RDBP: Difference between revisions

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Latest revision as of 09:02, 10 September 2017

Negative elongation factor E is a protein that in humans is encoded by the RDBP gene.^[1]

Function

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.^[1]

Interactions

RDBP has been shown to interact with:

References

↑ ^1.0 ^1.1 "Entrez Gene: RDBP RD RNA binding protein".
↑ ^2.0 ^2.1 ^2.2 Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Molecular and Cellular Biology. 23 (6): 1863–73. doi:10.1128/mcb.23.6.1863-1873.2003. PMC 149481. PMID 12612062.
↑ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/s0888-7543(03)00235-0. PMID 14667819.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Experimental and Clinical Immunogenetics. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631.
Stevens M, De Clercq E, Balzarini J (Sep 2006). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Medicinal Research Reviews. 26 (5): 595–625. doi:10.1002/med.20081. PMID 16838299.
Surowy CS, Hoganson G, Gosink J, Strunk K, Spritz RA (Jun 1990). "The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved". Gene. 90 (2): 299–302. doi:10.1016/0378-1119(90)90194-V. PMID 2119325.
Speiser PW, White PC (Dec 1989). "Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex". Dna. 8 (10): 745–51. doi:10.1089/dna.1989.8.745. PMID 2612324.
Lévi-Strauss M, Carroll MC, Steinmetz M, Meo T (Apr 1988). "A previously undetected MHC gene with an unusual periodic structure". Science. 240 (4849): 201–4. doi:10.1126/science.3353717. PMID 3353717.
Cheng J, Macon KJ, Volanakis JE (Sep 1993). "cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex". The Biochemical Journal. 294 (2): 589–93. doi:10.1042/bj2940589. PMC 1134496. PMID 8373374.
Lee SG, Song K (Jun 1997). "Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex". Molecules and Cells. 7 (3): 414–8. PMID 9264031.
Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H, Walter G (Nov 1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library". Nucleic Acids Research. 26 (21): 5007–8. doi:10.1093/nar/26.21.5007. PMC 147919. PMID 9776767.
Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Nov 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, Hasegawa J, Handa H (Apr 1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation". Cell. 97 (1): 41–51. doi:10.1016/S0092-8674(00)80713-8. PMID 10199401.
Ping YH, Rana TM (Apr 2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation". The Journal of Biological Chemistry. 276 (16): 12951–8. doi:10.1074/jbc.M006130200. PMID 11112772.
Yamaguchi Y, Inukai N, Narita T, Wada T, Handa H (May 2002). "Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA". Molecular and Cellular Biology. 22 (9): 2918–27. doi:10.1128/MCB.22.9.2918-2927.2002. PMC 133766. PMID 11940650.
Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Molecular and Cellular Biology. 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. PMC 149481. PMID 12612062.
Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (Dec 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Aiyar SE, Sun JL, Blair AL, Moskaluk CA, Lu YZ, Ye QN, Yamaguchi Y, Mukherjee A, Ren DM, Handa H, Li R (Sep 2004). "Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor". Genes & Development. 18 (17): 2134–46. doi:10.1101/gad.1214104. PMC 515291. PMID 15342491.

External links

FactorBook NELFe

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: RDBP RD RNA binding protein".

[pmid12612062-2] 2.0 ^2.1 ^2.2 Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Molecular and Cellular Biology. 23 (6): 1863–73. doi:10.1128/mcb.23.6.1863-1873.2003. PMC 149481. PMID 12612062.

[pmid14667819-3] Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/s0888-7543(03)00235-0. PMID 14667819.

