MEST (gene): Difference between revisions

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{{Infobox_gene}}
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'''Mesoderm-specific transcript homolog protein''' is a [[protein]] that in humans is encoded by the ''MEST'' [[gene]].<ref name="pmid8884280">{{cite journal |vauthors=Nishita Y, Yoshida I, Sado T, Takagi N | title = Genomic imprinting and chromosomal localization of the human MEST gene | journal = Genomics | volume = 36 | issue = 3 | pages = 539–42 |date=Feb 1997 | pmid = 8884280 | pmc =  | doi = 10.1006/geno.1996.0502 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MEST mesoderm specific transcript homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4232| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Mesoderm specific transcript homolog (mouse)
| HGNCid = 7028
| Symbol = MEST
| AltSymbols =; DKFZp686L18234; MGC111102; MGC8703; PEG1
| OMIM = 601029
| ECnumber = 
| Homologene = 1800
| MGIid = 96968
| GeneAtlas_image1 = PBB_GE_MEST_202016_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007498 |text = mesoderm development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4232
    | Hs_Ensembl = ENSG00000106484
    | Hs_RefseqProtein = NP_002393
    | Hs_RefseqmRNA = NM_002402
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 129913282
    | Hs_GenLoc_end = 129933365
    | Hs_Uniprot =   
    | Mm_EntrezGene = 17294
    | Mm_Ensembl = ENSMUSG00000051855
    | Mm_RefseqmRNA = XM_974235
    | Mm_RefseqProtein = XP_979329
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 30688063
    | Mm_GenLoc_end = 30698465
    | Mm_Uniprot = 
  }}
}}
'''Mesoderm specific transcript homolog (mouse)''', also known as '''MEST''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MEST mesoderm specific transcript homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4232| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the [alpha]/[beta] hydrolase fold family and has isoform specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.<ref name="entrez">{{cite web | title = Entrez Gene: MEST mesoderm specific transcript homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4232| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [alpha]/[beta] hydrolase fold family and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nishita Y, Yoshida I, Sado T, Takagi N |title=Genomic imprinting and chromosomal localization of the human MEST gene. |journal=Genomics |volume=36 |issue= 3 |pages= 539-42 |year= 1997 |pmid= 8884280 |doi= 10.1006/geno.1996.0502 }}
*{{cite journal   |vauthors=Kobayashi S, Kohda T, Miyoshi N, etal |title=Human PEG1/MEST, an imprinted gene on chromosome 7 |journal=Hum. Mol. Genet. |volume=6 |issue= 5 |pages= 781–6 |year= 1997 |pmid= 9158153 |doi=10.1093/hmg/6.5.781  }}
*{{cite journal | author=Kobayashi S, Kohda T, Miyoshi N, ''et al.'' |title=Human PEG1/MEST, an imprinted gene on chromosome 7. |journal=Hum. Mol. Genet. |volume=6 |issue= 5 |pages= 781-6 |year= 1997 |pmid= 9158153 |doi= }}
*{{cite journal   |vauthors=Riesewijk AM, Hu L, Schulz U, etal |title=Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses |journal=Genomics |volume=42 |issue= 2 |pages= 236–44 |year= 1997 |pmid= 9192843 |doi= 10.1006/geno.1997.4731 }}
*{{cite journal | author=Riesewijk AM, Hu L, Schulz U, ''et al.'' |title=Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses. |journal=Genomics |volume=42 |issue= 2 |pages= 236-44 |year= 1997 |pmid= 9192843 |doi= 10.1006/geno.1997.4731 }}
*{{cite journal   |vauthors=Cuisset L, Le Stunff C, Dupont JM, etal |title=PEG1 expression in maternal uniparental disomy 7 |journal=Ann. Genet. |volume=40 |issue= 4 |pages= 211–5 |year= 1998 |pmid= 9526615 |doi= }}
*{{cite journal | author=Cuisset L, Le Stunff C, Dupont JM, ''et al.'' |title=PEG1 expression in maternal uniparental disomy 7. |journal=Ann. Genet. |volume=40 |issue= 4 |pages= 211-5 |year= 1998 |pmid= 9526615 |doi= }}
