MZF1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
 
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Myeloid zinc finger 1''' is a [[protein]] that in humans is encoded by the ''MZF1'' [[gene]].<ref name="pmid1860835">{{cite journal | vauthors = Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K | title = A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells | journal = J Biol Chem | volume = 266 | issue = 22 | pages = 14183–7 | date = September 1991 | pmid = 1860835 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MZF1 myeloid zinc finger 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7593| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_MZF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fi2.
| PDB = {{PDB2|2fi2}}
| Name = Myeloid zinc finger 1
| HGNCid = 13108
| Symbol = MZF1
| AltSymbols =; MZF-1; MZF1B; ZNF42; ZSCAN6; Zfp98
| OMIM = 194550
| ECnumber = 
| Homologene = 9633
| MGIid = 107457
| GeneAtlas_image1 = PBB_GE_MZF1_40569_at_tn.png
| GeneAtlas_image2 = PBB_GE_MZF1_204139_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_MZF1_210336_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7593
    | Hs_Ensembl = ENSG00000099326
    | Hs_RefseqProtein = NP_003413
    | Hs_RefseqmRNA = NM_003422
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 63765097
    | Hs_GenLoc_end = 63776754
    | Hs_Uniprot = P28698
    | Mm_EntrezGene = 109889
    | Mm_Ensembl = ENSMUSG00000030380
    | Mm_RefseqmRNA = NM_145819
    | Mm_RefseqProtein = NP_665818
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 11943329
    | Mm_GenLoc_end = 11954844
    | Mm_Uniprot = 
  }}
}}
'''Myeloid zinc finger 1''', also known as '''MZF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MZF1 myeloid zinc finger 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7593| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
MZF1 has been shown to [[Protein-protein interaction|interact]] with [[SCAND1]].<ref name=pmid10777584>{{cite journal | vauthors = Sander TL, Haas AL, Peterson MJ, Morris JF | title = Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations  | journal = J. Biol. Chem. | volume = 275 | issue = 17 | pages = 12857–12867 | date = April 2000 | pmid = 10777584 | doi = 10.1074/jbc.275.17.12857 }}</ref>
{{PBB_Summary
In 2014, the laboratory of [[Nathan H. Lents]] showed that MZF-1 induces the [[Glyceraldehyde 3-phosphate dehydrogenase|GAPDH]] gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.<ref name="pmid25065746">{{cite journal | vauthors = Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH | title = The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol | journal = Biochem. Biophys. Res. Commun. | volume = 451 | issue = 1 | pages = 137–41 | year = 2014 | pmid = 25065746 | doi = 10.1016/j.bbrc.2014.07.082 }}</ref> The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.<ref>{{cite journal|doi=10.1002/jcp.25021 | volume=230 | issue=11 | title=Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment | journal=Journal of Cellular Physiology | pages=2634–2639 | vauthors=Piszczatowski RT}}</ref>
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bavisotto L, Kaushansky K, Lin N, Hromas R | title = Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro | journal = J. Exp. Med. | volume = 174 | issue = 5 | pages = 1097–1101 | year = 1991 | pmid = 1719120 | pmc = 2119006 | doi = 10.1084/jem.174.5.1097 }}
| citations =
* {{cite journal | vauthors = Sander TL, Haas AL, Peterson MJ, Morris JF | title = Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations | journal = J. Biol. Chem. | volume = 275 | issue = 17 | pages = 12857–12867 | year = 2000 | pmid = 10777584 | doi = 10.1074/jbc.275.17.12857 }}
*{{cite journal | author=Bavisotto L, Kaushansky K, Lin N, Hromas R |title=Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. |journal=J. Exp. Med. |volume=174 |issue= 5 |pages= 1097-101 |year= 1991 |pmid= 1719120 |doi= }}
* {{cite journal | vauthors = Peterson MJ, Morris JF | title = Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein | journal = Gene | volume = 254 | issue = 1–2 | pages = 105–118 | year = 2000 | pmid = 10974541 | doi = 10.1016/S0378-1119(00)00281-X }}
*{{cite journal  | author=Hromas R, Collins SJ, Hickstein D, ''et al.'' |title=A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14183-7 |year= 1991 |pmid= 1860835 |doi=  }}