[pmid17353931-4] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Negative elongation factor E''' is a [[protein]] that in humans is encoded by the ''RDBP'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RDBP RD RNA binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7936| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = no
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_RDBP_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x5p.
- | PDB = {{PDB2|1x5p}}, {{PDB2|2bz2}}
- | Name = RD RNA binding protein
- | HGNCid = 13974
- | Symbol = RDBP
- | AltSymbols =; RDP; RD; D6S45; NELF-E
- | OMIM = 154040
- | ECnumber =
- | Homologene = 2178
- | MGIid = 102744
- | GeneAtlas_image1 = PBB_GE_RDBP_209219_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7936
-    | Hs_Ensembl = ENSG00000204356
-    | Hs_RefseqProtein = NP_002895
-    | Hs_RefseqmRNA = NM_002904
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 32027844
-    | Hs_GenLoc_end = 32034843
-    | Hs_Uniprot = P18615
-    | Mm_EntrezGene = 27632
-    | Mm_Ensembl = ENSMUSG00000024369
-    | Mm_RefseqmRNA = NM_001045863
-    | Mm_RefseqProtein = NP_001039328
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 34458557
-    | Mm_GenLoc_end = 34464422
-    | Mm_Uniprot = Q3UIA1
-  }}
-}}
-'''RD RNA binding protein''', also known as '''RDBP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RDBP RD RNA binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7936| accessdate = }}</ref>
-<!-- Automatic updates to PBB_Summary by Protein Box Bot have been turned off.  See Template:PBB_Controls above. I am not sure if this is the right thing to do...I wanted to put in wikilinks.--[[User:Skoch3]] -->
+The protein encoded by this gene is part of a complex termed [[Negative elongation factor|negative elongation factor (NELF)]] which represses [[RNA polymerase II]] transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is part of a complex termed [[Negative elongation factor|negative elongation factor (NELF)]] which represses [[RNA polymerase II]] transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.<ref name="entrez">{{cite web | title = Entrez Gene: RDBP RD RNA binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7936| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+RDBP has been shown to [[Protein-protein interaction|interact]] with:
+* [[Cofactor of BRCA1]],<ref name = pmid12612062/><ref name = pmid14667819>{{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi =  10.1016/s0888-7543(03)00235-0}}</ref>
+* [[TH1L]],<ref name = pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue =  | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 | year=2007}}</ref><ref name = pmid12612062>{{cite journal | vauthors = Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H | title = Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 1863–73 | date = Mar 2003 | pmid = 12612062 | pmc = 149481 | doi =  10.1128/mcb.23.6.1863-1873.2003}}</ref>  and
+* [[WHSC2]].<ref name = pmid12612062/>
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Yu CY | title = Molecular genetics of the human MHC complement gene cluster | journal = Experimental and Clinical Immunogenetics | volume = 15 | issue = 4 | pages = 213–30 | year = 1999 | pmid = 10072631 | doi = 10.1159/000019075 }}
-| citations =
+* {{cite journal | vauthors = Stevens M, De Clercq E, Balzarini J | title = The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention | journal = Medicinal Research Reviews | volume = 26 | issue = 5 | pages = 595–625 | date = Sep 2006 | pmid = 16838299 | doi = 10.1002/med.20081 }}
-*{{cite journal  | author=Yu CY |title=Molecular genetics of the human MHC complement gene cluster. |journal=Exp. Clin. Immunogenet. |volume=15 |issue= 4 |pages= 213-30 |year= 1999 |pmid= 10072631 |doi=  }}
+* {{cite journal | vauthors = Surowy CS, Hoganson G, Gosink J, Strunk K, Spritz RA | title = The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved | journal = Gene | volume = 90 | issue = 2 | pages = 299–302 | date = Jun 1990 | pmid = 2119325 | doi = 10.1016/0378-1119(90)90194-V }}
-*{{cite journal  | author=Stevens M, De Clercq E, Balzarini J |title=The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention. |journal=Med Res Rev |volume=26 |issue= 5 |pages= 595-625 |year= 2007 |pmid= 16838299 |doi= 10.1002/med.20081 }}
+* {{cite journal | vauthors = Speiser PW, White PC | title = Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex | journal = Dna | volume = 8 | issue = 10 | pages = 745–51 | date = Dec 1989 | pmid = 2612324 | doi = 10.1089/dna.1989.8.745 }}
-*{{cite journal  | author=Surowy CS, Hoganson G, Gosink J, ''et al.'' |title=The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved. |journal=Gene |volume=90 |issue= 2 |pages= 299-302 |year= 1990 |pmid= 2119325 |doi=  }}
+* {{cite journal | vauthors = Lévi-Strauss M, Carroll MC, Steinmetz M, Meo T | title = A previously undetected MHC gene with an unusual periodic structure | journal = Science | volume = 240 | issue = 4849 | pages = 201–4 | date = Apr 1988 | pmid = 3353717 | doi = 10.1126/science.3353717 }}
-*{{cite journal  | author=Speiser PW, White PC |title=Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex. |journal=DNA |volume=8 |issue= 10 |pages= 745-51 |year= 1990 |pmid= 2612324 |doi=  }}
+* {{cite journal | vauthors = Cheng J, Macon KJ, Volanakis JE | title = cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex | journal = The Biochemical Journal | volume = 294 | issue = 2 | pages = 589–93 | date = Sep 1993 | pmid = 8373374 | pmc = 1134496 | doi =  10.1042/bj2940589}}
