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{{Infobox_gene}}
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'''Amphiphysin''' is a [[protein]] that in humans is encoded by the ''AMPH'' [[gene]].<ref name="pmid8245793">{{cite journal | vauthors = De Camilli P, Thomas A, Cofiell R, Folli F, Lichte B, Piccolo G, Meinck HM, Austoni M, Fassetta G, Bottazzo G, Bates D, Cartlidge N, Solimena M, Kilimann MW | title = The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer | journal = The Journal of Experimental Medicine | volume = 178 | issue = 6 | pages = 2219–23 | date = December 1993 | pmid = 8245793 | pmc = 2191289 | doi = 10.1084/jem.178.6.2219 | displayauthors = 8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AMPH amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=273| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)
| HGNCid = 471
| Symbol = AMPH
| AltSymbols =; AMPH1
| OMIM = 600418
| ECnumber = 
| Homologene = 36072
| MGIid = 103574
| GeneAtlas_image1 = PBB_GE_AMPH_205257_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 273
    | Hs_Ensembl = ENSG00000078053
    | Hs_RefseqProtein = NP_001626
    | Hs_RefseqmRNA = NM_001635
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 38389832
    | Hs_GenLoc_end = 38637545
    | Hs_Uniprot = P49418
    | Mm_EntrezGene = 218038
    | Mm_Ensembl = ENSMUSG00000021314
    | Mm_RefseqmRNA = NM_175007
    | Mm_RefseqProtein = NP_778172
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 18955836
    | Mm_GenLoc_end = 19158380
    | Mm_Uniprot = Q80YA2
  }}
}}
'''Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)''', also known as '''AMPH''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AMPH amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=273| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with [[stiff person syndrome]] who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: AMPH amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=273| accessdate = }}</ref>
}}


Amphiphysin is a brain-enriched [[protein]] with an N-terminal [[lipid]] interaction, dimerisation and [[cell membrane|membrane]] bending [[BAR domain]], a middle [[clathrin]] and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of [[dynamin]] to sites of clathrin-mediated [[endocytosis]]. There are 2 mammalian amphiphysins with similar overall structure. A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in [[muscle]] [[biological tissue|tissue]] and is involved in the formation and stabilization of the T-tubule network. In other tissues amphiphysin is likely involved in other membrane bending and curvature stabilization events.
Amphiphysin is a brain-enriched [[protein]] with an N-terminal [[lipid]] interaction, dimerisation and [[cell membrane|membrane]] bending [[BAR domain]], a middle [[clathrin]] and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of [[dynamin]] to sites of clathrin-mediated [[endocytosis]]. There are 2 mammalian amphiphysins with similar overall structure. A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in [[muscle]] [[biological tissue|tissue]] and is involved in the formation and stabilization of the T-tubule network. In other tissues amphiphysin is likely involved in other membrane bending and curvature stabilization events.


