| image_source =
| PDB =  
| Name = Milk fat globule-EGF factor 8 protein
| HGNCid = 7036
| Symbol = MFGE8
| AltSymbols =; BA46; EDIL1; HsT19888; OAcGD3S
| OMIM = 602281
| ECnumber = 
| Homologene = 4334
| MGIid = 102768
| GeneAtlas_image1 = PBB_GE_MFGE8_210605_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001786 |text = phosphatidylserine binding}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008429 |text = phosphatidylethanolamine binding}}
| Component = {{GNF_GO|id=GO:0005811 |text = lipid particle}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0019897 |text = extrinsic to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006910 |text = phagocytosis, recognition}} {{GNF_GO|id=GO:0006911 |text = phagocytosis, engulfment}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0050766 |text = positive regulation of phagocytosis}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4240
    | Hs_Ensembl = ENSG00000140545
    | Hs_RefseqProtein = NP_005919
    | Hs_RefseqmRNA = NM_005928
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 87242949
    | Hs_GenLoc_end = 87257646
    | Hs_Uniprot = Q08431
    | Mm_EntrezGene = 17304
    | Mm_Ensembl = ENSMUSG00000030605
    | Mm_RefseqmRNA = NM_001045489
    | Mm_RefseqProtein = NP_001038954
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 79007282
    | Mm_GenLoc_end = 79022526
    | Mm_Uniprot = Q3U8S9
  }}
}}
'''Milk fat globule-EGF factor 8 protein''', also known as '''MFGE8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4240| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
MFGE8 contains a [[phosphatidylserine]] (PS) binding domain, as well as an [[Arginine]]-[[Glycine]]-[[Aspartic acid]] motif, which enables the binding to [[integrins]]. MFGE8 binds PS, which is exposed on the surface of [[apoptotic]] cells. [[Opsonization]] of the apoptotic cells and binding to integrins on the surface of [[phagocytic cell]]s, mediates the engulfment of the dead cell.
{{PBB_Summary
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| summary_text =
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Peterson JA, Scallan CD, Ceriani RL, Hamosh M |title=Structural and functional aspects of three major glycoproteins of the human milk fat globule membrane. |journal=Adv. Exp. Med. Biol. |volume=501 |issue=  |pages= 179-87 |year= 2002 |pmid= 11787681 |doi=  }}
*{{cite journal  |vauthors=Peterson JA, Scallan CD, Ceriani RL, Hamosh M |title=Structural and functional aspects of three major glycoproteins of the human milk fat globule membrane. |journal=Adv. Exp. Med. Biol. |volume=501 |issue=  |pages= 179–87 |year= 2002 |pmid= 11787681 |doi=  10.1007/978-1-4615-1371-1_23}}
*{{cite journal | author=Larocca D, Peterson JA, Urrea R, ''et al.'' |title=A Mr 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains. |journal=Cancer Res. |volume=51 |issue= 18 |pages= 4994-8 |year= 1991 |pmid= 1909932 |doi=  }}
*{{cite journal   |vauthors=Larocca D, Peterson JA, Urrea R, etal |title=A Mr 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains. |journal=Cancer Res. |volume=51 |issue= 18 |pages= 4994–8 |year= 1991 |pmid= 1909932 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal | author=Couto JR, Taylor MR, Godwin SG, ''et al.'' |title=Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain. |journal=DNA Cell Biol. |volume=15 |issue= 4 |pages= 281-6 |year= 1996 |pmid= 8639264 |doi=  }}
*{{cite journal   |vauthors=Couto JR, Taylor MR, Godwin SG, etal |title=Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain. |journal=DNA Cell Biol. |volume=15 |issue= 4 |pages= 281–6 |year= 1996 |pmid= 8639264 |doi=10.1089/dna.1996.15.281 }}
*{{cite journal | author=Collins C, Nehlin JO, Stubbs JD, ''et al.'' |title=Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25. |journal=Genomics |volume=39 |issue= 1 |pages= 117-8 |year= 1997 |pmid= 9027496 |doi= 10.1006/geno.1996.4425 }}
*{{cite journal   |vauthors=Collins C, Nehlin JO, Stubbs JD, etal |title=Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25. |journal=Genomics |volume=39 |issue= 1 |pages= 117–8 |year= 1997 |pmid= 9027496 |doi= 10.1006/geno.1996.4425 }}
*{{cite journal | author=Aoki N, Ishii T, Ohira S, ''et al.'' |title=Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein. |journal=Biochim. Biophys. Acta |volume=1334 |issue= 2-3 |pages= 182-90 |year= 1997 |pmid= 9101712 |doi=  }}
*{{cite journal   |vauthors=Aoki N, Ishii T, Ohira S, etal |title=Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein. |journal=Biochim. Biophys. Acta |volume=1334 |issue= 2–3 |pages= 182–90 |year= 1997 |pmid= 9101712 |doi=  10.1016/s0304-4165(96)00091-8}}
*{{cite journal | author=Taylor MR, Couto JR, Scallan CD, ''et al.'' |title=Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion. |journal=DNA Cell Biol. |volume=16 |issue= 7 |pages= 861-9 |year= 1997 |pmid= 9260929 |doi=  }}
