KLK12: Difference between revisions

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Latest revision as of 06:32, 2 September 2017

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.^[1]^[2]^[3]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[3]

References

↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
↑ ^3.0 ^3.1 "Entrez Gene: KLK12 kallikrein-related peptidase 12".

Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891.
Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Res. 19 (4B): 2843–52. PMID 10652563.
Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID 10969073.
Yousef GM, Chang A, Scorilas A, Diamandis EP (2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochem. Biophys. Res. Commun. 276 (1): 125–33. doi:10.1006/bbrc.2000.3448. PMID 11006094.
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Yousef GM, Magklara A, Diamandis EP (2001). "KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer". Genomics. 69 (3): 331–41. doi:10.1006/geno.2000.6346. PMID 11056051.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Shinmura K, Tao H, Yamada H, et al. (2005). "Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity". Hum. Mutat. 24 (3): 273–4. doi:10.1002/humu.9270. PMID 15300858.
Memari N, Jiang W, Diamandis EP, Luo LY (2007). "Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)". Biol. Chem. 388 (4): 427–35. doi:10.1515/BC.2007.049. PMID 17391064.

External links

The MEROPS online database for peptidases and their inhibitors: S01.020

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid16800724-1] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.

[pmid16800723-2] Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.

[entrez-3] 3.0 ^3.1 "Entrez Gene: KLK12 kallikrein-related peptidase 12".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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+'''Kallikrein-12''' is a [[protein]] that in humans is encoded by the ''KLK12'' [[gene]].<ref name="pmid16800724">{{cite journal |vauthors=Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM | title = A comprehensive nomenclature for serine proteases with homology to tissue kallikreins | journal = Biol Chem | volume = 387 | issue = 6 | pages = 637–41 |date=Jun 2006 | pmid = 16800724 | pmc =  | doi = 10.1515/BC.2006.082 }}</ref><ref name="pmid16800723">{{cite journal | title = Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005 | journal = Biol Chem | volume = 387 | issue = 6 | pages = 635–824 |date=Jun 2006 | pmid = 16800723 | pmc =  | doi = 10.1515/BC.2006.081 | last1 =  Diamandis | first1 =  Eleftherios P. | last2 =  Deperthes | first2 =  David | last3 =  Lundwall | first3 =  Åke }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KLK12 kallikrein-related peptidase 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=43849| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Kallikrein-related peptidase 12
- | HGNCid = 6360
- | Symbol = KLK12
- | AltSymbols =; DKFZp686H1078; KLK-L5; KLKL5; MGC42603
- | OMIM = 605539
- | ECnumber =
- | Homologene = 44690
- | MGIid = 1916761
-  | GeneAtlas_image1 = PBB_GE_KLK12_220782_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
- | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
-  | Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 43849
-    | Hs_Ensembl = ENSG00000186474
-    | Hs_RefseqProtein = NP_062544
-    | Hs_RefseqmRNA = NM_019598
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 56224160
-    | Hs_GenLoc_end = 56230298
-    | Hs_Uniprot = Q9UKR0
-    | Mm_EntrezGene = 69511
-    | Mm_Ensembl = ENSMUSG00000044430
-    | Mm_RefseqmRNA = XM_001001728
-    | Mm_RefseqProtein = XP_001001728
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 43637693
-    | Mm_GenLoc_end = 43641620
-    | Mm_Uniprot =
-  }}
-}}
-'''Kallikrein-related peptidase 12''', also known as '''KLK12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLK12 kallikrein-related peptidase 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=43849| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
+{{PBB Summary
 | section_title =
-| summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: KLK12 kallikrein-related peptidase 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=43849| accessdate = }}</ref>
+| summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: KLK12 kallikrein-related peptidase 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=43849| accessdate = }}</ref>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Diamandis EP, Yousef GM, Luo LY, ''et al.'' |title=The new human kallikrein gene family: implications in carcinogenesis. |journal=Trends Endocrinol. Metab. |volume=11 |issue= 2 |pages= 54-60 |year= 2001 |pmid= 10675891 |doi=  }}
+*{{cite journal   |vauthors=Diamandis EP, Yousef GM, Luo LY, etal |title=The new human kallikrein gene family: implications in carcinogenesis. |journal=Trends Endocrinol. Metab. |volume=11 |issue= 2 |pages= 54–60 |year= 2001 |pmid= 10675891 |doi=  10.1016/S1043-2760(99)00225-8}}
-*{{cite journal  | author=Yousef GM, Luo LY, Diamandis EP |title=Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. |journal=Anticancer Res. |volume=19 |issue= 4B |pages= 2843-52 |year= 2000 |pmid= 10652563 |doi=  }}
+*{{cite journal  |vauthors=Yousef GM, Luo LY, Diamandis EP |title=Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. |journal=Anticancer Res. |volume=19 |issue= 4B |pages= 2843–52 |year= 2000 |pmid= 10652563 |doi=  }}
-*{{cite journal  | author=Harvey TJ, Hooper JD, Myers SA, ''et al.'' |title=Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37397-406 |year= 2001 |pmid= 10969073 |doi= 10.1074/jbc.M004525200 }}
+*{{cite journal   |vauthors=Harvey TJ, Hooper JD, Myers SA, etal |title=Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37397–406 |year= 2001 |pmid= 10969073 |doi= 10.1074/jbc.M004525200 }}
-*{{cite journal  | author=Yousef GM, Chang A, Scorilas A, Diamandis EP |title=Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 125-33 |year= 2000 |pmid= 11006094 |doi= 10.1006/bbrc.2000.3448 }}
+*{{cite journal  |vauthors=Yousef GM, Chang A, Scorilas A, Diamandis EP |title=Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 125–33 |year= 2000 |pmid= 11006094 |doi= 10.1006/bbrc.2000.3448 }}
-*{{cite journal  | author=Gan L, Lee I, Smith R, ''et al.'' |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119-30 |year= 2001 |pmid= 11054574 |doi=  }}
+*{{cite journal   |vauthors=Gan L, Lee I, Smith R, etal |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=10.1016/S0378-1119(00)00382-6  }}
-*{{cite journal  | author=Yousef GM, Magklara A, Diamandis EP |title=KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. |journal=Genomics |volume=69 |issue= 3 |pages= 331-41 |year= 2001 |pmid= 11056051 |doi= 10.1006/geno.2000.6346 }}
+*{{cite journal  |vauthors=Yousef GM, Magklara A, Diamandis EP |title=KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. |journal=Genomics |volume=69 |issue= 3 |pages= 331–41 |year= 2001 |pmid= 11056051 |doi= 10.1006/geno.2000.6346 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
+*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
-*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
+*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
-*{{cite journal  | author=Shinmura K, Tao H, Yamada H, ''et al.'' |title=Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. |journal=Hum. Mutat. |volume=24 |issue= 3 |pages= 273-4 |year= 2005 |pmid= 15300858 |doi= 10.1002/humu.9270 }}
+*{{cite journal   |vauthors=Shinmura K, Tao H, Yamada H, etal |title=Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. |journal=Hum. Mutat. |volume=24 |issue= 3 |pages= 273–4 |year= 2005 |pmid= 15300858 |doi= 10.1002/humu.9270 }}
-*{{cite journal  | author= |title=Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 635-824 |year= 2006 |pmid= 16800723 |doi= 10.1515/BC.2006.081 }}
+*{{cite journal  |vauthors=Memari N, Jiang W, Diamandis EP, Luo LY |title=Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). |journal=Biol. Chem. |volume=388 |issue= 4 |pages= 427–35 |year= 2007 |pmid= 17391064 |doi= 10.1515/BC.2007.049 }}
-*{{cite journal  | author=Lundwall A, Band V, Blaber M, ''et al.'' |title=A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 637-41 |year= 2006 |pmid= 16800724 |doi= 10.1515/BC.2006.082 }}
-*{{cite journal  | author=Memari N, Jiang W, Diamandis EP, Luo LY |title=Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). |journal=Biol. Chem. |volume=388 |issue= 4 |pages= 427-35 |year= 2007 |pmid= 17391064 |doi= 10.1515/BC.2007.049 }}
 }}
 {{refend}}
-{{protein-stub}}
+==External links==
-{{WikiDoc Sources}}
+* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=S01.020 S01.020]
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{gene-19-stub}}

KLK12: Difference between revisions

Latest revision as of 06:32, 2 September 2017

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