-*{{cite journal  | author=Lévi-Strauss M, Carroll MC, Steinmetz M, Meo T |title=A previously undetected MHC gene with an unusual periodic structure. |journal=Science |volume=240 |issue= 4849 |pages= 201-4 |year= 1988 |pmid= 3353717 |doi=  }}
+* {{cite journal | vauthors = Lee SG, Song K | title = Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex | journal = Molecules and Cells | volume = 7 | issue = 3 | pages = 414–8 | date = Jun 1997 | pmid = 9264031 | doi =  }}
-*{{cite journal  | author=Cheng J, Macon KJ, Volanakis JE |title=cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex. |journal=Biochem. J. |volume=294 ( Pt 2) |issue=  |pages= 589-93 |year= 1993 |pmid= 8373374 |doi=  }}
+* {{cite journal | vauthors = Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H, Walter G | title = A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library | journal = Nucleic Acids Research | volume = 26 | issue = 21 | pages = 5007–8 | date = Nov 1998 | pmid = 9776767 | pmc = 147919 | doi = 10.1093/nar/26.21.5007 }}
-*{{cite journal  | author=Lee SG, Song K |title=Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex. |journal=Mol. Cells |volume=7 |issue= 3 |pages= 414-8 |year= 1997 |pmid= 9264031 |doi=  }}
+* {{cite journal | vauthors = Yang Z, Shen L, Dangel AW, Wu LC, Yu CY | title = Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA | journal = Genomics | volume = 53 | issue = 3 | pages = 338–47 | date = Nov 1998 | pmid = 9799600 | doi = 10.1006/geno.1998.5499 }}
-*{{cite journal  | author=Büssow K, Cahill D, Nietfeld W, ''et al.'' |title=A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. |journal=Nucleic Acids Res. |volume=26 |issue= 21 |pages= 5007-8 |year= 1998 |pmid= 9776767 |doi=  }}
+* {{cite journal | vauthors = Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, Hasegawa J, Handa H | title = NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation | journal = Cell | volume = 97 | issue = 1 | pages = 41–51 | date = Apr 1999 | pmid = 10199401 | doi = 10.1016/S0092-8674(00)80713-8 }}
-*{{cite journal  | author=Yang Z, Shen L, Dangel AW, ''et al.'' |title=Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. |journal=Genomics |volume=53 |issue= 3 |pages= 338-47 |year= 1998 |pmid= 9799600 |doi= 10.1006/geno.1998.5499 }}
+* {{cite journal | vauthors = Ping YH, Rana TM | title = DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 16 | pages = 12951–8 | date = Apr 2001 | pmid = 11112772 | doi = 10.1074/jbc.M006130200 }}
-*{{cite journal  | author=Yamaguchi Y, Takagi T, Wada T, ''et al.'' |title=NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. |journal=Cell |volume=97 |issue= 1 |pages= 41-51 |year= 1999 |pmid= 10199401 |doi=  }}
+* {{cite journal | vauthors = Yamaguchi Y, Inukai N, Narita T, Wada T, Handa H | title = Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 2918–27 | date = May 2002 | pmid = 11940650 | pmc = 133766 | doi = 10.1128/MCB.22.9.2918-2927.2002 }}
-*{{cite journal  | author=Ping YH, Rana TM |title=DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12951-8 |year= 2001 |pmid= 11112772 |doi= 10.1074/jbc.M006130200 }}
+* {{cite journal | vauthors = Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H | title = Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 1863–73 | date = Mar 2003 | pmid = 12612062 | pmc = 149481 | doi = 10.1128/MCB.23.6.1863-1873.2003 }}
-*{{cite journal  | author=Yamaguchi Y, Inukai N, Narita T, ''et al.'' |title=Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 2918-27 |year= 2002 |pmid= 11940650 |doi=  }}
+* {{cite journal | vauthors = Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L | title = Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse | journal = Genome Research | volume = 13 | issue = 12 | pages = 2621–36 | date = Dec 2003 | pmid = 14656967 | pmc = 403804 | doi = 10.1101/gr.1736803 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
-*{{cite journal  | author=Narita T, Yamaguchi Y, Yano K, ''et al.'' |title=Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 1863-73 |year= 2003 |pmid= 12612062 |doi=  }}
+* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
-*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
+* {{cite journal | vauthors = Aiyar SE, Sun JL, Blair AL, Moskaluk CA, Lu YZ, Ye QN, Yamaguchi Y, Mukherjee A, Ren DM, Handa H, Li R | title = Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor | journal = Genes & Development | volume = 18 | issue = 17 | pages = 2134–46 | date = Sep 2004 | pmid = 15342491 | pmc = 515291 | doi = 10.1101/gad.1214104 }}
-*{{cite journal  | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
-*{{cite journal  | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi=  }}
-*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
-*{{cite journal  | author=Aiyar SE, Sun JL, Blair AL, ''et al.'' |title=Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. |journal=Genes Dev. |volume=18 |issue= 17 |pages= 2134-46 |year= 2004 |pmid= 15342491 |doi= 10.1101/gad.1214104 }}
-}}
 {{refend}}
-{{protein-stub}}
+== External links ==
-{{WikiDoc Sources}}
+* {{FactorBook|NELFe}}
+{{PDB Gallery|geneid=7936}}
+{{gene-6-stub}}

RDBP: Difference between revisions

Latest revision as of 09:02, 10 September 2017

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Function

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