*{{cite journal   |vauthors=Taylor MR, Couto JR, Scallan CD, etal |title=Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion. |journal=DNA Cell Biol. |volume=16 |issue= 7 |pages= 861–9 |year= 1997 |pmid= 9260929 |doi=10.1089/dna.1997.16.861 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Giuffrida MG, Cavaletto M, Giunta C, ''et al.'' |title=Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes. |journal=J. Protein Chem. |volume=17 |issue= 2 |pages= 143-8 |year= 1998 |pmid= 9535276 |doi=  }}
*{{cite journal   |vauthors=Giuffrida MG, Cavaletto M, Giunta C, etal |title=Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes. |journal=J. Protein Chem. |volume=17 |issue= 2 |pages= 143–8 |year= 1998 |pmid= 9535276 |doi=10.1023/A:1022531500370 }}
*{{cite journal | author=Newburg DS, Peterson JA, Ruiz-Palacios GM, ''et al.'' |title=Role of human-milk lactadherin in protection against symptomatic rotavirus infection. |journal=Lancet |volume=351 |issue= 9110 |pages= 1160-4 |year= 1998 |pmid= 9643686 |doi=  }}
*{{cite journal   |vauthors=Newburg DS, Peterson JA, Ruiz-Palacios GM, etal |title=Role of human-milk lactadherin in protection against symptomatic rotavirus infection. |journal=Lancet |volume=351 |issue= 9110 |pages= 1160–4 |year= 1998 |pmid= 9643686 |doi=10.1016/S0140-6736(97)10322-1 }}
*{{cite journal | author=Peterson JA, Hamosh M, Scallan CD, ''et al.'' |title=Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants. |journal=Pediatr. Res. |volume=44 |issue= 4 |pages= 499-506 |year= 1998 |pmid= 9773837 |doi=  }}
*{{cite journal   |vauthors=Peterson JA, Hamosh M, Scallan CD, etal |title=Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants. |journal=Pediatr. Res. |volume=44 |issue= 4 |pages= 499–506 |year= 1998 |pmid= 9773837 |doi=10.1203/00006450-199810000-00006 }}
*{{cite journal | author=Häggqvist B, Näslund J, Sletten K, ''et al.'' |title=Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 15 |pages= 8669-74 |year= 1999 |pmid= 10411933 |doi=  }}
*{{cite journal   |vauthors=Häggqvist B, Näslund J, Sletten K, etal |title=Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 15 |pages= 8669–74 |year= 1999 |pmid= 10411933 |doi=10.1073/pnas.96.15.8669  | pmc=17574 }}
*{{cite journal | author=Oshima K, Aoki N, Kato T, ''et al.'' |title=Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. |journal=Eur. J. Biochem. |volume=269 |issue= 4 |pages= 1209-18 |year= 2002 |pmid= 11856354 |doi=  }}
*{{cite journal   |vauthors=Oshima K, Aoki N, Kato T, etal |title=Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. |journal=Eur. J. Biochem. |volume=269 |issue= 4 |pages= 1209–18 |year= 2002 |pmid= 11856354 |doi=10.1046/j.1432-1033.2002.02758.x }}
*{{cite journal | author=Hanayama R, Tanaka M, Miwa K, ''et al.'' |title=Identification of a factor that links apoptotic cells to phagocytes. |journal=Nature |volume=417 |issue= 6885 |pages= 182-7 |year= 2002 |pmid= 12000961 |doi= 10.1038/417182a }}
*{{cite journal   |vauthors=Hanayama R, Tanaka M, Miwa K, etal |title=Identification of a factor that links apoptotic cells to phagocytes. |journal=Nature |volume=417 |issue= 6885 |pages= 182–7 |year= 2002 |pmid= 12000961 |doi= 10.1038/417182a }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Lee SH, Seo GS, Park PH, ''et al.'' |title=Increased expression of O-acetyl disialoganglioside synthase during rat liver fibrogenesis relates to stellate cell activation. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 3 |pages= 954-61 |year= 2003 |pmid= 12670504 |doi=  }}
*{{cite journal   |vauthors=Lee SH, Seo GS, Park PH, etal |title=Increased expression of O-acetyl disialoganglioside synthase during rat liver fibrogenesis relates to stellate cell activation. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 3 |pages= 954–61 |year= 2003 |pmid= 12670504 |doi=10.1016/S0006-291X(03)00448-0 }}
*{{cite journal | author=Rehman KS, Yin S, Mayhew BA, ''et al.'' |title=Human myometrial adaptation to pregnancy: cDNA microarray gene expression profiling of myometrium from non-pregnant and pregnant women. |journal=Mol. Hum. Reprod. |volume=9 |issue= 11 |pages= 681-700 |year= 2004 |pmid= 14561811 |doi=  }}
*{{cite journal   |vauthors=Rehman KS, Yin S, Mayhew BA, etal |title=Human myometrial adaptation to pregnancy: cDNA microarray gene expression profiling of myometrium from non-pregnant and pregnant women. |journal=Mol. Hum. Reprod. |volume=9 |issue= 11 |pages= 681–700 |year= 2004 |pmid= 14561811 |doi=10.1093/molehr/gag078 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Reches M, Gazit E |title=Amyloidogenic hexapeptide fragment of medin: homology to functional islet amyloid polypeptide fragments. |journal=Amyloid |volume=11 |issue= 2 |pages= 81-9 |year= 2005 |pmid= 15478463 |doi=  }}
*{{cite journal  |vauthors=Reches M, Gazit E |title=Amyloidogenic hexapeptide fragment of medin: homology to functional islet amyloid polypeptide fragments. |journal=Amyloid |volume=11 |issue= 2 |pages= 81–9 |year= 2005 |pmid= 15478463 |doi=10.1080/13506120412331272287 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-15-stub}}