*{{cite journal   |vauthors=Riesewijk AM, Blagitko N, Schinzel AA, etal |title=Evidence against a major role of PEG1/MEST in Silver-Russell syndrome |journal=Eur. J. Hum. Genet. |volume=6 |issue= 2 |pages= 114–20 |year= 1998 |pmid= 9781054 |doi= 10.1038/sj.ejhg.5200164 }}
*{{cite journal | author=Riesewijk AM, Blagitko N, Schinzel AA, ''et al.'' |title=Evidence against a major role of PEG1/MEST in Silver-Russell syndrome. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 2 |pages= 114-20 |year= 1998 |pmid= 9781054 |doi= 10.1038/sj.ejhg.5200164 }}
*{{cite journal   |vauthors=Pedersen IS, Dervan PA, Broderick D, etal |title=Frequent loss of imprinting of PEG1/MEST in invasive breast cancer |journal=Cancer Res. |volume=59 |issue= 21 |pages= 5449–51 |year= 1999 |pmid= 10554015 |doi= }}
*{{cite journal  | author=Pedersen IS, Dervan PA, Broderick D, ''et al.'' |title=Frequent loss of imprinting of PEG1/MEST in invasive breast cancer. |journal=Cancer Res. |volume=59 |issue= 21 |pages= 5449-51 |year= 1999 |pmid= 10554015 |doi=  }}
*{{cite journal  |vauthors=Kosaki K, Kosaki R, Craigen WJ, Matsuo N |title=Isoform-Specific Imprinting of the Human PEG1/MEST Gene |journal=Am. J. Hum. Genet. |volume=66 |issue= 1 |pages= 309–12 |year= 2000 |pmid= 10631159 |doi=10.1086/302712  | pmc=1288335 }}
*{{cite journal | author=Kosaki K, Kosaki R, Craigen WJ, Matsuo N |title=Isoform-specific imprinting of the human PEG1/MEST gene. |journal=Am. J. Hum. Genet. |volume=66 |issue= 1 |pages= 309-12 |year= 2000 |pmid= 10631159 |doi= }}
*{{cite journal   |vauthors=Mayer W, Hemberger M, Frank HG, etal |title=Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis |journal=Dev. Dyn. |volume=217 |issue= 1 |pages= 1–10 |year= 2000 |pmid= 10679925 |doi= 10.1002/(SICI)1097-0177(200001)217:1<1::AID-DVDY1>3.0.CO;2-4 }}
*{{cite journal  | author=Mayer W, Hemberger M, Frank HG, ''et al.'' |title=Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis. |journal=Dev. Dyn. |volume=217 |issue= 1 |pages= 1-10 |year= 2000 |pmid= 10679925 |doi= 10.1002/(SICI)1097-0177(200001)217:1<1::AID-DVDY1>3.0.CO;2-4 }}
*{{cite journal  |vauthors=Hayashida S, Yamasaki K, Asada Y, etal |title=Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32 |journal=Genomics |volume=66 |issue= 2 |pages= 221–5 |year= 2000 |pmid= 10860668 |doi= 10.1006/geno.2000.6206 }}
*{{cite journal | author=Hayashida S, Yamasaki K, Asada Y, ''et al.'' |title=Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. |journal=Genomics |volume=66 |issue= 2 |pages= 221-5 |year= 2000 |pmid= 10860668 |doi= 10.1006/geno.2000.6206 }}
*{{cite journal   |vauthors=Russo S, Bedeschi MF, Cogliati F, etal |title=Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression |journal=Clin. Dysmorphol. |volume=9 |issue= 3 |pages= 157–62 |year= 2000 |pmid= 10955473 |doi=10.1097/00019605-200009030-00001  }}
*{{cite journal | author=Russo S, Bedeschi MF, Cogliati F, ''et al.'' |title=Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression. |journal=Clin. Dysmorphol. |volume=9 |issue= 3 |pages= 157-62 |year= 2000 |pmid= 10955473 |doi= }}
*{{cite journal   |vauthors=Kerjean A, Dupont JM, Vasseur C, etal |title=Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis |journal=Hum. Mol. Genet. |volume=9 |issue= 14 |pages= 2183–7 |year= 2000 |pmid= 10958657 |doi=10.1093/hmg/9.14.2183  }}
*{{cite journal | author=Kerjean A, Dupont JM, Vasseur C, ''et al.'' |title=Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis. |journal=Hum. Mol. Genet. |volume=9 |issue= 14 |pages= 2183-7 |year= 2000 |pmid= 10958657 |doi=  }}
*{{cite journal   |vauthors=Kohda M, Hoshiya H, Katoh M, etal |title=Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma |journal=Mol. Carcinog. |volume=31 |issue= 4 |pages= 184–91 |year= 2001 |pmid= 11536368 |doi=10.1002/mc.1053 }}
