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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''CIITA''' is a human [[gene]] which encodes a [[protein]] called the '''class II, major histocompatibility complex, transactivator'''.<ref name="pmid8402893">{{cite journal | vauthors = Steimle V, Otten LA, Zufferey M, Mach B | title = Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome) | journal = Cell | volume = 75 | issue = 1 | pages = 135–46 | date = Oct 1993 | pmid = 8402893 | doi = 10.1016/S0092-8674(05)80090-X }}</ref>  Mutations in this gene are responsible for the [[bare lymphocyte syndrome]] in which the [[immune system]] is severely compromised and cannot effectively fight [[infection]].<ref name="pmid8402893"/> Chromosomal rearrangement of CIITA is involved in the pathogenesis of [[Hodgkin lymphoma]] and [[primary mediastinal B cell lymphoma]].<ref name="pmid21368758">{{cite journal | vauthors = Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD | title = MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers | journal = Nature | volume = 471 | issue = 7338 | pages = 377–81 | date = Mar 2011 | pmid = 21368758 | pmc = 3902849 | doi = 10.1038/nature09754 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
CIITA [[messenger RNA|mRNA]] can only be detected in [[human leukocyte antigen]] (HLA) system class II-positive cell lines and tissues. This highly restricted tissue distribution suggests that expression of HLA class II genes is to a large extent under the control of CIITA.<ref name="pmid8070816">{{cite journal | vauthors = Mach B, Steimle V, Reith W | title = MHC class II-deficient combined immunodeficiency: a disease of gene regulation | journal = Immunological Reviews | volume = 138 | issue = 1 | pages = 207–21 | date = Apr 1994 | pmid = 8070816 | doi = 10.1111/j.1600-065X.1994.tb00853.x }}</ref> However CIITA does not appear to directly bind to DNA.<ref name="pmid8070816"/> Instead CIITA functions through activation of the [[transcription factor]] [[RFX5]].<ref name="pmid9177217">{{cite journal | vauthors = Scholl T, Mahanta SK, Strominger JL | title = Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 12 | pages = 6330–4 | date = Jun 1997 | pmid = 9177217 | pmc = 21049 | doi = 10.1073/pnas.94.12.6330 | url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=9177217 }}</ref> Hence CIITA is classified as a transcriptional [[coactivator (genetics)|coactivator]].
| image = 
| image_source =
| PDB =  
| Name = Class II, major histocompatibility complex, transactivator
| HGNCid = 7067
| Symbol = CIITA
| AltSymbols =; C2TA; CIITA IV; MHC2TA; NLRA
| OMIM = 600005
| ECnumber = 
| Homologene = 207
| MGIid = 108445
| GeneAtlas_image1 = PBB_GE_CIITA_211884_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CIITA_210925_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0043130 |text = ubiquitin binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4261
    | Hs_Ensembl = ENSG00000179583
    | Hs_RefseqProtein = NP_000237
