MAL2 (gene): Difference between revisions
Jump to navigation
Jump to search
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})) |
m (→Further reading: task using AWB) |
||
Line 1: | Line 1: | ||
{{Infobox_gene}} | |||
{{ | '''Protein MAL2''' is a [[protein]] that in humans is encoded by the ''MAL2'' [[gene]].<ref name="pmid11549320">{{cite journal |vauthors=Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA | title = Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system | journal = Genomics | volume = 76 | issue = 1–3 | pages = 81–8 |date=Sep 2001 | pmid = 11549320 | pmc = | doi = 10.1006/geno.2001.6610 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAL2 mal, T-cell differentiation protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114569| accessdate = }}</ref> | ||
}} | |||
{{ | |||
| | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.<ref name="entrez">{{cite web | title = Entrez Gene: MAL2 mal, T-cell differentiation protein 2| url = | | summary_text = This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.<ref name="entrez">{{cite web | title = Entrez Gene: MAL2 mal, T-cell differentiation protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114569| accessdate = }}</ref> | ||
}} | }} | ||
==Interactions== | |||
MAL2 (gene) has been shown to [[Protein-protein interaction|interact]] with [[TPD52]].<ref name=pmid11549320 /> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Marazuela M, Alonso MA |title=Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue |journal=Histol. Histopathol. |volume=19 |issue= 3 |pages= 925–33 |year= 2004 |pmid= 15168355 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Rohan S, Tu JJ, Kao J, etal |title=Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes |journal=Clin. Cancer Res. |volume=12 |issue= 23 |pages= 6937–45 |year= 2007 |pmid= 17145811 |doi= 10.1158/1078-0432.CCR-06-1268 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Barbaric D, Byth K, Dalla-Pozza L, Byrne JA |title=Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations |journal=Leuk. Res. |volume=30 |issue= 11 |pages= 1355–63 |year= 2007 |pmid= 16620967 |doi= 10.1016/j.leukres.2006.03.009 }} | ||
*{{cite journal | | *{{cite journal |vauthors=de Marco MC, Puertollano R, Martínez-Menárguez JA, Alonso MA |title=Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells |journal=Traffic |volume=7 |issue= 1 |pages= 61–73 |year= 2006 |pmid= 16445687 |doi= 10.1111/j.1600-0854.2005.00361.x }} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Llorente A, de Marco MC, Alonso MA |title=Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line |journal=J. Cell Sci. |volume=117 |issue= Pt 22 |pages= 5343–51 |year= 2005 |pmid= 15466889 |doi= 10.1242/jcs.01420 }} | ||
*{{cite journal | *{{cite journal |vauthors=Marazuela M, Acevedo A, García-López MA, etal |title=Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia |journal=J. Histochem. Cytochem. |volume=52 |issue= 2 |pages= 243–52 |year= 2004 |pmid= 14729876 |doi= 10.1177/002215540405200212}} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Marazuela M, Martín-Belmonte F, García-López MA, etal |title=Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells |journal=Endocrinology |volume=145 |issue= 2 |pages= 1011–6 |year= 2004 |pmid= 14576188 |doi= 10.1210/en.2003-0652 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Boutros R, Bailey AM, Wilson SH, Byrne JA |title=Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins |journal=J. Mol. Biol. |volume=332 |issue= 3 |pages= 675–87 |year= 2003 |pmid= 12963375 |doi=10.1016/S0022-2836(03)00944-6 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=de Marco MC, Martín-Belmonte F, Kremer L, etal |title=MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells |journal=J. Cell Biol. |volume=159 |issue= 1 |pages= 37–44 |year= 2002 |pmid= 12370246 |doi= 10.1083/jcb.200206033 | pmc=2173496 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{ | <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> | ||
{{ | {{PBB_Controls | ||
| update_page = yes | |||
| require_manual_inspection = no | |||
| update_protein_box = yes | |||
| update_summary = yes | |||
| update_citations = yes | |||
}} | |||
{{gene-8-stub}} |
Latest revision as of 20:16, 8 November 2017
VALUE_ERROR (nil) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Aliases | |||||||
External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
|
| |||||
Ensembl |
|
| |||||
UniProt |
|
| |||||
RefSeq (mRNA) |
|
| |||||
RefSeq (protein) |
|
| |||||
Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
|
Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.[1][2]
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.[2]
Interactions
MAL2 (gene) has been shown to interact with TPD52.[1]
References
- ↑ 1.0 1.1 Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (Sep 2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
- ↑ 2.0 2.1 "Entrez Gene: MAL2 mal, T-cell differentiation protein 2".
Further reading
- Marazuela M, Alonso MA (2004). "Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue". Histol. Histopathol. 19 (3): 925–33. PMID 15168355.
- Rohan S, Tu JJ, Kao J, et al. (2007). "Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes". Clin. Cancer Res. 12 (23): 6937–45. doi:10.1158/1078-0432.CCR-06-1268. PMID 17145811.
- Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
- de Marco MC, Puertollano R, Martínez-Menárguez JA, Alonso MA (2006). "Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells". Traffic. 7 (1): 61–73. doi:10.1111/j.1600-0854.2005.00361.x. PMID 16445687.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Llorente A, de Marco MC, Alonso MA (2005). "Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line". J. Cell Sci. 117 (Pt 22): 5343–51. doi:10.1242/jcs.01420. PMID 15466889.
- Marazuela M, Acevedo A, García-López MA, et al. (2004). "Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia". J. Histochem. Cytochem. 52 (2): 243–52. doi:10.1177/002215540405200212. PMID 14729876.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Marazuela M, Martín-Belmonte F, García-López MA, et al. (2004). "Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells". Endocrinology. 145 (2): 1011–6. doi:10.1210/en.2003-0652. PMID 14576188.
- Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins". J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- de Marco MC, Martín-Belmonte F, Kremer L, et al. (2002). "MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells". J. Cell Biol. 159 (1): 37–44. doi:10.1083/jcb.200206033. PMC 2173496. PMID 12370246.
This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it. |