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{{ | '''Semenogelin-2''' is a [[protein]] that in humans is encoded by the ''SEMG2'' [[gene]].<ref name="pmid1517240">{{cite journal | vauthors = Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A | title = Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20 | journal = J Biol Chem | volume = 267 | issue = 25 | pages = 18080–4 |date=Oct 1992 | pmid = 1517240 | pmc = | doi = }}</ref><ref name="pmid9523691">{{cite journal | vauthors = Peter A, Lilja H, Lundwall A, Malm J | title = Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase | journal = Eur J Biochem | volume = 252 | issue = 2 | pages = 216–21 |date=Apr 1998 | pmid = 9523691 | pmc = | doi =10.1046/j.1432-1327.1998.2520216.x }}</ref><ref name="entrez"/> | ||
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| summary_text = The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.<ref name="entrez">{{cite web | title = Entrez Gene: SEMG2 semenogelin II| url = | | summary_text = The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.<ref name="entrez">{{cite web | title = Entrez Gene: SEMG2 semenogelin II| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6407| accessdate = }}</ref> | ||
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==See also== | |||
*[[Semenogelin]] | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Lilja H, Lundwall A |title=Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 10 |pages= 4559–63 |year= 1992 |pmid= 1584792 |doi=10.1073/pnas.89.10.4559 | pmc=49122 }} | ||
*{{cite journal | *{{cite journal |vauthors=Schneider K, Kausler W, Tripier D, etal |title=[Isolation and structure determination of two peptides occurring in human seminal plasma] |journal=Biol. Chem. Hoppe-Seyler |volume=370 |issue= 4 |pages= 353–6 |year= 1989 |pmid= 2757795 |doi= }} | ||
*{{cite journal | author= | *{{cite journal | author=Lundwall A |title=The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA |journal=Eur. J. Biochem. |volume=235 |issue= 3 |pages= 466–70 |year= 1996 |pmid= 8654389 |doi=10.1111/j.1432-1033.1996.00466.x }} | ||
*{{cite journal | *{{cite journal |vauthors=Malm J, Hellman J, Magnusson H, etal |title=Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 48–53 |year= 1996 |pmid= 8665951 |doi=10.1111/j.1432-1033.1996.0048q.x }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kise H, Nishioka J, Kawamura J, Suzuki K |title=Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 88–96 |year= 1996 |pmid= 8665956 |doi=10.1111/j.1432-1033.1996.0088q.x }} | ||
*{{cite journal | *{{cite journal |vauthors=Bjartell A, Malm J, Moller C, etal |title=Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry |journal=J. Androl. |volume=17 |issue= 1 |pages= 17–26 |year= 1997 |pmid= 8833737 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Ulvsbäck M, Lundwall A |title=Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon |journal=Eur. J. Biochem. |volume=245 |issue= 1 |pages= 25–31 |year= 1997 |pmid= 9128720 |doi=10.1111/j.1432-1033.1997.00025.x }} | ||
*{{cite journal | | *{{cite journal | vauthors=Lövgren J, Airas K, Lilja H |title=Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors |journal=Eur. J. Biochem. |volume=262 |issue= 3 |pages= 781–9 |year= 1999 |pmid= 10411640 |doi=10.1046/j.1432-1327.1999.00433.x }} | ||
*{{cite journal | | *{{cite journal | vauthors=Malm J, Hellman J, Hogg P, Lilja H |title=Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor |journal=Prostate |volume=45 |issue= 2 |pages= 132–9 |year= 2000 |pmid= 11027412 |doi=10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3 }} | ||
*{{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }} | |||
*{{cite journal | *{{cite journal |vauthors=Brillard-Bourdet M, Réhault S, Juliano L, etal |title=Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates |journal=Eur. J. Biochem. |volume=269 |issue= 1 |pages= 390–5 |year= 2002 |pmid= 11784334 |doi=10.1046/j.0014-2956.2001.02667.x }} | ||
*{{cite journal | | *{{cite journal | vauthors=Lundwall A, Bjartell A, Olsson AY, Malm J |title=Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues |journal=Mol. Hum. Reprod. |volume=8 |issue= 9 |pages= 805–10 |year= 2003 |pmid= 12200457 |doi=10.1093/molehr/8.9.805 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ek P, Malm J, Lilja H, etal |title=Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen |journal=J. Androl. |volume=23 |issue= 6 |pages= 806–14 |year= 2003 |pmid= 12399526 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Yoshida K, Yamasaki T, Yoshiike M, etal |title=Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma |journal=J. Androl. |volume=24 |issue= 6 |pages= 878–84 |year= 2004 |pmid= 14581514 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Jensen-Seaman MI, Li WH |title=Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen |journal=J. Mol. Evol. |volume=57 |issue= 3 |pages= 261–70 |year= 2004 |pmid= 14629036 |doi= 10.1007/s00239-003-2474-x }} | ||
*{{cite journal | *{{cite journal |vauthors=Dorus S, Evans PD, Wyckoff GJ, etal |title=Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity |journal=Nat. Genet. |volume=36 |issue= 12 |pages= 1326–9 |year= 2005 |pmid= 15531881 |doi= 10.1038/ng1471 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jonsson M, Linse S, Frohm B, etal |title=Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen |journal=Biochem. J. |volume=387 |issue= Pt 2 |pages= 447–53 |year= 2005 |pmid= 15563730 |doi= 10.1042/BJ20041424 | pmc=1134973 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Species | Human | Mouse | |||||
Entrez |
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Location (UCSC) | n/a | n/a | |||||
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Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.[1][2][3]
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.[3]
See also
References
- ↑ Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A (Oct 1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20". J Biol Chem. 267 (25): 18080–4. PMID 1517240.