==See also==
== Interactions ==
 
Amphiphysin has been shown to [[Protein-protein_interaction|interact]] with [[DNM1]],<ref name=pmid9341169>{{cite journal | vauthors = Micheva KD, Kay BK, McPherson PS | title = Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin | journal = The Journal of Biological Chemistry | volume = 272 | issue = 43 | pages = 27239–45 | date = October 1997 | pmid = 9341169 | doi = 10.1074/jbc.272.43.27239 }}</ref><ref name=pmid9348539>{{cite journal | vauthors = Wigge P, Köhler K, Vallis Y, Doyle CA, Owen D, Hunt SP, McMahon HT | title = Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis | journal = Molecular Biology of the Cell | volume = 8 | issue = 10 | pages = 2003–15 | date = October 1997 | pmid = 9348539 | pmc = 25662 | doi = 10.1091/mbc.8.10.2003 }}</ref><ref name=pmid9280305>{{cite journal | vauthors = McMahon HT, Wigge P, Smith C | title = Clathrin interacts specifically with amphiphysin and is displaced by dynamin | journal = FEBS Letters | volume = 413 | issue = 2 | pages = 319–22 | date = August 1997 | pmid = 9280305 | doi = 10.1016/S0014-5793(97)00928-9 }}</ref><ref name=pmid11877424>{{cite journal | vauthors = Chen-Hwang MC, Chen HR, Elzinga M, Hwang YW | title = Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate | journal = The Journal of Biological Chemistry | volume = 277 | issue = 20 | pages = 17597–604 | date = May 2002 | pmid = 11877424 | doi = 10.1074/jbc.M111101200 }}</ref><ref name=pmid9148966>{{cite journal | vauthors = Grabs D, Slepnev VI, Songyang Z, David C, Lynch M, Cantley LC, De Camilli P | title = The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence | journal = The Journal of Biological Chemistry | volume = 272 | issue = 20 | pages = 13419–25 | date = May 1997 | pmid = 9148966 | doi = 10.1074/jbc.272.20.13419 }}</ref> [[Phospholipase D1]],<ref name=pmid10764771>{{cite journal | vauthors = Lee C, Kim SR, Chung JK, Frohman MA, Kilimann MW, Rhee SG | title = Inhibition of phospholipase D by amphiphysins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 25 | pages = 18751–8 | date = June 2000 | pmid = 10764771 | doi = 10.1074/jbc.M001695200 }}</ref> [[CDK5R1]],<ref name=pmid11113134>{{cite journal | vauthors = Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P | title = Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 11 | pages = 8104–10 | date = March 2001 | pmid = 11113134 | doi = 10.1074/jbc.M008932200 }}</ref> [[PLD2]],<ref name=pmid10764771/> [[CABIN1]]<ref name=pmid10931822>{{cite journal | vauthors = Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH | title = The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis | journal = The Journal of Biological Chemistry | volume = 275 | issue = 44 | pages = 34017–20 | date = November 2000 | pmid = 10931822 | doi = 10.1074/jbc.C000429200 }}</ref> and [[SH3GL2]].<ref name=pmid9341169/><ref name=pmid12456676>{{cite journal | vauthors = Modregger J, Schmidt AA, Ritter B, Huttner WB, Plomann M | title = Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 6 | pages = 4160–7 | date = February 2003 | pmid = 12456676 | doi = 10.1074/jbc.M208568200 }}</ref>
 
