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{{Infobox_gene}}
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'''HLA class II histocompatibility antigen, DP(W2) beta chain''' is a [[protein]] that in humans is encoded by the ''HLA-DPB1'' [[gene]].
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Major histocompatibility complex, class II, DP beta 1
| HGNCid = 4940
| Symbol = HLA-DPB1
| AltSymbols =; DPB1; HLA-DP1B; MHC DPB1
| OMIM = 142858
| ECnumber = 
| Homologene = 88656
| MGIid = 
| GeneAtlas_image1 = PBB_GE_HLA-DPB1_201137_s_at_tn.png
| Function = {{GNF_GO|id=GO:0032395 |text = MHC class II receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3115
    | Hs_Ensembl = ENSG00000168383
    | Hs_RefseqProtein = NP_002112
    | Hs_RefseqmRNA = NM_002121
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 33151694
    | Hs_GenLoc_end = 33162956
    | Hs_Uniprot = P04232
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Major histocompatibility complex, class II, DP beta 1''', also known as '''HLA-DPB1''', is a human [[gene]].
 
 


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.<ref>{{cite web | title = Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3115| accessdate = }}</ref>
| summary_text = HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.<ref>{{cite web | title = Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3115| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist}}
{{reflist}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Mitsunaga S, Kuwata S, Tokunaga K, ''et al.'' |title=Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles. |journal=Hum. Immunol. |volume=34 |issue= 3 |pages= 203-11 |year= 1992 |pmid= 1358867 |doi=  }}
*{{cite journal  | author=Mitsunaga S |title=Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles |journal=Hum. Immunol. |volume=34 |issue= 3 |pages= 203–11 |year= 1992 |pmid= 1358867 |doi=10.1016/0198-8859(92)90113-2 |name-list-format=vanc| author2=Kuwata S | author3=Tokunaga K  | display-authors=3  | last4=Uchikawa  | first4=Chieko  | last5=Takahashi  | first5=Koki  | last6=Akaza  | first6=Tatsuya  | last7=Mitomi  | first7=Yoshitada  | last8=Juji  | first8=Takeo }}
*{{cite journal | author=Marsh SG, Bodmer JG |title=HLA class II nucleotide sequences, 1992. |journal=Tissue Antigens |volume=40 |issue= 5 |pages= 229-43 |year= 1993 |pmid= 1362295 |doi=  }}
*{{cite journal  |vauthors=Marsh SG, Bodmer JG |title=HLA class II nucleotide sequences, 1992 |journal=Tissue Antigens |volume=40 |issue= 5 |pages= 229–43 |year= 1993 |pmid= 1362295 |doi=10.1111/j.1399-0039.1992.tb02050.x }}
*{{cite journal  | author=Eiermann TH, Uhl S, Fakler J, Goldmann SF |title=A novel HLA-DPB1 sequence, DPB1*2301. |journal=Tissue Antigens |volume=40 |issue= 2 |pages= 108-10 |year= 1992 |pmid= 1412416 |doi=  }}
*{{cite journal  |vauthors=Eiermann TH, Uhl S, Fakler J, Goldmann SF |title=A novel HLA-DPB1 sequence, DPB1*2301 |journal=Tissue Antigens |volume=40 |issue= 2 |pages= 108–10 |year= 1992 |pmid= 1412416 |doi=10.1111/j.1399-0039.1992.tb01969.x }}
*{{cite journal  | author=Korioth F, Hartung K, Deicher H, Frey J |title=A new HLA-DPB1 allele from a patient with systemic lupus erythematosus. |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 216-9 |year= 1992 |pmid= 1529429 |doi=  }}
*{{cite journal  |vauthors=Korioth F, Hartung K, Deicher H, Frey J |title=A new HLA-DPB1 allele from a patient with systemic lupus erythematosus |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 216–9 |year= 1992 |pmid= 1529429 |doi=10.1111/j.1399-0039.1992.tb01938.x  }}
*{{cite journal  | author=de Koster HS, Kenter MJ, D'Amaro J, ''et al.'' |title=Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules. |journal=Immunogenetics |volume=34 |issue= 1 |pages= 12-22 |year= 1991 |pmid= 1713190 |doi= }}
*{{cite journal  | author=de Koster HS |title=Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules |journal=Immunogenetics |volume=34 |issue= 1 |pages= 12–22 |year= 1991 |pmid= 1713190 |doi=10.1007/BF00212307 |name-list-format=vanc| author2=Kenter MJ | author3=D'Amaro J  | display-authors=3  | last4=Luiten  | first4=R. M.  | last5=Schroeijers  | first5=W. E. M.  | last6=Giphart  | first6=M. J.  | last7=Termijtelen  | first7=A. }}