    | Hs_RefseqmRNA = NM_000246
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 10867648
    | Hs_GenLoc_end = 10926340
    | Hs_Uniprot = P33076
    | Mm_EntrezGene = 12265
    | Mm_Ensembl = ENSMUSG00000022504
    | Mm_RefseqmRNA = NM_007575
    | Mm_RefseqProtein = NP_031601
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 10393637
    | Mm_GenLoc_end = 10441141
    | Mm_Uniprot = Q3UU40
  }}
}}
'''CIITA''' is a [[transactivator]] of [[MHC class II]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The CIITA protein contains an acidic [[activator (genetics)|transcriptional activation]] domain, 4 LRRs ([[leucine-rich repeat]]s) and a [[guanosine triphosphate|GTP]] binding domain.<ref name="pmid11172716">{{cite journal | vauthors = Raval A, Howcroft TK, Weissman JD, Kirshner S, Zhu XS, Yokoyama K, Ting J, Singer DS | title = Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250 | journal = Molecular Cell | volume = 7 | issue = 1 | pages = 105–15 | date = Jan 2001 | pmid = 11172716 | doi = 10.1016/S1097-2765(01)00159-9 | url = http://linkinghub.elsevier.com/retrieve/pii/S1097-2765(01)00159-9 }}</ref> The protein uses GTP binding to facilitate its own transport into the nucleus.<ref name="pmid10464099">{{cite journal | vauthors = Harton JA, Cressman DE, Chin KC, Der CJ, Ting JP | title = GTP binding by class II transactivator: role in nuclear import | journal = Science | volume = 285 | issue = 5432 | pages = 1402–5 | date = Aug 1999 | pmid = 10464099 | doi = 10.1126/science.285.5432.1402 | url = http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=10464099 }}</ref> Once in the nucleus, the protein acts as a positive regulator of class II major histocompatibility complex [[gene transcription]], and is often referred to as the "master control factor" for the expression of these genes.<ref name="pmid10938095">{{cite journal | vauthors = Harton JA, Ting JP | title = Class II transactivator: mastering the art of major histocompatibility complex expression | journal = Molecular and Cellular Biology | volume = 20 | issue = 17 | pages = 6185–94 | date = Sep 2000 | pmid = 10938095 | pmc = 86093 | doi = 10.1128/MCB.20.17.6185-6194.2000 | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=10938095 }}</ref><ref name="pmid15162420">{{cite journal | vauthors = LeibundGut-Landmann S, Waldburger JM, Krawczyk M, Otten LA, Suter T, Fontana A, Acha-Orbea H, Reith W | title = Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes | journal = European Journal of Immunology | volume = 34 | issue = 6 | pages = 1513–25 | date = Jun 2004 | pmid = 15162420 | doi = 10.1002/eji.200424964 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the &quot;master control factor&quot; for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.<ref>{{cite web | title = Entrez Gene: CIITA class II, major histocompatibility complex, transactivator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4261| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}