== See also ==
* [[AP180]]
* [[AP180]]
* [[Epsin]]
* [[Epsin]]
==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|33em}}
| citations =
* {{cite journal | vauthors = Lichte B, Veh RW, Meyer HE, Kilimann MW | title = Amphiphysin, a novel protein associated with synaptic vesicles | journal = The EMBO Journal | volume = 11 | issue = 7 | pages = 2521–30 | date = July 1992 | pmid = 1628617 | pmc = 556727 }}
*{{cite journal | author=Lichte B, Veh RW, Meyer HE, Kilimann MW |title=Amphiphysin, a novel protein associated with synaptic vesicles. |journal=EMBO J. |volume=11 |issue= 7 |pages= 2521-30 |year= 1992 |pmid= 1628617 |doi= }}
* {{cite journal | vauthors = Yamamoto R, Li X, Winter S, Francke U, Kilimann MW | title = Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14 | journal = Human Molecular Genetics | volume = 4 | issue = 2 | pages = 265–8 | date = February 1995 | pmid = 7757077 | doi = 10.1093/hmg/4.2.265 }}
*{{cite journal | author=Yamamoto R, Li X, Winter S, ''et al.'' |title=Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14. |journal=Hum. Mol. Genet. |volume=4 |issue= 2 |pages= 265-8 |year= 1995 |pmid= 7757077 |doi= }}
* {{cite journal | vauthors = David C, Solimena M, De Camilli P | title = Autoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161 | journal = FEBS Letters | volume = 351 | issue = 1 | pages = 73–9 | date = August 1994 | pmid = 8076697 | doi = 10.1016/0014-5793(94)00826-4 }}
*{{cite journal | author=David C, Solimena M, De Camilli P |title=Autoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161. |journal=FEBS Lett. |volume=351 |issue= 1 |pages= 73-9 |year= 1994 |pmid= 8076697 |doi= }}
* {{cite journal | vauthors = David C, McPherson PS, Mundigl O, de Camilli P | title = A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 1 | pages = 331–5 | date = January 1996 | pmid = 8552632 | pmc = 40232 | doi = 10.1073/pnas.93.1.331 }}
*{{cite journal | author=De Camilli P, Thomas A, Cofiell R, ''et al.'' |title=The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer. |journal=J. Exp. Med. |volume=178 |issue= 6 |pages= 2219-23 |year= 1993 |pmid= 8245793 |doi= }}
* {{cite journal | vauthors = Grabs D, Slepnev VI, Songyang Z, David C, Lynch M, Cantley LC, De Camilli P | title = The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence | journal = The Journal of Biological Chemistry | volume = 272 | issue = 20 | pages = 13419–25 | date = May 1997 | pmid = 9148966 | doi = 10.1074/jbc.272.20.13419 }}
*{{cite journal | author=David C, McPherson PS, Mundigl O, de Camilli P |title=A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 331-5 |year= 1996 |pmid= 8552632 |doi= }}
* {{cite journal | vauthors = Butler MH, David C, Ochoa GC, Freyberg Z, Daniell L, Grabs D, Cremona O, De Camilli P | title = Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle | journal = The Journal of Cell Biology | volume = 137 | issue = 6 | pages = 1355–67 | date = June 1997 | pmid = 9182667 | pmc = 2132527 | doi = 10.1083/jcb.137.6.1355 }}
*{{cite journal | author=Grabs D, Slepnev VI, Songyang Z, ''et al.'' |title=The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. |journal=J. Biol. Chem. |volume=272 |issue= 20 |pages= 13419-25 |year= 1997 |pmid= 9148966 |doi= }}
* {{cite journal | vauthors = Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS | title = Identification and characterization of a nerve terminal-enriched amphiphysin isoform | journal = The Journal of Biological Chemistry | volume = 272 | issue = 26 | pages = 16700–6 | date = June 1997 | pmid = 9195986 | doi = 10.1074/jbc.272.26.16700 }}
*{{cite journal | author=Butler MH, David C, Ochoa GC, ''et al.'' |title=Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle. |journal=J. Cell Biol. |volume=137 |issue= 6 |pages= 1355-67 |year= 1997 |pmid= 9182667 |doi= }}
* {{cite journal | vauthors = McMahon HT, Wigge P, Smith C | title = Clathrin interacts specifically with amphiphysin and is displaced by dynamin | journal = FEBS Letters | volume = 413 | issue = 2 | pages = 319–22 | date = August 1997 | pmid = 9280305 | doi = 10.1016/S0014-5793(97)00928-9 }}
*{{cite journal | author=Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS |title=Identification and characterization of a nerve terminal-enriched amphiphysin isoform. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16700-6 |year= 1997 |pmid= 9195986 |doi= }}