*{{cite journal  | author=Vanderbeeken YE, Duchateau J, Colle H, ''et al.'' |title=Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes. |journal=Arch. Gynecol. Obstet. |volume=248 |issue= 4 |pages= 199-209 |year= 1991 |pmid= 1832848 |doi=  }}
*{{cite journal  | author=Vanderbeeken YE |title=Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes |journal=Arch. Gynecol. Obstet. |volume=248 |issue= 4 |pages= 199–209 |year= 1991 |pmid= 1832848 |doi=10.1007/BF02390359 |name-list-format=vanc| author2=Duchateau J  | author3=Colle H  | display-authors=3  | last4=Gregoire  | first4=M. | last5=Desseilles  | first5=P.  | last6=Lucas  | first6=A. }}
*{{cite journal | author=Piatier-Tonneau D, Gastinel LN, Amblard F, ''et al.'' |title=Interaction of CD4 with HLA class II antigens and HIV gp120. |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121-8 |year= 1991 |pmid= 1869305 |doi=  }}
*{{cite journal  | author=Piatier-Tonneau D |title=Interaction of CD4 with HLA class II antigens and HIV gp120 |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121–8 |year= 1991 |pmid= 1869305 |doi=10.1007/BF00211424 |name-list-format=vanc| author2=Gastinel LN | author3=Amblard F  | display-authors=3  | last4=Wojcik  | first4=Marianne  | last5=Vaigot  | first5=Pierre  | last6=Auffray  | first6=Charles  }}
*{{cite journal  | author=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion. |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526-31 |year= 1990 |pmid= 1967269 |doi=  }}
*{{cite journal  |vauthors=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526–31 |year= 1990 |pmid= 1967269 |doi=  }}
*{{cite journal  | author=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052-6 |year= 1991 |pmid= 1978941 |doi=  }}
*{{cite journal  |vauthors=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052–6 |year= 1991 |pmid= 1978941 |doi=10.1073/pnas.87.22.9052 | pmc=55099  }}
*{{cite journal  | author=Bugawan TL, Begovich AB, Erlich HA |title=Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes. |journal=Immunogenetics |volume=32 |issue= 4 |pages= 231-41 |year= 1990 |pmid= 2242906 |doi=  }}
*{{cite journal  |vauthors=Bugawan TL, Begovich AB, Erlich HA |title=Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes |journal=Immunogenetics |volume=32 |issue= 4 |pages= 231–41 |year= 1990 |pmid= 2242906 |doi=10.1007/BF00187094 }}
*{{cite journal | author=Lair B, Alber C, Yu WY, ''et al.'' |title=A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity. |journal=J. Immunol. |volume=141 |issue= 4 |pages= 1353-7 |year= 1988 |pmid= 2456351 |doi=  }}
*{{cite journal  | author=Lair B |title=A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity |journal=J. Immunol. |volume=141 |issue= 4 |pages= 1353–7 |year= 1988 |pmid= 2456351 |doi=  |name-list-format=vanc| author2=Alber C  | author3=Yu WY  | display-authors=3  | last4=Watts  | first4=R  | last5=Bahl  | first5=M  | last6=Karr  | first6=RW }}
*{{cite journal  | author=Bugawan TL, Horn GT, Long CM, ''et al.'' |title=Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci. |journal=J. Immunol. |volume=141 |issue= 11 |pages= 4024-30 |year= 1988 |pmid= 2460556 |doi=  }}
*{{cite journal  | author=Bugawan TL |title=Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci |journal=J. Immunol. |volume=141 |issue= 11 |pages= 4024–30 |year= 1988 |pmid= 2460556 |doi=  |name-list-format=vanc| author2=Horn GT | author3=Long CM  | display-authors=3  | last4=Mickelson  | first4=E  | last5=Hansen  | first5=JA  | last6=Ferrara  | first6=GB  | last7=Angelini  | first7=G  | last8=Erlich  | first8=HA }}
*{{cite journal  | author=Begovich AB, Bugawan TL, Nepom BS, ''et al.'' |title=A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 23 |pages= 9489-93 |year= 1990 |pmid= 2512583 |doi=  }}
*{{cite journal  | author=Begovich AB |title=A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 23 |pages= 9489–93 |year= 1990 |pmid= 2512583 |doi=10.1073/pnas.86.23.9489  | pmc=298522  |name-list-format=vanc| author2=Bugawan TL  | author3=Nepom BS  | display-authors=3  | last4=Klitz  | first4=W  | last5=Nepom  | first5=GT  | last6=Erlich  | first6=HA  }}
