CLDN6: Difference between revisions

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Latest revision as of 03:04, 15 November 2017

Claudin-6 is a protein that in humans is encoded by the CLDN6 gene.^[1]^[2]^[3] It belongs to the group of claudins.

References

↑ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
↑ Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus". J Virol. 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC 2268462. PMID 18234789.
↑ "Entrez Gene: CLDN6 claudin 6".

External links

Human CLDN6 genome location and CLDN6 gene details page in the UCSC Genome Browser.

Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Morita K, Sasaki H, Furuse M, Tsukita S (1999). "Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells". J. Cell Biol. 147 (1): 185–94. doi:10.1083/jcb.147.1.185. PMC 2164984. PMID 10508865.
Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
Turksen K, Troy TC (2001). "Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium". Dev. Dyn. 222 (2): 292–300. doi:10.1002/dvdy.1174. PMID 11668606.
Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. PMID 11912246.
Turksen K, Troy TC (2002). "Permeability barrier dysfunction in transgenic mice overexpressing claudin 6". Development. 129 (7): 1775–84. PMID 11923212.
Morita K, Furuse M, Yoshida Y, et al. (2002). "Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis". J. Invest. Dermatol. 118 (6): 1073–9. doi:10.1046/j.1523-1747.2002.01774.x. PMID 12060405.
Reyes JL, Lamas M, Martin D, et al. (2003). "The renal segmental distribution of claudins changes with development". Kidney Int. 62 (2): 476–87. doi:10.1046/j.1523-1755.2002.00479.x. PMID 12110008.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. doi:10.1021/acs.jproteome.5b00769. PMID 26680015.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[pmid9892664-1] Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.

[pmid18234789-2] Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus". J Virol. 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC 2268462. PMID 18234789.

