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{{Infobox_gene}}
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'''Hematopoietic cell signal transducer''' is a [[protein]] that in humans is encoded by the ''HCST'' [[gene]].<ref name="pmid10426994">{{cite journal |vauthors=Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH | title = An activating immunoreceptor complex formed by NKG2D and DAP10 | journal = Science | volume = 285 | issue = 5428 | pages = 730–2 |date=Aug 1999 | pmid = 10426994 | pmc =  | doi =10.1126/science.285.5428.730 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HCST hematopoietic cell signal transducer| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10870| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Hematopoietic cell signal transducer
| HGNCid = 16977
| Symbol = HCST
| AltSymbols =; DAP10; DKFZP586C1522; KAP10; PIK3AP
| OMIM = 604089
| ECnumber = 
| Homologene = 8024
| MGIid = 1344360
| Function =
| Component = {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10870
    | Hs_Ensembl = ENSG00000126264
    | Hs_RefseqProtein = NP_001007470
    | Hs_RefseqmRNA = NM_001007469
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 41085222
    | Hs_GenLoc_end = 41087015
    | Hs_Uniprot = 
    | Mm_EntrezGene = 23900
    | Mm_Ensembl = ENSMUSG00000064109
    | Mm_RefseqmRNA = NM_011827
    | Mm_RefseqProtein = NP_035957
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 30126473
    | Mm_GenLoc_end = 30128614
    | Mm_Uniprot =   
  }}
}}
'''Hematopoietic cell signal transducer''', also known as '''HCST''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HCST hematopoietic cell signal transducer| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10870| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: HCST hematopoietic cell signal transducer| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10870| accessdate = }}</ref>
| summary_text = This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: HCST hematopoietic cell signal transducer| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10870| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Karimi M, Cao TM, Baker JA, ''et al.'' |title=Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. |journal=J. Immunol. |volume=175 |issue= 12 |pages= 7819-28 |year= 2006 |pmid= 16339517 |doi=  }}
*{{cite journal   |vauthors=Karimi M, Cao TM, Baker JA, etal |title=Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. |journal=J. Immunol. |volume=175 |issue= 12 |pages= 7819–28 |year= 2006 |pmid= 16339517 |doi=  10.4049/jimmunol.175.12.7819}}
*{{cite journal | author=André P, Castriconi R, Espéli M, ''et al.'' |title=Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. |journal=Eur. J. Immunol. |volume=34 |issue= 4 |pages= 961-71 |year= 2004 |pmid= 15048706 |doi= 10.1002/eji.200324705 }}
*{{cite journal   |vauthors=André P, Castriconi R, Espéli M, etal |title=Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. |journal=Eur. J. Immunol. |volume=34 |issue= 4 |pages= 961–71 |year= 2004 |pmid= 15048706 |doi= 10.1002/eji.200324705 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Billadeau DD, Upshaw JL, Schoon RA, ''et al.'' |title=NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. |journal=Nat. Immunol. |volume=4 |issue= 6 |pages= 557-64 |year= 2003 |pmid= 12740575 |doi= 10.1038/ni929 }}
*{{cite journal   |vauthors=Billadeau DD, Upshaw JL, Schoon RA, etal |title=NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. |journal=Nat. Immunol. |volume=4 |issue= 6 |pages= 557–64 |year= 2003 |pmid= 12740575 |doi= 10.1038/ni929 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Diefenbach A, Tomasello E, Lucas M, ''et al.'' |title=Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1142-9 |year= 2002 |pmid= 12426565 |doi= 10.1038/ni858 }}
*{{cite journal   |vauthors=Diefenbach A, Tomasello E, Lucas M, etal |title=Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1142–9 |year= 2002 |pmid= 12426565 |doi= 10.1038/ni858 }}
*{{cite journal | author=Gilfillan S, Ho EL, Cella M, ''et al.'' |title=NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1150-5 |year= 2002 |pmid= 12426564 |doi= 10.1038/ni857 }}
*{{cite journal   |vauthors=Gilfillan S, Ho EL, Cella M, etal |title=NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1150–5 |year= 2002 |pmid= 12426564 |doi= 10.1038/ni857 }}
*{{cite journal | author=Yim D, Jie HB, Sotiriadis J, ''et al.'' |title=Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D. |journal=Immunogenetics |volume=53 |issue= 3 |pages= 243-9 |year= 2001 |pmid= 11398969 |doi=  }}
*{{cite journal   |vauthors=Yim D, Jie HB, Sotiriadis J, etal |title=Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D. |journal=Immunogenetics |volume=53 |issue= 3 |pages= 243–9 |year= 2001 |pmid= 11398969 |doi=10.1007/s002510100321 }}
*{{cite journal | author=Cosman D, Müllberg J, Sutherland CL, ''et al.'' |title=ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. |journal=Immunity |volume=14 |issue= 2 |pages= 123-33 |year= 2001 |pmid= 11239445 |doi=  }}
*{{cite journal   |vauthors=Cosman D, Müllberg J, Sutherland CL, etal |title=ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. |journal=Immunity |volume=14 |issue= 2 |pages= 123–33 |year= 2001 |pmid= 11239445 |doi=10.1016/S1074-7613(01)00095-4 }}
*{{cite journal | author=Wu J, Cherwinski H, Spies T, ''et al.'' |title=DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. |journal=J. Exp. Med. |volume=192 |issue= 7 |pages= 1059-68 |year= 2000 |pmid= 11015446 |doi=  }}
*{{cite journal   |vauthors=Wu J, Cherwinski H, Spies T, etal |title=DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. |journal=J. Exp. Med. |volume=192 |issue= 7 |pages= 1059–68 |year= 2000 |pmid= 11015446 |doi=10.1084/jem.192.7.1059  | pmc=2193316 }}
*{{cite journal | author=Chang C, Dietrich J, Harpur AG, ''et al.'' |title=Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. |journal=J. Immunol. |volume=163 |issue= 9 |pages= 4651-4 |year= 1999 |pmid= 10528161 |doi=  }}
*{{cite journal   |vauthors=Chang C, Dietrich J, Harpur AG, etal |title=Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. |journal=J. Immunol. |volume=163 |issue= 9 |pages= 4651–4 |year= 1999 |pmid= 10528161 |doi=  }}
*{{cite journal  | author=Wu J, Song Y, Bakker AB, ''et al.'' |title=An activating immunoreceptor complex formed by NKG2D and DAP10. |journal=Science |volume=285 |issue= 5428 |pages= 730-2 |year= 1999 |pmid= 10426994 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:30, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.[1][2]

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.[2]

References

  1. ↑ Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH (Aug 1999). "An activating immunoreceptor complex formed by NKG2D and DAP10". Science. 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994.
  2. ↑ 2.0 2.1 "Entrez Gene: HCST hematopoietic cell signal transducer".

Further reading



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