COTL1: Difference between revisions
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{{ | '''Coactosin-like protein''' ('''COTL1''' or '''CLP''') is a [[protein]] that in humans is encoded by the ''COTL1'' [[gene]].<ref name="pmid10051563">{{cite journal | vauthors = Provost P, Samuelsson B, Rådmark O | title = Interaction of 5-lipoxygenase with cellular proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 5 | pages = 1881–5 | date = Apr 1999 | pmid = 10051563 | pmc = 26705 | doi = 10.1073/pnas.96.5.1881 }}</ref><ref name="pmid9326934">{{cite journal | vauthors = Chen KS, Manian P, Koeuth T, Potocki L, Zhao Q, Chinault AC, Lee CC, Lupski JR | title = Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome | journal = Nat. Genet. | volume = 17 | issue = 2 | pages = 154–63 | date = Nov 1997 | pmid = 9326934 | pmc = | doi = 10.1038/ng1097-154 }}</ref><ref name="pmid16924104">{{cite journal | vauthors = Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O | title = Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 35 | pages = 13150–5 | date = Sep 2006 | pmid = 16924104 | pmc = 1559768 | doi = 10.1073/pnas.0605150103 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23406| accessdate = }}</ref> | ||
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== Function == | |||
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with and thereby stabilizes [[5-lipoxygenase]] (ALOX5). Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.<ref name="entrez" /> | |||
==References== | == Interactions == | ||
{{reflist| | |||
==Further reading== | COTL1 has been shown to [[Protein-protein interaction|interact]] with ALOX5.<ref name=pmid11297527>{{cite journal | vauthors = Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O | title = 5-Lipoxygenase interacts with coactosin-like protein | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16520–7 | date = May 2001 | pmid = 11297527 | doi = 10.1074/jbc.M011205200 }}</ref> ALOX5 is the first committed enzyme in the metabolism of [[arachidonic acid]] to an array of biologically important [[cell signaling]] agents: '''a)''' the pro-inflammatory mediator, [[leukotriene B4]] (LTB4); '''b)''' the airways constrictors, [[LTC4]], [[LTD4]], and [[LTE4]]; '''c)''' the [[5-hydroxyeicosatetraenoic acid]] family of pro-inflammatory and pro-allergic reactions mediators, [[5-HETE]] and [[5-oxo-eicosatetraenoic acid]]. ALOX5 also contributes to the metabolism of arachidonic acid and other [[polyunsaturated fatty acids]] to agents which act block inflammation and allergic reactions, the [[specialized pro-resolving mediators]] of the [[lipoxin]] and [[resolvin]] subclasses. Based on in vitro studies, COTL1 serves to stabilize ALOX5, acting as a [[chaperone (protein)|chaperone]] or scaffold, to avert the enzyme's inactivation and thereby to promote its metabolic activity.<ref name="pmid24313690">{{cite journal | vauthors = Anwar Y, Sabir JS, Qureshi MI, Saini KS | title = 5-lipoxygenase: a promising drug target against inflammatory diseases-biochemical and pharmacological regulation | journal = Current Drug Targets | volume = 15 | issue = 4 | pages = 410–22 | year = 2014 | pmid = 24313690 | doi = 10.2174/1389450114666131209110745| url = }}</ref> | ||
== References == | |||
{{reflist}} | |||
==External links== | |||
* {{UCSC gene info|COTL1}} | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB | title = cDNA clones contain autonomous replication activity | journal = Biochim. Biophys. Acta | volume = 1174 | issue = 3 | pages = 241–57 | year = 1993 | pmid = 7690594 | doi = 10.1016/0167-4781(93)90193-h }} | |||
* {{cite journal | vauthors = Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O | title = 5-Lipoxygenase interacts with coactosin-like protein | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16520–7 | year = 2001 | pmid = 11297527 | doi = 10.1074/jbc.M011205200 }} | |||
*{{cite journal | * {{cite journal | vauthors = Provost P, Doucet J, Stock A, Gerisch G, Samuelsson B, Rådmark O | title = Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75 | journal = Biochem. J. | volume = 359 | issue = Pt 2 | pages = 255–63 | year = 2001 | pmid = 11583571 | pmc = 1222143 | doi = 10.1042/0264-6021:3590255 }} | ||