[entrez-3] "Entrez Gene: CLDN6 claudin 6".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Claudin-6''' is a [[protein]] that in humans is encoded by the ''CLDN6'' [[gene]].<ref name="pmid9892664">{{cite journal | vauthors = Morita K, Furuse M, Fujimoto K, Tsukita S | title = Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 2 | pages = 511–6 |date=Mar 1999 | pmid = 9892664 | pmc = 15167 | doi =10.1073/pnas.96.2.511  }}</ref><ref name="pmid18234789">{{cite journal | vauthors = Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T | title = The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus | journal = J Virol | volume = 82 | issue = 7 | pages = 3555–60 |date=Mar 2008 | pmid = 18234789 | pmc = 2268462 | doi = 10.1128/JVI.01977-07 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLDN6 claudin 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9074| accessdate = }}</ref> It belongs to the group of [[claudin]]s.
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Claudin 6
- | HGNCid = 2048
- | Symbol = CLDN6
- | AltSymbols =;
- | OMIM =
- | ECnumber =
- | Homologene = 10300
- | MGIid = 1859284
- | GeneAtlas_image1 = PBB_GE_CLDN6_208474_at_tn.png
-  | Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0016338 |text = calcium-independent cell-cell adhesion}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9074
-    | Hs_Ensembl = ENSG00000184697
-    | Hs_RefseqProtein = NP_067018
-    | Hs_RefseqmRNA = NM_021195
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 16
-    | Hs_GenLoc_start = 3004715
-    | Hs_GenLoc_end = 3008187
-    | Hs_Uniprot = P56747
-    | Mm_EntrezGene = 54419
-    | Mm_Ensembl = ENSMUSG00000023906
-    | Mm_RefseqmRNA = NM_018777
-    | Mm_RefseqProtein = NP_061247
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 23406987
-    | Mm_GenLoc_end = 23410062
-    | Mm_Uniprot = Q0GH64
-  }}
-}}
-'''Claudin 6''', also known as '''CLDN6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLDN6 claudin 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9074| accessdate = }}</ref>
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@@ Line 55: / Line 9: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CLDN6}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Kniesel U, Wolburg H |title=Tight junctions of the blood-brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57-76 |year= 2000 |pmid= 10690502 |doi=  }}
+*{{cite journal  | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836  }}
-*{{cite journal  | author=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93-8 |year= 2001 |pmid= 11247307 |doi=  }}
+*{{cite journal  | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x  }}
-*{{cite journal  | author=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285-93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
+*{{cite journal  | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
-*{{cite journal  | author=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531-6 |year= 2003 |pmid= 12231346 |doi=  }}
+*{{cite journal  | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9  }}
-*{{cite journal  | author=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1-44 |year= 2003 |pmid= 12475568 |doi=  }}
+*{{cite journal  | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8  }}
-*{{cite journal  | author=Morita K, Furuse M, Fujimoto K, Tsukita S |title=Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 511-6 |year= 1999 |pmid= 9892664 |doi=  }}
+*{{cite journal  | vauthors=Morita K, Sasaki H, Furuse M, Tsukita S |title=Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells |journal=J. Cell Biol. |volume=147 |issue= 1 |pages= 185–94 |year= 1999 |pmid= 10508865 |doi=10.1083/jcb.147.1.185  | pmc=2164984  }}
-*{{cite journal  | author=Morita K, Sasaki H, Furuse M, Tsukita S |title=Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. |journal=J. Cell Biol. |volume=147 |issue= 1 |pages= 185-94 |year= 1999 |pmid= 10508865 |doi=  }}
+*{{cite journal  | vauthors=Itoh M, Furuse M, Morita K |title=Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351–63 |year= 2000 |pmid= 10601346 |doi=10.1083/jcb.147.6.1351  | pmc=2168087  |display-authors=etal}}
-*{{cite journal  | author=Itoh M, Furuse M, Morita K, ''et al.'' |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351-63 |year= 2000 |pmid= 10601346 |doi=  }}
+*{{cite journal  | vauthors=Turksen K, Troy TC |title=Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium |journal=Dev. Dyn. |volume=222 |issue= 2 |pages= 292–300 |year= 2001 |pmid= 11668606 |doi= 10.1002/dvdy.1174 }}
-*{{cite journal  | author=Turksen K, Troy TC |title=Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium. |journal=Dev. Dyn. |volume=222 |issue= 2 |pages= 292-300 |year= 2001 |pmid= 11668606 |doi= 10.1002/dvdy.1174 }}
+*{{cite journal  | vauthors=Kiuchi-Saishin Y, Gotoh S, Furuse M |title=Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 4 |pages= 875–86 |year= 2002 |pmid= 11912246 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Kiuchi-Saishin Y, Gotoh S, Furuse M, ''et al.'' |title=Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 4 |pages= 875-86 |year= 2002 |pmid= 11912246 |doi=  }}
+*{{cite journal  | vauthors=Turksen K, Troy TC |title=Permeability barrier dysfunction in transgenic mice overexpressing claudin 6 |journal=Development |volume=129 |issue= 7 |pages= 1775–84 |year= 2002 |pmid= 11923212 |doi=  }}
-*{{cite journal  | author=Turksen K, Troy TC |title=Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. |journal=Development |volume=129 |issue= 7 |pages= 1775-84 |year= 2002 |pmid= 11923212 |doi=  }}
+*{{cite journal  | vauthors=Morita K, Furuse M, Yoshida Y |title=Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis |journal=J. Invest. Dermatol. |volume=118 |issue= 6 |pages= 1073–9 |year= 2002 |pmid= 12060405 |doi= 10.1046/j.1523-1747.2002.01774.x |display-authors=etal}}
-*{{cite journal  | author=Morita K, Furuse M, Yoshida Y, ''et al.'' |title=Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis. |journal=J. Invest. Dermatol. |volume=118 |issue= 6 |pages= 1073-9 |year= 2002 |pmid= 12060405 |doi= 10.1046/j.1523-1747.2002.01774.x }}
+*{{cite journal  | vauthors=Reyes JL, Lamas M, Martin D |title=The renal segmental distribution of claudins changes with development |journal=Kidney Int. |volume=62 |issue= 2 |pages= 476–87 |year= 2003 |pmid= 12110008 |doi= 10.1046/j.1523-1755.2002.00479.x |display-authors=etal}}
-*{{cite journal  | author=Reyes JL, Lamas M, Martin D, ''et al.'' |title=The renal segmental distribution of claudins changes with development. |journal=Kidney Int. |volume=62 |issue= 2 |pages= 476-87 |year= 2003 |pmid= 12110008 |doi= 10.1046/j.1523-1755.2002.00479.x }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Katoh M, Katoh M |title=CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 683–9 |year= 2004 |pmid= 12736707 |doi=  10.3892/ijmm.11.6.683}}
-*{{cite journal  | author=Katoh M, Katoh M |title=CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 683-9 |year= 2004 |pmid= 12736707 |doi=  }}
 }}
+* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 }}
 {{refend}}
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+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
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+{{gene-16-stub}}

CLDN6: Difference between revisions

Latest revision as of 03:04, 15 November 2017

References

External links

Further reading

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