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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cell division cycle 23 homolog (S. cerevisiae)''', also known as '''CDC23''', is a [[protein]] that, in humans, is encoded by the ''CDC23'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8697| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cell division cycle 23 homolog (S. cerevisiae)
| HGNCid = 1724
| Symbol = CDC23
| AltSymbols =; APC8
| OMIM = 603462
| ECnumber = 
| Homologene = 3426
| MGIid = 1098815
| GeneAtlas_image1 = PBB_GE_CDC23_202892_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005680 |text = anaphase-promoting complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000080 |text = G1 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007080 |text = mitotic metaphase plate congression}} {{GNF_GO|id=GO:0007096 |text = regulation of exit from mitosis}} {{GNF_GO|id=GO:0030071 |text = regulation of mitotic metaphase/anaphase transition}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8697
    | Hs_Ensembl = ENSG00000094880
    | Hs_RefseqProtein = NP_004652
    | Hs_RefseqmRNA = NM_004661
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 137551259
    | Hs_GenLoc_end = 137576918
    | Hs_Uniprot = Q9UJX2
    | Mm_EntrezGene = 52563
    | Mm_Ensembl = ENSMUSG00000024370
    | Mm_RefseqmRNA = NM_178347
    | Mm_RefseqProtein = NP_848124
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 34756484
    | Mm_GenLoc_end = 34776537
    | Mm_Uniprot = Q3TEF0
  }}
}}
'''Cell division cycle 23 homolog (S. cerevisiae)''', also known as '''CDC23''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8697| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for [[cell cycle]] progression through the G2/M transition. This protein is a component of [[anaphase-promoting complex]] (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of [[cyclin B]]-[[ubiquitin]] conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the [[tetratricopeptide|TPR]] (tetratricopeptide repeat), a protein domain important for protein-protein interaction.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.<ref name="entrez">{{cite web | title = Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8697| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CDC23 has been shown to [[Protein-protein interaction|interact]] with [[CDC27]].<ref name=pmid12956947>{{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | date = Sep 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 }}</ref><ref name=pmid10922056>{{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8 | date = Aug 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CDC23}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4  | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56  | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW | title = Identification of a cullin homology region in a subunit of the anaphase-promoting complex | journal = Science | volume = 279 | issue = 5354 | pages = 1219–22  | date = Feb 1998 | pmid = 9469815 | doi = 10.1126/science.279.5354.1219 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Zhao N, Lai F, Fernald AA, Eisenbart JD, Espinosa R, Wang PW, Le Beau MM | title = Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias | journal = Genomics | volume = 53 | issue = 2 | pages = 184–90  | date = Oct 1998 | pmid = 9790767 | doi = 10.1006/geno.1998.5473 }}
*{{cite journal | author=Yu H, Peters JM, King RW, ''et al.'' |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219-22 |year= 1998 |pmid= 9469815 |doi= }}
* {{cite journal | vauthors = Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM | title = Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex | journal = The Journal of Biological Chemistry | volume = 274 | issue = 20 | pages = 14500–7  | date = May 1999 | pmid = 10318877 | doi = 10.1074/jbc.274.20.14500 }}
*{{cite journal | author=Zhao N, Lai F, Fernald AA, ''et al.'' |title=Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. |journal=Genomics |volume=53 |issue= 2 |pages= 184-90 |year= 1998 |pmid= 9790767 |doi= 10.1006/geno.1998.5473 }}
* {{cite journal | vauthors = Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM | title = Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11317–22  | date = Sep 1999 | pmid = 10500174 | pmc = 18031 | doi = 10.1073/pnas.96.20.11317 }}
*{{cite journal | author=Grossberger R, Gieffers C, Zachariae W, ''et al.'' |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500-7 |year= 1999 |pmid= 10318877 |doi= }}
* {{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8  | date = Aug 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 }}
*{{cite journal | author=Gieffers C, Peters BH, Kramer ER, ''et al.'' |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317-22 |year= 1999 |pmid= 10500174 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | year = 2001 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Gmachl M, Gieffers C, Podtelejnikov AV, ''et al.'' |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973-8 |year= 2000 |pmid= 10922056 |doi= }}
* {{cite journal | vauthors = Walker MG | title = Drug target discovery by gene expression analysis: cell cycle genes | journal = Current Cancer Drug Targets | volume = 1 | issue = 1 | pages = 73–83 | year = 2002 | date = May 2001 | pmid = 12188893 | doi = 10.2174/1568009013334241 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A | title = Alterations of anaphase-promoting complex genes in human colon cancer cells | journal = Oncogene | volume = 22 | issue = 10 | pages = 1486–90  | date = Mar 2003 | pmid = 12629511 | doi = 10.1038/sj.onc.1206224 }}
*{{cite journal | author=Walker MG |title=Drug target discovery by gene expression analysis: cell cycle genes. |journal=Current cancer drug targets |volume=1 |issue= 1 |pages= 73-83 |year= 2002 |pmid= 12188893 |doi= }}
* {{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | year = 2004 | date = Sep 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM | title = Mitotic regulation of the human anaphase-promoting complex by phosphorylation | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6598–609 | year = 2004 | date = Dec 2003 | pmid = 14657031 | pmc = 291822 | doi = 10.1093/emboj/cdg627 }}
*{{cite journal | author=Wang Q, Moyret-Lalle C, Couzon F, ''et al.'' |title=Alterations of anaphase-promoting complex genes in human colon cancer cells. |journal=Oncogene |volume=22 |issue= 10 |pages= 1486-90 |year= 2003 |pmid= 12629511 |doi= 10.1038/sj.onc.1206224 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5  | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Vodermaier HC, Gieffers C, Maurer-Stroh S, ''et al.'' |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459-68 |year= 2004 |pmid= 12956947 |doi= }}
* {{cite journal | vauthors = Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain | journal = Molecular & Cellular Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | year = 2005 | date = Nov 2004 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 }}
*{{cite journal | author=Kraft C, Herzog F, Gieffers C, ''et al.'' |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598-609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6  | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92  | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:25, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.[1]

Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.[1]

Interactions

CDC23 has been shown to interact with CDC27.[2][3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)".
  2. ↑ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
  3. ↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

External links

Further reading


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