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{{Infobox_gene}}
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'''Lymphocyte antigen 6E''' is a [[protein]] that in humans is encoded by the ''LY6E'' [[gene]].<ref name="pmid8757598">{{cite journal | vauthors = Capone MC, Gorman DM, Ching EP, Zlotnik A | title = Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family | journal = J Immunol | volume = 157 | issue = 3 | pages = 969–73 | date = Sep 1996 | pmid = 8757598 | pmc =  | doi =  }}</ref><ref name="pmid8650192">{{cite journal | vauthors = Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z | title = RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 12 | pages = 5910–4 | date = Jul 1996 | pmid = 8650192 | pmc = 39161 | doi = 10.1073/pnas.93.12.5910 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4061| accessdate = }}</ref> Increased expression of ''Ly6E'' is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.<ref>{{Cite journal|last=Luo|first=Linlin|last2=McGarvey|first2=Peter|last3=Madhavan|first3=Subha|last4=Kumar|first4=Rakesh|last5=Gusev|first5=Yuriy|last6=Upadhyay|first6=Geeta|date=2016-02-03|title=Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome|journal=Oncotarget|doi=10.18632/oncotarget.7163|issn=1949-2553|pmid=26862846|volume=7|pmc=4905465|pages=11165–93}}</ref> Ly6E is associated with drug resistance and tumor immune escape in breast cancer.<ref>{{Cite journal|last=Hossiny|first=Midrar A.|last2=Luo|first2=Linlin|last3=Frazier|first3=William R.|last4=Steiner|first4=Noriko|last5=Gusev|first5=Yuriy|last6=Kallakury|first6=Bhaskar|last7=Glasgow|first7=Eric|last8=Creswell|first8=Karen|last9=Madhavan|first9=Subha|last10=Kumar|first10=Rakesh|last11=Upadhyay|first11=Geeta|date=2016-04-11|title=Ly6E/K signaling to TGF-ß promotes breast cancer progression, immune escape and drug resistance|url=http://cancerres.aacrjournals.org/content/early/2016/04/08/0008-5472.CAN-15-2654|journal=Cancer Research|language=en|pages=canres.2654.2015|doi=10.1158/0008-5472.CAN-15-2654|issn=0008-5472|volume=76}}</ref> Further research is required to validate Ly6E for translation research. [http://www.telmarc.com/Documents/White%20Papers/133LY6.pdf]
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{Reflist}}
| image = 
| image_source = 
| PDB =
| Name = Lymphocyte antigen 6 complex, locus E
| HGNCid = 6727
| Symbol = LY6E
| AltSymbols =; RIG-E; RIGE; SCA-2; SCA2; TSA-1
| OMIM = 601384
| ECnumber = 
| Homologene = 56411
| MGIid = 106651
| GeneAtlas_image1 = PBB_GE_LY6E_202145_at_tn.png
| Function = {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4061
    | Hs_Ensembl = ENSG00000160932
    | Hs_RefseqProtein = NP_002337
    | Hs_RefseqmRNA = NM_002346
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 144171274
    | Hs_GenLoc_end = 144175190
    | Hs_Uniprot = Q16553
    | Mm_EntrezGene = 17069
    | Mm_Ensembl = ENSMUSG00000022587
    | Mm_RefseqmRNA = NM_008529
    | Mm_RefseqProtein = NP_032555
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 74782872
    | Mm_GenLoc_end = 74787158
    | Mm_Uniprot = Q99JA5
  }}
}}
'''Lymphocyte antigen 6 complex, locus E''', also known as '''LY6E''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4061| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB | title = A gain of novel tissue specificity in the human Ly-6 gene E48 | journal = J. Immunol. | volume = 159 | issue = 10 | pages = 4879–86 | year = 1997 | pmid = 9366413 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Mao M, Yu M, Tong JH, ''et al.'' |title=RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 12 |pages= 5910-4 |year= 1996 |pmid= 8650192 |doi=  }}
* {{cite journal | vauthors = Shan X, Bourdeau A, Rhoton A, Wells DE, Cohen EH, Landgraf BE, Palfree RG | title = Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1 | journal = J. Immunol. | volume = 160 | issue = 1 | pages = 197–208 | year = 1998 | pmid = 9551972 | doi =  }}
*{{cite journal  | author=Capone MC, Gorman DM, Ching EP, Zlotnik A |title=Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family. |journal=J. Immunol. |volume=157 |issue= 3 |pages= 969-73 |year= 1996 |pmid= 8757598 |doi=  }}
