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{{Infobox_gene}}
{{PBB_Controls
'''Metallothionein 1X''', also known as '''MT1X''', is a [[protein]] which in humans is encoded by the [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MT1X metallothionein 1X| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4501| accessdate = }}</ref><ref name="pmid2286373">{{cite journal |vauthors=West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI | title = Human metallothionein genes: structure of the functional locus at 16q13 | journal = Genomics | volume = 8 | issue = 3 | pages = 513–8 |date=November 1990 | pmid = 2286373 | doi = 10.1016/0888-7543(90)90038-V | url =  }}</ref><ref name="pmid8049263">{{cite journal |vauthors=Stennard FA, Holloway AF, Hamilton J, West AK | title = Characterisation of six additional human metallothionein genes | journal = Biochim. Biophys. Acta | volume = 1218 | issue = 3 | pages = 357–65 |date=August 1994 | pmid = 8049263 | doi = 10.1016/0167-4781(94)90189-9| url = | issn = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
* [[Metallothionein]]
| image = PBB_Protein_MT1X_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhu.
| PDB = {{PDB2|1mhu}}, {{PDB2|1mrb}}, {{PDB2|1mrt}}
| Name = Metallothionein 1X
| HGNCid = 7405
| Symbol = MT1X
| AltSymbols =; MT1; MT-1l
| OMIM = 156359
| ECnumber = 
| Homologene = 88734
| MGIid = 
| GeneAtlas_image1 = PBB_GE_MT1X_204326_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_MT1X_208581_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046870 |text = cadmium ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006882 |text = cellular zinc ion homeostasis}} {{GNF_GO|id=GO:0007263 |text = nitric oxide mediated signal transduction}} {{GNF_GO|id=GO:0010038 |text = response to metal ion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4501
    | Hs_Ensembl = ENSG00000187193
    | Hs_RefseqProtein = NP_005943
    | Hs_RefseqmRNA = NM_005952
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 55273894
    | Hs_GenLoc_end = 55275608
    | Hs_Uniprot = P80297
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Metallothionein 1X''', also known as '''MT1X''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MT1X metallothionein 1X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4501| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=West AK, Stallings R, Hildebrand CE, ''et al.'' |title=Human metallothionein genes: structure of the functional locus at 16q13. |journal=Genomics |volume=8 |issue= 3 |pages= 513-8 |year= 1991 |pmid= 2286373 |doi=  }}
*{{cite journal   |vauthors=West AK, Stallings R, Hildebrand CE, etal |title=Human metallothionein genes: structure of the functional locus at 16q13. |journal=Genomics |volume=8 |issue= 3 |pages= 513–8 |year= 1991 |pmid= 2286373 |doi=10.1016/0888-7543(90)90038-V }}
*{{cite journal  | author=Stennard FA, Holloway AF, Hamilton J, West AK |title=Characterisation of six additional human metallothionein genes. |journal=Biochim. Biophys. Acta |volume=1218 |issue= 3 |pages= 357-65 |year= 1994 |pmid= 8049263 |doi=  }}
*{{cite journal  |vauthors=Stennard FA, Holloway AF, Hamilton J, West AK |title=Characterisation of six additional human metallothionein genes. |journal=Biochim. Biophys. Acta |volume=1218 |issue= 3 |pages= 357–65 |year= 1994 |pmid= 8049263 |doi=  10.1016/0167-4781(94)90189-9}}
*{{cite journal | author=Pauwels M, van Weyenbergh J, Soumillion A, ''et al.'' |title=Induction by zinc of specific metallothionein isoforms in human monocytes. |journal=Eur. J. Biochem. |volume=220 |issue= 1 |pages= 105-10 |year= 1994 |pmid= 8119276 |doi=  }}
*{{cite journal   |vauthors=Pauwels M, van Weyenbergh J, Soumillion A, etal |title=Induction by zinc of specific metallothionein isoforms in human monocytes. |journal=Eur. J. Biochem. |volume=220 |issue= 1 |pages= 105–10 |year= 1994 |pmid= 8119276 |doi=10.1111/j.1432-1033.1994.tb18603.x }}
*{{cite journal | author=Mididoddi S, McGuirt JP, Sens MA, ''et al.'' |title=Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. |journal=Toxicol. Lett. |volume=85 |issue= 1 |pages= 17-27 |year= 1996 |pmid= 8619255 |doi=  }}
*{{cite journal   |vauthors=Mididoddi S, McGuirt JP, Sens MA, etal |title=Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. |journal=Toxicol. Lett. |volume=85 |issue= 1 |pages= 17–27 |year= 1996 |pmid= 8619255 |doi=10.1016/0378-4274(96)03632-6 }}
*{{cite journal  | author=Holloway AF, Stennard FA, West AK |title=Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. |journal=FEBS Lett. |volume=404 |issue= 1 |pages= 41-4 |year= 1997 |pmid= 9074634 |doi=  }}
