MED25: Difference between revisions

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Identifiers
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Orthologs
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Latest revision as of 06:20, 4 September 2017

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.^[1]^[2]^[3]

Interactions

MED25 has been shown to interact with MED4.^[4]

References

↑ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ "Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)".
↑ Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.

Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (Apr 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (Aug 2002). "A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein". Biochemical and Biophysical Research Communications. 296 (2): 281–7. doi:10.1016/S0006-291X(02)00872-0. PMID 12163014.
Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, Berti L, Meisterernst M (Dec 2003). "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells". The EMBO Journal. 22 (24): 6494–504. doi:10.1093/emboj/cdg619. PMC 291814. PMID 14657022.
Yang F, DeBeaumont R, Zhou S, Näär AM (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2339–44. doi:10.1073/pnas.0308676100. PMC 356952. PMID 14983011.
Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG (Jul 2005). "MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription". Molecular Cell. 19 (1): 89–100. doi:10.1016/j.molcel.2005.05.015. PMID 15989967.
Lee HK, Park UH, Kim EJ, Um SJ (Aug 2007). "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation". The EMBO Journal. 26 (15): 3545–57. doi:10.1038/sj.emboj.7601797. PMC 1949011. PMID 17641689.

External links

GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid9110174-1] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

[pmid11230166-2] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-3] "Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)".

[pmid14638676-4] Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.

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[2]

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[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Mediator of RNA polymerase II transcription subunit 25''' is an [[enzyme]] that in humans is encoded by the ''MED25'' [[gene]].<ref name="pmid9110174">{{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}</ref><ref name="pmid11230166">{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81857| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)
- | HGNCid = 28845
- | Symbol = MED25
- | AltSymbols =; P78; ACID1; ARC92; DKFZp434K0512; MGC70671; TCBAP0758
- | OMIM =
- | ECnumber =
- | Homologene = 12614
- | MGIid = 1922863
- | GeneAtlas_image1 = PBB_GE_MED25_215897_at_tn.png
- | GeneAtlas_image2 = PBB_GE_MED25_208110_x_at_tn.png
- | Function =
- | Component =
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 81857
-    | Hs_Ensembl = ENSG00000104973
-    | Hs_RefseqProtein = NP_112235
-    | Hs_RefseqmRNA = NM_030973
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 55013358
-    | Hs_GenLoc_end = 55033848
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 75613
-    | Mm_Ensembl = ENSMUSG00000002968
-    | Mm_RefseqmRNA = NM_029365
-    | Mm_RefseqProtein = NP_083641
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 44747433
-    | Mm_GenLoc_end = 44760451
-    | Mm_Uniprot =
-  }}
-}}
-'''Mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)''', also known as '''MED25''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81857| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+MED25 has been shown to [[Protein-protein interaction|interact]] with [[MED4]].<ref name=pmid14638676>{{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation | journal = Nature | volume = 398 | issue = 6730 | pages = 828–32 | date = Apr 1999 | pmid = 10235267 | doi = 10.1038/19789 }}
-| citations =
+* {{cite journal | vauthors = Wang C, McCarty IM, Balazs L, Li Y, Steiner MS | title = A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 2 | pages = 281–7 | date = Aug 2002 | pmid = 12163014 | doi = 10.1016/S0006-291X(02)00872-0 }}
-*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
+* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 49671–4 | date = Dec 2003 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 }}
-*{{cite journal  | author=Näär AM, Beaurang PA, Zhou S, ''et al.'' |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828-32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 }}
+* {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+* {{cite journal | vauthors = Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, Berti L, Meisterernst M | title = A novel docking site on Mediator is critical for activation by VP16 in mammalian cells | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6494–504 | date = Dec 2003 | pmid = 14657022 | pmc = 291814 | doi = 10.1093/emboj/cdg619 }}
-*{{cite journal  | author=Wang C, McCarty IM, Balazs L, ''et al.'' |title=A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 2 |pages= 281-7 |year= 2002 |pmid= 12163014 |doi=  }}
+* {{cite journal | vauthors = Yang F, DeBeaumont R, Zhou S, Näär AM | title = The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2339–44 | date = Feb 2004 | pmid = 14983011 | pmc = 356952 | doi = 10.1073/pnas.0308676100 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Molecular Cell | volume = 14 | issue = 5 | pages = 685–91 | date = Jun 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 }}
-*{{cite journal  | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671-4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
+* {{cite journal | vauthors = Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG | title = MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription | journal = Molecular Cell | volume = 19 | issue = 1 | pages = 89–100 | date = Jul 2005 | pmid = 15989967 | doi = 10.1016/j.molcel.2005.05.015 }}
-*{{cite journal  | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
+* {{cite journal | vauthors = Lee HK, Park UH, Kim EJ, Um SJ | title = MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation | journal = The EMBO Journal | volume = 26 | issue = 15 | pages = 3545–57 | date = Aug 2007 | pmid = 17641689 | pmc = 1949011 | doi = 10.1038/sj.emboj.7601797 }}
-*{{cite journal  | author=Mittler G, Stühler T, Santolin L, ''et al.'' |title=A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6494-504 |year= 2004 |pmid= 14657022 |doi= 10.1093/emboj/cdg619 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Yang F, DeBeaumont R, Zhou S, Näär AM |title=The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2339-44 |year= 2004 |pmid= 14983011 |doi=  }}
-*{{cite journal  | author=Sato S, Tomomori-Sato C, Parmely TJ, ''et al.'' |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685-91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 }}
-*{{cite journal  | author=Zhang X, Krutchinsky A, Fukuda A, ''et al.'' |title=MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. |journal=Mol. Cell |volume=19 |issue= 1 |pages= 89-100 |year= 2005 |pmid= 15989967 |doi= 10.1016/j.molcel.2005.05.015 }}
-*{{cite journal  | author=Lee HK, Park UH, Kim EJ, Um SJ |title=MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. |journal=EMBO J. |volume=26 |issue= 15 |pages= 3545-57 |year= 2007 |pmid= 17641689 |doi= 10.1038/sj.emboj.7601797 }}
-}}
 {{refend}}
-{{protein-stub}}
+== External links ==
-{{WikiDoc Sources}}
+* [https://www.ncbi.nlm.nih.gov/books/NBK1285/  GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2]
+{{gene-19-stub}}

MED25: Difference between revisions

Latest revision as of 06:20, 4 September 2017

Contents

Interactions

References

Further reading

External links

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