- ↑ Peter A, Lilja H, Lundwall A, Malm J (Apr 1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase". Eur J Biochem. 252 (2): 216–21. doi:10.1046/j.1432-1327.1998.2520216.x. PMID 9523691.
- ↑ 3.0 3.1 "Entrez Gene: SEMG2 semenogelin II".
Further reading
- Lilja H, Lundwall A (1992). "Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4559–63. doi:10.1073/pnas.89.10.4559. PMC 49122. PMID 1584792.
- Schneider K, Kausler W, Tripier D, et al. (1989). "[Isolation and structure determination of two peptides occurring in human seminal plasma]". Biol. Chem. Hoppe-Seyler. 370 (4): 353–6. PMID 2757795.
- Lundwall A (1996). "The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA". Eur. J. Biochem. 235 (3): 466–70. doi:10.1111/j.1432-1033.1996.00466.x. PMID 8654389.
- Malm J, Hellman J, Magnusson H, et al. (1996). "Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II". Eur. J. Biochem. 238 (1): 48–53. doi:10.1111/j.1432-1033.1996.0048q.x. PMID 8665951.
- Kise H, Nishioka J, Kawamura J, Suzuki K (1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor". Eur. J. Biochem. 238 (1): 88–96. doi:10.1111/j.1432-1033.1996.0088q.x. PMID 8665956.
- Bjartell A, Malm J, Moller C, et al. (1997). "Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry". J. Androl. 17 (1): 17–26. PMID 8833737.
- Ulvsbäck M, Lundwall A (1997). "Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon". Eur. J. Biochem. 245 (1): 25–31. doi:10.1111/j.1432-1033.1997.00025.x. PMID 9128720.
- Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". Eur. J. Biochem. 262 (3): 781–9. doi:10.1046/j.1432-1327.1999.00433.x. PMID 10411640.
- Malm J, Hellman J, Hogg P, Lilja H (2000). "Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor". Prostate. 45 (2): 132–9. doi:10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3. PMID 11027412.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Brillard-Bourdet M, Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates". Eur. J. Biochem. 269 (1): 390–5. doi:10.1046/j.0014-2956.2001.02667.x. PMID 11784334.
- Lundwall A, Bjartell A, Olsson AY, Malm J (2003). "Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues". Mol. Hum. Reprod. 8 (9): 805–10. doi:10.1093/molehr/8.9.805. PMID 12200457.
- Ek P, Malm J, Lilja H, et al. (2003). "Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen". J. Androl. 23 (6): 806–14. PMID 12399526.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yoshida K, Yamasaki T, Yoshiike M, et al. (2004). "Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma". J. Androl. 24 (6): 878–84. PMID 14581514.
- Jensen-Seaman MI, Li WH (2004). "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen". J. Mol. Evol. 57 (3): 261–70. doi:10.1007/s00239-003-2474-x. PMID 14629036.
- Dorus S, Evans PD, Wyckoff GJ, et al. (2005). "Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity". Nat. Genet. 36 (12): 1326–9. doi:10.1038/ng1471. PMID 15531881.
- Jonsson M, Linse S, Frohm B, et al. (2005). "Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen". Biochem. J. 387 (Pt 2): 447–53. doi:10.1042/BJ20041424. PMC 1134973. PMID 15563730.
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