Latest revision as of 06:25, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein which in humans is encoded by the MFGE8 gene.[1][2]

Species distribution

Mfge8 is secreted protein found in vertebrates, including mammals as well as birds.

Function

MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fiber in arteries.[3] An amyloid fragment of MFGE8 known as medin accumulates in the aorta with aging.[4] MFGE8 in the vasculature of adults can induce recovery from ischemia by facilitating angiogenesis.[5] It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer.[6]

MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells. Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.

References

  1. ↑ "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein".
  2. ↑ Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G (January 1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics. 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496.
  3. ↑ Larsson A, Peng S, Persson H, Rosenbloom J, Abrams WR, Wassberg E, Thelin S, Sletten K, Gerwins P, Westermark P (June 2006). "Lactadherin binds to elastin--a starting point for medin amyloid formation?". Amyloid. 13 (2): 78–85. doi:10.1080/13506120600722530. PMID 16911961.
  4. ↑ Peng S, Glennert J, Westermark P (June 2005). "Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body". Amyloid. 12 (2): 96–102. doi:10.1080/13506120500107006. PMID 16011985.
  5. ↑ Silvestre JS, Théry C, Hamard G, Boddaert J, Aguilar B, Delcayre A, Houbron C, Tamarat R, Blanc-Brude O, Heeneman S, Clergue M, Duriez M, Merval R, Lévy B, Tedgui A, Amigorena S, Mallat Z (May 2005). "Lactadherin promotes VEGF-dependent neovascularization". Nat. Med. 11 (5): 499–506. doi:10.1038/nm1233. PMID 15834428.
  6. ↑ Raymond A, Ensslin MA, Shur BD (April 2009). "SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions". J. Cell. Biochem. 106 (6): 957–66. doi:10.1002/jcb.22076. PMC 2742659. PMID 19204935.

Further reading



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