ZNRD1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''DNA-directed RNA polymerase I subunit RPA12''' is an [[enzyme]] that in humans is encoded by the ''ZNRD1'' [[gene]].<ref name="pmid8938444">{{cite journal | vauthors = Lepourcelet M, Andrieux N, Giffon T, Pichon L, Hampe A, Galibert F, Mosser J | title = Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence | journal = Genomics | volume = 37 | issue = 3 | pages = 316–26 | date = Nov 1996 | pmid = 8938444 | pmc =  | doi = 10.1006/geno.1996.0566 }}</ref><ref name="pmid10662553">{{cite journal | vauthors = Fan W, Wang Z, Kyzysztof F, Prange C, Lennon G | title = A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region | journal = Genomics | volume = 63 | issue = 1 | pages = 139–41 | date = Jan 2000 | pmid = 10662553 | pmc = | doi = 10.1006/geno.1999.6040 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNRD1 zinc ribbon domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30834| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zinc ribbon domain containing 1
| HGNCid = 13182
| Symbol = ZNRD1
| AltSymbols =; HTEX-6; MGC13376; Rpa12; hZR14; tctex-6
| OMIM = 607525
| ECnumber = 
| Homologene = 40960
| MGIid = 1913386
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003899 |text = DNA-directed RNA polymerase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006354 |text = RNA elongation}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 30834
    | Hs_Ensembl = ENSG00000066379
    | Hs_RefseqProtein = NP_055411
    | Hs_RefseqmRNA = NM_014596
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 30137015
    | Hs_GenLoc_end = 30140665
    | Hs_Uniprot = Q9P1U0
    | Mm_EntrezGene = 66136
    | Mm_Ensembl = ENSMUSG00000036315
    | Mm_RefseqmRNA = NM_023162
    | Mm_RefseqProtein = NP_075651
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 36562411
    | Mm_GenLoc_end = 36566535
    | Mm_Uniprot = Q791N7
  }}
}}
'''Zinc ribbon domain containing 1''', also known as '''ZNRD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNRD1 zinc ribbon domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30834| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein with similarity to the ''[[Saccharomyces cerevisiae]]'' Rpa12p subunit of [[RNA polymerase I]]. [[Alternate splicing]] of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: ZNRD1 zinc ribbon domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30834| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J | title = Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes | journal = Mammalian Genome | volume = 11 | issue = 12 | pages = 1127–31 | date = Dec 2000 | pmid = 11130983 | doi = 10.1007/s003350010213 }}
*{{cite journal  | author=Lepourcelet M, Andrieux N, Giffon T, ''et al.'' |title=Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence. |journal=Genomics |volume=37 |issue= 3 |pages= 316-26 |year= 1997 |pmid= 8938444 |doi=  }}
* {{cite journal | vauthors = Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D | title = Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein | journal = Cancer Biology & Therapy | volume = 3 | issue = 4 | pages = 377–81 | date = Apr 2004 | pmid = 14726695 | doi = 10.4161/cbt.3.4.724 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y, Lan M, Sun L, Fan D | title = Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene | journal = Biochemical and Biophysical Research Communications | volume = 321 | issue = 3 | pages = 611–6 | date = Aug 2004 | pmid = 15358150 | doi = 10.1016/j.bbrc.2004.07.007 }}
*{{cite journal  | author=Fan W, Wang Z, Kyzysztof F, ''et al.'' |title=A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region. |journal=Genomics |volume=63 |issue= 1 |pages= 139-41 |year= 2000 |pmid= 10662553 |doi= 10.1006/geno.1999.6040 }}
* {{cite journal | vauthors = Hong L, Han Y, Shi R, Shao X, Sun L, Zhang Y, Huang D, Chen Z, Zhang G, Liang J, Hu S, Fan D | title = ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase | journal = Cancer Biology & Therapy | volume = 4 | issue = 1 | pages = 60–4 | date = Jan 2005 | pmid = 15662122 | doi = 10.4161/cbt.4.1.1375 }}
*{{cite journal | author=Coriton O, Lepourcelet M, Hampe A, ''et al.'' |title=Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes. |journal=Mamm. Genome |volume=11 |issue= 12 |pages= 1127-31 |year= 2001 |pmid= 11130983 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
* {{cite journal | vauthors = Hong L, Zhao Y, Han Y, Guo W, Jin H, Qiao T, Che Z, Fan D | title = Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells | journal = Carcinogenesis | volume = 28 | issue = 8 | pages = 1622–8 | date = Aug 2007 | pmid = 17389617 | doi = 10.1093/carcin/bgm064 }}
*{{cite journal  | author=Shi Y, Zhang Y, Zhao Y, ''et al.'' |title=Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein. |journal=Cancer Biol. Ther. |volume=3 |issue= 4 |pages= 377-81 |year= 2004 |pmid= 14726695 |doi= }}
* {{cite journal | vauthors = Hong L, Wang J, Zhao Y, Han Z, Zhou X, Guo W, Zhang X, Jin H, Wu K, Ding J, Fan D | title = DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1 | journal = Cancer Investigation | volume = 25 | issue = 8 | pages = 699–705 | date = Dec 2007 | pmid = 18058465 | doi = 10.1080/07357900701566304 }}
*{{cite journal | author=Hong L, Zhang Y, Liu N, ''et al.'' |title=Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 611-6 |year= 2004 |pmid= 15358150 |doi= 10.1016/j.bbrc.2004.07.007 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hong L, Han Y, Shi R, ''et al.'' |title=ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase. |journal=Cancer Biol. Ther. |volume=4 |issue= 1 |pages= 60-4 |year= 2005 |pmid= 15662122 |doi= }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Hong L, Zhao Y, Han Y, ''et al.'' |title=Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells. |journal=Carcinogenesis |volume=28 |issue= 8 |pages= 1622-8 |year= 2007 |pmid= 17389617 |doi= 10.1093/carcin/bgm064 }}
*{{cite journal | author=Hong L, Wang J, Zhao Y, ''et al.'' |title=DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1. |journal=Cancer Invest. |volume=25 |issue= 8 |pages= 699-705 |year= 2007 |pmid= 18058465 |doi= 10.1080/07357900701566304 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-6-stub}}
{{WikiDoc Sources}}