*{{cite journal | author=Kohda M, Hoshiya H, Katoh M, ''et al.'' |title=Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma. |journal=Mol. Carcinog. |volume=31 |issue= 4 |pages= 184-91 |year= 2001 |pmid= 11536368 |doi= }}
*{{cite journal   |vauthors=Miozzo M, Grati FR, Bulfamante G, etal |title=Post-zygotic origin of complete maternal chromosome 7 isodisomy and consequent loss of placental PEG1/MEST expression |journal=Placenta |volume=22 |issue= 10 |pages= 813–21 |year= 2002 |pmid= 11718568 |doi= 10.1053/plac.2001.0728 }}
*{{cite journal | author=Miozzo M, Grati FR, Bulfamante G, ''et al.'' |title=Post-zygotic origin of complete maternal chromosome 7 isodisomy and consequent loss of placental PEG1/MEST expression. |journal=Placenta |volume=22 |issue= 10 |pages= 813-21 |year= 2002 |pmid= 11718568 |doi= 10.1053/plac.2001.0728 }}
*{{cite journal   |vauthors=Kobayashi S, Uemura H, Kohda T, etal |title=No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients |journal=Am. J. Med. Genet. |volume=104 |issue= 3 |pages= 225–31 |year= 2002 |pmid= 11754049 |doi=10.1002/ajmg.10022  }}
*{{cite journal | author=Kobayashi S, Uemura H, Kohda T, ''et al.'' |title=No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients. |journal=Am. J. Med. Genet. |volume=104 |issue= 3 |pages= 225-31 |year= 2002 |pmid= 11754049 |doi= }}
*{{cite journal   |vauthors=Li T, Vu TH, Lee KO, etal |title=An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13518–27 |year= 2002 |pmid= 11821432 |doi= 10.1074/jbc.M200458200 }}
*{{cite journal | author=Li T, Vu TH, Lee KO, ''et al.'' |title=An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13518-27 |year= 2002 |pmid= 11821432 |doi= 10.1074/jbc.M200458200 }}
*{{cite journal   |vauthors=Bonora E, Bacchelli E, Levy ER, etal |title=Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region |journal=Mol. Psychiatry |volume=7 |issue= 3 |pages= 289–301 |year= 2002 |pmid= 11920156 |doi= 10.1038/sj.mp.4001004 }}
*{{cite journal | author=Bonora E, Bacchelli E, Levy ER, ''et al.'' |title=Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. |journal=Mol. Psychiatry |volume=7 |issue= 3 |pages= 289-301 |year= 2002 |pmid= 11920156 |doi= 10.1038/sj.mp.4001004 }}
*{{cite journal   |vauthors=Pedersen IS, Dervan P, McGoldrick A, etal |title=Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer |journal=Hum. Mol. Genet. |volume=11 |issue= 12 |pages= 1449–53 |year= 2002 |pmid= 12023987 |doi=10.1093/hmg/11.12.1449  }}
*{{cite journal | author=Pedersen IS, Dervan P, McGoldrick A, ''et al.'' |title=Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer. |journal=Hum. Mol. Genet. |volume=11 |issue= 12 |pages= 1449-53 |year= 2002 |pmid= 12023987 |doi=  }}
*{{cite journal   |vauthors=Nakabayashi K, Bentley L, Hitchins MP, etal |title=Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32 |journal=Hum. Mol. Genet. |volume=11 |issue= 15 |pages= 1743–56 |year= 2003 |pmid= 12095916 |doi=10.1093/hmg/11.15.1743 }}
*{{cite journal | author=Nakabayashi K, Bentley L, Hitchins MP, ''et al.'' |title=Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. |journal=Hum. Mol. Genet. |volume=11 |issue= 15 |pages= 1743-56 |year= 2003 |pmid= 12095916 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:24, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.[1][2]

This gene encodes a member of the [alpha]/[beta] hydrolase fold family and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.[2]

References

  1. ↑ Nishita Y, Yoshida I, Sado T, Takagi N (Feb 1997). "Genomic imprinting and chromosomal localization of the human MEST gene". Genomics. 36 (3): 539–42. doi:10.1006/geno.1996.0502. PMID 8884280.
  2. ↑ 2.0 2.1 "Entrez Gene: MEST mesoderm specific transcript homolog (mouse)".

Further reading



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