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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Coactosin-like protein''' ('''COTL1''' or '''CLP''') is a [[protein]] that in humans is encoded by the ''COTL1'' [[gene]].<ref name="pmid10051563">{{cite journal | vauthors = Provost P, Samuelsson B, Rådmark O | title = Interaction of 5-lipoxygenase with cellular proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 5 | pages = 1881–5  | date = Apr 1999 | pmid = 10051563 | pmc = 26705 | doi = 10.1073/pnas.96.5.1881 }}</ref><ref name="pmid9326934">{{cite journal | vauthors = Chen KS, Manian P, Koeuth T, Potocki L, Zhao Q, Chinault AC, Lee CC, Lupski JR | title = Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome | journal = Nat. Genet. | volume = 17 | issue = 2 | pages = 154–63  | date = Nov 1997 | pmid = 9326934 | pmc =  | doi = 10.1038/ng1097-154 }}</ref><ref name="pmid16924104">{{cite journal | vauthors = Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O | title = Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 35 | pages = 13150–5  | date = Sep 2006 | pmid = 16924104 | pmc = 1559768 | doi = 10.1073/pnas.0605150103 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23406| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_COTL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t2l.
| PDB = {{PDB2|1t2l}}, {{PDB2|1t3x}}, {{PDB2|1t3y}}, {{PDB2|1tmw}}, {{PDB2|1udm}}, {{PDB2|1vfq}}, {{PDB2|1wm4}}, {{PDB2|1wnj}}
| Name = Coactosin-like 1 (Dictyostelium)
| HGNCid = 18304
| Symbol = COTL1
| AltSymbols =; CLP; FLJ43657; MGC19733
| OMIM = 606748
| ECnumber = 
| Homologene = 10898
| MGIid = 1919292
| GeneAtlas_image1 = PBB_GE_COTL1_221059_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COTL1_gnf1h03101_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23406
    | Hs_Ensembl = ENSG00000103187
    | Hs_RefseqProtein = NP_066972
    | Hs_RefseqmRNA = NM_021149
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 83156709
    | Hs_GenLoc_end = 83209188
    | Hs_Uniprot = Q14019
    | Mm_EntrezGene = 72042
    | Mm_Ensembl = ENSMUSG00000031827
    | Mm_RefseqmRNA = NM_028071
    | Mm_RefseqProtein = NP_082347
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 122695202
    | Mm_GenLoc_end = 122726517
    | Mm_Uniprot = Q544F6
  }}
}}
'''Coactosin-like 1 (Dictyostelium)''', also known as '''COTL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23406| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with and thereby stabilizes [[5-lipoxygenase]] (ALOX5). Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.<ref name="entrez">{{cite web | title = Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23406| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
COTL1 has been shown to [[Protein-protein interaction|interact]] with ALOX5.<ref name=pmid11297527>{{cite journal | vauthors = Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O | title = 5-Lipoxygenase interacts with coactosin-like protein | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16520–7  | date = May 2001 | pmid = 11297527 | doi = 10.1074/jbc.M011205200 }}</ref>  ALOX5 is the first committed enzyme in the metabolism of [[arachidonic acid]] to an array of biologically important [[cell signaling]] agents: '''a)''' the pro-inflammatory mediator, [[leukotriene B4]] (LTB4); '''b)''' the airways constrictors, [[LTC4]], [[LTD4]], and [[LTE4]]; '''c)''' the [[5-hydroxyeicosatetraenoic acid]] family of pro-inflammatory and pro-allergic reactions mediators, [[5-HETE]] and [[5-oxo-eicosatetraenoic acid]]. ALOX5 also contributes to the metabolism of arachidonic acid and other [[polyunsaturated fatty acids]] to agents which act block inflammation and allergic reactions, the [[specialized pro-resolving mediators]] of the [[lipoxin]] and [[resolvin]] subclasses. Based on in vitro studies, COTL1 serves to stabilize ALOX5, acting as a [[chaperone (protein)|chaperone]] or scaffold, to avert the enzyme's inactivation and thereby to promote its metabolic activity.<ref name="pmid24313690">{{cite journal | vauthors = Anwar Y, Sabir JS, Qureshi MI, Saini KS | title = 5-lipoxygenase: a promising drug target against inflammatory diseases-biochemical and pharmacological regulation | journal = Current Drug Targets | volume = 15 | issue = 4 | pages = 410–22 | year = 2014 | pmid = 24313690 | doi = 10.2174/1389450114666131209110745| url = }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|COTL1}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB | title = cDNA clones contain autonomous replication activity | journal = Biochim. Biophys. Acta | volume = 1174 | issue = 3 | pages = 241–57 | year = 1993 | pmid = 7690594 | doi = 10.1016/0167-4781(93)90193-h }}
| citations =
* {{cite journal | vauthors = Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O | title = 5-Lipoxygenase interacts with coactosin-like protein | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16520–7 | year = 2001 | pmid = 11297527 | doi = 10.1074/jbc.M011205200 }}
*{{cite journal | author=Wu C, Friedlander P, Lamoureux C, ''et al.'' |title=cDNA clones contain autonomous replication activity. |journal=Biochim. Biophys. Acta |volume=1174 |issue= 3 |pages= 241-57 |year= 1993 |pmid= 7690594 |doi=  }}
* {{cite journal | vauthors = Provost P, Doucet J, Stock A, Gerisch G, Samuelsson B, Rådmark O | title = Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75 | journal = Biochem. J. | volume = 359 | issue = Pt 2 | pages = 255–63 | year = 2001 | pmid = 11583571 | pmc = 1222143 | doi = 10.1042/0264-6021:3590255 }}
