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{{Infobox_gene}}
{{PBB_Controls
'''Zinc-alpha-2-glycoprotein''' is a [[protein]] that in humans is encoded by the ''AZGP1'' [[gene]].<ref name="pmid2049092">{{cite journal | vauthors = Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I | title = Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene | journal = Biochem Biophys Res Commun | volume = 177 | issue = 2 | pages = 696–703 |date=Jul 1991 | pmid = 2049092 | pmc =  | doi =10.1016/0006-291X(91)91844-3  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=563| accessdate = }}</ref>
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This gene expresses a soluble [[protein]] that stimulates [[lipolysis]], induces a reduction in [[body fat]] in [[mouse|mice]], is associated with the [[cachexia]] related to [[cancer]], and is known to be expressed in secretory cells of [[lung]] [[epithelium]].<ref name=smoking>{{cite journal | title = Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human| journal=Chest | volume=135 | issue=5 | pages=1197–208 | year=2009 | pmid=19188554 | doi = 10.1378/chest.08-1024 | last1 = Vanni | first1 = H | last2 = Kazeros | first2 = A | last3 = Wang | first3 = R | last4 = Harvey | first4 = BG | last5 = Ferris | first5 = B | last6 = De | first6 = BP | last7 = Carolan | first7 = BJ | last8 = Hübner | first8 = RH | last9 = O'Connor | first9 = TP | last10=Crystal | first10=R. G. | pmc = 2679098 | display-authors=8 }}</ref> In 2009, it was found that [[smoking]] increases expression of this gene, which is why [[smoking cessation]] leads to weight gain.<ref name="smoking"/> Zinc-alpha-2-glycoprotein levels also rise with onset of Diabetes 2, which accounts for weight loss thereafter.
{{GNF_Protein_box
| image = PBB_Protein_AZGP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t7v.
| PDB = {{PDB2|1t7v}}, {{PDB2|1t7w}}, {{PDB2|1t7x}}, {{PDB2|1t7y}}, {{PDB2|1t7z}}, {{PDB2|1t80}}, {{PDB2|1zag}}, {{PDB2|2icn}}
| Name = Alpha-2-glycoprotein 1, zinc-binding
| HGNCid = 910
| Symbol = AZGP1
| AltSymbols =; ZA2G; ZAG
| OMIM = 194460
| ECnumber =
| Homologene = 915
| MGIid = 103163
| GeneAtlas_image1 = PBB_GE_AZGP1_209309_at_tn.png
| GeneAtlas_image2 = PBB_GE_AZGP1_217014_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004540 |text = ribonuclease activity}} {{GNF_GO|id=GO:0005504 |text = fatty acid binding}} {{GNF_GO|id=GO:0008320 |text = protein carrier activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
| Process = {{GNF_GO|id=GO:0002474 |text = antigen processing and presentation of peptide antigen via MHC class I}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 563
    | Hs_Ensembl = ENSG00000160862
    | Hs_RefseqProtein = NP_001176
    | Hs_RefseqmRNA = NM_001185
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 99402290
    | Hs_GenLoc_end = 99411623
    | Hs_Uniprot = P25311
    | Mm_EntrezGene = 12007
    | Mm_Ensembl = ENSMUSG00000037053
    | Mm_RefseqmRNA = NM_013478
    | Mm_RefseqProtein = NP_038506
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 138211324
    | Mm_GenLoc_end = 138220018
    | Mm_Uniprot = Q9DBB7
  }}
}}
'''Alpha-2-glycoprotein 1, zinc-binding''', also known as '''AZGP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=563| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|AZGP1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Freije JP, Fueyo A, Uría J, López-Otín C |title=Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. |journal=FEBS Lett. |volume=290 |issue= 1-2 |pages= 247-9 |year= 1991 |pmid= 1915885 |doi=  }}
*{{cite journal  | vauthors=Freije JP, Fueyo A, Uría J, López-Otín C |title=Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. |journal=FEBS Lett. |volume=290 |issue= 1–2 |pages= 247–9 |year= 1991 |pmid= 1915885 |doi=10.1016/0014-5793(91)81271-9 }}