* {{cite journal | vauthors = Nakatsura T, Senju S, Ito M, Nishimura Y, Itoh K | title = Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method | journal = Eur. J. Immunol. | volume = 32 | issue = 3 | pages = 826–36 | year = 2002 | pmid = 11870627 | doi = 10.1002/1521-4141(200203)32:3<826::AID-IMMU826>3.0.CO;2-Y }} | |||
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }} | |||
*{{cite journal | * {{cite journal | vauthors = Dai H, Wu J, Xu Y, Yajun T, Husheng D, Shi Y | title = 1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N | journal = J. Biomol. NMR | volume = 29 | issue = 3 | pages = 455–6 | year = 2004 | pmid = 15213466 | doi = 10.1023/B:JNMR.0000032550.18424.aa }} | ||
*{{cite journal | * {{cite journal | vauthors = Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W | title = Expression, purification and preliminary crystallographic studies of human coactosin-like protein | journal = Acta Crystallogr. D | volume = 60 | issue = Pt 9 | pages = 1651–3 | year = 2004 | pmid = 15333945 | doi = 10.1107/S0907444904016701 }} | ||
*{{cite journal | * {{cite journal | vauthors = Li X, Liu X, Lou Z, Duan X, Wu H, Liu Y, Rao Z | title = Crystal structure of human coactosin-like protein at 1.9 A resolution | journal = Protein Sci. | volume = 13 | issue = 11 | pages = 2845–51 | year = 2004 | pmid = 15459340 | pmc = 2286586 | doi = 10.1110/ps.04937304 }} | ||
* {{cite journal | vauthors = Li X, Liu X, Zhao Q, Liu Y, Duan X, Rao Z | title = Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP) | journal = Acta Crystallogr. D | volume = 60 | issue = Pt 12 Pt 2 | pages = 2387–8 | year = 2004 | pmid = 15583396 | doi = 10.1107/S0907444904028112 }} | |||
*{{cite journal | * {{cite journal | vauthors = Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, Martens L, Goethals M, Vandekerckhove J | title = Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC | journal = Proteomics | volume = 5 | issue = 14 | pages = 3589–99 | year = 2005 | pmid = 16097034 | doi = 10.1002/pmic.200401217 }} | ||
*{{cite journal | * {{cite journal | vauthors = Dai H, Huang W, Xu J, Yao B, Xiong S, Ding H, Tang Y, Liu H, Wu J, Shi Y | title = Binding model of human coactosin-like protein with filament actin revealed by mutagenesis | journal = Biochim. Biophys. Acta | volume = 1764 | issue = 11 | pages = 1688–700 | year = 2006 | pmid = 17070122 | doi = 10.1016/j.bbapap.2006.06.017 }} | ||
*{{cite journal | |||
*{{cite journal | |||
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{{refend}} | {{refend}} | ||
{{ | {{PDB Gallery|geneid=23406}} | ||
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Coactosin-like protein (COTL1 or CLP) is a protein that in humans is encoded by the COTL1 gene.[1][2][3][4]
Function
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with and thereby stabilizes 5-lipoxygenase (ALOX5). Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.[4]
Interactions
COTL1 has been shown to interact with ALOX5.[5] ALOX5 is the first committed enzyme in the metabolism of arachidonic acid to an array of biologically important cell signaling agents: a) the pro-inflammatory mediator, leukotriene B4 (LTB4); b) the airways constrictors, LTC4, LTD4, and LTE4; c) the 5-hydroxyeicosatetraenoic acid family of pro-inflammatory and pro-allergic reactions mediators, 5-HETE and 5-oxo-eicosatetraenoic acid. ALOX5 also contributes to the metabolism of arachidonic acid and other polyunsaturated fatty acids to agents which act block inflammation and allergic reactions, the specialized pro-resolving mediators of the lipoxin and resolvin subclasses. Based on in vitro studies, COTL1 serves to stabilize ALOX5, acting as a chaperone or scaffold, to avert the enzyme's inactivation and thereby to promote its metabolic activity.[6]
References
- ↑ Provost P, Samuelsson B, Rådmark O (Apr 1999). "Interaction of 5-lipoxygenase with cellular proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881–5. doi:10.1073/pnas.96.5.1881. PMC 26705. PMID 10051563.