==Further reading==
CIITA has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
{{div col|colwidth=20em}}
{{PBB_Further_reading
* [[MAPK1]],<ref name = pmid18245089>{{cite journal | vauthors = Voong LN, Slater AR, Kratovac S, Cressman DE | title = Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator | journal = The Journal of Biological Chemistry | volume = 283 | issue = 14 | pages = 9031–9 | date = Apr 2008 | pmid = 18245089 | pmc = 2431044 | doi = 10.1074/jbc.M706487200 }}</ref>
| citations =  
* [[Nuclear receptor coactivator 1]],<ref name = pmid12933903>{{cite journal | vauthors = Tzortzakaki E, Spilianakis C, Zika E, Kretsovali A, Papamatheakis J | title = Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways | journal = Molecular Endocrinology | volume = 17 | issue = 12 | pages = 2509–18 | date = Dec 2003 | pmid = 12933903 | doi = 10.1210/me.2002-0439 }}</ref>
*{{cite journal | author=Mach B, Steimle V, Martinez-Soria E, Reith W |title=Regulation of MHC class II genes: lessons from a disease. |journal=Annu. Rev. Immunol. |volume=14 |issue= |pages= 301-31 |year= 1996 |pmid= 8717517 |doi= 10.1146/annurev.immunol.14.1.301 }}
* [[RFX5]],<ref name = pmid9177217 /><ref name = pmid11003667>{{cite journal | vauthors = Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V | title = CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation | journal = Molecular and Cellular Biology | volume = 20 | issue = 20 | pages = 7716–25 | date = Oct 2000 | pmid = 11003667 | pmc = 86349 | doi =  10.1128/mcb.20.20.7716-7725.2000}}</ref>
*{{cite journal  | author=Boss JM |title=Regulation of transcription of MHC class II genes. |journal=Curr. Opin. Immunol. |volume=9 |issue= 1 |pages= 107-13 |year= 1997 |pmid= 9039770 |doi=  }}
* [[RFXANK]],<ref name = pmid11003667/><ref name = pmid11463838>{{cite journal | vauthors = Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM | title = Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome | journal = Molecular and Cellular Biology | volume = 21 | issue = 16 | pages = 5566–76 | date = Aug 2001 | pmid = 11463838 | pmc = 87278 | doi = 10.1128/MCB.21.16.5566-5576.2001 }}</ref>
*{{cite journal | author=LeibundGut-Landmann S, Waldburger JM, Krawczyk M, ''et al.'' |title=Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes. |journal=Eur. J. Immunol. |volume=34 |issue= 6 |pages= 1513-25 |year= 2004 |pmid= 15162420 |doi= 10.1002/eji.200424964 }}
* [[XPO1]],<ref name = pmid18245089/><ref name = pmid12517958>{{cite journal | vauthors = Raval A, Weissman JD, Howcroft TK, Singer DS | title = The GTP-binding domain of class II transactivator regulates its nuclear export | journal = Journal of Immunology | volume = 170 | issue = 2 | pages = 922–30 | date = Jan 2003 | pmid = 12517958 | doi = 10.4049/jimmunol.170.2.922}}</ref>  and
*{{cite journal  | author=Ting JP, Davis BK |title=CATERPILLER: a novel gene family important in immunity, cell death, and diseases. |journal=Annu. Rev. Immunol. |volume=23 |issue= |pages= 387-414 |year= 2005 |pmid= 15771576 |doi= 10.1146/annurev.immunol.23.021704.115616 }}
* [[ZXDC]].<ref>{{cite journal | vauthors = Al-Kandari W, Jambunathan S, Navalgund V, Koneni R, Freer M, Parimi N, Mudhasani R, Fontes JD | title = ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription | journal = Molecular Immunology | volume = 44 | issue = 4 | pages = 311–21 | date = Jan 2007 | pmid = 16600381 | pmc = 1624858 | doi = 10.1016/j.molimm.2006.02.029 }}</ref><ref>{{cite journal | vauthors = Al-Kandari W, Koneni R, Navalgund V, Aleksandrova A, Jambunathan S, Fontes JD | title = The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription | journal = Journal of Molecular Biology | volume = 369 | issue = 5 | pages = 1175–87 | date = Jun 2007 | pmid = 17493635 | pmc = 1963517 | doi = 10.1016/j.jmb.2007.04.033 }}</ref>