*{{cite journal  | author=Scholl P, Diez A, Mourad W, ''et al.'' |title=Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 11 |pages= 4210-4 |year= 1989 |pmid= 2542966 |doi=  }}
*{{cite journal  | author=Scholl P |title=Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 11 |pages= 4210–4 |year= 1989 |pmid= 2542966 |doi=10.1073/pnas.86.11.4210  | pmc=287420  |name-list-format=vanc| author2=Diez A  | author3=Mourad W  | display-authors=3  | last4=Parsonnet  | first4=J  | last5=Geha  | first5=RS  | last6=Chatila  | first6=T  }}
*{{cite journal  | author=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. |journal=Nature |volume=339 |issue= 6225 |pages= 548-51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0 }}
*{{cite journal  |vauthors=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding |journal=Nature |volume=339 |issue= 6225 |pages= 548–51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0 }}
*{{cite journal | author=Lee JS, Sartoris S, Briata P, ''et al.'' |title=Sequence polymorphism of HLA-DP beta chains. |journal=Immunogenetics |volume=29 |issue= 5 |pages= 346-9 |year= 1989 |pmid= 2714855 |doi=  }}
*{{cite journal  | author=Lee JS |title=Sequence polymorphism of HLA-DP beta chains |journal=Immunogenetics |volume=29 |issue= 5 |pages= 346–9 |year= 1989 |pmid= 2714855 |doi=10.1007/BF00352845  |name-list-format=vanc| author2=Sartoris S  | author3=Briata P  | display-authors=3  | last4=Choi  | first4=Ed  | last5=Cullen  | first5=Constance  | last6=Lepaslier  | first6=Denis  | last7=Yunis  | first7=Ivan  }}
*{{cite journal  | author=Compagnone-Post P, Turco E, Robinson C, Trucco M |title=The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene. |journal=Genomics |volume=2 |issue= 1 |pages= 8-13 |year= 1988 |pmid= 2838415 |doi=  }}
*{{cite journal  |vauthors=Compagnone-Post P, Turco E, Robinson C, Trucco M |title=The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene |journal=Genomics |volume=2 |issue= 1 |pages= 8–13 |year= 1988 |pmid= 2838415 |doi=10.1016/0888-7543(88)90103-6  }}
*{{cite journal | author=Diamond DC, Sleckman BP, Gregory T, ''et al.'' |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715-7 |year= 1988 |pmid= 2846691 |doi=  }}
*{{cite journal  | author=Diamond DC |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120 |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715–7 |year= 1988 |pmid= 2846691 |doi=  |name-list-format=vanc| author2=Sleckman BP  | author3=Gregory T  | display-authors=3  | last4=Lasky  | first4=LA  | last5=Greenstein  | first5=JL  | last6=Burakoff  | first6=SJ  }}
*{{cite journal  | author=Ando A, Inoko H, Kimura M, ''et al.'' |title=Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains. |journal=Hum. Immunol. |volume=17 |issue= 3 |pages= 355-67 |year= 1987 |pmid= 2878910 |doi=  }}
*{{cite journal  | author=Ando A |title=Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains |journal=Hum. Immunol. |volume=17 |issue= 3 |pages= 355–67 |year= 1987 |pmid= 2878910 |doi=10.1016/0198-8859(86)90286-7  |name-list-format=vanc| author2=Inoko H  | author3=Kimura M  | display-authors=3  | last4=Ogata  | first4=Sachie  | last5=Tsuji  | first5=Kimiyoshi  }}
*{{cite journal  | author=Kelly A, Trowsdale J |title=Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes. |journal=Nucleic Acids Res. |volume=13 |issue= 5 |pages= 1607-21 |year= 1985 |pmid= 2987832 |doi=  }}
*{{cite journal  |vauthors=Kelly A, Trowsdale J |title=Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes |journal=Nucleic Acids Res. |volume=13 |issue= 5 |pages= 1607–21 |year= 1985 |pmid= 2987832 |doi=10.1093/nar/13.5.1607  | pmc=341099 }}
}}
}}
{{refend}}
{{refend}}


{{WH}}
{{Surface antigens}}
{{WS}}
 
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Latest revision as of 00:48, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.[1]

See also

References

  1. ↑ "Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1".

Further reading



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