STARD3NL: Difference between revisions

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{{Infobox_gene}}
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'''MENTHO''' or STARD3 N-terminal like protein ('''STARD3NL''') is an [[integral membrane protein]] of unknown function.<ref name="entrez">{{cite web | title = Entrez Gene: STARD3NL STARD3 N-terminal like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83930| accessdate = }}</ref> As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as [[MLN64]], but lacks the [[StAR-related transfer domain]] (START) that characterizes all other proteins given the "STARD" (START domain-containing) name. The [[N-terminus|N-terminal]] domain is called a [[MENTAL domain|MENTAL]] (MLN64 N-terminal) domain.
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Like MLN64, MENTHO is widely expressed in tissues of the body.  Within the [[Cell (biology)|cell]], it localizes to the membranes of [[endosome|late endosome]]s and may interact there with MLN64.  It is suggested that in combination with MLN64, this protein helps regulate the flow of [[cholesterol]] through the endosomal pathway.<ref name="pmid16709157">{{cite journal  | vauthors=Alpy F, Tomasetto C |title=MLN64 and MENTHO, two mediators of endosomal cholesterol transport. |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 343–5 |year= 2006 |pmid= 16709157 |doi= 10.1042/BST0340343 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = STARD3 N-terminal like
| HGNCid = 19169
| Symbol = STARD3NL
| AltSymbols =; MENTHO; MGC3251
| OMIM = 
| ECnumber = 
| Homologene = 11501
| MGIid = 1923455
| GeneAtlas_image1 = PBB_GE_STARD3NL_gnf1h09044_s_at_tn.png
  | Function =
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83930
    | Hs_Ensembl = ENSG00000010270
    | Hs_RefseqProtein = NP_114405
    | Hs_RefseqmRNA = NM_032016
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 38184376
    | Hs_GenLoc_end = 38236760
    | Hs_Uniprot = O95772
    | Mm_EntrezGene = 76205
    | Mm_Ensembl = ENSMUSG00000003062
    | Mm_RefseqmRNA = NM_024270
    | Mm_RefseqProtein = NP_077232
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 19365141
    | Mm_GenLoc_end = 19403217
    | Mm_Uniprot = Q3U852
  }}
}}
'''STARD3 N-terminal like''', also known as '''STARD3NL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STARD3NL STARD3 N-terminal like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83930| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Alpy F, Tomasetto C |title=MLN64 and MENTHO, two mediators of endosomal cholesterol transport. |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 343-5 |year= 2006 |pmid= 16709157 |doi= 10.1042/BST0340343 }}
*{{cite journal  |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  | vauthors=Alpy F, Wendling C, Rio MC, Tomasetto C |title=MENTHO, an MLN64 homologue devoid of the START domain. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50780–7 |year= 2003 |pmid= 12393907 |doi=10.1074/jbc.M208290200 }}
*{{cite journal  | author=Alpy F, Wendling C, Rio MC, Tomasetto C |title=MENTHO, an MLN64 homologue devoid of the START domain. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50780-7 |year= 2003 |pmid= 12393907 |doi= 10.1074/jbc. M208290200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Tuckey RC, Bose HS, Czerwionka I, Miller WL |title=Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria. |journal=Endocrinology |volume=145 |issue= 4 |pages= 1700–7 |year= 2004 |pmid= 14715710 |doi= 10.1210/en.2003-1034 }}
*{{cite journal  | author=Tuckey RC, Bose HS, Czerwionka I, Miller WL |title=Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria. |journal=Endocrinology |volume=145 |issue= 4 |pages= 1700-7 |year= 2004 |pmid= 14715710 |doi= 10.1210/en.2003-1034 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Alpy F, Latchumanan VK, Kedinger V, etal |title=Functional characterization of the MENTAL domain. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 17945–52 |year= 2005 |pmid= 15718238 |doi=10.1074/jbc.M500723200 }}
*{{cite journal | author=Alpy F, Latchumanan VK, Kedinger V, ''et al.'' |title=Functional characterization of the MENTAL domain. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 17945-52 |year= 2005 |pmid= 15718238 |doi= 10.1074/jbc. M500723200 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, ''in vivo'', and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, ''in vivo'', and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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==External links==
* {{MeshName|STARD3NL+protein,+human}}
 
[[Category:Integral membrane proteins]]
 
 
{{gene-7-stub}}

Latest revision as of 07:10, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MENTHO or STARD3 N-terminal like protein (STARD3NL) is an integral membrane protein of unknown function.[1] As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as MLN64, but lacks the StAR-related transfer domain (START) that characterizes all other proteins given the "STARD" (START domain-containing) name. The N-terminal domain is called a MENTAL (MLN64 N-terminal) domain.

Like MLN64, MENTHO is widely expressed in tissues of the body. Within the cell, it localizes to the membranes of late endosomes and may interact there with MLN64. It is suggested that in combination with MLN64, this protein helps regulate the flow of cholesterol through the endosomal pathway.[2]


References

  1. ↑ "Entrez Gene: STARD3NL STARD3 N-terminal like".
  2. ↑ Alpy F, Tomasetto C (2006). "MLN64 and MENTHO, two mediators of endosomal cholesterol transport". Biochem. Soc. Trans. 34 (Pt 3): 343–5. doi:10.1042/BST0340343. PMID 16709157.

Further reading


External links


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