*{{cite journal  | author=Pöschlová N, Masek K, Krsiak M |title=Effect of 5,6-dihydroxytryptamine on social behaviour in mice [proceedings]. |journal=Act Nerv Super (Praha) |volume=18 |issue= 3 |pages= 229-30 |year= 1977 |pmid= 1007865 |doi=  }}
{{Div col end}}
*{{cite journal | author=Pereira SN, Castagna RC, Gressler JF, ''et al.'' |title=[Dura-mater valve bank] |journal=Arq. Bras. Cardiol. |volume=29 |issue= 4 |pages= 277-80 |year= 1977 |pmid= 1008718 |doi=  }}
*{{cite journal  | author=Riley JL, Westerheide SD, Price JA, ''et al.'' |title=Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). |journal=Immunity |volume=2 |issue= 5 |pages= 533-43 |year= 1995 |pmid= 7749984 |doi=  }}
*{{cite journal  | author=Steimle V, Otten LA, Zufferey M, Mach B |title=Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). |journal=Cell |volume=75 |issue= 1 |pages= 135-46 |year= 1993 |pmid= 8402893 |doi=  }}
*{{cite journal  | author=Brown JA, He XF, Westerheide SD, Boss JM |title=Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5. |journal=Immunogenetics |volume=43 |issue= 1-2 |pages= 88-91 |year= 1996 |pmid= 8537130 |doi=  }}
*{{cite journal  | author=Bontron S, Steimle V, Ucla C, ''et al.'' |title=Two novel mutations in the MHC class II transactivator CIITA in a second patient from MHC class II deficiency complementation group A. |journal=Hum. Genet. |volume=99 |issue= 4 |pages= 541-6 |year= 1997 |pmid= 9099848 |doi= }}
*{{cite journal | author=Mahanta SK, Scholl T, Yang FC, Strominger JL |title=Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6324-9 |year= 1997 |pmid= 9177216 |doi= }}
*{{cite journal  | author=Scholl T, Mahanta SK, Strominger JL |title=Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6330-4 |year= 1997 |pmid= 9177217 |doi=  }}
*{{cite journal | author=Muhlethaler-Mottet A, Otten LA, Steimle V, Mach B |title=Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. |journal=EMBO J. |volume=16 |issue= 10 |pages= 2851-60 |year= 1997 |pmid= 9184229 |doi= 10.1093/emboj/16.10.2851 }}
*{{cite journal | author=Piskurich JF, Wang Y, Linhoff MW, ''et al.'' |title=Identification of distinct regions of 5' flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene. |journal=J. Immunol. |volume=160 |issue= 1 |pages= 233-40 |year= 1998 |pmid= 9551976 |doi= }}
*{{cite journal  | author=Harton JA, Cressman DE, Chin KC, ''et al.'' |title=GTP binding by class II transactivator: role in nuclear import. |journal=Science |volume=285 |issue= 5432 |pages= 1402-5 |year= 1999 |pmid= 10464099 |doi=  }}
*{{cite journal | author=Quan V, Towey M, Sacks S, Kelly AP |title=Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA. |journal=Immunogenetics |volume=49 |issue= 11-12 |pages= 957-63 |year= 1999 |pmid= 10501838 |doi= }}
*{{cite journal  | author=Abendroth A, Slobedman B, Lee E, ''et al.'' |title=Modulation of major histocompatibility class II protein expression by varicella-zoster virus. |journal=J. Virol. |volume=74 |issue= 4 |pages= 1900-7 |year= 2000 |pmid= 10644363 |doi=  }}
*{{cite journal  | author=Kanazawa S, Okamoto T, Peterlin BM |title=Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. |journal=Immunity |volume=12 |issue= 1 |pages= 61-70 |year= 2000 |pmid= 10661406 |doi=  }}
}}
{{refend}}


