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{{ | '''Adapter protein CIKS''' is a [[protein]] that in humans is encoded by the ''TRAF3IP2'' [[gene]].<ref name="pmid10962033">{{cite journal | vauthors = Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U | title = CIKS, a connection to Ikappa B kinase and stress-activated protein kinase | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 19 | pages = 10494–9 |date=Oct 2000 | pmid = 10962033 | pmc = 27052 | doi = 10.1073/pnas.190245697 }}</ref><ref name="pmid10962024">{{cite journal | vauthors = Li X, Commane M, Nie H, Hua X, Chatterjee-Kishore M, Wald D, Haag M, Stark GR | title = Act1, an NF-kappa B-activating protein | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 19 | pages = 10489–93 |date=Oct 2000 | pmid = 10962024 | pmc = 27051 | doi = 10.1073/pnas.160265197 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRAF3IP2 TRAF3 interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10758| accessdate = }}</ref> | ||
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| summary_text = This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.<ref name="entrez">{{cite web | title = Entrez Gene: TRAF3IP2 TRAF3 interacting protein 2| url = | | summary_text = This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.<ref name="entrez">{{cite web | title = Entrez Gene: TRAF3IP2 TRAF3 interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10758| accessdate = }}</ref> | ||
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==Interactions== | |||
TRAF3IP2 has been shown to [[Protein-protein interaction|interact]] with [[IKBKG]].<ref name=pmid10962033 /><ref name=pmid10962024 /> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
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*{{cite journal | *{{cite journal |vauthors=Morelli C, Magnanini C, Mungall AJ, etal |title=Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia. |journal=Gene |volume=252 |issue= 1–2 |pages= 217–25 |year= 2000 |pmid= 10903453 |doi=10.1016/S0378-1119(00)00231-6 }} | ||
*{{cite journal | vauthors=Qian Y, Zhao Z, Jiang Z, Li X |title=Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 14 |pages= 9386–91 |year= 2002 |pmid= 12089335 |doi= 10.1073/pnas.142294499 | pmc=123150 }} | |||
*{{cite journal |vauthors=Chariot A, Leonardi A, Muller J, etal |title=Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37029–36 |year= 2002 |pmid= 12133833 |doi= 10.1074/jbc.M205069200 }} | |||
*{{cite journal | | *{{cite journal | vauthors=Xia YF, Li YD, Li X, Geng JG |title=Identification of alternatively spliced Act1 and implications for its roles in oncogenesis |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 2 |pages= 406–12 |year= 2002 |pmid= 12163033 |doi=10.1016/S0006-291X(02)00887-2 }} | ||
*{{cite journal | *{{cite journal | vauthors=Kanamori M, Kai C, Hayashizaki Y, Suzuki H |title=NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6 |journal=FEBS Lett. |volume=532 |issue= 1–2 |pages= 241–6 |year= 2003 |pmid= 12459498 |doi=10.1016/S0014-5793(02)03688-8 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Matsuda A, Suzuki Y, Honda G, etal |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mauro C, Vito P, Mellone S, etal |title=Role of the adaptor protein CIKS in the activation of the IKK complex |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 1 |pages= 84–90 |year= 2003 |pmid= 12943667 |doi=10.1016/S0006-291X(03)01532-8 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | ||
*{{cite journal | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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| Location (UCSC) | n/a | n/a | |||||
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Adapter protein CIKS is a protein that in humans is encoded by the TRAF3IP2 gene.[1][2][3]
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.[3]
Interactions
TRAF3IP2 has been shown to interact with IKBKG.[1][2]
References
- ↑ 1.0 1.1 Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U (Oct 2000). "CIKS, a connection to Ikappa B kinase and stress-activated protein kinase". Proc Natl Acad Sci U S A. 97 (19): 10494–9. doi:10.1073/pnas.190245697. PMC 27052. PMID 10962033.
- ↑ 2.0 2.1 Li X, Commane M, Nie H, Hua X, Chatterjee-Kishore M, Wald D, Haag M, Stark GR (Oct 2000). "Act1, an NF-kappa B-activating protein". Proc Natl Acad Sci U S A. 97 (19): 10489–93. doi:10.1073/pnas.160265197. PMC 27051. PMID 10962024.
- ↑ 3.0 3.1 "Entrez Gene: TRAF3IP2 TRAF3 interacting protein 2".
Further reading
- Morelli C, Magnanini C, Mungall AJ, et al. (2000). "Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia". Gene. 252 (1–2): 217–25. doi:10.1016/S0378-1119(00)00231-6. PMID 10903453.
- Qian Y, Zhao Z, Jiang Z, Li X (2002). "Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9386–91. doi:10.1073/pnas.142294499. PMC 123150. PMID 12089335.
- Chariot A, Leonardi A, Muller J, et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.
- Xia YF, Li YD, Li X, Geng JG (2002). "Identification of alternatively spliced Act1 and implications for its roles in oncogenesis". Biochem. Biophys. Res. Commun. 296 (2): 406–12. doi:10.1016/S0006-291X(02)00887-2. PMID 12163033.
- Kanamori M, Kai C, Hayashizaki Y, Suzuki H (2003). "NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6". FEBS Lett. 532 (1–2): 241–6. doi:10.1016/S0014-5793(02)03688-8. PMID 12459498.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
- Mauro C, Vito P, Mellone S, et al. (2003). "Role of the adaptor protein CIKS in the activation of the IKK complex". Biochem. Biophys. Res. Commun. 309 (1): 84–90. doi:10.1016/S0006-291X(03)01532-8. PMID 12943667.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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