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{{Infobox_gene}}
'''Transcription factor TFIIIB component B homolog''' also known as '''TFIIIB150''' is a [[protein]] that in humans is encoded by the ''BDP1'' [[gene]].<ref name="pmid11214970">{{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 6 | pages = 347–55 |date=Feb 2001 | pmid = 11214970 | pmc =  | doi =10.1093/dnares/7.6.347  }}</ref><ref name="pmid11040218">{{cite journal | vauthors = Schramm L, Pendergrast PS, Sun Y, Hernandez N | title = Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters | journal = Genes Dev | volume = 14 | issue = 20 | pages = 2650–63 |date=Nov 2000 | pmid = 11040218 | pmc = 316990 | doi =10.1101/gad.836400  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55814| accessdate = }}</ref>
== Function ==
TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits [[RNA polymerase III]] to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by {{SWL|target=casein kinase 2|type=phosphorylated_by}} during [[mitosis]], resulting in its release from [[chromatin]] and suppression of polymerase III transcription.<ref name="entrez" />
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | vauthors=Chu WM, Wang Z, Roeder RG, Schmid CW |title=RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2 |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14755–61 |year= 1997 |pmid= 9169441 |doi=10.1074/jbc.272.23.14755  }}
*{{cite journal  | vauthors=Wang Z, Roeder RG |title=Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation |journal=Genes Dev. |volume=11 |issue= 10 |pages= 1315–26 |year= 1997 |pmid= 9171375 |doi=10.1101/gad.11.10.1315  }}
*{{cite journal  | vauthors=Nagase T, Ishikawa K, Kikuno R |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=10.1093/dnares/6.5.337  |display-authors=etal}}
*{{cite journal  | vauthors=Kelter AR, Herchenbach J, Wirth B |title=The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1 |journal=Genomics |volume=70 |issue= 3 |pages= 315–26 |year= 2001 |pmid= 11161782 |doi= 10.1006/geno.2000.6396 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Hu P, Wu S, Hernandez N |title=A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2 |journal=Mol. Cell |volume=12 |issue= 3 |pages= 699–709 |year= 2003 |pmid= 14527415 |doi=10.1016/j.molcel.2003.08.011  }}
*{{cite journal  | vauthors=Fairley JA, Scott PH, White RJ |title=TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo |journal=EMBO J. |volume=22 |issue= 21 |pages= 5841–50 |year= 2003 |pmid= 14592981 |doi= 10.1093/emboj/cdg544  | pmc=275401 }}
*{{cite journal  | vauthors=Weser S, Gruber C, Hafner HM |title=Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27022–9 |year= 2004 |pmid= 15096501 |doi= 10.1074/jbc.M312790200 |display-authors=etal}}
*{{cite journal  | vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 |display-authors=etal}}
*{{cite journal  | vauthors=Hu P, Samudre K, Wu S |title=CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression |journal=Mol. Cell |volume=16 |issue= 1 |pages= 81–92 |year= 2004 |pmid= 15469824 |doi= 10.1016/j.molcel.2004.09.008 |display-authors=etal}}
*{{cite journal  | vauthors=Schoenen F, Wirth B |title=The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB |journal=Biol. Chem. |volume=387 |issue= 3 |pages= 277–84 |year= 2006 |pmid= 16542149 |doi= 10.1515/BC.2006.037 }}
*{{cite journal  | vauthors=Johnson SS, Zhang C, Fromm J |title=Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases |journal=Mol. Cell |volume=26 |issue= 3 |pages= 367–79 |year= 2007 |pmid= 17499043 |doi= 10.1016/j.molcel.2007.03.021 |display-authors=etal}}
}}
{{refend}}
==External links==
* {{FactorBook|BDP1}}
* {{UCSC gene info|BDP1}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
| HGNCid = 13652
| Symbol = BDP1
| AltSymbols =; TFIIIB90; DKFZp686C01233; DKFZp686K0831; HSA238520; KIAA1241; KIAA1689; TAF3B1; TFC5; TFIIIB''; TFIIIB150; TFNR
| OMIM = 607012
| ECnumber = 
| Homologene = 34582
| MGIid = 1347077
| GeneAtlas_image1 = PBB_GE_BDP1_gnf1h09674_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55814