* {{cite journal | vauthors = Micheva KD, Ramjaun AR, Kay BK, McPherson PS | title = SH3 domain-dependent interactions of endophilin with amphiphysin | journal = FEBS Letters | volume = 414 | issue = 2 | pages = 308–12 | date = September 1997 | pmid = 9315708 | doi = 10.1016/S0014-5793(97)01016-8 }}
*{{cite journal | author=McMahon HT, Wigge P, Smith C |title=Clathrin interacts specifically with amphiphysin and is displaced by dynamin. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 319-22 |year= 1997 |pmid= 9280305 |doi= }}
* {{cite journal | vauthors = Wigge P, Köhler K, Vallis Y, Doyle CA, Owen D, Hunt SP, McMahon HT | title = Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis | journal = Molecular Biology of the Cell | volume = 8 | issue = 10 | pages = 2003–15 | date = October 1997 | pmid = 9348539 | pmc = 25662 | doi = 10.1091/mbc.8.10.2003 }}
*{{cite journal | author=Micheva KD, Ramjaun AR, Kay BK, McPherson PS |title=SH3 domain-dependent interactions of endophilin with amphiphysin. |journal=FEBS Lett. |volume=414 |issue= 2 |pages= 308-12 |year= 1997 |pmid= 9315708 |doi= }}
* {{cite journal | vauthors = Floyd S, Butler MH, Cremona O, David C, Freyberg Z, Zhang X, Solimena M, Tokunaga A, Ishizu H, Tsutsui K, De Camilli P | title = Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer | journal = Molecular Medicine | volume = 4 | issue = 1 | pages = 29–39 | date = January 1998 | pmid = 9513187 | pmc = 2230265 | displayauthors = 8 }}
*{{cite journal | author=Wigge P, Köhler K, Vallis Y, ''et al.'' |title=Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. |journal=Mol. Biol. Cell |volume=8 |issue= 10 |pages= 2003-15 |year= 1997 |pmid= 9348539 |doi= }}
* {{cite journal | vauthors = Ramjaun AR, McPherson PS | title = Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites | journal = Journal of Neurochemistry | volume = 70 | issue = 6 | pages = 2369–76 | date = June 1998 | pmid = 9603201 | doi = 10.1046/j.1471-4159.1998.70062369.x }}
*{{cite journal | author=Floyd S, Butler MH, Cremona O, ''et al.'' |title=Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. |journal=Mol. Med. |volume=4 |issue= 1 |pages= 29-39 |year= 1998 |pmid= 9513187 |doi= }}
* {{cite journal | vauthors = Slepnev VI, Ochoa GC, Butler MH, Grabs D, De Camilli P | title = Role of phosphorylation in regulation of the assembly of endocytic coat complexes | journal = Science | volume = 281 | issue = 5378 | pages = 821–4 | date = August 1998 | pmid = 9694653 | doi = 10.1126/science.281.5378.821 }}
*{{cite journal | author=Ramjaun AR, McPherson PS |title=Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites. |journal=J. Neurochem. |volume=70 |issue= 6 |pages= 2369-76 |year= 1998 |pmid= 9603201 |doi= }}
* {{cite journal | vauthors = Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N, Hoffmüller U, Schneider-Mergener J, Cesareni G | title = The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity | journal = The Journal of Biological Chemistry | volume = 274 | issue = 45 | pages = 32001–7 | date = November 1999 | pmid = 10542231 | doi = 10.1074/jbc.274.45.32001 }}
*{{cite journal | author=Slepnev VI, Ochoa GC, Butler MH, ''et al.'' |title=Role of phosphorylation in regulation of the assembly of endocytic coat complexes. |journal=Science |volume=281 |issue= 5378 |pages= 821-4 |year= 1998 |pmid= 9694653 |doi= }}
* {{cite journal | vauthors = Slepnev VI, Ochoa GC, Butler MH, De Camilli P | title = Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites | journal = The Journal of Biological Chemistry | volume = 275 | issue = 23 | pages = 17583–9 | date = June 2000 | pmid = 10748223 | doi = 10.1074/jbc.M910430199 }}
*{{cite journal | author=Cestra G, Castagnoli L, Dente L, ''et al.'' |title=The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32001-7 |year= 1999 |pmid= 10542231 |doi= }}
* {{cite journal | vauthors = Lee C, Kim SR, Chung JK, Frohman MA, Kilimann MW, Rhee SG | title = Inhibition of phospholipase D by amphiphysins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 25 | pages = 18751–8 | date = June 2000 | pmid = 10764771 | doi = 10.1074/jbc.M001695200 }}
*{{cite journal | author=Slepnev VI, Ochoa GC, Butler MH, De Camilli P |title=Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17583-9 |year= 2000 |pmid= 10748223 |doi= 10.1074/jbc.M910430199 }}
* {{cite journal | vauthors = Onofri F, Giovedi S, Kao HT, Valtorta F, Bongiorno Borbone L, De Camilli P, Greengard P, Benfenati F | title = Specificity of the binding of synapsin I to Src homology 3 domains | journal = The Journal of Biological Chemistry | volume = 275 | issue = 38 | pages = 29857–67 | date = September 2000 | pmid = 10899172 | doi = 10.1074/jbc.M006018200 }}
