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{{Infobox_gene}}
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'''Kinesin-like protein KIF22''' is a [[protein]] that in humans is encoded by the ''KIF22'' [[gene]].<ref name="pmid8599929">{{cite journal |vauthors=Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T | title = Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle | journal = EMBO J | volume = 15 | issue = 3 | pages = 457–67 |date=April 1996 | pmid = 8599929 | pmc = 449964 | doi =  }}</ref><ref name="pmid11416179">{{cite journal |vauthors=Miki H, Setou M, Kaneshiro K, Hirokawa N | title = All kinesin superfamily protein, KIF, genes in mouse and human | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 13 | pages = 7004–11 |date=June 2001 | pmid = 11416179 | pmc = 34614 | doi = 10.1073/pnas.111145398 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIF22 kinesin family member 22| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3835| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Kinesin family member 22
| HGNCid = 6391
| Symbol = KIF22
| AltSymbols =; KID; KNSL4; OBP; OBP-1; OBP-2
| OMIM = 603213
| ECnumber = 
| Homologene = 32011
| MGIid = 109233
| GeneAtlas_image1 = PBB_GE_KIF22_202183_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KIF22_216969_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
  | Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0007067 |text = mitosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3835
    | Hs_Ensembl = ENSG00000079616
    | Hs_RefseqProtein = NP_015556
    | Hs_RefseqmRNA = NM_007317
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 29709549
    | Hs_GenLoc_end = 29724205
    | Hs_Uniprot = Q14807
    | Mm_EntrezGene = 110033
    | Mm_Ensembl = ENSMUSG00000030677
    | Mm_RefseqmRNA = NM_145588
    | Mm_RefseqProtein = NP_663563
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126818879
    | Mm_GenLoc_end = 126833568
    | Mm_Uniprot = Q3V300
  }}
}}
'''Kinesin family member 22''', also known as '''KIF22''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIF22 kinesin family member 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3835| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance.<ref name="entrez">{{cite web | title = Entrez Gene: KIF22 kinesin family member 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3835| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.<ref name="entrez"/>
}}
}}
==Interactions==
KIF22 has been shown to [[Protein-protein interaction|interact]] with [[SIAH1]].<ref name="pmid11146551">{{cite journal |vauthors=Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F | title = SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis | journal = Oncogene | volume = 19 | issue = 52 | pages = 5997–6006 | year = 2000 | pmid = 11146551 | doi = 10.1038/sj.onc.1204002 }}</ref>
==Clinical relevance==
Mutations in this gene have been shown to cause developmental disorders such as [[Spondyloepimetaphyseal dysplasia]] with joint laxity.<ref name="pmid22152677">{{cite journal |vauthors=Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ | title = Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type | journal = Am. J. Hum. Genet. | volume = 89 | issue = 6 | pages = 760–6 |date=December 2011 | pmid = 22152677 | doi = 10.1016/j.ajhg.2011.10.015 | pmc=3234366}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Miki H, Setou M, Kaneshiro K, Hirokawa N |title=All kinesin superfamily protein, KIF, genes in mouse and human. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7004-11 |year= 2001 |pmid= 11416179 |doi= 10.1073/pnas.111145398 }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Zhang S, Nonoyama M |title=The cellular proteins that bind specifically to the Epstein-Barr virus origin of plasmid DNA replication belong to a gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 7 |pages= 2843–7 |year= 1994 |pmid= 8146198 |doi=10.1073/pnas.91.7.2843  | pmc=43467 }}
*{{cite journal | author=Zhang S, Nonoyama M |title=The cellular proteins that bind specifically to the Epstein-Barr virus origin of plasmid DNA replication belong to a gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 7 |pages= 2843-7 |year= 1994 |pmid= 8146198 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal | author=Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, ''et al.'' |title=Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. |journal=EMBO J. |volume=15 |issue= 3 |pages= 457-67 |year= 1996 |pmid= 8599929 |doi= }}
*{{cite journal   |vauthors=Song J, Murakami H, Tsutsui H, etal |title=Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ) |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20603–14 |year= 1998 |pmid= 9685418 |doi=10.1074/jbc.273.32.20603  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Song J, Murakami H, Yang ZQ, etal |title=Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2 |journal=Genomics |volume=52 |issue= 3 |pages= 374–7 |year= 1998 |pmid= 9790757 |doi= 10.1006/geno.1998.5452 }}
*{{cite journal | author=Song J, Murakami H, Tsutsui H, ''et al.'' |title=Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ). |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20603-14 |year= 1998 |pmid= 9685418 |doi= }}
*{{cite journal   |vauthors=Loftus BJ, Kim UJ, Sneddon VP, etal |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
*{{cite journal  | author=Song J, Murakami H, Yang ZQ, ''et al.'' |title=Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2. |journal=Genomics |volume=52 |issue= 3 |pages= 374-7 |year= 1998 |pmid= 9790757 |doi= 10.1006/geno.1998.5452 }}
