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{{Infobox_gene}}
{{PBB_Controls
'''Bystin''' is a [[protein]] that in humans is encoded by the ''BYSL'' [[gene]].<ref name="pmid9925933">{{cite journal | vauthors = Pack SD, Pak E, Tanigami A, Ledbetter DH, Fukuda MN | title = Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 83 | issue = 1–2 | pages = 76–7 | date = Mar 1999 | pmid = 9925933 | pmc =  | doi = 10.1159/000015131 }}</ref><ref name="pmid17381424">{{cite journal | vauthors = Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D | title = Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis | journal = Biochem J | volume = 404 | issue = 3 | pages = 373–81 | date = May 2007 | pmid = 17381424 | pmc = 1896285 | doi = 10.1042/BJ20061597 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BYSL bystin-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=705| accessdate = }}</ref>
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Bystin-like
| HGNCid = 1157
| Symbol = BYSL
| AltSymbols =; BYSTIN
| OMIM = 603871
| ECnumber = 
| Homologene = 2991
| MGIid = 1858419
| GeneAtlas_image1 = PBB_GE_BYSL_203612_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 705
    | Hs_Ensembl = ENSG00000112578
    | Hs_RefseqProtein = NP_004044
    | Hs_RefseqmRNA = NM_004053
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 41996943
    | Hs_GenLoc_end = 42008762
    | Hs_Uniprot = Q13895
    | Mm_EntrezGene = 53414
    | Mm_Ensembl = ENSMUSG00000023988
    | Mm_RefseqmRNA = NM_016859
    | Mm_RefseqProtein = NP_058555
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 47063271
    | Mm_GenLoc_end = 47074675
    | Mm_Uniprot = Q543N4
  }}
}}
'''Bystin-like''', also known as '''BYSL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BYSL bystin-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=705| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi.<ref name="entrez">{{cite web | title = Entrez Gene: BYSL bystin-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=705| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
BYSL has been shown to [[Protein-protein interaction|interact]] with [[TROAP]].<ref name=pmid9560222>{{cite journal | vauthors = Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN | title = A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells | journal = [[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] | volume = 95 | issue = 9 | pages = 5027–32 | date = Apr 1998 | pmid = 9560222 | pmc = 20207 | doi = 10.1073/pnas.95.9.5027 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|BYSL}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN | title = A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 9 | pages = 5027–32 | year = 1998 | pmid = 9560222 | pmc = 20207 | doi = 10.1073/pnas.95.9.5027 }}
| citations =
* {{cite journal | vauthors = Suzuki N, Nakayama J, Shih IM, Aoki D, Nozawa S, Fukuda MN | title = Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. | journal = Biol. Reprod. | volume = 60 | issue = 3 | pages = 621–7 | year = 1999 | pmid = 10026108 | doi = 10.1095/biolreprod60.3.621 }}
*{{cite journal | author=Suzuki N, Zara J, Sato T, ''et al.'' |title=A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 9 |pages= 5027-32 |year= 1998 |pmid= 9560222 |doi= }}
* {{cite journal | vauthors = Nakayama J, Aoki D, Suga T, Akama TO, Ishizone S, Yamaguchi H, Imakawa K, Nadano D, Fazleabas AT, Katsuyama T, Nozawa S, Fukuda MN | title = Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. | journal = Am. J. Pathol. | volume = 163 | issue = 6 | pages = 2211–9 | year = 2004 | pmid = 14633596 | pmc = 1892375 | doi = 10.1016/S0002-9440(10)63579-1 }}
*{{cite journal  | author=Pack SD, Pak E, Tanigami A, ''et al.'' |title=Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 76-7 |year= 1999 |pmid= 9925933 |doi=  }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Suzuki N, Nakayama J, Shih IM, ''et al.'' |title=Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. |journal=Biol. Reprod. |volume=60 |issue= 3 |pages= 621-7 |year= 1999 |pmid= 10026108 |doi=  }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Nakayama J, Aoki D, Suga T, ''et al.'' |title=Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. |journal=Am. J. Pathol. |volume=163 |issue= 6 |pages= 2211-9 |year= 2004 |pmid= 14633596 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Miyoshi M, Okajima T, Matsuda T, ''et al.'' |title=Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. |journal=Biochem. J. |volume=404 |issue= 3 |pages= 373-81 |year= 2007 |pmid= 17381424 |doi= 10.1042/BJ20061597 }}
}}
{{refend}}
{{refend}}


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{{DEFAULTSORT:Bysl}}
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Latest revision as of 02:15, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bystin is a protein that in humans is encoded by the BYSL gene.[1][2][3]

Function

Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi.[3]

Interactions

BYSL has been shown to interact with TROAP.[4]

References

  1. ↑ Pack SD, Pak E, Tanigami A, Ledbetter DH, Fukuda MN (Mar 1999). "Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 76–7. doi:10.1159/000015131. PMID 9925933.
  2. ↑ Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D (May 2007). "Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis". Biochem J. 404 (3): 373–81. doi:10.1042/BJ20061597. PMC 1896285. PMID 17381424.
  3. ↑ 3.0 3.1 "Entrez Gene: BYSL bystin-like".
  4. ↑ Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN (Apr 1998). "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5027–32. doi:10.1073/pnas.95.9.5027. PMC 20207. PMID 9560222.

External links

Further reading



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