GP2 (gene): Difference between revisions

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{{Infobox_gene}}
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'''Pancreatic secretory granule membrane major glycoprotein GP2''' is a [[protein]] that in humans is encoded by the ''GP2'' [[gene]].<ref name="pmid9605860">{{cite journal |vauthors=Fukuoka SI, Suzuki M, Okabayashi K, Takahashi E | title = Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 79 | issue = 3–4 | pages = 231–2 |date=Jun 1998 | pmid = 9605860 | pmc =  | doi =10.1159/000134730 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2813| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Glycoprotein 2 (zymogen granule membrane)
| HGNCid = 4441
| Symbol = GP2
| AltSymbols =; DKFZp779K0533; ZAP75
| OMIM = 602977
| ECnumber = 
| Homologene = 1151
| MGIid = 1914383
| GeneAtlas_image1 = PBB_GE_GP2_206681_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_GP2_208473_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GP2_214324_at_tn.png
| Function = {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2813
    | Hs_Ensembl = ENSG00000169347
    | Hs_RefseqProtein = NP_001007241
    | Hs_RefseqmRNA = NM_001007240
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 20228398
    | Hs_GenLoc_end = 20246403
    | Hs_Uniprot = P55259
    | Mm_EntrezGene = 67133
    | Mm_Ensembl = ENSMUSG00000030954
    | Mm_RefseqmRNA = NM_025989
    | Mm_RefseqProtein = NP_080265
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 119233693
    | Mm_GenLoc_end = 119250421
    | Mm_Uniprot = Q0VDQ3
  }}
}}
'''Glycoprotein 2 (zymogen granule membrane)''', also known as '''GP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2813| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Jacob M, Lainé J, LeBel D |title=Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase. |journal=Biochem. Cell Biol. |volume=70 |issue= 10-11 |pages= 1105-14 |year= 1993 |pmid= 1284286 |doi=  }}
*{{cite journal  |vauthors=Jacob M, Lainé J, LeBel D |title=Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase |journal=Biochem. Cell Biol. |volume=70 |issue= 10–11 |pages= 1105–14 |year= 1993 |pmid= 1284286 |doi=10.1139/o92-156 }}
*{{cite journal  | author=Fukuoka S, Freedman SD, Yu H, ''et al.'' |title=GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1189-93 |year= 1992 |pmid= 1531535 |doi=  }}
*{{cite journal  |vauthors=Fukuoka S, Freedman SD, Yu H |title=GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1189–93 |year= 1992 |pmid= 1531535 |doi=10.1073/pnas.89.4.1189 | pmc=48414  |display-authors=etal}}
*{{cite journal  | author=Paul E, Leblond FA, LeBel D |title=In resting conditions, the pancreatic granule membrane protein GP-2 is secreted by cleavage of its glycosylphosphatidylinositol anchor. |journal=Biochem. J. |volume=277 ( Pt 3) |issue=  |pages= 879-81 |year= 1991 |pmid= 1651706 |doi=  }}
*{{cite journal  |vauthors=Paul E, Leblond FA, LeBel D |title=In resting conditions, the pancreatic granule membrane protein GP-2 is secreted by cleavage of its glycosylphosphatidylinositol anchor |journal=Biochem. J. |volume=277 |issue=  3|pages= 879–81 |year= 1991 |pmid= 1651706 |doi= | pmc=1151326 }}
*{{cite journal  | author=Fukuoka S, Freedman SD, Scheele GA |title=A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2898-902 |year= 1991 |pmid= 2011597 |doi=  }}
*{{cite journal  |vauthors=Fukuoka S, Freedman SD, Scheele GA |title=A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2898–902 |year= 1991 |pmid= 2011597 |doi=10.1073/pnas.88.7.2898  | pmc=51347 }}
*{{cite journal  | author=Rindler MJ, Hoops TC |title=The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate. |journal=Eur. J. Cell Biol. |volume=53 |issue= 1 |pages= 154-63 |year= 1991 |pmid= 2076702 |doi=  }}
*{{cite journal  |vauthors=Rindler MJ, Hoops TC |title=The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate |journal=Eur. J. Cell Biol. |volume=53 |issue= 1 |pages= 154–63 |year= 1991 |pmid= 2076702 |doi=  }}
*{{cite journal  | author=Hoops TC, Ivanov I, Cui Z, ''et al.'' |title=Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells. |journal=J. Biol. Chem. |volume=268 |issue= 34 |pages= 25694-705 |year= 1994 |pmid= 7503984 |doi=  }}
