CYP39A1: Difference between revisions
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New page: {{protein |Name=cytochrome P450, family 39, subfamily A, polypeptide 1 |caption= |image= |width= |HGNCid=17449 |Symbol=CYP39A1 |AltSymbols= |EntrezGene= 51302 |OMIM= 605994 |RefSeq= NM_016... |
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'''CYP39A1''' ('''cy'''tochrome '''P'''450, family '''39''', subfamily '''A''', polypeptide '''1''') also known as '''oxysterol 7-α-hydroxylase 2''' is a [[protein]] | '''CYP39A1''' ('''cy'''tochrome '''P'''450, family '''39''', subfamily '''A''', polypeptide '''1''') also known as '''oxysterol 7-α-hydroxylase 2''' is a [[protein]] that in humans is encoded by the ''CYP39A1'' [[gene]].<ref name="pmid10748047">{{cite journal | vauthors = Li-Hawkins J, Lund EG, Bronson AD, Russell DW | title = Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 16543–9 |date=June 2000 | pmid = 10748047 | doi = 10.1074/jbc.M001810200 | url = | issn = }}</ref> | ||
This gene encodes a member of the [[cytochrome P450]] superfamily of [[enzyme]]s. The cytochrome P450 proteins are [[monooxygenase]]s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This [[endoplasmic reticulum]] protein is involved in the conversion of [[cholesterol]] to [[bile acid]]s. Its substrates include the oxysterols 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol.<ref name="entrez_2532">{{cite web | title = Entrez Gene: CYP39A1 | url = | This gene encodes a member of the [[cytochrome P450]] superfamily of [[enzyme]]s. The cytochrome P450 proteins are [[monooxygenase]]s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This [[endoplasmic reticulum]] protein is involved in the conversion of [[cholesterol]] to [[bile acid]]s. Its substrates include the oxysterols 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol.<ref name="entrez_2532">{{cite web | title = Entrez Gene: CYP39A1 | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51302 | accessdate = }}</ref> | ||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||
==External links== | |||
* {{UCSC gene info|CYP39A1}} | |||
==Further reading== | |||
{{refbegin | 2}} | |||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |display-authors=etal}} | |||
*{{cite journal |vauthors=Nelson DR, Zeldin DC, Hoffman SM |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001 |display-authors=etal}} | |||
*{{cite journal |vauthors=Harrington JJ, Sherf B, Rundlett S |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 |display-authors=etal}} | |||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 |display-authors=etal}} | |||
*{{cite journal |vauthors=Fourgeux C, Martine L, Björkhem I |title=Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. |journal=Invest. Ophthalmol. Vis. Sci. |volume=50 |issue= 12 |pages= 5712–7 |year= 2009 |pmid= 19553612 |doi= 10.1167/iovs.09-3655 |display-authors=etal}} | |||
{{refend}} | |||
{{NLM content}} | {{NLM content}} | ||
{{Cytochrome P450}} | {{Cytochrome P450}} | ||
{{ | {{gene-6-stub}} | ||
Latest revision as of 10:15, 30 August 2017
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CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1) also known as oxysterol 7-α-hydroxylase 2 is a protein that in humans is encoded by the CYP39A1 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol.[2]
References
- ↑ Li-Hawkins J, Lund EG, Bronson AD, Russell DW (June 2000). "Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol". J. Biol. Chem. 275 (22): 16543–9. doi:10.1074/jbc.M001810200. PMID 10748047.
- ↑ "Entrez Gene: CYP39A1".
External links
- Human CYP39A1 genome location and CYP39A1 gene details page in the UCSC Genome Browser.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
- Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Fourgeux C, Martine L, Björkhem I, et al. (2009). "Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels". Invest. Ophthalmol. Vis. Sci. 50 (12): 5712–7. doi:10.1167/iovs.09-3655. PMID 19553612.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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