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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Synaptopodin''' is a [[protein]] that in humans is encoded by the ''SYNPO'' [[gene]].<ref name="pmid9314539">{{cite journal | vauthors = Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J, Kriz W | title = Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes | journal = The Journal of Cell Biology | volume = 139 | issue = 1 | pages = 193–204 | date = Oct 1997 | pmid = 9314539 | pmc = 2139823 | doi = 10.1083/jcb.139.1.193 }}</ref><ref name="pmid10470851">{{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = Jun 1999 | pmid = 10470851 | pmc =  | doi = 10.1093/dnares/6.3.197 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SYNPO synaptopodin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11346| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Synaptopodin
| HGNCid = 30672
| Symbol = SYNPO
| AltSymbols =; KIAA1029
| OMIM = 608155
| ECnumber = 
| Homologene = 5274
| MGIid = 1099446
| GeneAtlas_image1 = PBB_GE_SYNPO_202796_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}}
| Process = {{GNF_GO|id=GO:0030865 |text = cortical cytoskeleton organization and biogenesis}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11346
    | Hs_Ensembl = ENSG00000171992
    | Hs_RefseqProtein = NP_009217
    | Hs_RefseqmRNA = NM_007286
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 149960835
    | Hs_GenLoc_end = 150018962
    | Hs_Uniprot = Q8N3V7
    | Mm_EntrezGene = 104027
    | Mm_Ensembl = ENSMUSG00000043079
    | Mm_RefseqmRNA = XM_894564
    | Mm_RefseqProtein = XP_899657
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 60719360
    | Mm_GenLoc_end = 60755202
    | Mm_Uniprot = Q3TBE2
  }}
}}
'''Synaptopodin''', also known as '''SYNPO''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SYNPO synaptopodin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11346| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SYNPO synaptopodin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11346| accessdate = }}</ref>
}}


==References==
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM]<ref name="entrez"/>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
SYNPO has been shown to [[Protein-protein interaction|interact]] with [[MAGI1]].<ref name=pmid12042308>{{cite journal | vauthors = Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B | title = Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30183–90 | date = Aug 2002 | pmid = 12042308 | doi = 10.1074/jbc.M203072200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | date = Sep 1995 | pmid = 7566098 | doi = <!-- none available --> | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format = PDF }}
| citations =
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal  | author=Mundel P, Heid HW, Mundel TM, ''et al.'' |title=Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. |journal=J. Cell Biol. |volume=139 |issue= 1 |pages= 193-204 |year= 1998 |pmid= 9314539 |doi=  }}
* {{cite journal | vauthors = Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B | title = Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30183–90 | date = Aug 2002 | pmid = 12042308 | doi = 10.1074/jbc.M203072200 }}
*{{cite journal  | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE | title = Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways | journal = The Journal of Clinical Investigation | volume = 114 | issue = 5 | pages = 643–51 | date = Sep 2004 | pmid = 15343382 | pmc = 514582 | doi = 10.1172/JCI21004 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Patrie KM, Drescher AJ, Welihinda A, ''et al.'' |title=Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30183-90 |year= 2002 |pmid= 12042308 |doi= 10.1074/jbc.M203072200 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = Jan 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kremerskothen J, Plaas C, Kindler S, Frotscher M, Barnekow A | title = Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein | journal = Journal of Neurochemistry | volume = 92 | issue = 3 | pages = 597–606 | date = Feb 2005 | pmid = 15659229 | doi = 10.1111/j.1471-4159.2004.02888.x }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Asanuma K, Kim K, Oh J, Giardino L, Chabanis S, Faul C, Reiser J, Mundel P | title = Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner | journal = The Journal of Clinical Investigation | volume = 115 | issue = 5 | pages = 1188–98 | date = May 2005 | pmid = 15841212 | pmc = 1070637 | doi = 10.1172/JCI23371 }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Husain M, D'Agati VD, He JC, Klotman ME, Klotman PE | title = HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN | journal = AIDS | volume = 19 | issue = 17 | pages = 1975–80 | date = Nov 2005 | pmid = 16260903 | doi = 10.1097/01.aids.0000191918.42110.27 }}
*{{cite journal | author=He JC, Husain M, Sunamoto M, ''et al.'' |title=Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. |journal=J. Clin. Invest. |volume=114 |issue= 5 |pages= 643-51 |year= 2004 |pmid= 15343382 |doi= 10.1172/JCI200421004 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
* {{cite journal | vauthors = Hirakawa M, Tsuruya K, Yotsueda H, Tokumoto M, Ikeda H, Katafuchi R, Fujimi S, Hirakata H, Iida M | title = Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis | journal = Life Sciences | volume = 79 | issue = 8 | pages = 757–63 | date = Jul 2006 | pmid = 16564554 | doi = 10.1016/j.lfs.2006.02.031 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
* {{cite journal | vauthors = Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P | title = Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 485–91 | date = May 2006 | pmid = 16622418 | doi = 10.1038/ncb1400 }}
*{{cite journal | author=Kremerskothen J, Plaas C, Kindler S, ''et al.'' |title=Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein. |journal=J. Neurochem. |volume=92 |issue= 3 |pages= 597-606 |year= 2005 |pmid= 15659229 |doi= 10.1111/j.1471-4159.2004.02888.x }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Asanuma K, Kim K, Oh J, ''et al.'' |title=Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. |journal=J. Clin. Invest. |volume=115 |issue= 5 |pages= 1188-98 |year= 2005 |pmid= 15841212 |doi= 10.1172/JCI200523371 }}
* {{cite journal | vauthors = Garovic VD, Wagner SJ, Petrovic LM, Gray CE, Hall P, Sugimoto H, Kalluri R, Grande JP | title = Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia | journal = Nephrology, Dialysis, Transplantation | volume = 22 | issue = 4 | pages = 1136–43 | date = Apr 2007 | pmid = 17255128 | doi = 10.1093/ndt/gfl711 }}
*{{cite journal | author=Husain M, D'Agati VD, He JC, ''et al.'' |title=HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. |journal=AIDS |volume=19 |issue= 17 |pages= 1975-80 |year= 2006 |pmid= 16260903 |doi= }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Hirakawa M, Tsuruya K, Yotsueda H, ''et al.'' |title=Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis. |journal=Life Sci. |volume=79 |issue= 8 |pages= 757-63 |year= 2006 |pmid= 16564554 |doi= 10.1016/j.lfs.2006.02.031 }}
*{{cite journal | author=Asanuma K, Yanagida-Asanuma E, Faul C, ''et al.'' |title=Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 485-91 |year= 2006 |pmid= 16622418 |doi= 10.1038/ncb1400 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Garovic VD, Wagner SJ, Petrovic LM, ''et al.'' |title=Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 4 |pages= 1136-43 |year= 2007 |pmid= 17255128 |doi= 10.1093/ndt/gfl711 }}
}}
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Latest revision as of 07:23, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Synaptopodin is a protein that in humans is encoded by the SYNPO gene.[1][2][3]

Function

Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM][3]

Interactions

SYNPO has been shown to interact with MAGI1.[4]

References

  1. ↑ Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J, Kriz W (Oct 1997). "Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes". The Journal of Cell Biology. 139 (1): 193–204. doi:10.1083/jcb.139.1.193. PMC 2139823. PMID 9314539.
  2. ↑ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  3. ↑ 3.0 3.1 "Entrez Gene: SYNPO synaptopodin".
  4. ↑ Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". The Journal of Biological Chemistry. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SYNPO&oldid=1420427"