ARL4A: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ADP-ribosylation factor-like protein 4A''' is a [[protein]] that in humans is encoded by the ''ARL4A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARL4A ADP-ribosylation factor-like 4A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10124| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ADP-ribosylation factor-like 4A
| HGNCid = 695
| Symbol = ARL4A
| AltSymbols =; ARL4
| OMIM = 604786
| ECnumber = 
| Homologene = 4194
| MGIid = 99437
| GeneAtlas_image1 = PBB_GE_ARL4A_205020_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10124
    | Hs_Ensembl = ENSG00000122644
    | Hs_RefseqProtein = NP_001032241
    | Hs_RefseqmRNA = NM_001037164
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 12693006
    | Hs_GenLoc_end = 12697084
    | Hs_Uniprot = P40617
    | Mm_EntrezGene = 11861
    | Mm_Ensembl = ENSMUSG00000047446
    | Mm_RefseqmRNA = NM_001039515
    | Mm_RefseqProtein = NP_001034604
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 40543714
    | Mm_GenLoc_end = 40548410
    | Mm_Uniprot = Q3UUY4
  }}
}}
'''ADP-ribosylation factor-like 4A''', also known as '''ARL4A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARL4A ADP-ribosylation factor-like 4A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10124| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ARL4A ADP-ribosylation factor-like 4A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10124| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ARL4A has been shown to [[Protein-protein interaction|interact]] with [[Karyopherin alpha 2]].<ref name=pmid10980193>{{cite journal | vauthors = Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ | title = ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli | journal = J. Biol. Chem. | volume = 275 | issue = 48 | pages = 37815–23 | date = December 2000 | pmid = 10980193 | doi = 10.1074/jbc.M002470200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC | title = Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. | journal = Genomics | volume = 23 | issue = 1 | pages = 42–50 | year = 1995 | pmid = 7829101 | doi = 10.1006/geno.1994.1457 }}
| citations =
* {{cite journal | vauthors = Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG | title = ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. | journal = FEBS Lett. | volume = 456 | issue = 3 | pages = 384–8 | year = 1999 | pmid = 10462049 | doi = 10.1016/S0014-5793(99)00759-0 }}
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
* {{cite journal | vauthors = Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ | title = ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. | journal = J. Biol. Chem. | volume = 275 | issue = 48 | pages = 37815–23 | year = 2001 | pmid = 10980193 | doi = 10.1074/jbc.M002470200 }}
*{{cite journal | author=Jacobs S, Schilf C, Fliegert F, ''et al.'' |title=ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. |journal=FEBS Lett. |volume=456 |issue= 3 |pages= 384-8 |year= 1999 |pmid= 10462049 |doi= }}
* {{cite journal | vauthors = Hofmann I, Thompson A, Sanderson CM, Munro S | title = The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. | journal = Curr. Biol. | volume = 17 | issue = 8 | pages = 711–6 | year = 2007 | pmid = 17398095 | doi = 10.1016/j.cub.2007.03.007 }}
*{{cite journal | author=Lin CY, Huang PH, Liao WL, ''et al.'' |title=ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37815-23 |year= 2001 |pmid= 10980193 |doi= 10.1074/jbc.M002470200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hofmann I, Thompson A, Sanderson CM, Munro S |title=The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. |journal=Curr. Biol. |volume=17 |issue= 8 |pages= 711-6 |year= 2007 |pmid= 17398095 |doi= 10.1016/j.cub.2007.03.007 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|ARL4A}}
* {{UCSC gene details|ARL4A}}
 
 
{{gene-7-stub}}

Latest revision as of 02:14, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.[1]

Function

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.[1]

Interactions

ARL4A has been shown to interact with Karyopherin alpha 2.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A".
  2. ↑ Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.

Further reading

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
  • Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG (1999). "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal". FEBS Lett. 456 (3): 384–8. doi:10.1016/S0014-5793(99)00759-0. PMID 10462049.
  • Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (2001). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.
  • Hofmann I, Thompson A, Sanderson CM, Munro S (2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane". Curr. Biol. 17 (8): 711–6. doi:10.1016/j.cub.2007.03.007. PMID 17398095.

External links


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