*{{cite journal | author=Lee C, Kim SR, Chung JK, ''et al.'' |title=Inhibition of phospholipase D by amphiphysins. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 18751-8 |year= 2000 |pmid= 10764771 |doi= 10.1074/jbc.M001695200 }}
* {{cite journal | vauthors = Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH | title = The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis | journal = The Journal of Biological Chemistry | volume = 275 | issue = 44 | pages = 34017–20 | date = November 2000 | pmid = 10931822 | doi = 10.1074/jbc.C000429200 }}
*{{cite journal | author=Onofri F, Giovedi S, Kao HT, ''et al.'' |title=Specificity of the binding of synapsin I to Src homology 3 domains. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29857-67 |year= 2000 |pmid= 10899172 |doi= 10.1074/jbc.M006018200 }}
* {{cite journal | vauthors = Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P | title = Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 11 | pages = 8104–10 | date = March 2001 | pmid = 11113134 | doi = 10.1074/jbc.M008932200 }}
*{{cite journal | author=Lai MM, Luo HR, Burnett PE, ''et al.'' |title=The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34017-20 |year= 2000 |pmid= 10931822 |doi= 10.1074/jbc.C000429200 }}
* {{cite journal | vauthors = Leventis PA, Chow BM, Stewart BA, Iyengar B, Campos AR, Boulianne GL | title = Drosophila Amphiphysin is a post-synaptic protein required for normal locomotion but not endocytosis | journal = Traffic | volume = 2 | issue = 11 | pages = 839–50 | date = November 2001 | pmid = 11733051 | doi = 10.1034/j.1600-0854.2001.21113.x }}
*{{cite journal | author=Floyd SR, Porro EB, Slepnev VI, ''et al.'' |title=Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8104-10 |year= 2001 |pmid= 11113134 |doi= 10.1074/jbc.M008932200 }}
* {{cite journal | vauthors = Zhang B, Zelhof AC | title = Amphiphysins: raising the BAR for synaptic vesicle recycling and membrane dynamics. Bin-Amphiphysin-Rvsp | journal = Traffic | volume = 3 | issue = 7 | pages = 452–60 | date = July 2002 | pmid = 12047553 | doi = 10.1034/j.1600-0854.2002.30702.x }} Review.
}}
* {{cite journal | vauthors = Zelhof AC, Bao H, Hardy RW, Razzaq A, Zhang B, Doe CQ | title = Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis | journal = Development | volume = 128 | issue = 24 | pages = 5005–15 | date = December 2001 | pmid = 11748137 }}
* {{cite journal | vauthors = Mathew D, Popescu A, Budnik V | title = Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling | journal = The Journal of Neuroscience | volume = 23 | issue = 33 | pages = 10710–6 | date = November 2003 | pmid = 14627656 }}
* {{cite journal | vauthors = Takei K, Slepnev VI, Haucke V, De Camilli P | title = Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis | journal = Nature Cell Biology | volume = 1 | issue = 1 | pages = 33–9 | date = May 1999 | pmid = 10559861 | doi = 10.1038/9004 }}
* {{cite journal | vauthors = Peter BJ, Kent HM, Mills IG, Vallis Y, Butler PJ, Evans PR, McMahon HT | title = BAR domains as sensors of membrane curvature: the amphiphysin BAR structure | journal = Science | volume = 303 | issue = 5657 | pages = 495–9 | date = January 2004 | pmid = 14645856 | doi = 10.1126/science.1092586 | url = http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=14645856 }}
* {{cite journal | vauthors = Evergren E, Marcucci M, Tomilin N, Löw P, Slepnev V, Andersson F, Gad H, Brodin L, De Camilli P, Shupliakov O | title = Amphiphysin is a component of clathrin coats formed during synaptic vesicle recycling at the lamprey giant synapse | journal = Traffic | volume = 5 | issue = 7 | pages = 514–28 | date = July 2004 | pmid = 15180828 | doi = 10.1111/j.1398-9219.2004.00198.x | url = http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1398-9219&date=2004&volume=5&issue=7&spage=514 | displayauthors = 8 }}
* {{cite journal | vauthors = Razzaq A, Robinson IM, McMahon HT, Skepper JN, Su Y, Zelhof AC, Jackson AP, Gay NJ, O'Kane CJ | title = Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila | journal = Genes & Development | volume = 15 | issue = 22 | pages = 2967–79 | date = November 2001 | pmid = 11711432 | pmc = 312829 | doi = 10.1101/gad.207801 | url = http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11711432 }}
{{refend}}
{{refend}}