*{{cite journal  | author=Tada T, Ohkubo I, Niwa M, ''et al.'' |title=Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues. |journal=J. Histochem. Cytochem. |volume=39 |issue= 9 |pages= 1221-6 |year= 1991 |pmid= 1918940 |doi=  }}
*{{cite journal  | vauthors=Tada T, Ohkubo I, Niwa M |title=Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues |journal=J. Histochem. Cytochem. |volume=39 |issue= 9 |pages= 1221–6 |year= 1991 |pmid= 1918940 |doi=  10.1177/39.9.1918940|display-authors=etal}}
*{{cite journal  | author=Ueyama H, Niwa M, Tada T, ''et al.'' |title=Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene. |journal=Biochem. Biophys. Res. Commun. |volume=177 |issue= 2 |pages= 696-703 |year= 1991 |pmid= 2049092 |doi=  }}
*{{cite journal  | vauthors=Araki T, Gejyo F, Takagaki K |title=Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 3 |pages= 679–83 |year= 1988 |pmid= 3422450 |doi=10.1073/pnas.85.3.679 | pmc=279618  |display-authors=etal}}
*{{cite journal  | author=Araki T, Gejyo F, Takagaki K, ''et al.'' |title=Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 3 |pages= 679-83 |year= 1988 |pmid= 3422450 |doi=  }}
*{{cite journal  | vauthors=Shibata S, Miura K |title=Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine |journal=Nephron |volume=31 |issue= 2 |pages= 170–6 |year= 1982 |pmid= 6896906 |doi=  10.1159/000182638}}
*{{cite journal  | author=Shibata S, Miura K |title=Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine. |journal=Nephron |volume=31 |issue= 2 |pages= 170-6 |year= 1982 |pmid= 6896906 |doi=  }}
*{{cite journal  | vauthors=Ueyama H, Deng HX, Ohkubo I |title=Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein |journal=Biochemistry |volume=32 |issue= 48 |pages= 12968–76 |year= 1994 |pmid= 8241150 |doi=10.1021/bi00211a004 }}
*{{cite journal  | author=Ueyama H, Deng HX, Ohkubo I |title=Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein. |journal=Biochemistry |volume=32 |issue= 48 |pages= 12968-76 |year= 1994 |pmid= 8241150 |doi=  }}
*{{cite journal  | vauthors=Freije JP, Fueyo A, Uría JA |title=Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes |journal=Genomics |volume=18 |issue= 3 |pages= 575–87 |year= 1994 |pmid= 8307568 |doi=10.1016/S0888-7543(05)80359-3 |display-authors=etal}}
*{{cite journal  | author=Freije JP, Fueyo A, Uría JA, ''et al.'' |title=Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes. |journal=Genomics |volume=18 |issue= 3 |pages= 575-87 |year= 1994 |pmid= 8307568 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Sánchez LM, López-Otín C, Bjorkman PJ |title=Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4626–30 |year= 1997 |pmid= 9114041 |doi=10.1073/pnas.94.9.4626  | pmc=20774  }}
*{{cite journal  | author=Sánchez LM, López-Otín C, Bjorkman PJ |title=Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4626-30 |year= 1997 |pmid= 9114041 |doi=  }}
*{{cite journal  | vauthors=Brysk MM, Lei G, Rajaraman S |title=Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia |journal=In Vivo |volume=11 |issue= 3 |pages= 271–4 |year= 1997 |pmid= 9239523 |doi=  |display-authors=etal}}
*{{cite journal  | author=Brysk MM, Lei G, Rajaraman S, ''et al.'' |title=Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia. |journal=In Vivo |volume=11 |issue= 3 |pages= 271-4 |year= 1997 |pmid= 9239523 |doi= }}
*{{cite journal  | vauthors=Lei G, Arany I, Selvanayagam P |title=Detection and cloning of epidermal zinc-alpha 2-glycoprotein cDNA and expression in normal human skin and in tumors |journal=J. Cell. Biochem. |volume=67 |issue= 2 |pages= 216–22 |year= 1997 |pmid= 9328826 |doi=10.1002/(SICI)1097-4644(19971101)67:2<216::AID-JCB6>3.0.CO;2-#  |display-authors=etal}}
*{{cite journal  | author=Lei G, Arany I, Selvanayagam P, ''et al.'' |title=Detection and cloning of epidermal zinc-alpha 2-glycoprotein cDNA and expression in normal human skin and in tumors. |journal=J. Cell. Biochem. |volume=67 |issue= 2 |pages= 216-22 |year= 1997 |pmid= 9328826 |doi=  }}
