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{{Infobox_gene}}
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'''Neuronal cell adhesion molecule''' is a [[protein]] that in humans is encoded by the ''NRCAM'' [[gene]].<ref name="pmid8812479">{{cite journal | vauthors = Lane RP, Chen XN, Yamakawa K, Vielmetter J, Korenberg JR, Dreyer WJ | title = Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31 | journal = Genomics | volume = 35 | issue = 3 | pages = 456–65 |date=Dec 1996 | pmid = 8812479 | pmc =  | doi = 10.1006/geno.1996.0385 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NRCAM neuronal cell adhesion molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4897| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_NRCAM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uen.
| PDB = {{PDB2|1uen}}, {{PDB2|1uey}}
| Name = Neuronal cell adhesion molecule
| HGNCid = 7994
| Symbol = NRCAM
| AltSymbols =; KIAA0343; MGC138845; MGC138846
| OMIM = 601581
| ECnumber =
| Homologene = 21041
| MGIid = 104750
  | GeneAtlas_image1 = PBB_GE_NRCAM_204105_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NRCAM_216959_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030506 |text = ankyrin binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0043005 |text = neuron projection}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0007413 |text = axonal fasciculation}} {{GNF_GO|id=GO:0007416 |text = synaptogenesis}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0030516 |text = regulation of axon extension}} {{GNF_GO|id=GO:0045162 |text = clustering of voltage-gated sodium channels}} {{GNF_GO|id=GO:0045666 |text = positive regulation of neuron differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4897
    | Hs_Ensembl = ENSG00000091129
    | Hs_RefseqProtein = NP_001032209
    | Hs_RefseqmRNA = NM_001037132
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 107575318
    | Hs_GenLoc_end = 107884062
    | Hs_Uniprot = Q92823
    | Mm_EntrezGene = 319504
    | Mm_Ensembl = ENSMUSG00000020598
    | Mm_RefseqmRNA = NM_176930
    | Mm_RefseqProtein = NP_795904
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 45199270
    | Mm_GenLoc_end = 45469135
    | Mm_Uniprot = Q6QRP1
  }}
}}
'''Neuronal cell adhesion molecule''', also known as '''NRCAM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NRCAM neuronal cell adhesion molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4897| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: NRCAM neuronal cell adhesion molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4897| accessdate = }}</ref>
| summary_text = [[Cell adhesion molecules]] (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism<ref>{{cite journal |journal= Int J Neuropsychopharmacol |year=2008 |title= Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism  |vauthors=Marui T, Funatogawa I, Koishi S, etal |doi=10.1017/S1461145708009127 |pmid=18664314 |volume= 12 |issue= 1 |pages= 1–10}}</ref> and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Grumet M |title=Nr-CAM: a cell adhesion molecule with ligand and receptor functions. |journal=Cell Tissue Res. |volume=290 |issue= 2 |pages= 423-8 |year= 1997 |pmid= 9321706 |doi=  }}
*{{cite journal  | author=Grumet M |title=Nr-CAM: a cell adhesion molecule with ligand and receptor functions |journal=Cell Tissue Res. |volume=290 |issue= 2 |pages= 423–8 |year= 1997 |pmid= 9321706 |doi=10.1007/s004410050949 }}
*{{cite journal | author=Lane RP, Chen XN, Yamakawa K, ''et al.'' |title=Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31. |journal=Genomics |volume=35 |issue= 3 |pages= 456-65 |year= 1996 |pmid= 8812479 |doi= 10.1006/geno.1996.0385 }}
*{{cite journal   |vauthors=Sakurai T, Lustig M, Nativ M, etal |title=Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta |journal=J. Cell Biol. |volume=136 |issue= 4 |pages= 907–18 |year= 1997 |pmid= 9049255 |doi=10.1083/jcb.136.4.907  | pmc=2132488  }}
*{{cite journal | author=Sakurai T, Lustig M, Nativ M, ''et al.'' |title=Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. |journal=J. Cell Biol. |volume=136 |issue= 4 |pages= 907-18 |year= 1997 |pmid= 9049255 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Nakajima D, etal |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=10.1093/dnares/4.2.141 }}
*{{cite journal | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi= }}
*{{cite journal   |vauthors=Wang B, Williams H, Du JS, etal |title=Alternative splicing of human NrCAM in neural and nonneural tissues |journal=Mol. Cell. Neurosci. |volume=10 |issue= 5–6 |pages= 287–95 |year= 1998 |pmid= 9604207 |doi= 10.1006/mcne.1997.0658 }}
*{{cite journal  | author=Wang B, Williams H, Du JS, ''et al.'' |title=Alternative splicing of human NrCAM in neural and nonneural tissues. |journal=Mol. Cell. Neurosci. |volume=10 |issue= 5-6 |pages= 287-95 |year= 1998 |pmid= 9604207 |doi= 10.1006/mcne.1997.0658 }}
*{{cite journal  | vauthors=Moré MI, Kirsch FP, Rathjen FG |title=Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation |journal=J. Cell Biol. |volume=154 |issue= 1 |pages= 187–96 |year= 2001 |pmid= 11449000 |doi=10.1083/jcb.200104038  | pmc=2196853  }}
*{{cite journal  | author=Moré MI, Kirsch FP, Rathjen FG |title=Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation. |journal=J. Cell Biol. |volume=154 |issue= 1 |pages= 187-96 |year= 2001 |pmid= 11449000 |doi=  }}