== External links ==
== External links ==
* [http://www.endocytosis.org/Amphiphysin/amphiphysin.html Bringing your curves to the bar, amphiphysin home page]
* [http://www.endocytosis.org/Amphiphysin/amphiphysin.html Bringing your curves to the bar, amphiphysin home page]
*http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10559861&query_hl=3&itool=pubmed_docsum
* {{UCSC gene info|AMPH}}
*http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14645856&query_hl=1&itool=pubmed_docsum
*http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15180828&query_hl=3&itool=pubmed_docsum
*http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11711432&query_hl=6&itool=pubmed_docsum


{{protein-stub}}
[[Category:Proteins]]

Latest revision as of 03:03, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human

Amphiphysin is a protein that in humans is encoded by the AMPH gene.[1][2]

Function

This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff person syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.[2]

Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of dynamin to sites of clathrin-mediated endocytosis. There are 2 mammalian amphiphysins with similar overall structure. A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in muscle tissue and is involved in the formation and stabilization of the T-tubule network. In other tissues amphiphysin is likely involved in other membrane bending and curvature stabilization events.

Interactions

Amphiphysin has been shown to interact with DNM1,[3][4][5][6][7] Phospholipase D1,[8] CDK5R1,[9] PLD2,[8] CABIN1[10] and SH3GL2.[3][11]

See also

References

  1. ↑ De Camilli P, Thomas A, Cofiell R, Folli F, Lichte B, Piccolo G, Meinck HM, Austoni M, et al. (December 1993). "The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer". The Journal of Experimental Medicine. 178 (6): 2219–23. doi:10.1084/jem.178.6.2219. PMC 2191289. PMID 8245793.
  2. ↑ 2.0 2.1 "Entrez Gene: AMPH amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)".
  3. ↑ 3.0 3.1 Micheva KD, Kay BK, McPherson PS (October 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". The Journal of Biological Chemistry. 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. PMID 9341169.
  4. ↑ Wigge P, Köhler K, Vallis Y, Doyle CA, Owen D, Hunt SP, McMahon HT (October 1997). "Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis". Molecular Biology of the Cell. 8 (10): 2003–15. doi:10.1091/mbc.8.10.2003. PMC 25662. PMID 9348539.
  5. ↑ McMahon HT, Wigge P, Smith C (August 1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin". FEBS Letters. 413 (2): 319–22. doi:10.1016/S0014-5793(97)00928-9. PMID 9280305.
  6. ↑ Chen-Hwang MC, Chen HR, Elzinga M, Hwang YW (May 2002). "Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate". The Journal of Biological Chemistry. 277 (20): 17597–604. doi:10.1074/jbc.M111101200. PMID 11877424.
  7. ↑ Grabs D, Slepnev VI, Songyang Z, David C, Lynch M, Cantley LC, De Camilli P (May 1997). "The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence". The Journal of Biological Chemistry. 272 (20): 13419–25. doi:10.1074/jbc.272.20.13419. PMID 9148966.
  8. ↑ 8.0 8.1 Lee C, Kim SR, Chung JK, Frohman MA, Kilimann MW, Rhee SG (June 2000). "Inhibition of phospholipase D by amphiphysins". The Journal of Biological Chemistry. 275 (25): 18751–8. doi:10.1074/jbc.M001695200. PMID 10764771.
  9. ↑ Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P (March 2001). "Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2". The Journal of Biological Chemistry. 276 (11): 8104–10. doi:10.1074/jbc.M008932200. PMID 11113134.
  10. ↑ Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH (November 2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". The Journal of Biological Chemistry. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
  11. ↑ Modregger J, Schmidt AA, Ritter B, Huttner WB, Plomann M (February 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". The Journal of Biological Chemistry. 278 (6): 4160–7. doi:10.1074/jbc.M208568200. PMID 12456676.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=Amphiphysin&oldid=1422011"