- ↑ Chen KS, Manian P, Koeuth T, Potocki L, Zhao Q, Chinault AC, Lee CC, Lupski JR (Nov 1997). "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome". Nat. Genet. 17 (2): 154–63. doi:10.1038/ng1097-154. PMID 9326934.
- ↑ Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O (Sep 2006). "Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production". Proc. Natl. Acad. Sci. U.S.A. 103 (35): 13150–5. doi:10.1073/pnas.0605150103. PMC 1559768. PMID 16924104.
- ↑ 4.0 4.1 "Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)".
- ↑ Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O (May 2001). "5-Lipoxygenase interacts with coactosin-like protein". J. Biol. Chem. 276 (19): 16520–7. doi:10.1074/jbc.M011205200. PMID 11297527.
- ↑ Anwar Y, Sabir JS, Qureshi MI, Saini KS (2014). "5-lipoxygenase: a promising drug target against inflammatory diseases-biochemical and pharmacological regulation". Current Drug Targets. 15 (4): 410–22. doi:10.2174/1389450114666131209110745. PMID 24313690.
External links
- Human COTL1 genome location and COTL1 gene details page in the UCSC Genome Browser.
Further reading
- Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB (1993). "cDNA clones contain autonomous replication activity". Biochim. Biophys. Acta. 1174 (3): 241–57. doi:10.1016/0167-4781(93)90193-h. PMID 7690594.
- Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O (2001). "5-Lipoxygenase interacts with coactosin-like protein". J. Biol. Chem. 276 (19): 16520–7. doi:10.1074/jbc.M011205200. PMID 11297527.
- Provost P, Doucet J, Stock A, Gerisch G, Samuelsson B, Rådmark O (2001). "Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75". Biochem. J. 359 (Pt 2): 255–63. doi:10.1042/0264-6021:3590255. PMC 1222143. PMID 11583571.
- Nakatsura T, Senju S, Ito M, Nishimura Y, Itoh K (2002). "Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method". Eur. J. Immunol. 32 (3): 826–36. doi:10.1002/1521-4141(200203)32:3<826::AID-IMMU826>3.0.CO;2-Y. PMID 11870627.
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Dai H, Wu J, Xu Y, Yajun T, Husheng D, Shi Y (2004). "1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N". J. Biomol. NMR. 29 (3): 455–6. doi:10.1023/B:JNMR.0000032550.18424.aa. PMID 15213466.
- Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W (2004). "Expression, purification and preliminary crystallographic studies of human coactosin-like protein". Acta Crystallogr. D. 60 (Pt 9): 1651–3. doi:10.1107/S0907444904016701. PMID 15333945.
- Li X, Liu X, Lou Z, Duan X, Wu H, Liu Y, Rao Z (2004). "Crystal structure of human coactosin-like protein at 1.9 A resolution". Protein Sci. 13 (11): 2845–51. doi:10.1110/ps.04937304. PMC 2286586. PMID 15459340.
- Li X, Liu X, Zhao Q, Liu Y, Duan X, Rao Z (2004). "Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP)". Acta Crystallogr. D. 60 (Pt 12 Pt 2): 2387–8. doi:10.1107/S0907444904028112. PMID 15583396.
- Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, Martens L, Goethals M, Vandekerckhove J (2005). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.
- Dai H, Huang W, Xu J, Yao B, Xiong S, Ding H, Tang Y, Liu H, Wu J, Shi Y (2006). "Binding model of human coactosin-like protein with filament actin revealed by mutagenesis". Biochim. Biophys. Acta. 1764 (11): 1688–700. doi:10.1016/j.bbapap.2006.06.017. PMID 17070122.
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