NOLA2: Difference between revisions

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'''H/ACA ribonucleoprotein complex subunit 2''' is a [[protein]] that in humans is encoded by the ''NHP2'' [[gene]].<ref name="pmid11074001">{{cite journal | vauthors = Pogacic V, Dragon F, Filipowicz W | title = Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10 | journal = Mol Cell Biol | volume = 20 | issue = 23 | pages = 9028–40 |date=Dec 2000 | pmid = 11074001 | pmc = 86556 | doi =10.1128/MCB.20.23.9028-9040.2000 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55651| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)
| HGNCid = 14377
| Symbol = NOLA2
| AltSymbols =; NHP2; NHP2P
| OMIM = 606470
| ECnumber =
| Homologene = 5524
| MGIid = 1098547
| GeneAtlas_image1 = PBB_GE_NOLA2_209104_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NOLA2_216583_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0030515 |text = snoRNA binding}} {{GNF_GO|id=GO:0030559 |text = rRNA pseudouridylation guide activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005732 |text = small nucleolar ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006365 |text = 35S primary transcript processing}} {{GNF_GO|id=GO:0031118 |text = rRNA pseudouridine synthesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55651
    | Hs_Ensembl = ENSG00000145912
    | Hs_RefseqProtein = NP_001030005
    | Hs_RefseqmRNA = NM_001034833
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 177509074
    | Hs_GenLoc_end = 177513567
    | Hs_Uniprot = Q9NX24
    | Mm_EntrezGene = 52530
    | Mm_Ensembl = ENSMUSG00000001056
    | Mm_RefseqmRNA = NM_026631
    | Mm_RefseqProtein = NP_080907
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 51463196
    | Mm_GenLoc_end = 51467137
    | Mm_Uniprot = Q9CRB2
  }}
}}
'''Nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)''', also known as '''NOLA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55651| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55651| accessdate = }}</ref>
| summary_text = This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Henras A, Henry Y, Bousquet-Antonelli C, ''et al.'' |title=Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. |journal=EMBO J. |volume=17 |issue= 23 |pages= 7078-90 |year= 1999 |pmid= 9843512 |doi= 10.1093/emboj/17.23.7078 }}
*{{cite journal   |vauthors=Henras A, Henry Y, Bousquet-Antonelli C, etal |title=Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. |journal=EMBO J. |volume=17 |issue= 23 |pages= 7078–90 |year= 1999 |pmid= 9843512 |doi= 10.1093/emboj/17.23.7078 | pmc=1171055 }}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
*{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934 }}
*{{cite journal  | author=Pogacić V, Dragon F, Filipowicz W |title=Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 9028-40 |year= 2000 |pmid= 11074001 |doi=  }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal   |vauthors=Kang HS, Jung HM, Jun DY, etal |title=Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells. |journal=Biochim. Biophys. Acta |volume=1575 |issue= 1-3 |pages= 31–9 |year= 2002 |pmid= 12020816 |doi=  10.1016/s0167-4781(02)00240-3}}
*{{cite journal | author=Kang HS, Jung HM, Jun DY, ''et al.'' |title=Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells. |journal=Biochim. Biophys. Acta |volume=1575 |issue= 1-3 |pages= 31-9 |year= 2002 |pmid= 12020816 |doi=  }}
*{{cite journal   |vauthors=Scherl A, Couté Y, Déon C, etal |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Wang C, Meier UT |title=Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. |journal=EMBO J. |volume=23 |issue= 8 |pages= 1857–67 |year= 2005 |pmid= 15044956 |doi= 10.1038/sj.emboj.7600181 | pmc=394235 }}
*{{cite journal  | author=Wang C, Meier UT |title=Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. |journal=EMBO J. |volume=23 |issue= 8 |pages= 1857-67 |year= 2005 |pmid= 15044956 |doi= 10.1038/sj.emboj.7600181 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | vauthors=Slizhikova DK, Vinogradova TV, Sverdlov ED |title=[The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer] |journal=Bioorg. Khim. |volume=31 |issue= 2 |pages= 195–9 |year= 2005 |pmid= 15889794 |doi=  }}
*{{cite journal  | author=Slizhikova DK, Vinogradova TV, Sverdlov ED |title=[The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer] |journal=Bioorg. Khim. |volume=31 |issue= 2 |pages= 195-9 |year= 2005 |pmid= 15889794 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 11:49, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene.[1][2]

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ↑ Pogacic V, Dragon F, Filipowicz W (Dec 2000). "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10". Mol Cell Biol. 20 (23): 9028–40. doi:10.1128/MCB.20.23.9028-9040.2000. PMC 86556. PMID 11074001.
  2. ↑ 2.0 2.1 "Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)".

Further reading



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