* {{cite journal | vauthors = Takahashi K, Matsumoto C, Ra C | title = FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1 | journal = Biochem. J. | volume = 386 | issue = Pt 1 | pages = 191–200 | year = 2005 | pmid = 15453830 | pmc = 1134781 | doi = 10.1042/BJ20040775 }}
*{{cite journal | author=Sander TL, Haas AL, Peterson MJ, Morris JF |title=Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations. |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 12857-67 |year= 2000 |pmid= 10777584 |doi= }}
* {{cite journal | vauthors = Kang NY, Park YD, Choi HJ, Kim KS, Lee YC, Kim CH | title = Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene | journal = Mol. Cells | volume = 18 | issue = 2 | pages = 157–62 | year = 2005 | pmid = 15528990 | doi =  }}
*{{cite journal | author=Peterson MJ, Morris JF |title=Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. |journal=Gene |volume=254 |issue= 1-2 |pages= 105-18 |year= 2000 |pmid= 10974541 |doi= }}
* {{cite journal | vauthors = Le Mée S, Fromigué O, Marie PJ | title = Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts | journal = Exp. Cell Res. | volume = 302 | issue = 1 | pages = 129–142 | year = 2005 | pmid = 15541732 | doi = 10.1016/j.yexcr.2004.08.028 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C | title = LDOC1, a novel MZF-1-interacting protein, induces apoptosis | journal = FEBS Lett. | volume = 579 | issue = 3 | pages = 604–608 | year = 2005 | pmid = 15670815 | doi = 10.1016/j.febslet.2004.12.030 }}
*{{cite journal | author=Takahashi K, Matsumoto C, Ra C |title=FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1. |journal=Biochem. J. |volume=386 |issue= Pt 1 |pages= 191-200 |year= 2005 |pmid= 15453830 |doi= 10.1042/BJ20040775 }}
* {{cite journal | vauthors = Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, Liu JY | title = PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells | journal = Biochem. Biophys. Res. Commun. | volume = 339 | issue = 1 | pages = 217–225 | year = 2006 | pmid = 16297876 | doi = 10.1016/j.bbrc.2005.11.015 }}
*{{cite journal | author=Kang NY, Park YD, Choi HJ, ''et al.'' |title=Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene. |journal=Mol. Cells |volume=18 |issue= 2 |pages= 157-62 |year= 2005 |pmid= 15528990 |doi=  }}
* {{cite journal | vauthors = Peterson FC, Hayes PL, Waltner JK, Heisner AK, Jensen DR, Sander TL, Volkman BF | title = Structure of the SCAN domain from the tumor suppressor protein MZF1 | journal = J. Mol. Biol. | volume = 363 | issue = 1 | pages = 137–147 | year = 2006 | pmid = 16950398 | pmc = 1941711 | doi = 10.1016/j.jmb.2006.07.063 }}
*{{cite journal | author=Le Mée S, Fromigué O, Marie PJ |title=Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. |journal=Exp. Cell Res. |volume=302 |issue= 1 |pages= 129-42 |year= 2005 |pmid= 15541732 |doi= 10.1016/j.yexcr.2004.08.028 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–648 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Inoue M, Takahashi K, Niide O, ''et al.'' |title=LDOC1, a novel MZF-1-interacting protein, induces apoptosis. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 604-8 |year= 2005 |pmid= 15670815 |doi= 10.1016/j.febslet.2004.12.030 }}
*{{cite journal | author=Hsieh YH, Wu TT, Tsai JH, ''et al.'' |title=PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells. |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue= 1 |pages= 217-25 |year= 2006 |pmid= 16297876 |doi= 10.1016/j.bbrc.2005.11.015 }}
*{{cite journal | author=Peterson FC, Hayes PL, Waltner JK, ''et al.'' |title=Structure of the SCAN domain from the tumor suppressor protein MZF1. |journal=J. Mol. Biol. |volume=363 |issue= 1 |pages= 137-47 |year= 2006 |pmid= 16950398 |doi= 10.1016/j.jmb.2006.07.063 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=7593}}
{{WikiDoc Sources}}
 
 
{{gene-19-stub}}

Latest revision as of 07:16, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.[1][2]

Interactions

MZF1 has been shown to interact with SCAND1.[3] In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.[4] The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.[5]

References

  1. ↑ Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem. 266 (22): 14183–7. PMID 1860835.
  2. ↑ "Entrez Gene: MZF1 myeloid zinc finger 1".
  3. ↑ Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
  4. ↑ Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.
  5. ↑ Piszczatowski RT. "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment". Journal of Cellular Physiology. 230 (11): 2634–2639. doi:10.1002/jcp.25021.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=MZF1&oldid=1418914"