*{{cite journal  |vauthors=Funabiki H, Murray AW |title=The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement |journal=Cell |volume=102 |issue= 4 |pages= 411–24 |year= 2000 |pmid= 10966104 |doi=10.1016/S0092-8674(00)00047-7  }}
*{{cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
*{{cite journal   |vauthors=Antonio C, Ferby I, Wilhelm H, etal |title=Xkid, a chromokinesin required for chromosome alignment on the metaphase plate |journal=Cell |volume=102 |issue= 4 |pages= 425–35 |year= 2000 |pmid= 10966105 |doi=10.1016/S0092-8674(00)00048-9  }}
*{{cite journal | author=Funabiki H, Murray AW |title=The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. |journal=Cell |volume=102 |issue= 4 |pages= 411-24 |year= 2000 |pmid= 10966104 |doi= }}
*{{cite journal   |vauthors=Germani A, Bruzzoni-Giovanelli H, Fellous A, etal |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis |journal=Oncogene |volume=19 |issue= 52 |pages= 5997–6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002 }}
*{{cite journal  | author=Antonio C, Ferby I, Wilhelm H, ''et al.'' |title=Xkid, a chromokinesin required for chromosome alignment on the metaphase plate. |journal=Cell |volume=102 |issue= 4 |pages= 425-35 |year= 2000 |pmid= 10966105 |doi=  }}
*{{cite journal  |vauthors=Levesque AA, Compton DA |title=The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles |journal=J. Cell Biol. |volume=154 |issue= 6 |pages= 1135–46 |year= 2001 |pmid= 11564754 |doi= 10.1083/jcb.200106093 | pmc=2150818 }}
*{{cite journal | author=Germani A, Bruzzoni-Giovanelli H, Fellous A, ''et al.'' |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997-6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Levesque AA, Compton DA |title=The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. |journal=J. Cell Biol. |volume=154 |issue= 6 |pages= 1135-46 |year= 2001 |pmid= 11564754 |doi= 10.1083/jcb.200106093 }}
*{{cite journal   |vauthors=Yajima J, Edamatsu M, Watai-Nishii J, etal |title=The human chromokinesin Kid is a plus end-directed microtubule-based motor |journal=EMBO J. |volume=22 |issue= 5 |pages= 1067–74 |year= 2003 |pmid= 12606572 |doi= 10.1093/emboj/cdg102  | pmc=150335 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Shiroguchi K, Ohsugi M, Edamatsu M, etal |title=The second microtubule-binding site of monomeric kid enhances the microtubule affinity |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22460–5 |year= 2003 |pmid= 12692123 |doi= 10.1074/jbc.M212274200 }}
*{{cite journal | author=Yajima J, Edamatsu M, Watai-Nishii J, ''et al.'' |title=The human chromokinesin Kid is a plus end-directed microtubule-based motor. |journal=EMBO J. |volume=22 |issue= 5 |pages= 1067-74 |year= 2003 |pmid= 12606572 |doi= 10.1093/emboj/cdg102 }}
*{{cite journal   |vauthors=Ohsugi M, Tokai-Nishizumi N, Shiroguchi K, etal |title=Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes |journal=EMBO J. |volume=22 |issue= 9 |pages= 2091–103 |year= 2003 |pmid= 12727876 |doi= 10.1093/emboj/cdg208  | pmc=156080 }}
*{{cite journal  | author=Shiroguchi K, Ohsugi M, Edamatsu M, ''et al.'' |title=The second microtubule-binding site of monomeric kid enhances the microtubule affinity. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22460-5 |year= 2003 |pmid= 12692123 |doi= 10.1074/jbc.M212274200 }}
*{{cite journal  |vauthors=Venkatesh LK, Gettemeier T, Chinnadurai G |title=A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein |journal=J. Virol. |volume=77 |issue= 13 |pages= 7236–43 |year= 2003 |pmid= 12805422 |doi=10.1128/JVI.77.13.7236-7243.2003  | pmc=164832  }}
*{{cite journal | author=Ohsugi M, Tokai-Nishizumi N, Shiroguchi K, ''et al.'' |title=Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes. |journal=EMBO J. |volume=22 |issue= 9 |pages= 2091-103 |year= 2003 |pmid= 12727876 |doi= 10.1093/emboj/cdg208 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Venkatesh LK, Gettemeier T, Chinnadurai G |title=A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein. |journal=J. Virol. |volume=77 |issue= 13 |pages= 7236-43 |year= 2003 |pmid= 12805422 |doi=  }}
*{{cite journal  |vauthors=Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T |title=The chromokinesin Kid is required for maintenance of proper metaphase spindle size |journal=Mol. Biol. Cell |volume=16 |issue= 11 |pages= 5455–63 |year= 2006 |pmid= 16176979 |doi= 10.1091/mbc.E05-03-0244 | pmc=1266440 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T |title=The chromokinesin Kid is required for maintenance of proper metaphase spindle size. |journal=Mol. Biol. Cell |volume=16 |issue= 11 |pages= 5455-63 |year= 2006 |pmid= 16176979 |doi= 10.1091/mbc.E05-03-0244 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:26, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.[1][2][3]

The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.[3]

Interactions

KIF22 has been shown to interact with SIAH1.[4]

Clinical relevance

Mutations in this gene have been shown to cause developmental disorders such as Spondyloepimetaphyseal dysplasia with joint laxity.[5]

References

  1. ↑ Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T (April 1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle". EMBO J. 15 (3): 457–67. PMC 449964. PMID 8599929.
  2. ↑ Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
  3. ↑ 3.0 3.1 "Entrez Gene: KIF22 kinesin family member 22".
  4. ↑ Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
  5. ↑ Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ (December 2011). "Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type". Am. J. Hum. Genet. 89 (6): 760–6. doi:10.1016/j.ajhg.2011.10.015. PMC 3234366. PMID 22152677.

Further reading



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