*{{cite journal  | vauthors=Dry K, Kenwrick S, Rosenthal A, Platzer M |title=The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily |journal=Gene |volume=273 |issue= 1 |pages= 115–22 |year= 2001 |pmid= 11483367 |doi=10.1016/S0378-1119(01)00493-0 }}
*{{cite journal  | author=Dry K, Kenwrick S, Rosenthal A, Platzer M |title=The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily. |journal=Gene |volume=273 |issue= 1 |pages= 115-22 |year= 2001 |pmid= 11483367 |doi=  }}
*{{cite journal  | vauthors=Jenkins SM, Bennett V |title=Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 739–46 |year= 2002 |pmid= 11724816 |doi= 10.1083/jcb.200109026 | pmc=2150881 }}
*{{cite journal | author=Jenkins SM, Bennett V |title=Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 739-46 |year= 2002 |pmid= 11724816 |doi= 10.1083/jcb.200109026 }}
*{{cite journal   |vauthors=Aitkenhead M, Wang SJ, Nakatsu MN, etal |title=Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM |journal=Microvasc. Res. |volume=63 |issue= 2 |pages= 159–71 |year= 2002 |pmid= 11866539 |doi= 10.1006/mvre.2001.2380 }}
*{{cite journal | author=Aitkenhead M, Wang SJ, Nakatsu MN, ''et al.'' |title=Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. |journal=Microvasc. Res. |volume=63 |issue= 2 |pages= 159-71 |year= 2002 |pmid= 11866539 |doi= 10.1006/mvre.2001.2380 }}
*{{cite journal   |vauthors=Pavlou O, Theodorakis K, Falk J, etal |title=Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members |journal=Mol. Cell. Neurosci. |volume=20 |issue= 3 |pages= 367–81 |year= 2002 |pmid= 12139915 |doi=10.1006/mcne.2002.1105  }}
*{{cite journal | author=Pavlou O, Theodorakis K, Falk J, ''et al.'' |title=Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members. |journal=Mol. Cell. Neurosci. |volume=20 |issue= 3 |pages= 367-81 |year= 2002 |pmid= 12139915 |doi= }}
*{{cite journal   |vauthors=Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, etal |title=Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis |journal=Genes Dev. |volume=16 |issue= 16 |pages= 2058–72 |year= 2002 |pmid= 12183361 |doi= 10.1101/gad.227502  | pmc=186445 }}
*{{cite journal  | author=Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, ''et al.'' |title=Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. |journal=Genes Dev. |volume=16 |issue= 16 |pages= 2058-72 |year= 2002 |pmid= 12183361 |doi= 10.1101/gad.227502 }}
*{{cite journal  | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902  | pmc=187542 }}
*{{cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Custer AW, Kazarinova-Noyes K, Sakurai T, etal |title=The role of the ankyrin-binding protein NrCAM in node of Ranvier formation |journal=J. Neurosci. |volume=23 |issue= 31 |pages= 10032–9 |year= 2003 |pmid= 14602817 |doi= }}
*{{cite journal | author=Custer AW, Kazarinova-Noyes K, Sakurai T, ''et al.'' |title=The role of the ankyrin-binding protein NrCAM in node of Ranvier formation. |journal=J. Neurosci. |volume=23 |issue= 31 |pages= 10032-9 |year= 2003 |pmid= 14602817 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Hutcheson HB, Olson LM, Bradford Y, etal |title=Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes |journal=BMC Med. Genet. |volume=5|pages= 12 |year= 2004 |pmid= 15128462 |doi= 10.1186/1471-2350-5-12 | pmc=420465 }}
*{{cite journal | author=Hutcheson HB, Olson LM, Bradford Y, ''et al.'' |title=Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes. |journal=BMC Med. Genet. |volume=5 |issue=  |pages= 12 |year= 2004 |pmid= 15128462 |doi= 10.1186/1471-2350-5-12 }}
*{{cite journal   |vauthors=Bonora E, Lamb JA, Barnby G, etal |title=Mutation screening and association analysis of six candidate genes for autism on chromosome 7q |journal=Eur. J. Hum. Genet. |volume=13 |issue= 2 |pages= 198–207 |year= 2005 |pmid= 15523497 |doi= 10.1038/sj.ejhg.5201315 }}
*{{cite journal | author=Bonora E, Lamb JA, Barnby G, ''et al.'' |title=Mutation screening and association analysis of six candidate genes for autism on chromosome 7q. |journal=Eur. J. Hum. Genet. |volume=13 |issue= 2 |pages= 198-207 |year= 2005 |pmid= 15523497 |doi= 10.1038/sj.ejhg.5201315 }}
*{{cite journal   |vauthors=Ishiguro H, Liu QR, Gong JP, etal |title=NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice |journal=Neuropsychopharmacology |volume=31 |issue= 3 |pages= 572–84 |year= 2006 |pmid= 16123759 |doi= 10.1038/sj.npp.1300855 }}
*{{cite journal | author=Ishiguro H, Liu QR, Gong JP, ''et al.'' |title=NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. |journal=Neuropsychopharmacology |volume=31 |issue= 3 |pages= 572-84 |year= 2006 |pmid= 16123759 |doi= 10.1038/sj.npp.1300855 }}
}}
}}
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{{refend}}
{{PDB Gallery|geneid=4897}}
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Latest revision as of 13:14, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.[1][2]

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism[3] and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]

References

  1. ↑ Lane RP, Chen XN, Yamakawa K, Vielmetter J, Korenberg JR, Dreyer WJ (Dec 1996). "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31". Genomics. 35 (3): 456–65. doi:10.1006/geno.1996.0385. PMID 8812479.
  2. ↑ 2.0 2.1 "Entrez Gene: NRCAM neuronal cell adhesion molecule".
  3. ↑ Marui T, Funatogawa I, Koishi S, et al. (2008). "Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism". Int J Neuropsychopharmacol. 12 (1): 1–10. doi:10.1017/S1461145708009127. PMID 18664314.

Further reading



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