ULBP1: Difference between revisions

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Latest revision as of 05:44, 10 August 2016

UL16 binding protein 1 (ULBP1) is a cell surface glycoprotein encoded by ULBP1 gene located on the chromosome 6.^[1]^[2] ULBP1 is related to MHC class I molecules, but its gene maps outside the MHC locus.^[1]^[2] The domain structure of ULBP1 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP1 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.^[1]^[2] It functions as a stress-induced ligand for NKG2D receptor.^[1] ULBP1 is, for example, upregulated during HCMV infection.^[3] Binding of HCMV-encoded UL16 glycoprotein to ULBP1 interferes with cell surface localization of ULBP1; this represents another mechanism by which HCMV-infected cells might escape the immune system.^[3]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
↑ ^2.0 ^2.1 ^2.2 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.
↑ ^3.0 ^3.1 Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology. 171 (2): 902–8. doi:10.4049/jimmunol.171.2.902. PMID 12847260.

Cerwenka A, Lanier LL (May 2003). "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer". Tissue Antigens. 61 (5): 335–43. doi:10.1034/j.1399-0039.2003.00070.x. PMID 12753652.
Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T (2001). "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family". Immunogenetics. 53 (4): 279–87. doi:10.1007/s002510100325. PMID 11491531.
Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D (Jan 2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells". Journal of Immunology. 168 (2): 671–9. doi:10.4049/jimmunol.168.2.671. PMID 11777960.
Dunn C, Chalupny NJ, Sutherland CL, Dosch S, Sivakumar PV, Johnson DC, Cosman D (Jun 2003). "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity". The Journal of Experimental Medicine. 197 (11): 1427–39. doi:10.1084/jem.20022059. PMC 2193902. PMID 12782710.
Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology. 171 (2): 902–8. doi:10.4049/jimmunol.171.2.902. PMID 12847260.
Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM (Apr 2004). "Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D". The Journal of Experimental Medicine. 199 (7): 1005–10. doi:10.1084/jem.20032194. PMC 2211882. PMID 15051759.
Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J (Jul 2004). "Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D". Journal of Immunology. 173 (2): 1078–84. doi:10.4049/jimmunol.173.2.1078. PMID 15240696.
López-Soto A, Quiñones-Lombraña A, López-Arbesú R, López-Larrea C, González S (Oct 2006). "Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor". The Journal of Biological Chemistry. 281 (41): 30419–30. doi:10.1074/jbc.M604868200. PMID 16901903.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[pmid11239445-1] 1.0 ^1.1 ^1.2 ^1.3 Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.

[pmid11827464-2] 2.0 ^2.1 ^2.2 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.

[:0-3] 3.0 ^3.1 Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology. 171 (2): 902–8. doi:10.4049/jimmunol.171.2.902. PMID 12847260.

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[2]

[3]