*{{cite journal  | author=Chen KS, Manian P, Koeuth T, ''et al.'' |title=Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome. |journal=Nat. Genet. |volume=17 |issue= 2 |pages= 154-63 |year= 1997 |pmid= 9326934 |doi= 10.1038/ng1097-154 }}
* {{cite journal | vauthors = Nakatsura T, Senju S, Ito M, Nishimura Y, Itoh K | title = Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method | journal = Eur. J. Immunol. | volume = 32 | issue = 3 | pages = 826–36 | year = 2002 | pmid = 11870627 | doi = 10.1002/1521-4141(200203)32:3<826::AID-IMMU826>3.0.CO;2-Y }}
*{{cite journal  | author=Provost P, Samuelsson B, Rådmark O |title=Interaction of 5-lipoxygenase with cellular proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1881-5 |year= 1999 |pmid= 10051563 |doi=  }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal | author=Provost P, Doucet J, Hammarberg T, ''et al.'' |title=5-Lipoxygenase interacts with coactosin-like protein. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16520-7 |year= 2001 |pmid= 11297527 |doi= 10.1074/jbc.M011205200 }}
* {{cite journal | vauthors = Dai H, Wu J, Xu Y, Yajun T, Husheng D, Shi Y | title = 1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N | journal = J. Biomol. NMR | volume = 29 | issue = 3 | pages = 455–6 | year = 2004 | pmid = 15213466 | doi = 10.1023/B:JNMR.0000032550.18424.aa }}
*{{cite journal | author=Provost P, Doucet J, Stock A, ''et al.'' |title=Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75. |journal=Biochem. J. |volume=359 |issue= Pt 2 |pages= 255-63 |year= 2001 |pmid= 11583571 |doi= }}
* {{cite journal | vauthors = Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W | title = Expression, purification and preliminary crystallographic studies of human coactosin-like protein | journal = Acta Crystallogr. D | volume = 60 | issue = Pt 9 | pages = 1651–3 | year = 2004 | pmid = 15333945 | doi = 10.1107/S0907444904016701 }}
*{{cite journal | author=Nakatsura T, Senju S, Ito M, ''et al.'' |title=Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method. |journal=Eur. J. Immunol. |volume=32 |issue= 3 |pages= 826-36 |year= 2002 |pmid= 11870627 |doi= }}
* {{cite journal | vauthors = Li X, Liu X, Lou Z, Duan X, Wu H, Liu Y, Rao Z | title = Crystal structure of human coactosin-like protein at 1.9 A resolution | journal = Protein Sci. | volume = 13 | issue = 11 | pages = 2845–51 | year = 2004 | pmid = 15459340 | pmc = 2286586 | doi = 10.1110/ps.04937304 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Li X, Liu X, Zhao Q, Liu Y, Duan X, Rao Z | title = Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP) | journal = Acta Crystallogr. D | volume = 60 | issue = Pt 12 Pt 2 | pages = 2387–8 | year = 2004 | pmid = 15583396 | doi = 10.1107/S0907444904028112 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
* {{cite journal | vauthors = Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, Martens L, Goethals M, Vandekerckhove J | title = Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC | journal = Proteomics | volume = 5 | issue = 14 | pages = 3589–99 | year = 2005 | pmid = 16097034 | doi = 10.1002/pmic.200401217 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Dai H, Huang W, Xu J, Yao B, Xiong S, Ding H, Tang Y, Liu H, Wu J, Shi Y | title = Binding model of human coactosin-like protein with filament actin revealed by mutagenesis | journal = Biochim. Biophys. Acta | volume = 1764 | issue = 11 | pages = 1688–700 | year = 2006 | pmid = 17070122 | doi = 10.1016/j.bbapap.2006.06.017 }}
*{{cite journal  | author=Dai H, Wu J, Xu Y, ''et al.'' |title=1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N. |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 455-6 |year= 2005 |pmid= 15213466 |doi= 10.1023/B:JNMR.0000032550.18424.aa }}
*{{cite journal | author=Liu L, Wang Y, Zhang P, ''et al.'' |title=Expression, purification and preliminary crystallographic studies of human coactosin-like protein. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=60 |issue= Pt 9 |pages= 1651-3 |year= 2005 |pmid= 15333945 |doi= 10.1107/S0907444904016701 }}
*{{cite journal | author=Li X, Liu X, Lou Z, ''et al.'' |title=Crystal structure of human coactosin-like protein at 1.9 A resolution. |journal=Protein Sci. |volume=13 |issue= 11 |pages= 2845-51 |year= 2005 |pmid= 15459340 |doi= 10.1110/ps.04937304 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Li X, Liu X, Zhao Q, ''et al.'' |title=Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP). |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=60 |issue= Pt 12 Pt 2 |pages= 2387-8 |year= 2005 |pmid= 15583396 |doi= 10.1107/S0907444904028112 }}
*{{cite journal | author=Gevaert K, Staes A, Van Damme J, ''et al.'' |title=Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. |journal=Proteomics |volume=5 |issue= 14 |pages= 3589-99 |year= 2006 |pmid= 16097034 |doi= 10.1002/pmic.200401217 }}
*{{cite journal | author=Rakonjac M, Fischer L, Provost P, ''et al.'' |title=Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 35 |pages= 13150-5 |year= 2006 |pmid= 16924104 |doi= 10.1073/pnas.0605150103 }}
*{{cite journal  | author=Dai H, Huang W, Xu J, ''et al.'' |title=Binding model of human coactosin-like protein with filament actin revealed by mutagenesis. |journal=Biochim. Biophys. Acta |volume=1764 |issue= 11 |pages= 1688-700 |year= 2006 |pmid= 17070122 |doi= 10.1016/j.bbapap.2006.06.017 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=23406}}
{{WikiDoc Sources}}
 