* {{cite journal | vauthors = Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T | title = Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex | journal = J. Biol. Chem. | volume = 273 | issue = 20 | pages = 12301–6 | year = 1998 | pmid = 9575182 | doi = 10.1074/jbc.273.20.12301 }}
*{{cite journal | author=Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB |title=A gain of novel tissue specificity in the human Ly-6 gene E48. |journal=J. Immunol. |volume=159 |issue= 10 |pages= 4879-86 |year= 1997 |pmid= 9366413 |doi=  }}
* {{cite journal | vauthors = Ding L, Shevach EM | title = Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen | journal = Immunology | volume = 104 | issue = 1 | pages = 28–36 | year = 2001 | pmid = 11576217 | pmc = 1783287 | doi = 10.1046/j.1365-2567.2001.01275.x }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ | title = Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland | journal = Mol. Cell. Biol. | volume = 22 | issue = 3 | pages = 946–52 | year = 2002 | pmid = 11784869 | pmc = 133557 | doi = 10.1128/MCB.22.3.946-952.2002 }}
*{{cite journal | author=Shan X, Bourdeau A, Rhoton A, ''et al.'' |title=Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1. |journal=J. Immunol. |volume=160 |issue= 1 |pages= 197-208 |year= 1998 |pmid= 9551972 |doi=  }}
* {{cite journal | vauthors = de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, Nieuwenhuis EJ, Stigter-van Walsum M, Snow GB, Brakenhoff RH | title = Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma | journal = Int. J. Cancer | volume = 103 | issue = 6 | pages = 768–74 | year = 2003 | pmid = 12516096 | doi = 10.1002/ijc.10903 }}
*{{cite journal | author=Kosugi A, Saitoh S, Noda S, ''et al.'' |title=Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex. |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12301-6 |year= 1998 |pmid= 9575182 |doi= }}
*{{cite journal | author=Ding L, Shevach EM |title=Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen. |journal=Immunology |volume=104 |issue= 1 |pages= 28-36 |year= 2001 |pmid= 11576217 |doi= }}
*{{cite journal  | author=Tulin EE, Onoda N, Nakata Y, ''et al.'' |title=SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6338-47 |year= 2002 |pmid= 11714798 |doi=  }}
*{{cite journal | author=Zammit DJ, Berzins SP, Gill JW, ''et al.'' |title=Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland. |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 946-52 |year= 2002 |pmid= 11784869 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, ''et al.'' |title=Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma. |journal=Int. J. Cancer |volume=103 |issue= 6 |pages= 768-74 |year= 2003 |pmid= 12516096 |doi= 10.1002/ijc.10903 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:14, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.[1][2][3] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.[4] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.[5] Further research is required to validate Ly6E for translation research. [2]

References

  1. ↑ Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol. 157 (3): 969–73. PMID 8757598.
  2. ↑ Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A. 93 (12): 5910–4. doi:10.1073/pnas.93.12.5910. PMC 39161. PMID 8650192.
  3. ↑ "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E".
  4. ↑ Luo, Linlin; McGarvey, Peter; Madhavan, Subha; Kumar, Rakesh; Gusev, Yuriy; Upadhyay, Geeta (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. 7: 11165–93. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMC 4905465. PMID 26862846.
  5. ↑ Hossiny, Midrar A.; Luo, Linlin; Frazier, William R.; Steiner, Noriko; Gusev, Yuriy; Kallakury, Bhaskar; Glasgow, Eric; Creswell, Karen; Madhavan, Subha; Kumar, Rakesh; Upadhyay, Geeta (2016-04-11). "Ly6E/K signaling to TGF-ß promotes breast cancer progression, immune escape and drug resistance". Cancer Research. 76: canres.2654.2015. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472.

Further reading


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