==External links==
== See also ==
* [[MHC class II]]
{{-}}
== References ==
{{Reflist|33em}}
 
== External links ==
* {{MeshName|MHC+class+II+transactivator+protein}}
* {{MeshName|MHC+class+II+transactivator+protein}}
[[Category:LRR proteins]]  
* {{UCSC gene info|CIITA}}
{{NLM content}}
 
[[Category:LRR proteins]]
[[Category:NOD-like receptors]]


{{NLM content}}
{{gene-16-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:20, 21 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator.[1] Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection.[1] Chromosomal rearrangement of CIITA is involved in the pathogenesis of Hodgkin lymphoma and primary mediastinal B cell lymphoma.[2]

Function

CIITA mRNA can only be detected in human leukocyte antigen (HLA) system class II-positive cell lines and tissues. This highly restricted tissue distribution suggests that expression of HLA class II genes is to a large extent under the control of CIITA.[3] However CIITA does not appear to directly bind to DNA.[3] Instead CIITA functions through activation of the transcription factor RFX5.[4] Hence CIITA is classified as a transcriptional coactivator.

The CIITA protein contains an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain.[5] The protein uses GTP binding to facilitate its own transport into the nucleus.[6] Once in the nucleus, the protein acts as a positive regulator of class II major histocompatibility complex gene transcription, and is often referred to as the "master control factor" for the expression of these genes.[7][8]

Interactions

CIITA has been shown to interact with:

See also

References

  1. ↑ 1.0 1.1 Steimle V, Otten LA, Zufferey M, Mach B (Oct 1993). "Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)". Cell. 75 (1): 135–46. doi:10.1016/S0092-8674(05)80090-X. PMID 8402893.
  2. ↑ Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD (Mar 2011). "MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers". Nature. 471 (7338): 377–81. doi:10.1038/nature09754. PMC 3902849. PMID 21368758.
  3. ↑ 3.0 3.1 Mach B, Steimle V, Reith W (Apr 1994). "MHC class II-deficient combined immunodeficiency: a disease of gene regulation". Immunological Reviews. 138 (1): 207–21. doi:10.1111/j.1600-065X.1994.tb00853.x. PMID 8070816.
  4. ↑ 4.0 4.1 Scholl T, Mahanta SK, Strominger JL (Jun 1997). "Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6330–4. doi:10.1073/pnas.94.12.6330. PMC 21049. PMID 9177217.
  5. ↑ Raval A, Howcroft TK, Weissman JD, Kirshner S, Zhu XS, Yokoyama K, Ting J, Singer DS (Jan 2001). "Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250". Molecular Cell. 7 (1): 105–15. doi:10.1016/S1097-2765(01)00159-9. PMID 11172716.
  6. ↑ Harton JA, Cressman DE, Chin KC, Der CJ, Ting JP (Aug 1999). "GTP binding by class II transactivator: role in nuclear import". Science. 285 (5432): 1402–5. doi:10.1126/science.285.5432.1402. PMID 10464099.
  7. ↑ Harton JA, Ting JP (Sep 2000). "Class II transactivator: mastering the art of major histocompatibility complex expression". Molecular and Cellular Biology. 20 (17): 6185–94. doi:10.1128/MCB.20.17.6185-6194.2000. PMC 86093. PMID 10938095.
  8. ↑ LeibundGut-Landmann S, Waldburger JM, Krawczyk M, Otten LA, Suter T, Fontana A, Acha-Orbea H, Reith W (Jun 2004). "Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes". European Journal of Immunology. 34 (6): 1513–25. doi:10.1002/eji.200424964. PMID 15162420.
  9. ↑ 9.0 9.1 Voong LN, Slater AR, Kratovac S, Cressman DE (Apr 2008). "Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator". The Journal of Biological Chemistry. 283 (14): 9031–9. doi:10.1074/jbc.M706487200. PMC 2431044. PMID 18245089.
  10. ↑ Tzortzakaki E, Spilianakis C, Zika E, Kretsovali A, Papamatheakis J (Dec 2003). "Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways". Molecular Endocrinology. 17 (12): 2509–18. doi:10.1210/me.2002-0439. PMID 12933903.
  11. ↑ 11.0 11.1 Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V (Oct 2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation". Molecular and Cellular Biology. 20 (20): 7716–25. doi:10.1128/mcb.20.20.7716-7725.2000. PMC 86349. PMID 11003667.
  12. ↑ Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM (Aug 2001). "Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome". Molecular and Cellular Biology. 21 (16): 5566–76. doi:10.1128/MCB.21.16.5566-5576.2001. PMC 87278. PMID 11463838.
  13. ↑ Raval A, Weissman JD, Howcroft TK, Singer DS (Jan 2003). "The GTP-binding domain of class II transactivator regulates its nuclear export". Journal of Immunology. 170 (2): 922–30. doi:10.4049/jimmunol.170.2.922. PMID 12517958.
  14. ↑ Al-Kandari W, Jambunathan S, Navalgund V, Koneni R, Freer M, Parimi N, Mudhasani R, Fontes JD (Jan 2007). "ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription". Molecular Immunology. 44 (4): 311–21. doi:10.1016/j.molimm.2006.02.029. PMC 1624858. PMID 16600381.
  15. ↑ Al-Kandari W, Koneni R, Navalgund V, Aleksandrova A, Jambunathan S, Fontes JD (Jun 2007). "The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription". Journal of Molecular Biology. 369 (5): 1175–87. doi:10.1016/j.jmb.2007.04.033. PMC 1963517. PMID 17493635.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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