 
{{gene-16-stub}}

Latest revision as of 09:57, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Coactosin-like protein (COTL1 or CLP) is a protein that in humans is encoded by the COTL1 gene.[1][2][3][4]

Function

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with and thereby stabilizes 5-lipoxygenase (ALOX5). Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.[4]

Interactions

COTL1 has been shown to interact with ALOX5.[5] ALOX5 is the first committed enzyme in the metabolism of arachidonic acid to an array of biologically important cell signaling agents: a) the pro-inflammatory mediator, leukotriene B4 (LTB4); b) the airways constrictors, LTC4, LTD4, and LTE4; c) the 5-hydroxyeicosatetraenoic acid family of pro-inflammatory and pro-allergic reactions mediators, 5-HETE and 5-oxo-eicosatetraenoic acid. ALOX5 also contributes to the metabolism of arachidonic acid and other polyunsaturated fatty acids to agents which act block inflammation and allergic reactions, the specialized pro-resolving mediators of the lipoxin and resolvin subclasses. Based on in vitro studies, COTL1 serves to stabilize ALOX5, acting as a chaperone or scaffold, to avert the enzyme's inactivation and thereby to promote its metabolic activity.[6]

References

  1. ↑ Provost P, Samuelsson B, Rådmark O (Apr 1999). "Interaction of 5-lipoxygenase with cellular proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881–5. doi:10.1073/pnas.96.5.1881. PMC 26705. PMID 10051563.
  2. ↑ Chen KS, Manian P, Koeuth T, Potocki L, Zhao Q, Chinault AC, Lee CC, Lupski JR (Nov 1997). "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome". Nat. Genet. 17 (2): 154–63. doi:10.1038/ng1097-154. PMID 9326934.
  3. ↑ Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O (Sep 2006). "Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production". Proc. Natl. Acad. Sci. U.S.A. 103 (35): 13150–5. doi:10.1073/pnas.0605150103. PMC 1559768. PMID 16924104.
  4. ↑ 4.0 4.1 "Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)".
  5. ↑ Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O (May 2001). "5-Lipoxygenase interacts with coactosin-like protein". J. Biol. Chem. 276 (19): 16520–7. doi:10.1074/jbc.M011205200. PMID 11297527.
  6. ↑ Anwar Y, Sabir JS, Qureshi MI, Saini KS (2014). "5-lipoxygenase: a promising drug target against inflammatory diseases-biochemical and pharmacological regulation". Current Drug Targets. 15 (4): 410–22. doi:10.2174/1389450114666131209110745. PMID 24313690.

External links

Further reading


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