*{{cite journal  |vauthors=Holloway AF, Stennard FA, West AK |title=Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. |journal=FEBS Lett. |volume=404 |issue= 1 |pages= 41–4 |year= 1997 |pmid= 9074634 |doi=10.1016/S0014-5793(97)00082-3 }}
*{{cite journal | author=Garrett SH, Somji S, Todd JH, ''et al.'' |title=Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals. |journal=Environ. Health Perspect. |volume=106 |issue= 12 |pages= 825-32 |year= 1999 |pmid= 9831543 |doi=  }}
*{{cite journal   |vauthors=Garrett SH, Somji S, Todd JH, etal |title=Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals. |journal=Environ. Health Perspect. |volume=106 |issue= 12 |pages= 825–32 |year= 1999 |pmid= 9831543 |doi=10.2307/3434126  | pmc=1533231  | publisher=Brogan &#38  | jstor=3434126 }}
*{{cite journal | author=Hellemans G, Soumillion A, Proost P, ''et al.'' |title=Metallothioneins in human kidneys and associated tumors. |journal=Nephron |volume=83 |issue= 4 |pages= 331-40 |year= 2000 |pmid= 10575295 |doi=  }}
*{{cite journal   |vauthors=Hellemans G, Soumillion A, Proost P, etal |title=Metallothioneins in human kidneys and associated tumors |journal=Nephron |volume=83 |issue= 4 |pages= 331–40 |year= 2000 |pmid= 10575295 |doi=10.1159/000045425 }}
*{{cite journal | author=Garrett SH, Sens MA, Shukla D, ''et al.'' |title=Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. |journal=Prostate |volume=43 |issue= 2 |pages= 125-35 |year= 2000 |pmid= 10754528 |doi=  }}
*{{cite journal   |vauthors=Garrett SH, Sens MA, Shukla D, etal |title=Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer |journal=Prostate |volume=43 |issue= 2 |pages= 125–35 |year= 2000 |pmid= 10754528 |doi=10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S }}
*{{cite journal  | author=Vandeghinste N, Proost P, De Ley M |title=Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 2 |pages= 419-33 |year= 2000 |pmid= 10774930 |doi=  }}
*{{cite journal  |vauthors=Vandeghinste N, Proost P, De Ley M |title=Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 2 |pages= 419–33 |year= 2000 |pmid= 10774930 |doi=  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Rahman MT, De Ley M |title=Metallothionein isogene transcription in red blood cell precursors from human cord blood. |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 849-56 |year= 2001 |pmid= 11168427 |doi=  }}
*{{cite journal  |vauthors=Rahman MT, De Ley M |title=Metallothionein isogene transcription in red blood cell precursors from human cord blood |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 849–56 |year= 2001 |pmid= 11168427 |doi=10.1046/j.1432-1327.2001.01947.x }}
*{{cite journal | author=Garrett SH, Belcastro M, Sens MA, ''et al.'' |title=Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells. |journal=J. Toxicol. Environ. Health Part A |volume=64 |issue= 4 |pages= 343-55 |year= 2001 |pmid= 11693492 |doi=  }}
*{{cite journal   |vauthors=Garrett SH, Belcastro M, Sens MA, etal |title=Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells |journal=J. Toxicol. Environ. Health Part A |volume=64 |issue= 4 |pages= 343–55 |year= 2001 |pmid= 11693492 |doi=10.1080/152873901316981321 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Izmailova E, Bertley FM, Huang Q, ''et al.'' |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191-7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal   |vauthors=Izmailova E, Bertley FM, Huang Q, etal |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal | author=Anderson NL, Polanski M, Pieper R, ''et al.'' |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311-26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
*{{cite journal   |vauthors=Anderson NL, Polanski M, Pieper R, etal |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources |journal=Mol. Cell. Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4501}}
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{{protein-stub}}
{{gene-16-stub}}
{{WikiDoc Sources}}

Latest revision as of 07:00, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Metallothionein 1X, also known as MT1X, is a protein which in humans is encoded by the gene.[1][2][3]

See also

References

  1. ↑ "Entrez Gene: MT1X metallothionein 1X".
  2. ↑ West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (November 1990). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
  3. ↑ Stennard FA, Holloway AF, Hamilton J, West AK (August 1994). "Characterisation of six additional human metallothionein genes". Biochim. Biophys. Acta. 1218 (3): 357–65. doi:10.1016/0167-4781(94)90189-9. PMID 8049263.

Further reading



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