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{{Infobox_gene}}
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'''Galactosylceramide sulfotransferase''' is an [[enzyme]] that in humans is encoded by the ''GAL3ST1'' [[gene]].<ref name="pmid9847074">{{cite journal | title = Toward a complete human genome sequence | journal = Genome Res | volume = 8 | issue = 11 | pages = 1097–108 |date=Jan 1999 | pmid = 9847074 | pmc =  | doi =  10.1101/gr.8.11.1097}}</ref><ref name="pmid9030544">{{cite journal |vauthors=Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y | title = Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase | journal = J Biol Chem | volume = 272 | issue = 8 | pages = 4864–8 |date=Apr 1997 | pmid = 9030544 | pmc =  | doi =10.1074/jbc.272.8.4864 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9514| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Galactose-3-O-sulfotransferase 1
| HGNCid = 24240
| Symbol = GAL3ST1
| AltSymbols =; CST
| OMIM = 602300
  | ECnumber =   
| Homologene = 3574
| MGIid = 1858277
| GeneAtlas_image1 = PBB_GE_GAL3ST1_205670_at_tn.png
| Function = {{GNF_GO|id=GO:0001733 |text = galactosylceramide sulfotransferase activity}} {{GNF_GO|id=GO:0008146 |text = sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006487 |text = protein amino acid N-linked glycosylation}} {{GNF_GO|id=GO:0006682 |text = galactosylceramide biosynthetic process}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0009058 |text = biosynthetic process}} {{GNF_GO|id=GO:0042552 |text = myelination}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9514
    | Hs_Ensembl = ENSG00000128242
    | Hs_RefseqProtein = NP_004852
    | Hs_RefseqmRNA = NM_004861
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 29280624
    | Hs_GenLoc_end = 29286748
    | Hs_Uniprot = Q99999
    | Mm_EntrezGene = 53897
    | Mm_Ensembl = ENSMUSG00000049721
    | Mm_RefseqmRNA = NM_016922
    | Mm_RefseqProtein = NP_058618
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 3883639
    | Mm_GenLoc_end = 3899329
    | Mm_Uniprot = Q5SQ23
  }}
}}
'''Galactose-3-O-sulfotransferase 1''', also known as '''GAL3ST1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9514| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.<ref name="entrez">{{cite web | title = Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9514| accessdate = }}</ref>
| summary_text = Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Siegrist HP, Jutzi H, Steck AJ, ''et al.'' |title=Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures. |journal=Biochim. Biophys. Acta |volume=489 |issue= 1 |pages= 58-63 |year= 1977 |pmid= 911873 |doi=  }}
*{{cite journal  | author=Siegrist HP |title=Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures |journal=Biochim. Biophys. Acta |volume=489 |issue= 1 |pages= 58–63 |year= 1977 |pmid= 911873 |doi= 10.1016/0005-2760(77)90231-4|name-list-format=vanc| author2=Jutzi H  | author3=Steck AJ  | display-authors=3  | last4=Burkart  | first4=T  | last5=Wiesmann  | first5=U  | last6=Herschkowitz  | first6=N }}
*{{cite journal  | author=Stein C, Gieselmann V, Kreysing J, ''et al.'' |title=Cloning and expression of human arylsulfatase A. |journal=J. Biol. Chem. |volume=264 |issue= 2 |pages= 1252-9 |year= 1989 |pmid= 2562955 |doi=  }}
*{{cite journal  | author=Stein C |title=Cloning and expression of human arylsulfatase A |journal=J. Biol. Chem. |volume=264 |issue= 2 |pages= 1252–9 |year= 1989 |pmid= 2562955 |doi= |name-list-format=vanc| author2=Gieselmann V  | author3=Kreysing J  | display-authors=3  | last4=Schmidt  | first4=B  | last5=Pohlmann  | first5=R  | last6=Waheed  | first6=A  | last7=Meyer  | first7=HE  | last8=O'Brien  | first8=JS  | last9=Von Figura  | first9=K }}
*{{cite journal  | author=Fleischer B, Zambrano F |title=Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney. |journal=Biochem. Biophys. Res. Commun. |volume=52 |issue= 3 |pages= 951-8 |year= 1973 |pmid= 4710574 |doi=  }}
*{{cite journal  |vauthors=Fleischer B, Zambrano F |title=Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney |journal=Biochem. Biophys. Res. Commun. |volume=52 |issue= 3 |pages= 951–8 |year= 1973 |pmid= 4710574 |doi=10.1016/0006-291X(73)91029-2 }}