*{{cite journal  |vauthors=Hoops TC, Ivanov I, Cui Z |title=Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells |journal=J. Biol. Chem. |volume=268 |issue= 34 |pages= 25694–705 |year= 1994 |pmid= 7503984 |doi=  |display-authors=etal}}
*{{cite journal  | author=Freedman SD, Sakamoto K, Scheele GA |title=Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells. |journal=Am. J. Physiol. |volume=267 |issue= 1 Pt 1 |pages= G40-51 |year= 1994 |pmid= 7519402 |doi=  }}
*{{cite journal  |vauthors=Freedman SD, Sakamoto K, Scheele GA |title=Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells |journal=Am. J. Physiol. |volume=267 |issue= 1 Pt 1 |pages= G40–51 |year= 1994 |pmid= 7519402 |doi=  }}
*{{cite journal  | author=Wong SM, Lowe AW |title=Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas. |journal=Gene |volume=171 |issue= 2 |pages= 311-2 |year= 1996 |pmid= 8666297 |doi= }}
*{{cite journal  |vauthors=Wong SM, Lowe AW |title=Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas |journal=Gene |volume=171 |issue= 2 |pages= 311–2 |year= 1996 |pmid= 8666297 |doi=10.1016/0378-1119(96)00065-0 }}
*{{cite journal  | author=Fukuoka SI, Suzuki M, Okabayashi K, Takahashi E |title=Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 231-2 |year= 1998 |pmid= 9605860 |doi= }}
*{{cite journal  | author=Fukuoka S |title=Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2 |journal=Biochim. Biophys. Acta |volume=1491 |issue= 1–3 |pages= 376–80 |year= 2000 |pmid= 10760606 |doi=  10.1016/S0167-4781(00)00057-9}}
*{{cite journal  | author=Fukuoka S |title=Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2. |journal=Biochim. Biophys. Acta |volume=1491 |issue= 1-3 |pages= 376-80 |year= 2000 |pmid= 10760606 |doi=  }}
*{{cite journal  |vauthors=Parker EM, Zaman MM, Freedman SD |title=GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin |journal=Pancreas |volume=21 |issue= 3 |pages= 219–25 |year= 2001 |pmid= 11039464 |doi=10.1097/00006676-200010000-00001 }}
*{{cite journal  | author=Parker EM, Zaman MM, Freedman SD |title=GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin. |journal=Pancreas |volume=21 |issue= 3 |pages= 219-25 |year= 2001 |pmid= 11039464 |doi=  }}
*{{cite journal  |vauthors=Kalus I, Hodel A, Koch A |title=Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains |journal=Biochem. J. |volume=362 |issue= Pt 2 |pages= 433–42 |year= 2002 |pmid= 11853552 |doi=10.1042/0264-6021:3620433  | pmc=1222404 |display-authors=etal}}
*{{cite journal  | author=Kalus I, Hodel A, Koch A, ''et al.'' |title=Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains. |journal=Biochem. J. |volume=362 |issue= Pt 2 |pages= 433-42 |year= 2002 |pmid= 11853552 |doi=  }}
*{{cite journal  |vauthors=Tsujii-Hayashi Y, Kitahara M, Yamagaki T |title=A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47493–9 |year= 2003 |pmid= 12324456 |doi= 10.1074/jbc.M206572200 |display-authors=etal}}
*{{cite journal  | author=Tsujii-Hayashi Y, Kitahara M, Yamagaki T, ''et al.'' |title=A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47493-9 |year= 2003 |pmid= 12324456 |doi= 10.1074/jbc.M206572200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Tamiya G, Shinya M, Imanishi T |title=Whole genome association study of rheumatoid arthritis using 27 039 microsatellites |journal=Hum. Mol. Genet. |volume=14 |issue= 16 |pages= 2305–21 |year= 2005 |pmid= 16000323 |doi= 10.1093/hmg/ddi234 |display-authors=etal}}
*{{cite journal  | author=Tamiya G, Shinya M, Imanishi T, ''et al.'' |title=Whole genome association study of rheumatoid arthritis using 27 039 microsatellites. |journal=Hum. Mol. Genet. |volume=14 |issue= 16 |pages= 2305-21 |year= 2005 |pmid= 16000323 |doi= 10.1093/hmg/ddi234 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 08:55, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene.[1][2]


References

  1. ↑ Fukuoka SI, Suzuki M, Okabayashi K, Takahashi E (Jun 1998). "Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 231–2. doi:10.1159/000134730. PMID 9605860.
  2. ↑ "Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane)".

Further reading



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