*{{cite journal  | vauthors=Ogikubo O, Maeda T, Yamane T |title=Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 257–62 |year= 1998 |pmid= 9813179 |doi=10.1006/bbrc.1998.9614 |display-authors=etal}}
*{{cite journal  | author=Ogikubo O, Maeda T, Yamane T, ''et al.'' |title=Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 257-62 |year= 1998 |pmid= 9813179 |doi=  }}
*{{cite journal  | vauthors=Sánchez LM, Chirino AJ, Bjorkman P |title=Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules |journal=Science |volume=283 |issue= 5409 |pages= 1914–9 |year= 1999 |pmid= 10206894 |doi=10.1126/science.283.5409.1914 }}
*{{cite journal  | author=Sánchez LM, Chirino AJ, Bjorkman P |title=Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules. |journal=Science |volume=283 |issue= 5409 |pages= 1914-9 |year= 1999 |pmid= 10206894 |doi=  }}
*{{cite journal  | vauthors=Lei G, Brysk H, Arany I |title=Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line |journal=J. Cell. Biochem. |volume=75 |issue= 1 |pages= 160–9 |year= 1999 |pmid= 10462714 |doi=10.1002/(SICI)1097-4644(19991001)75:1<160::AID-JCB16>3.0.CO;2-B |display-authors=etal}}
*{{cite journal  | author=Lei G, Brysk H, Arany I, ''et al.'' |title=Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line. |journal=J. Cell. Biochem. |volume=75 |issue= 1 |pages= 160-9 |year= 1999 |pmid= 10462714 |doi=  }}
*{{cite journal  | vauthors=Davidsson P, Nilsson CL |title=Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry |journal=Biochim. Biophys. Acta |volume=1473 |issue= 2–3 |pages= 391–9 |year= 2000 |pmid= 10594376 |doi=  10.1016/s0304-4165(99)00197-x}}
*{{cite journal  | author=Davidsson P, Nilsson CL |title=Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry. |journal=Biochim. Biophys. Acta |volume=1473 |issue= 2-3 |pages= 391-9 |year= 2000 |pmid= 10594376 |doi= }}
*{{cite journal  | vauthors=Kennedy MW, Heikema AP, Cooper A |title=Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 35008–13 |year= 2001 |pmid= 11425849 |doi= 10.1074/jbc.C100301200 |display-authors=etal}}
*{{cite journal  | author=Kennedy MW, Heikema AP, Cooper A, ''et al.'' |title=Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 35008-13 |year= 2001 |pmid= 11425849 |doi= 10.1074/jbc.C100301200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Scherer SW, Cheung J, MacDonald JR |title=Human chromosome 7: DNA sequence and biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961 |display-authors=etal}}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | vauthors=BURGI W, SCHMID K |title=Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma |journal=J. Biol. Chem. |volume=236 |issue=  |pages= 1066–74 |year= 1998 |pmid= 13689030 |doi=  }}
*{{cite journal  | author=BURGI W, SCHMID K |title=Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma. |journal=J. Biol. Chem. |volume=236 |issue=  |pages= 1066-74 |year= 1998 |pmid= 13689030 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=563}}
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Latest revision as of 18:30, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene.[1][2]

This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium.[3] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.[3] Zinc-alpha-2-glycoprotein levels also rise with onset of Diabetes 2, which accounts for weight loss thereafter.


References

  1. ↑ Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene". Biochem Biophys Res Commun. 177 (2): 696–703. doi:10.1016/0006-291X(91)91844-3. PMID 2049092.
  2. ↑ "Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding".
  3. ↑ 3.0 3.1 Vanni, H; Kazeros, A; Wang, R; Harvey, BG; Ferris, B; De, BP; Carolan, BJ; Hübner, RH; et al. (2009). "Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human". Chest. 135 (5): 1197–208. doi:10.1378/chest.08-1024. PMC 2679098. PMID 19188554.

External links

Further reading



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