*{{cite journal  | author=Farrell DF, McKhann GM |title=Characterization of cerebroside sulfotransferase from rat brain. |journal=J. Biol. Chem. |volume=246 |issue= 15 |pages= 4694-702 |year= 1971 |pmid= 5562350 |doi=  }}
*{{cite journal  |vauthors=Farrell DF, McKhann GM |title=Characterization of cerebroside sulfotransferase from rat brain |journal=J. Biol. Chem. |volume=246 |issue= 15 |pages= 4694–702 |year= 1971 |pmid= 5562350 |doi=  }}
*{{cite journal  | author=Costantino-Ceccarini E, Waehneldt TV, Ginalski H, ''et al.'' |title=Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development. |journal=Neurochem. Res. |volume=7 |issue= 1 |pages= 1-12 |year= 1982 |pmid= 6280086 |doi=  }}
*{{cite journal  | author=Costantino-Ceccarini E |title=Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development |journal=Neurochem. Res. |volume=7 |issue= 1 |pages= 1–12 |year= 1982 |pmid= 6280086 |doi=10.1007/BF00965064  |name-list-format=vanc| author2=Waehneldt TV  | author3=Ginalski H  | display-authors=3  | last4=Burgisser  | first4=Philippe  | last5=Reigner  | first5=Jacqueline  | last6=Matthieu  | first6=Jean-Marie }}
*{{cite journal  | author=Benjamins JA, Hadden T, Skoff RP |title=Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain. |journal=J. Neurochem. |volume=38 |issue= 1 |pages= 233-41 |year= 1982 |pmid= 6955451 |doi=  }}
*{{cite journal  |vauthors=Benjamins JA, Hadden T, Skoff RP |title=Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain |journal=J. Neurochem. |volume=38 |issue= 1 |pages= 233–41 |year= 1982 |pmid= 6955451 |doi=10.1111/j.1471-4159.1982.tb10875.x }}
*{{cite journal  | author=Honke K, Yamane M, Ishii A, ''et al.'' |title=Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells. |journal=J. Biochem. |volume=119 |issue= 3 |pages= 421-7 |year= 1996 |pmid= 8830034 |doi=  }}
*{{cite journal  | author=Honke K |title=Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells |journal=J. Biochem. |volume=119 |issue= 3 |pages= 421–7 |year= 1996 |pmid= 8830034 |doi=  10.1093/oxfordjournals.jbchem.a021258|name-list-format=vanc| author2=Yamane M  | author3=Ishii A  | display-authors=3  | last4=Kobayashi  | first4=T | last5=Makita  | first5=A }}
*{{cite journal  | author=Honke K, Tsuda M, Hirahara Y, ''et al.'' |title=Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase. |journal=J. Biol. Chem. |volume=272 |issue= 8 |pages= 4864-8 |year= 1997 |pmid= 9030544 |doi= }}
*{{cite journal  | author=Tsuda M |title=Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2672–9 |year= 2000 |pmid= 10785389 |doi=10.1046/j.1432-1327.2000.01281.x  |name-list-format=vanc| author2=Egashira M  | author3=Niikawa N  | display-authors=3  | last4=Wada  | first4=Yoshinao  | last5=Honke  | first5=Koichi }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  |vauthors=Eckhardt M, Fewou SN, Ackermann I, Gieselmann V |title=N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase |journal=Biochem. J. |volume=368 |issue= Pt 1 |pages= 317–24 |year= 2002 |pmid= 12175333 |doi= 10.1042/BJ20020946 | pmc=1222978 }}
*{{cite journal  | author=Tsuda M, Egashira M, Niikawa N, ''et al.'' |title=Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2672-9 |year= 2000 |pmid= 10785389 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Eckhardt M, Fewou SN, Ackermann I, Gieselmann V |title=N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase. |journal=Biochem. J. |volume=368 |issue= Pt 1 |pages= 317-24 |year= 2002 |pmid= 12175333 |doi= 10.1042/BJ20020946 }}
*{{cite journal  | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604  |name-list-format=vanc| author2=Wright CL  | author3=Edwards CA  | display-authors=3  | last4=Davis  | first4=Matthew P  | last5=Grinham  | first5=James A  | last6=Cole  | first6=Charlotte G  | last7=Goward  | first7=Melanie E  | last8=Aguado  | first8=Begoña  | last9=Mallya  | first9=Meera }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 08:37, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.[1][2][3]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.[3]

References

  1. ↑ "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. Jan 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
  2. ↑ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.
  3. ↑ 3.0 3.1 "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

Further reading



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