Latest revision as of 10:37, 3 December 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA-directed RNA polymerase I subunit RPA12 is an enzyme that in humans is encoded by the ZNRD1 gene.[1][2][3]

Function

This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.[3]

References

  1. ↑ Lepourcelet M, Andrieux N, Giffon T, Pichon L, Hampe A, Galibert F, Mosser J (Nov 1996). "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence". Genomics. 37 (3): 316–26. doi:10.1006/geno.1996.0566. PMID 8938444.
  2. ↑ Fan W, Wang Z, Kyzysztof F, Prange C, Lennon G (Jan 2000). "A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region". Genomics. 63 (1): 139–41. doi:10.1006/geno.1999.6040. PMID 10662553.
  3. ↑ 3.0 3.1 "Entrez Gene: ZNRD1 zinc ribbon domain containing 1".

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J (Dec 2000). "Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes". Mammalian Genome. 11 (12): 1127–31. doi:10.1007/s003350010213. PMID 11130983.
  • Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D (Apr 2004). "Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein". Cancer Biology & Therapy. 3 (4): 377–81. doi:10.4161/cbt.3.4.724. PMID 14726695.
  • Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y, Lan M, Sun L, Fan D (Aug 2004). "Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene". Biochemical and Biophysical Research Communications. 321 (3): 611–6. doi:10.1016/j.bbrc.2004.07.007. PMID 15358150.
  • Hong L, Han Y, Shi R, Shao X, Sun L, Zhang Y, Huang D, Chen Z, Zhang G, Liang J, Hu S, Fan D (Jan 2005). "ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase". Cancer Biology & Therapy. 4 (1): 60–4. doi:10.4161/cbt.4.1.1375. PMID 15662122.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Hong L, Zhao Y, Han Y, Guo W, Jin H, Qiao T, Che Z, Fan D (Aug 2007). "Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells". Carcinogenesis. 28 (8): 1622–8. doi:10.1093/carcin/bgm064. PMID 17389617.
  • Hong L, Wang J, Zhao Y, Han Z, Zhou X, Guo W, Zhang X, Jin H, Wu K, Ding J, Fan D (Dec 2007). "DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1". Cancer Investigation. 25 (8): 699–705. doi:10.1080/07357900701566304. PMID 18058465.
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