    | Hs_Ensembl = ENSG00000145734
    | Hs_RefseqProtein = NP_060899
    | Hs_RefseqmRNA = NM_018429
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 70787451
    | Hs_GenLoc_end = 70899402
    | Hs_Uniprot = 
    | Mm_EntrezGene = 544971
    | Mm_Ensembl = ENSMUSG00000049658
    | Mm_RefseqmRNA = XM_127501
    | Mm_RefseqProtein = XP_127501
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 101118254
    | Mm_GenLoc_end = 101175878
    | Mm_Uniprot = 
  }}
}}
'''B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB''', also known as '''BDP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55814| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.<ref name="entrez">{{cite web | title = Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55814| accessdate = }}</ref>
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Chu WM, Wang Z, Roeder RG, Schmid CW |title=RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14755-61 |year= 1997 |pmid= 9169441 |doi=  }}
*{{cite journal  | author=Wang Z, Roeder RG |title=Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. |journal=Genes Dev. |volume=11 |issue= 10 |pages= 1315-26 |year= 1997 |pmid= 9171375 |doi=  }}
*{{cite journal  | author=Nagase T, Ishikawa K, Kikuno R, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337-45 |year= 2000 |pmid= 10574462 |doi=  }}
*{{cite journal  | author=Schramm L, Pendergrast PS, Sun Y, Hernandez N |title=Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. |journal=Genes Dev. |volume=14 |issue= 20 |pages= 2650-63 |year= 2000 |pmid= 11040218 |doi=  }}
*{{cite journal  | author=Kelter AR, Herchenbach J, Wirth B |title=The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1. |journal=Genomics |volume=70 |issue= 3 |pages= 315-26 |year= 2001 |pmid= 11161782 |doi= 10.1006/geno.2000.6396 }}
*{{cite journal  | author=Nagase T, Kikuno R, Hattori A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347-55 |year= 2001 |pmid= 11214970 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hu P, Wu S, Hernandez N |title=A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 699-709 |year= 2003 |pmid= 14527415 |doi=  }}
*{{cite journal  | author=Fairley JA, Scott PH, White RJ |title=TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo. |journal=EMBO J. |volume=22 |issue= 21 |pages= 5841-50 |year= 2003 |pmid= 14592981 |doi= 10.1093/emboj/cdg544 }}
*{{cite journal  | author=Weser S, Gruber C, Hafner HM, ''et al.'' |title=Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27022-9 |year= 2004 |pmid= 15096501 |doi= 10.1074/jbc.M312790200 }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | author=Hu P, Samudre K, Wu S, ''et al.'' |title=CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression. |journal=Mol. Cell |volume=16 |issue= 1 |pages= 81-92 |year= 2004 |pmid= 15469824 |doi= 10.1016/j.molcel.2004.09.008 }}
*{{cite journal  | author=Schoenen F, Wirth B |title=The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB. |journal=Biol. Chem. |volume=387 |issue= 3 |pages= 277-84 |year= 2006 |pmid= 16542149 |doi= 10.1515/BC.2006.037 }}
*{{cite journal  | author=Johnson SS, Zhang C, Fromm J, ''et al.'' |title=Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases. |journal=Mol. Cell |volume=26 |issue= 3 |pages= 367-79 |year= 2007 |pmid= 17499043 |doi= 10.1016/j.molcel.2007.03.021 }}
}}
{{refend}}


{{protein-stub}}
{{gene-5-stub}}
{{WikiDoc Sources}}

Latest revision as of 02:33, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor TFIIIB component B homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.[1][2][3]

Function

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.[3]

References

  1. ↑ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  2. ↑ Schramm L, Pendergrast PS, Sun Y, Hernandez N (Nov 2000). "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters". Genes Dev. 14 (20): 2650–63. doi:10.1101/gad.836400. PMC 316990. PMID 11040218.
  3. ↑ 3.0 3.1 "Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB".

Further reading

External links



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