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-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''UL16 binding protein 1''' ('''ULBP1''') is a cell surface [[glycoprotein]] encoded by ''ULBP1'' gene located on the chromosome 6.<ref name="pmid11239445">{{cite journal | vauthors = Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ | title = ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor | journal = Immunity | volume = 14 | issue = 2 | pages = 123–33 | date = Feb 2001 | pmid = 11239445 | pmc =  | doi = 10.1016/S1074-7613(01)00095-4 }}</ref><ref name="pmid11827464">{{cite journal | vauthors = Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S | title = A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3 | journal = Genomics | volume = 79 | issue = 1 | pages = 114–23 | date = Jan 2002 | pmid = 11827464 | pmc =  | doi = 10.1006/geno.2001.6673 }}</ref> ULBP1 is related to [[MHC class I]] molecules, but its gene maps outside the MHC locus.<ref name="pmid11239445" /><ref name="pmid11827464" /> The domain structure of ULBP1 differs significantly from those of conventional [[MHC class I]] molecules. It does not contain the α3 domain and the transmembrane segment. ULBP1 is thus composed of only the α1α2 domain which is linked to the cell membrane by the [[Glycophosphatidylinositol|GPI anchor]].<ref name="pmid11239445" /><ref name="pmid11827464" /> It functions as a [[Induced-self antigen|stress-induced]] ligand for [[NKG2D]] receptor.<ref name="pmid11239445" /> ULBP1 is, for example, upregulated during [[Human cytomegalovirus|HCMV]] infection.<ref name=":0">{{cite journal | vauthors = Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C | title = Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein | language = en | journal = Journal of Immunology | volume = 171 | issue = 2 | pages = 902–8 | date = Jul 2003 | pmid = 12847260 | doi = 10.4049/jimmunol.171.2.902 | url = http://www.jimmunol.org/content/171/2/902 }}</ref> Binding of HCMV-encoded UL16 glycoprotein to ULBP1 interferes with cell surface localization of ULBP1; this represents another mechanism by which HCMV-infected cells might escape the immune system.<ref name=":0" />
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== References ==
-{{GNF_Protein_box
+{{reflist}}
- | image =
- | image_source =
- | PDB =
- | Name = UL16 binding protein 1
- | HGNCid = 14893
- | Symbol = ULBP1
- | AltSymbols =; RAET1I
- | OMIM = 605697
- | ECnumber =
- | Homologene = 69396
- | MGIid = 1925027
- | GeneAtlas_image1 = PBB_GE_ULBP1_221323_at_tn.png
- | Function = {{GNF_GO|id=GO:0032393 |text = MHC class I receptor activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
- | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
- | Process = {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 80329
-    | Hs_Ensembl = ENSG00000111981
-    | Hs_RefseqProtein = NP_079494
-    | Hs_RefseqmRNA = NM_025218
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 150326836
-    | Hs_GenLoc_end = 150336537
-    | Hs_Uniprot = Q9BZM6
-    | Mm_EntrezGene = 77777
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA = NM_029975
-    | Mm_RefseqProtein = NP_084251
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''UL16 binding protein 1''', also known as '''ULBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ULBP1 UL16 binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80329| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Further reading ==
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
-{{reflist|2}}
-==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Cerwenka A, Lanier LL | title = NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 335–43 | date = May 2003 | pmid = 12753652 | doi = 10.1034/j.1399-0039.2003.00070.x }}
-| citations =
+* {{cite journal | vauthors = Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T | title = Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family | journal = Immunogenetics | volume = 53 | issue = 4 | pages = 279–87 | year = 2001 | pmid = 11491531 | doi = 10.1007/s002510100325 }}
-*{{cite journal  | author=Cerwenka A, Lanier LL |title=NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. |journal=Tissue Antigens |volume=61 |issue= 5 |pages= 335-43 |year= 2004 |pmid= 12753652 |doi=  }}
+* {{cite journal | vauthors = Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D | title = UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells | journal = Journal of Immunology | volume = 168 | issue = 2 | pages = 671–9 | date = Jan 2002 | pmid = 11777960 | doi = 10.4049/jimmunol.168.2.671 }}
-*{{cite journal  | author=Cosman D, Müllberg J, Sutherland CL, ''et al.'' |title=ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. |journal=Immunity |volume=14 |issue= 2 |pages= 123-33 |year= 2001 |pmid= 11239445 |doi=  }}
+* {{cite journal | vauthors = Dunn C, Chalupny NJ, Sutherland CL, Dosch S, Sivakumar PV, Johnson DC, Cosman D | title = Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity | journal = The Journal of Experimental Medicine | volume = 197 | issue = 11 | pages = 1427–39 | date = Jun 2003 | pmid = 12782710 | pmc = 2193902 | doi = 10.1084/jem.20022059 }}
-*{{cite journal  | author=Steinle A, Li P, Morris DL, ''et al.'' |title=Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 279-87 |year= 2001 |pmid= 11491531 |doi=  }}
+* {{cite journal | vauthors = Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C | title = Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein | journal = Journal of Immunology | volume = 171 | issue = 2 | pages = 902–8 | date = Jul 2003 | pmid = 12847260 | doi = 10.4049/jimmunol.171.2.902 }}
-*{{cite journal  | author=Sutherland CL, Chalupny NJ, Schooley K, ''et al.'' |title=UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. |journal=J. Immunol. |volume=168 |issue= 2 |pages= 671-9 |year= 2002 |pmid= 11777960 |doi=  }}
+* {{cite journal | vauthors = Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM | title = Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D | journal = The Journal of Experimental Medicine | volume = 199 | issue = 7 | pages = 1005–10 | date = Apr 2004 | pmid = 15051759 | pmc = 2211882 | doi = 10.1084/jem.20032194 }}
-*{{cite journal  | author=Radosavljevic M, Cuillerier B, Wilson MJ, ''et al.'' |title=A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. |journal=Genomics |volume=79 |issue= 1 |pages= 114-23 |year= 2002 |pmid= 11827464 |doi= 10.1006/geno.2001.6673 }}
+* {{cite journal | vauthors = Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J | title = Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D | journal = Journal of Immunology | volume = 173 | issue = 2 | pages = 1078–84 | date = Jul 2004 | pmid = 15240696 | doi = 10.4049/jimmunol.173.2.1078 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = López-Soto A, Quiñones-Lombraña A, López-Arbesú R, López-Larrea C, González S | title = Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor | journal = The Journal of Biological Chemistry | volume = 281 | issue = 41 | pages = 30419–30 | date = Oct 2006 | pmid = 16901903 | doi = 10.1074/jbc.M604868200 }}
-*{{cite journal  | author=Dunn C, Chalupny NJ, Sutherland CL, ''et al.'' |title=Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. |journal=J. Exp. Med. |volume=197 |issue= 11 |pages= 1427-39 |year= 2003 |pmid= 12782710 |doi= 10.1084/jem.20022059 }}
-*{{cite journal  | author=Rölle A, Mousavi-Jazi M, Eriksson M, ''et al.'' |title=Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 902-8 |year= 2003 |pmid= 12847260 |doi=  }}
-*{{cite journal  | author=Eleme K, Taner SB, Onfelt B, ''et al.'' |title=Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. |journal=J. Exp. Med. |volume=199 |issue= 7 |pages= 1005-10 |year= 2004 |pmid= 15051759 |doi= 10.1084/jem.20032194 }}
-*{{cite journal  | author=Bacon L, Eagle RA, Meyer M, ''et al.'' |title=Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. |journal=J. Immunol. |volume=173 |issue= 2 |pages= 1078-84 |year= 2004 |pmid= 15240696 |doi=  }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=López-Soto A, Quiñones-Lombraña A, López-Arbesú R, ''et al.'' |title=Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30419-30 |year= 2006 |pmid= 16901903 |doi= 10.1074/jbc.M604868200 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{gene-6-stub}}
-{{WikiDoc Sources}}

ULBP1: Difference between revisions

Latest revision as of 05:44, 10 August 2016

References

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